LOCUS       NM_212487               3434 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus keratin 78 (Krt78), mRNA.
ACCESSION   NM_212487 XM_285151
VERSION     NM_212487.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3434)
  AUTHORS   Langbein L, Eckhart L, Fischer H, Rogers MA, Praetzel-Wunder S,
            Parry DA, Kittstein W and Schweizer J.
  TITLE     Localisation of keratin K78 in the basal layer and first suprabasal
            layers of stratified epithelia completes expression catalogue of
            type II keratins and provides new insights into sequential keratin
            expression
  JOURNAL   Cell Tissue Res 363 (3), 735-750 (2016)
   PUBMED   26340985
  REMARK    GeneRIF: K78 is strongly expressed in the basal and parabasal cell
            layers with decreasing intensity in the lower suprabasal cells of
            keratinising and non-keratinising squamous epithelia and
            keratinocyte cultures.
REFERENCE   2  (bases 1 to 3434)
  AUTHORS   Kumar V, Bouameur JE, Bar J, Rice RH, Hornig-Do HT, Roop DR,
            Schwarz N, Brodesser S, Thiering S, Leube RE, Wiesner RJ, Vijayaraj
            P, Brazel CB, Heller S, Binder H, Loffler-Wirth H, Seibel P and
            Magin TM.
  TITLE     A keratin scaffold regulates epidermal barrier formation,
            mitochondrial lipid composition, and activity
  JOURNAL   J Cell Biol 211 (5), 1057-1075 (2015)
   PUBMED   26644517
  REMARK    Erratum:[J Cell Biol. 2016 Mar 28;212(7):877. PMID: 27002167]
REFERENCE   3  (bases 1 to 3434)
  AUTHORS   Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM,
            Maltais L, Omary MB, Parry DA, Rogers MA and Wright MW.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   4  (bases 1 to 3434)
  AUTHORS   Hesse M, Zimek A, Weber K and Magin TM.
  TITLE     Comprehensive analysis of keratin gene clusters in humans and
            rodents
  JOURNAL   Eur J Cell Biol 83 (1), 19-26 (2004)
   PUBMED   15085952
REFERENCE   5  (bases 1 to 3434)
  AUTHORS   Carninci P, Waki K, Shiraki T, Konno H, Shibata K, Itoh M, Aizawa
            K, Arakawa T, Ishii Y, Sasaki D, Bono H, Kondo S, Sugahara Y, Saito
            R, Osato N, Fukuda S, Sato K, Watahiki A, Hirozane-Kishikawa T,
            Nakamura M, Shibata Y, Yasunishi A, Kikuchi N, Yoshiki A, Kusakabe
            M, Gustincich S, Beisel K, Pavan W, Aidinis V, Nakagawara A, Held
            WA, Iwata H, Kono T, Nakauchi H, Lyons P, Wells C, Hume DA,
            Fagiolini M, Hensch TK, Brinkmeier M, Camper S, Hirota J, Mombaerts
            P, Muramatsu M, Okazaki Y, Kawai J and Hayashizaki Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY792966.1, BK004080.1 and AK146611.1.
            
            On Apr 20, 2007 this sequence version replaced NM_212487.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK004080.1, BC119600.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                BY792966.1         2-64
            64-2414             BK004080.1         1-2351
            2415-3434           AK146611.1         1719-2738
FEATURES             Location/Qualifiers
     source          1..3434
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.15 cM"
     gene            1..3434
                     /gene="Krt78"
                     /gene_synonym="2310030B04Rik; Kb40"
                     /note="keratin 78"
                     /db_xref="GeneID:332131"
                     /db_xref="MGI:MGI:1917529"
     exon            1..429
                     /gene="Krt78"
                     /gene_synonym="2310030B04Rik; Kb40"
                     /inference="alignment:Splign:2.1.0"
     exon            430..644
                     /gene="Krt78"
                     /gene_synonym="2310030B04Rik; Kb40"
                     /inference="alignment:Splign:2.1.0"
     exon            645..705
                     /gene="Krt78"
                     /gene_synonym="2310030B04Rik; Kb40"
                     /inference="alignment:Splign:2.1.0"
     exon            706..801
                     /gene="Krt78"
                     /gene_synonym="2310030B04Rik; Kb40"
                     /inference="alignment:Splign:2.1.0"
     exon            802..966
                     /gene="Krt78"
                     /gene_synonym="2310030B04Rik; Kb40"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1092
                     /gene="Krt78"
                     /gene_synonym="2310030B04Rik; Kb40"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1313
                     /gene="Krt78"
                     /gene_synonym="2310030B04Rik; Kb40"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1348
                     /gene="Krt78"
                     /gene_synonym="2310030B04Rik; Kb40"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..3434
                     /gene="Krt78"
                     /gene_synonym="2310030B04Rik; Kb40"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaagcacat acaccgtgac catctccagt ctgtctgaag ctgcgggcct gtttgtctct
       61 gccatgtctc tctctccatg ccgggcccag aggggcttca gcgcccactc agcgtgttct
      121 gccttttcag gggctcgggg caggactggc ttcagcagca ggagccttag ttcctccagg
      181 agatgcagag gaagctcttg tgggagggcc tggggggcag agaccaggca agggatacgg
      241 tttgggcagg gtaagggagg gcctggattt tcccagtgcc ctccaggggg catccaagca
      301 gtgactgtcg accagagtct gctgacccca ctgaagatcg aggttgaccc ccagttccag
      361 gtggtgaaga cacaggagac tcgagagatc agaagcctca acaaccaatt cgcctccttc
      421 attgacaagg tgcgcttcct ggagcaacag aacaaggtac tggagaccaa gtgggagctg
      481 ctgcagcagc tgcagggcaa tcgcagccct cagggtctag agtgcatctt cgaaacctgc
      541 ctagcccgac tcaggcagca gctggaggag ctgcagagag agcgaagggc tctggactct
      601 gagctgaaga cctatcagga ccaggaggat gaatataagt ccaagtatga ccaggaagcg
      661 tacaagcacg cctctgtgca gaatgatttt gtggtcctta agaaggacgt ggatgaggtt
      721 ttccagagca agatggattt ggaaggcaac ctggagtctc tgaaagaaca cgtctgcttc
      781 ttgacacgtc tgtatgaaga agaactggga cagctgaaga cgcaggcaga cgacatgtct
      841 gtggtgctgt ccatggataa caatcgttgc ttggacttca gcgacatcat tgctgaggtc
      901 cgtgcccgtt acgaggagat cacgcggact agcaaggccg aggctgaggc tgtgttccag
      961 accaagtacc aggaactcca ggaatcagcc cagcttcaag ggaacagcat gaaggaagcg
     1021 caggtgcaga tttcccagct tcggcaggcc atacataggc tgcagagtca gattgggagc
     1081 ctcaggaagc agaatgacag tctgcagtcg gccatcgctg atgctgagca gcaaggggag
     1141 atggctgtga gggatgccca ggccaagctg gatgagctgg aggctgccct gagaacagcc
     1201 aagcaggaca tggcacagat gctacgtgac taccaggaac tgatgggcac gaagttgtcc
     1261 ctggatgtgg agatcgccat gtaccggagg ttgctggaga gtgaggagtg caggatatcc
     1321 acggagcaca ccagccaggt cactgtgtct ataacagagg gcagcattgt gcctggaaga
     1381 acttgtggag gccaagtagt tgtgcctgga agaattggta caggccaagt ggtcatgcct
     1441 ggaagggaat gtggaggtca tgtggtcatg cctggaagag gatctggagg ccaggtgacc
     1501 attcctggaa gaggatctgg aggccaggtg accgtgccta gaggagaatg tggaggccag
     1561 gtgaccatgc ctgggagagg atctggaggc caggtgacca tgcctgggag aggatctgga
     1621 ggccaggtga ccattcctgg aagaggatct ggaggccaag tgactgtgcc tgggagagga
     1681 tctggaggcc aagtgaccat acctgggaga ggatctggag gccaggtgac cattcctgga
     1741 agaggatctg gaggccaagt gaccgtgcct gggagaggat ctggaggcca ggtgaccatt
     1801 cctgggagag gatctggagg ccaggtgacc attcctggaa gagaatctgg aggccaggtg
     1861 accattcctg gaagagaatc tggaggccag gtgaccatgc ctggaagaga atatggaggc
     1921 caggtgacca ttcctggaag agaatctgga ggccaggtga ccatgcctgg aagaggatct
     1981 ggaggccagg tgaccatgcc tgggagagga tctggaggcc aggtgaccgt gcctggaaga
     2041 gaatatggag gccaggtgac cgtgcctggg agaggatctg gaggccaggt gaccgtgcct
     2101 gggagagaat atggaggcca ggtgaccgtg cctagaggag aatgtggagg ccaggtgaca
     2161 gtgcctggaa gagaatatgg aggccaggtg accatgccta gaggagaatg tgggggtcaa
     2221 gtgaccatgc ctggaagaga atatggaggc caggtgacca tgcctggaag agaatctgga
     2281 ggccaggtga ccgtgcctgg aagagaatat ggaggccagg tgaccatgcc tagaggagaa
     2341 tgtggaggcc aggtgaccgt gcctggaaga gaatatggag gccaggtgac catgcctaga
     2401 ggagaatgtg ggggtcaagt gaccatgcct ggaagagaat atggaggcca ggtgaccgtg
     2461 cctagaagag agtgtggagg ccaggtgacc gtgcctggaa gagaatatgg aggccaggtg
     2521 accatgcctg gaagagaatc tggaggccag gtgaccgtgc ctgggagaga atatggaggc
     2581 caggtgaccg tgcctagagg agaatgtgga ggccaggtga ccgtgcctgg gagagaatat
     2641 ggaggccagg tgaccgtgcc tagaggagaa tgtggaggcc aggtgaccgt gcctggaaga
     2701 gaatatggag gccaggtgac catgcctaga ggagaatgtg gaggccaggt gaccgtgcct
     2761 agaggagaat gtgggggtca agtgaccatg cctggaagag aatatggagg ccaggtgacc
     2821 gtgcctggaa gagaatatgg aggccagatg accatgcctg gaagagaatg tggaggccaa
     2881 gaggtcattc ctagaggaga atgtgggggt caagtggtca tgcctggaca agaatgtgga
     2941 ggccaagcag ttattccgag aggagactgt ggaagccaag tggtcattcc tagagaagaa
     3001 tgtgggggtc aagtgtccat gcccagagga gaatgtggag gccaagtggg cacttgtggc
     3061 cacagaggct ggcaaggcag ctttgggtct ggaggctgct ctagcatcgt tactggtggc
     3121 ttcgagatcc cccagggatc tggatacagc cccaccatgg gttcctgttc cgtatctggc
     3181 tcaggcttca gttctggctc tggctccagc tgccgcacca tcctgaagaa gacagtggaa
     3241 tcaagtcgga agatgtctgt catttattga gtgaccaggc agtcacatcc cttctgagcc
     3301 cagaagcctt gctctgagct catcccccaa tgtccaatgt ccacagcccg aggcagccca
     3361 ctgggcactg gagaaagtca ataaagtctg gcttgcctgc tgtcccaagt ggtcaggggc
     3421 aggtcctgct ctgc
//
