LOCUS       NM_146063               2113 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus keratin 79 (Krt79), mRNA.
ACCESSION   NM_146063
VERSION     NM_146063.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2113)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2113)
  AUTHORS   Veniaminova,N.A., Jia,Y.Y., Hartigan,A.M., Huyge,T.J., Tsai,S.Y.,
            Grachtchouk,M., Nakagawa,S., Dlugosz,A.A., Atwood,S.X. and
            Wong,S.Y.
  TITLE     Distinct mechanisms for sebaceous gland self-renewal and
            regeneration provide durability in response to injury
  JOURNAL   Cell Rep 42 (9), 113121 (2023)
   PUBMED   37715952
REFERENCE   3  (bases 1 to 2113)
  AUTHORS   Kim,D., Choi,I., Ha,S.K. and Gonzalez,F.J.
  TITLE     Keratin 79 is a PPARA target that is highly expressed by liver
            damage
  JOURNAL   Biochem Biophys Res Commun 650, 132-136 (2023)
   PUBMED   36796223
REFERENCE   4  (bases 1 to 2113)
  AUTHORS   Urbanek,M.E. and Zuo,J.
  TITLE     Genetic predisposition to tinnitus in the UK Biobank population
  JOURNAL   Sci Rep 11 (1), 18150 (2021)
   PUBMED   34518561
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2113)
  AUTHORS   Veniaminova,N.A., Grachtchouk,M., Doane,O.J., Peterson,J.K.,
            Quigley,D.A., Lull,M.V., Pyrozhenko,D.V., Nair,R.R., Patrick,M.T.,
            Balmain,A., Dlugosz,A.A., Tsoi,L.C. and Wong,S.Y.
  TITLE     Niche-Specific Factors Dynamically Regulate Sebaceous Gland Stem
            Cells in the Skin
  JOURNAL   Dev Cell 51 (3), 326-340 (2019)
   PUBMED   31564613
REFERENCE   6  (bases 1 to 2113)
  AUTHORS   Mesler,A.L., Veniaminova,N.A., Lull,M.V. and Wong,S.Y.
  TITLE     Hair Follicle Terminal Differentiation Is Orchestrated by Distinct
            Early and Late Matrix Progenitors
  JOURNAL   Cell Rep 19 (4), 809-821 (2017)
   PUBMED   28445731
REFERENCE   7  (bases 1 to 2113)
  AUTHORS   Veniaminova,N.A., Vagnozzi,A.N., Kopinke,D., Do,T.T.,
            Murtaugh,L.C., Maillard,I., Dlugosz,A.A., Reiter,J.F. and Wong,S.Y.
  TITLE     Keratin 79 identifies a novel population of migratory epithelial
            cells that initiates hair canal morphogenesis and regeneration
  JOURNAL   Development 140 (24), 4870-4880 (2013)
   PUBMED   24198274
  REMARK    GeneRIF: migratory keratinocytes express keratin 79 and stream out
            of the hair germ and into the epidermis prior to lumen formation in
            the embryo.
REFERENCE   8  (bases 1 to 2113)
  AUTHORS   Kunisada,M., Cui,C.Y., Piao,Y., Ko,M.S. and Schlessinger,D.
  TITLE     Requirement for Shh and Fox family genes at different stages in
            sweat gland development
  JOURNAL   Hum Mol Genet 18 (10), 1769-1778 (2009)
   PUBMED   19270025
REFERENCE   9  (bases 1 to 2113)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   10 (bases 1 to 2113)
  AUTHORS   Lemay,A.M. and Haston,C.K.
  TITLE     Bleomycin-induced pulmonary fibrosis susceptibility genes in
            AcB/BcA recombinant congenic mice
  JOURNAL   Physiol Genomics 23 (1), 54-61 (2005)
   PUBMED   16179420
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC031593.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031593.1, BC019155.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2113
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.14 cM"
     gene            1..2113
                     /gene="Krt79"
                     /note="keratin 79"
                     /db_xref="GeneID:223917"
                     /db_xref="MGI:MGI:2385030"
     exon            1..578
                     /gene="Krt79"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1706
                     /gene="Krt79"
                     /note="K79; CK-79; cytokeratin-79; type-II keratin Kb38"
                     /codon_start=1
                     /product="keratin, type II cytoskeletal 79"
                     /protein_id="NP_666175.1"
                     /db_xref="CCDS:CCDS27867.1"
                     /db_xref="GeneID:223917"
                     /db_xref="MGI:MGI:2385030"
                     /translation="MRSSLSRQTFSTKGGFSSNSASGGGGSRMRTSYSSVTMSRGSGG
                     GGGVRSGSSSGGFGSRSLYNLGGKNISVSMACGASSGRALGGFGSGAYVGLGASRQTF
                     GPVCPPGGIQEVTVNQSLLTPLNVEIDPEIQRVRTQEREQIKTLNNKFASFIDKVRFL
                     EQQNKVLETKWALLQEQSQNTGVARSLEPFFENYLSTLRRQLDTKQSERGRLDMELRN
                     VQDNLEDFKNKYEDEINKRTALENEFVLLKKDVDAAYMGRMDLHGKVDSLTQEIDFLQ
                     QLFEMELSQVQTNVSDTNVILSMDNNRNLDLDSIIAEVKAQYELIAQKSRAEAESWYQ
                     TKYEELQVTAGKHGDSLRDTKNEIAELTRTTQRLQGEVDAAKKQCQQLQTAIAEAEQN
                     GEMALKDAKKKLGDLDTALHQAKEDLARMLREYQDLVSVKLALDMEIATYRKLLESEE
                     SRMSGDCPSAISISVTGNSTSVCAGGTAGFGNGLSLGGAGGASKGGFGSSVSYGAAKG
                     GQVSGGTSILRKTTTVKTSSRRY"
     exon            579..796
                     /gene="Krt79"
                     /inference="alignment:Splign:2.1.0"
     exon            797..857
                     /gene="Krt79"
                     /inference="alignment:Splign:2.1.0"
     exon            858..953
                     /gene="Krt79"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1118
                     /gene="Krt79"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1244
                     /gene="Krt79"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1465
                     /gene="Krt79"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1500
                     /gene="Krt79"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..2097
                     /gene="Krt79"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2073..2078
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt79"
                     /note="hexamer: AATAAA"
     polyA_site      2097
                     /gene="Krt79"
                     /note="major polyA site"
ORIGIN      
        1 atggaaccca gggccagccc agctgggaaa agataaaaag gtgtttggtg gctcagtagc
       61 tcactccggc tgattccctc ctgctctcag ctgctttctc gctgacaatc atgcggtcct
      121 ctttgtccag gcagactttc tccactaaag gaggcttcag ctctaactca gccagcggag
      181 gtggtgggag tcggatgcga accagctaca gctcagtgac tatgtccagg gggagcggcg
      241 gtggcggtgg ggtccgctct gggtccagct ccgggggctt tggcagccgg agcctctaca
      301 acttgggagg caagaatatc tccgtcagca tggcttgtgg ggcctcctct ggccgggcac
      361 taggaggctt tggcagtggg gcctatgtgg gcctaggggc tagcaggcag acatttgggc
      421 cagtctgtcc tcccgggggc atccaggaag tcactgtcaa ccagagcctg ctgacgcctc
      481 tcaatgtgga gatagacccc gagattcagc gggtgcgcac ccaggagcgc gagcagatca
      541 agaccctcaa caacaagttt gcctccttta ttgataaggt acgcttcctg gaacaacaga
      601 acaaggtgct ggagacgaag tgggcgctgc tgcaggagca gagccagaac acgggggtcg
      661 ccaggagcct ggagcctttc tttgagaatt acctgagcac cctgaggagg cagctggata
      721 ccaaacagag cgagcggggc cggctggata tggagctgag gaacgtacag gataatctgg
      781 aggacttcaa gaacaagtat gaggatgaaa tcaacaaacg cactgccctg gagaatgagt
      841 ttgtgctgct caagaaggat gtagatgccg catacatggg cagaatggat ctgcatggca
      901 aagtggacag cttgacacaa gagattgact tcctgcaaca gctctttgag atggagctga
      961 gccaagtgca gaccaatgtg tctgacacca acgtgatact gtccatggac aacaaccgca
     1021 acctggactt ggacagcatc atcgctgaag tcaaagccca gtatgagctg atcgcccaga
     1081 agagtcgggc tgaggctgag tcctggtacc agaccaaata tgaagaactg caggtgacag
     1141 ctgggaagca cggggacagc cttcgagaca ctaaaaatga gatcgcagaa ctcactcgca
     1201 ccactcagag actgcagggc gaggtggatg cagccaagaa gcagtgccag cagctgcaga
     1261 cagccatcgc agaagcagag cagaatgggg agatggcgct caaggacgct aagaagaagc
     1321 ttggagatct agacacagcc ctgcatcagg ccaaggagga cctggcccgg atgctgcgtg
     1381 aataccagga tcttgtgagc gtcaagctgg ccctggatat ggagatcgcc acctaccgca
     1441 agctgctgga gagcgaggag agcaggatgt ctggagattg tcccagcgca atcagcatct
     1501 cggtgaccgg caactctacc tccgtttgcg caggcggcac ggctggcttc gggaacggcc
     1561 tctctctggg cggggctggc ggggccagca agggcggctt tggttctagt gtgagctatg
     1621 gcgctgccaa aggcggtcag gtctctgggg gaacctccat cctacggaag accactacag
     1681 tcaagacctc tagccggaga tactagcagc aaggctttga gagttgggcc ttggtccttg
     1741 cgctggtcat ggcttctcag gaccgcagag gctgagtatt tgtagtgcac aatttacata
     1801 taatttgcat ttgggaaagg gctcaaatct actcaggttt ttctccttgg ttatgcagtg
     1861 gaatgggagg gaagttaggg tcaccagctg gttgatttgg gggtgacctg accatttaga
     1921 gggggtagga tgtccagttc tacgttttca cctcagcaga tctgctgagt tcagggcaag
     1981 ctggaggagg cagaaggggt tgccagagac ctgcagctcc ttatccttgt cacctcacgg
     2041 tcaagtccct gtctgtgcct gtgatgtgtc tcaataaaca acaactacct accgcaaaaa
     2101 aaaaaaaaaa aaa
//
