LOCUS       NM_028770               3067 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus keratin 80 (Krt80), mRNA.
ACCESSION   NM_028770 XM_001004637 XM_001004638 XM_001004639 XM_001004642
            XM_283319 XM_895080 XM_902578 XM_902582 XM_916627 XM_924348
            XM_924355 XM_924358
VERSION     NM_028770.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3067)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3067)
  AUTHORS   Morita,R., Sanzen,N., Sasaki,H., Hayashi,T., Umeda,M.,
            Yoshimura,M., Yamamoto,T., Shibata,T., Abe,T., Kiyonari,H.,
            Furuta,Y., Nikaido,I. and Fujiwara,H.
  TITLE     Tracing the origin of hair follicle stem cells
  JOURNAL   Nature 594 (7864), 547-552 (2021)
   PUBMED   34108685
REFERENCE   3  (bases 1 to 3067)
  AUTHORS   Bray,D.J., Walsh,T.R., Noro,M.G. and Notman,R.
  TITLE     Complete Structure of an Epithelial Keratin Dimer: Implications for
            Intermediate Filament Assembly
  JOURNAL   PLoS One 10 (7), e0132706 (2015)
   PUBMED   26181054
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3067)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   5  (bases 1 to 3067)
  AUTHORS   Smithson,G., Beamer,W.G., Shultz,K.L., Christianson,S.W.,
            Shultz,L.D. and Kincade,P.W.
  TITLE     Increased B lymphopoiesis in genetically sex steroid-deficient
            hypogonadal (hpg) mice
  JOURNAL   J Exp Med 180 (2), 717-720 (1994)
   PUBMED   8046347
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB843716.1, BC120601.1, AK004811.2 and AC163018.3.
            
            On Jul 12, 2018 this sequence version replaced NM_028770.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC120601.1, SRR13948564.4200180.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                BB843716.1         2-38
            38-1811             BC120601.1         1-1774
            1812-3059           AK004811.2         1564-2811
            3060-3067           AC163018.3         145758-145765       c
FEATURES             Location/Qualifiers
     source          1..3067
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.78 cM"
     gene            1..3067
                     /gene="Krt80"
                     /gene_synonym="1200016G03Rik; 2310041I20Rik; CK-80; K80;
                     Kb20"
                     /note="keratin 80"
                     /db_xref="GeneID:74127"
                     /db_xref="MGI:MGI:1921377"
     exon            1..408
                     /gene="Krt80"
                     /gene_synonym="1200016G03Rik; 2310041I20Rik; CK-80; K80;
                     Kb20"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1467
                     /gene="Krt80"
                     /gene_synonym="1200016G03Rik; 2310041I20Rik; CK-80; K80;
                     Kb20"
                     /note="cytokeratin-80; type-II keratin Kb20"
                     /codon_start=1
                     /product="keratin, type II cytoskeletal 80"
                     /protein_id="NP_083046.2"
                     /db_xref="CCDS:CCDS37216.1"
                     /db_xref="GeneID:74127"
                     /db_xref="MGI:MGI:1921377"
                     /translation="MAYRSCVVGFSSLSGCEMTPAGSPQPGTSGWGSCGLPGPGFSSR
                     SLTSCRPAGTIPKVTVNPSLLVPLDLKVDPAVQQQKNQEKEEMKALNDKFASLIGKVQ
                     ALEQRNQLLETRWSFLQGQGSATFDLSHHYETFQGRLQEELRKVSQERGQLEANLLQV
                     LEKVEEFRVRYEDEISKRTDLEFTFVQLKKDLDAECLRRTELETKLKGLQGFLELMRT
                     VYEQELKDLTAQVKDVSVTVGLDSRCHIDLSGIVEEVKAQYDAIAARSLEEAEAYSRS
                     QLEERAARSAEFGNSLQSSRCEIADLNVRIQKLRSQIVSVKSHCLKLEENIKVAEEQG
                     ELAFQDAKDKMAQLENALQKAKQDMARQLREYQDLMNTKLALDIEIATYHKLMEGEES
                     RMDLPSATVVSTVKSGCRTTASKSGLTKTSSRKKKNRRGPVIKITEMSEKYLSQESEA
                     SE"
     exon            409..617
                     /gene="Krt80"
                     /gene_synonym="1200016G03Rik; 2310041I20Rik; CK-80; K80;
                     Kb20"
                     /inference="alignment:Splign:2.1.0"
     exon            618..678
                     /gene="Krt80"
                     /gene_synonym="1200016G03Rik; 2310041I20Rik; CK-80; K80;
                     Kb20"
                     /inference="alignment:Splign:2.1.0"
     exon            679..774
                     /gene="Krt80"
                     /gene_synonym="1200016G03Rik; 2310041I20Rik; CK-80; K80;
                     Kb20"
                     /inference="alignment:Splign:2.1.0"
     exon            775..939
                     /gene="Krt80"
                     /gene_synonym="1200016G03Rik; 2310041I20Rik; CK-80; K80;
                     Kb20"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1065
                     /gene="Krt80"
                     /gene_synonym="1200016G03Rik; 2310041I20Rik; CK-80; K80;
                     Kb20"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1286
                     /gene="Krt80"
                     /gene_synonym="1200016G03Rik; 2310041I20Rik; CK-80; K80;
                     Kb20"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1342
                     /gene="Krt80"
                     /gene_synonym="1200016G03Rik; 2310041I20Rik; CK-80; K80;
                     Kb20"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..3067
                     /gene="Krt80"
                     /gene_synonym="1200016G03Rik; 2310041I20Rik; CK-80; K80;
                     Kb20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3038..3043
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt80"
                     /gene_synonym="1200016G03Rik; 2310041I20Rik; CK-80; K80;
                     Kb20"
                     /note="hexamer: AATAAA"
     polyA_site      3062
                     /gene="Krt80"
                     /gene_synonym="1200016G03Rik; 2310041I20Rik; CK-80; K80;
                     Kb20"
                     /note="major polyA site"
ORIGIN      
        1 agtccccagc cggccctgga tgtgacagga ggcggctgcc agccaccaac tccaaatctc
       61 cctagctcac tggtgagccc tccggctccc aggcccaggg gggccaccat ggcctaccgc
      121 tcctgcgtcg ttggcttcag cagcctcagc ggctgtgaga tgacccctgc gggcagtccc
      181 cagcctggga cctcaggatg gggcagctgt gggctccctg ggcctggctt cagctctcga
      241 agcctcacaa gctgcaggcc agctggcacc atccccaagg tgactgtgaa ccccagcctg
      301 ctggtgcctc tggacctcaa ggtggatcca gctgttcaac agcagaagaa tcaagaaaag
      361 gaggagatga aggctctcaa tgataaattt gcctccctga ttggcaaggt ccaagctctg
      421 gagcaacgca accaactgct ggagacccga tggagcttcc tgcagggcca gggatcagcc
      481 accttcgacc tcagccacca ttatgagaca ttccagggcc ggctgcagga ggagcttcgt
      541 aaagtgagcc aagagcgggg acagctggag gccaacctgt tgcaggtgtt agagaaggtg
      601 gaggagtttc gcgtcaggta tgaggacgag atctccaagc gcacagacct ggagtttacc
      661 tttgtccagc tgaagaagga cctggatgct gagtgtctcc gaagaactga actggaaacc
      721 aaactgaagg gcctgcaggg cttcctagag ctgatgagaa cagtctatga gcaggagctg
      781 aaagacctta cagcccaagt gaaggacgtg tctgtgactg tgggcctgga cagccgctgc
      841 cacatcgacc tgagcggcat cgtggaggaa gtgaaggccc agtatgacgc catcgctgct
      901 cgaagcctgg aggaggctga agcatattca cggagccagc ttgaggagcg agctgcccgc
      961 tcagcggagt tcgggaacag cctccaaagc agccgctgtg agattgcaga cctcaacgtg
     1021 cgcatccaga agctgcggtc tcagatcgtc tccgtcaaga gccattgcct aaaactggag
     1081 gagaacatca aggtggctga ggagcaagga gaactggcct tccaggacgc caaggacaag
     1141 atggcccagc tggagaatgc cctgcagaag gccaagcagg acatggcccg gcagttgcgc
     1201 gagtatcagg atctcatgaa caccaagctg gctctggaca tagagatagc cacctaccac
     1261 aagctgatgg aaggagaaga aagccggatg gacctgcctt ctgccactgt ggtcagtact
     1321 gtgaaatctg gatgcagaac cactgcctcc aagtctggcc tcaccaagac ctcctcccgg
     1381 aagaagaaga accgcagagg cccagtgatc aagatcactg agatgtcaga gaaatatctc
     1441 tcccaggaat cagaggcctc agagtaagac agcaacccca gaaagagcct caagtcactt
     1501 ccactgcagc cgacttaagc taaactcaag aacgtggcct ggagcctcca ggttgggagg
     1561 agagacactg aacggggtga agtgggttct ggctgagact gggtttctct gggtggtcag
     1621 agagaaccgg cagctccatt cctcatccgc gtctcatttg ccacctctag tctcctggcc
     1681 acagcttgtc ctggcgggca aaggggatct tggggcctgc cacctctccg ctcctctgaa
     1741 gatcctcttc ccacgtagct ctgacaaggt gcttgacttc tgcccactgc ttgccctgac
     1801 ttctgcctca gccttgcctt gcctctgcct ctaaaccgag gctggcatcc tcgcccacta
     1861 gccaggacat agactgggct gaaggataca cttggacttt gtcttgtata tggtgttcct
     1921 gcgcctgggg gctgaggact cctagacccc ctgcctccaa gcctcccaga cacctgacag
     1981 tattggggga cgaaaggctt gatgtgttag acaaaagcct gagccccaga gtggcccaga
     2041 tgcctgcatg tacccccttc cagggacctg acttcaaagc tattctggac aagccaccac
     2101 cctaggagca gaagccagag ataagagtct gacaccaggc cttgcctccc ctccctgcca
     2161 ttctaggttg tgccaccatc ctgaaatctg ggctctggct ccagccaggg tctctccaac
     2221 ctcaacattt gtctttggca cagcaggcac tagagcccta gagcctgcca gaaatgccca
     2281 tctcccccaa atctcacttc ctagggcctc tgttctatcc cctaagacgg tccacccagt
     2341 tctccccacc cccgcccctc ccttcctcca agcttactcc ccctgccttt ggtgggccat
     2401 gaagaaggct gagcctggga agatctggaa gtttcgtagg cataaatttg gtccaggaag
     2461 ccccaacaag ggccttcaaa ggactcaacc caagggagcc attctgtatc caccatgggt
     2521 gtctgtgtgt tccagccctg gctcccacct ctggggtttg tggagcacag cagtgccagc
     2581 cttccgatgc caccagcctc attctgcctc cctttattcc caagacccat gtcctggctc
     2641 ctgcctcacc tcctctccta gcccacctcc cattcctgct tctcattctc ccagacctgg
     2701 tttcctcaag gcccctggcc ctccaggcct gcagggagtg ttgataggct gccagctcct
     2761 ccaggccaaa ggaacccagc aatacacact taaccctaga gtccccgaag cgggtgctca
     2821 gtgctgcttt ctctcgggct attaatccat ttccaaggga gcaatcctca gtgggacatg
     2881 aaatatagaa catatatatt attttttcat aacttatgtg gcttttaact tattgcttcc
     2941 cttcctgttt ctgcatgata agtgctgagt atactatcag gattttagag aactcattcc
     3001 agccacctgc tagactggct gacttgggca aggggtgaat aaagtactga gattcatcca
     3061 cagataa
//
