LOCUS       NM_001166157            1857 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus keratin 81 (Krt81), mRNA.
ACCESSION   NM_001166157
VERSION     NM_001166157.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1857)
  AUTHORS   Fleger-Weckmann,A., Ustun,Y., Kloepper,J., Paus,R., Bloch,W.,
            Chen,Z.L., Wegner,J., Sorokin,L., Langbein,L., Eckes,B.,
            Zigrino,P., Krieg,T. and Nischt,R.
  TITLE     Deletion of the epidermis derived laminin gamma1 chain leads to
            defects in the regulation of late hair morphogenesis
  JOURNAL   Matrix Biol 56, 42-56 (2016)
   PUBMED   27234308
REFERENCE   2  (bases 1 to 1857)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   3  (bases 1 to 1857)
  AUTHORS   Poirier,C., Yoshiki,A., Fujiwara,K., Guenet,J.L. and Kusakabe,M.
  TITLE     Hague (Hag). A new mouse hair mutation with an unstable
            semidominant allele
  JOURNAL   Genetics 162 (2), 831-840 (2002)
   PUBMED   12399393
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC103674.10 and AC157583.9.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF312018.1, SRR7345562.2074496.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN04095722
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-437               AC103674.10        34563-34999         c
            438-646             AC103674.10        33761-33969         c
            647-707             AC157583.9         185251-185311       c
            708-803             AC157583.9         184790-184885       c
            804-968             AC157583.9         184459-184623       c
            969-1094            AC157583.9         184110-184235       c
            1095-1315           AC157583.9         183613-183833       c
            1316-1347           AC157583.9         183357-183388       c
            1348-1857           AC157583.9         182550-183059       c
FEATURES             Location/Qualifiers
     source          1..1857
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.9 cM"
     gene            1..1857
                     /gene="Krt81"
                     /gene_synonym="Krt2-19"
                     /note="keratin 81"
                     /db_xref="GeneID:64818"
                     /db_xref="MGI:MGI:1928858"
     exon            1..437
                     /gene="Krt81"
                     /gene_synonym="Krt2-19"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1514
                     /gene="Krt81"
                     /gene_synonym="Krt2-19"
                     /note="K81; type II hair keratin Hb1; keratin complex 2,
                     basic, gene 19"
                     /codon_start=1
                     /product="keratin, type II cuticular Hb1"
                     /protein_id="NP_001159629.1"
                     /db_xref="CCDS:CCDS49734.1"
                     /db_xref="GeneID:64818"
                     /db_xref="MGI:MGI:1928858"
                     /translation="MTCGSGFCGRAFSCASACGPRPGRCCISAAPYRGISCYRGLSGG
                     FGSQSVCGAFRSGSCGRSFGYRSGGICGPSPPCITTVSVNESLLTPLNLEIDPNAQCV
                     KHEEKEQIKCLNSKFAAFIDKVRFLEQQNKLLETKWQFYQNRKCCESNMEPLFEGYIE
                     ALRREAECVEADSGRLAAELNHAQESMEGYKKRYEEEVSLRATAENEFVALKKDVDCA
                     YLRKSDLEANAEALTQETDFLRRMYDEETRILHSHISDTSIVVKMDNSRDLNMDCVVA
                     EIKAQYDDIASRSRAEAESWYRTKCEEIKATVIRHGETLRRTREEINELNRMIQRLTA
                     EIENAKCQNTKLEAAVTQSEQQGEAALADARCKLAELEGALQKAKQDMACLLKEYQEV
                     MNSKLGLDVEITTYRRLLEGEEQRLCEGVGAVNVCVSSSRGGVVCGDLCVSGSRPVIG
                     SACSAPCSGNLAVNTGLCAPCGSAVSCGRKC"
     exon            438..646
                     /gene="Krt81"
                     /gene_synonym="Krt2-19"
                     /inference="alignment:Splign:2.1.0"
     exon            647..707
                     /gene="Krt81"
                     /gene_synonym="Krt2-19"
                     /inference="alignment:Splign:2.1.0"
     exon            708..803
                     /gene="Krt81"
                     /gene_synonym="Krt2-19"
                     /inference="alignment:Splign:2.1.0"
     exon            804..968
                     /gene="Krt81"
                     /gene_synonym="Krt2-19"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1094
                     /gene="Krt81"
                     /gene_synonym="Krt2-19"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1315
                     /gene="Krt81"
                     /gene_synonym="Krt2-19"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1347
                     /gene="Krt81"
                     /gene_synonym="Krt2-19"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1857
                     /gene="Krt81"
                     /gene_synonym="Krt2-19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1832..1837
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt81"
                     /gene_synonym="Krt2-19"
                     /note="hexamer: AATAAA"
     polyA_site      1855
                     /gene="Krt81"
                     /gene_synonym="Krt2-19"
                     /note="major polyA site"
ORIGIN      
        1 acattggagc tgccaccagg actacggagc tcccatccag aacgcttcag cccatcttca
       61 gaagcaccat gacctgtgga tcaggattct gtggccgcgc cttcagctgc gcctcagcct
      121 gcggacccag gcccggccgc tgctgcatct ctgcagctcc ctacaggggc atctcctgct
      181 accgcggact ctcagggggc ttcggcagcc agagtgtctg tggggccttc cgctctggct
      241 cctgtggacg cagcttcggg taccgctctg gaggcatctg cgggcccagc ccaccctgca
      301 tcaccaccgt ttctgtcaat gagagcctgc tcacgcccct gaacctggag atcgacccca
      361 atgctcagtg tgtgaagcat gaggagaagg agcagatcaa gtgtctcaac agcaagttcg
      421 cagccttcat cgacaaggtg cgcttcctgg agcagcagaa caagctgctg gagaccaagt
      481 ggcagttcta ccagaaccgc aagtgctgtg agagcaacat ggagcctctg ttcgagggct
      541 acatcgaggc gctgaggcgg gaagctgagt gtgtggaggc cgacagcggg aggctggctg
      601 ctgagctcaa ccatgcacag gagtccatgg agggctacaa gaagagatac gaggaggaag
      661 tttctctgag agccacggcc gagaatgagt ttgtggctct gaagaaggat gtggactgtg
      721 cctacctgcg caagtcagat ctggaggcca acgcagaggc actgacccag gagaccgact
      781 tcctgaggag aatgtatgac gaggagaccc gcatcctcca ttcccacatc tcagacacct
      841 ccatcgtcgt caagatggac aacagccggg acctgaacat ggactgtgtc gtggctgaga
      901 tcaaggctca gtatgatgac attgccagcc gcagccgtgc tgaggctgag tcctggtacc
      961 gcaccaagtg tgaggagata aaggccacag tgatccggca tggagagact ctgcgccgca
     1021 ccagagagga gatcaatgag ctgaacagaa tgatccagag gctgactgct gagatcgaga
     1081 atgccaagtg ccagaacacc aagctggagg ctgctgtgac ccagtctgag cagcagggag
     1141 aggctgccct tgctgatgcc cgctgcaagc tggctgagct ggagggtgcc ctgcagaagg
     1201 ccaagcagga catggcctgc ctgctcaagg agtaccagga ggtgatgaac tccaagctgg
     1261 ggctggacgt tgagatcacc acctacaggc gcctgctgga gggcgaggaa cagagactgt
     1321 gtgaaggtgt aggagctgtg aatgtctgtg tcagcagctc ccgaggagga gtcgtatgtg
     1381 gggacctgtg tgtgtcaggt tccaggccag tgatcggcag tgcctgcagc gccccctgca
     1441 gcgggaactt ggcggtgaac acaggcctgt gcgcaccctg tggttcagct gtgtcctgtg
     1501 gccgtaaatg ttaaaaactg cgttcacatc ctggccctgg catagcattt cgccctgagc
     1561 catctctagc tgaccaatat tgggacctag aacaaggggc tcagtcactt gctcactttg
     1621 aagcgaccct ctcactctag gctcctctgg tctctctaga ccacgccctt gttctcagaa
     1681 gtgaatactg gcttctagaa gtccctttgg agctgcaggg tggggagtct gggggcaggg
     1741 ctagaacacc acctatcctg ccttaactgt gagccagtag ctagagagcc acagtccccc
     1801 ctccctctaa tctttgtctt gatctgtttc caataaatta atgtagtcaa ctctgca
//
