LOCUS       NM_031170               1805 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus keratin 8 (Krt8), mRNA.
ACCESSION   NM_031170
VERSION     NM_031170.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1805)
  AUTHORS   Chen,X., Tober,J., Dominguez,M., Tang,A.T., Bockman,J., Yang,J.,
            Mani,S., Lee,C.N., Chen,M., Thillaikumaran,T., Mericko-Ishizuka,P.,
            Mainigi,M., Speck,N.A. and Kahn,M.L.
  TITLE     Lineage tracing studies suggest that the placenta is not a de novo
            source of hematopoietic stem cells
  JOURNAL   PLoS Biol 23 (1), e3003003 (2025)
   PUBMED   39874373
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1805)
  AUTHORS   Ide,H., Miike,K., Ohmori,T., Maruyama,K., Izumi,Y., Tanigawa,S. and
            Nishinakamura,R.
  TITLE     Mouse embryonic kidney transplantation identifies maturation
            defects in the medulla
  JOURNAL   Sci Rep 14 (1), 30293 (2024)
   PUBMED   39639083
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1805)
  AUTHORS   Chen,R., Fan,R., Chen,F., Govindasamy,N., Brinkmann,H.,
            Stehling,M., Adams,R.H., Jeong,H.W. and Bedzhov,I.
  TITLE     Analyzing embryo dormancy at single-cell resolution reveals dynamic
            transcriptional responses and activation of integrin-Yap/Taz
            prosurvival signaling
  JOURNAL   Cell Stem Cell 31 (9), 1262-1279 (2024)
   PUBMED   39047740
REFERENCE   4  (bases 1 to 1805)
  AUTHORS   Kostic,L., Leung,C., Ahmad Murad,K., Kancheva,S., Perna,S., Lee,B.
            and Barker,N.
  TITLE     Lgr5 marks stem/progenitor cells contributing to epithelial and
            muscle development in the mouse esophagus
  JOURNAL   Nat Commun 15 (1), 7145 (2024)
   PUBMED   39164270
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1805)
  AUTHORS   Song,L., Li,Q., Xia,L., Sahay,A.E., Qiu,Q., Li,Y., Li,H.,
            Sasaki,K., Susztak,K., Wu,H. and Wan,L.
  TITLE     Single-cell multiomics reveals ENL mutation perturbs kidney
            developmental trajectory by rewiring gene regulatory landscape
  JOURNAL   Nat Commun 15 (1), 5937 (2024)
   PUBMED   39009564
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1805)
  AUTHORS   Beier,D.R., Dushkin,H. and Sussman,D.J.
  TITLE     Mapping genes in the mouse using single-strand conformation
            polymorphism analysis of recombinant inbred strains and
            interspecific crosses
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 9102-9106 (1992)
   PUBMED   1409609
REFERENCE   7  (bases 1 to 1805)
  AUTHORS   Hart,C.P., Compton,J.G., Langley,S.H., Hunihan,L., LeClair,K.P.,
            Zelent,A., Roderick,T.H. and Ruddle,F.H.
  TITLE     Genetic linkage analysis of the murine developmental mutant velvet
            coat (Ve) and the distal chromosome 15 developmental genes Hox-3.1,
            Rar-g, Wnt-1, and Krt-2
  JOURNAL   J Exp Zool 263 (1), 83-95 (1992)
   PUBMED   1379621
REFERENCE   8  (bases 1 to 1805)
  AUTHORS   Baribault,H. and Oshima,R.G.
  TITLE     Polarized and functional epithelia can form after the targeted
            inactivation of both mouse keratin 8 alleles
  JOURNAL   J Cell Biol 115 (6), 1675-1684 (1991)
   PUBMED   1721911
REFERENCE   9  (bases 1 to 1805)
  AUTHORS   Tamai,Y., Takemoto,Y., Matsumoto,M., Morita,T., Matsushiro,A. and
            Nozaki,M.
  TITLE     Sequence of EndoA gene encoding mouse cytokeratin and its
            methylation state in the CpG-rich region
  JOURNAL   Gene 104 (2), 169-176 (1991)
   PUBMED   1717348
REFERENCE   10 (bases 1 to 1805)
  AUTHORS   Zhao,S.Y.
  TITLE     [Mouse type II cytokeratin genes CK-4 and CK-8 mapped on chromosome
            15]
  JOURNAL   Yi Chuan Xue Bao 18 (6), 490-494 (1991)
   PUBMED   1722687
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK145777.1.
            
            On Sep 7, 2006 this sequence version replaced NM_031170.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145777.1, AK166854.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1805
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.2 cM"
     gene            1..1805
                     /gene="Krt8"
                     /gene_synonym="Card2; EndoA; K8; Krt-2.8; Krt2-8; TROMA-1"
                     /note="keratin 8"
                     /db_xref="GeneID:16691"
                     /db_xref="MGI:MGI:96705"
     exon            1..445
                     /gene="Krt8"
                     /gene_synonym="Card2; EndoA; K8; Krt-2.8; Krt2-8; TROMA-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1576
                     /gene="Krt8"
                     /gene_synonym="Card2; EndoA; K8; Krt-2.8; Krt2-8; TROMA-1"
                     /note="keratin complex 2, basic, gene 8 (MGD|MGI:96705
                     GB|AK077597, evidence: BLASTN, 100%, match=1775);
                     putative; CK-8; cytokeratin endo A; type-II keratin Kb8;
                     cytokeratin-8"
                     /codon_start=1
                     /product="keratin, type II cytoskeletal 8"
                     /protein_id="NP_112447.2"
                     /db_xref="CCDS:CCDS27868.1"
                     /db_xref="GeneID:16691"
                     /db_xref="MGI:MGI:96705"
                     /translation="MSIRVTQKSYKMSTSGPRAFSSRSFTSGPGARISSSSFSRVGSS
                     SSSFRGSMGTGVGLGGFGGAGVGGITAVTVNQSLLSPLKLEVDPNIQAVRTQEKEQIK
                     SLNNKFASFIDKVRFLEQQNKMLETKWSLLQQQKTSRSNMDNMFESYINNLRRQLEAL
                     GQEKLKLEAELGNMQGLVEDFKNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVELES
                     RLEGLTDEINFLRQIHEEEIRELQSQISDTSVVLSMDNSRSLDMDGIIAEVRAQYEDI
                     ANRSRAEAETMYQIKYEELQTLAGKHGDDLRRTKTEISEMNRNINRLQAEIEALKGQR
                     ASLEAAIADAEQRGEMAIKDAQTKLAELEAALQRAKQDMARQLREYQELMNVKLALDI
                     EITTYRKLLEGEESRLESGMQNMSIHTKTTSGYSGGLSSSYGGLTSPGFSYGMSSFQP
                     GFGSAGGSNTFSRTTKAVVVKKIETRDGKLVSESSDVVSK"
     exon            446..654
                     /gene="Krt8"
                     /gene_synonym="Card2; EndoA; K8; Krt-2.8; Krt2-8; TROMA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            655..715
                     /gene="Krt8"
                     /gene_synonym="Card2; EndoA; K8; Krt-2.8; Krt2-8; TROMA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            716..811
                     /gene="Krt8"
                     /gene_synonym="Card2; EndoA; K8; Krt-2.8; Krt2-8; TROMA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            812..976
                     /gene="Krt8"
                     /gene_synonym="Card2; EndoA; K8; Krt-2.8; Krt2-8; TROMA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1102
                     /gene="Krt8"
                     /gene_synonym="Card2; EndoA; K8; Krt-2.8; Krt2-8; TROMA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1323
                     /gene="Krt8"
                     /gene_synonym="Card2; EndoA; K8; Krt-2.8; Krt2-8; TROMA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1382
                     /gene="Krt8"
                     /gene_synonym="Card2; EndoA; K8; Krt-2.8; Krt2-8; TROMA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1805
                     /gene="Krt8"
                     /gene_synonym="Card2; EndoA; K8; Krt-2.8; Krt2-8; TROMA-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1782..1787
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt8"
                     /gene_synonym="Card2; EndoA; K8; Krt-2.8; Krt2-8; TROMA-1"
                     /note="putative"
     polyA_site      1805
                     /gene="Krt8"
                     /gene_synonym="Card2; EndoA; K8; Krt-2.8; Krt2-8; TROMA-1"
                     /note="putative"
ORIGIN      
        1 ataaagggcc ttcgctgggc gctgtcccac cgtctagaag cagctgctta gctcgctctc
       61 gaacctccgt cttcagctca ctgccttcgc tccagacttc accatgtcca tcagggtgac
      121 tcagaaatcc tacaagatgt ccacctccgg tccccgggcc ttcagcagcc gctcgttcac
      181 gagtggaccc ggtgcccgca tcagctcttc cagcttttcc cgggtgggca gcagcagcag
      241 cagcttccgg ggaagcatgg gcaccggcgt gggtctgggc ggctttggcg gggctggtgt
      301 cgggggcatc acagccgtca cggtgaacca gagcctgttg agccccttga agctggaggt
      361 ggaccccaac atccaggctg tgcgcactca ggagaaggag cagattaaat ccctgaacaa
      421 caagttcgcc tccttcattg acaaggtgcg cttcctggag cagcagaaca agatgctgga
      481 gaccaagtgg agcctgttgc agcagcagaa gacgtcgagg agcaacatgg acaacatgtt
      541 tgagagctac atcaacaacc tccgccggca gctggaagcc ctgggccagg agaagctgaa
      601 gctggaggct gagcttggca acatgcaggg cctggtggag gacttcaaga ataagtatga
      661 ggatgagatc aacaagcgta cagagatgga gaatgaattt gtcctcatca agaaggatgt
      721 ggacgaagca tacatgaaca aggtggaact agagtcccgc ctggaaggac tgaccgacga
      781 gatcaacttc ctccggcaga tccatgaaga ggagatccgt gagttgcagt ctcagatctc
      841 agacacgtct gtggtgctgt ctatggacaa cagccgctcc ctggacatgg atggcatcat
      901 cgctgaagtt cgtgcccagt acgaggacat tgccaatcgc agccgagctg aggctgaaac
      961 catgtaccag attaagtatg aggaattgca gaccctggct gggaagcacg gggatgatct
     1021 gcgccgcaca aagacagaga tctccgagat gaaccgcaac atcaaccgcc tgcaggcgga
     1081 gattgaagcc ctcaaaggcc agagggcatc gttggaggca gccatcgctg atgctgagca
     1141 gcgtggggag atggccatta aggatgccca gaccaagctg gctgagctgg aggctgccct
     1201 gcaacgggcc aagcaggaca tggccaggca gctgcgcgag taccaggagc ttatgaacgt
     1261 caagctggcc ctggacatcg agatcaccac ctaccgcaag ctgctggagg gggaggagag
     1321 caggctggag tctgggatgc agaacatgag cattcatacg aagaccacca gcggctactc
     1381 aggaggactg agttcatcct atgggggact cactagccct ggcttcagct acggaatgag
     1441 ctccttccag cccggcttcg gttctgccgg gggatccaac actttcagcc gcaccaccaa
     1501 ggctgtggtt gtgaagaaga ttgaaacccg agatgggaag ctggtgtccg agtcttctga
     1561 tgtcgtgtcc aagtgaatgg ccactgaagt ccttgccagc ctgagctcct gcagctgctc
     1621 agggctcacg gggagacagc tgtatggcag agtgcaggga actagagacc cgtccgagga
     1681 tcagccctaa tcctctggcc aaccttagga ggaatttcct atctgggata tcccaatggc
     1741 ttctgcctcc catccaaacc caattcagtt gtattttcta aaataaagcc tcagctggct
     1801 ctgtc
//
