LOCUS       NM_001003667            2940 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus keratin 77 (Krt77), mRNA.
ACCESSION   NM_001003667 XM_128265
VERSION     NM_001003667.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2940)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2940)
  AUTHORS   Madon-Simon,M., Grad,I., Bayo,P., Perez,P. and Picard,D.
  TITLE     Defective glucocorticoid receptor signaling and
            keratinocyte-autonomous defects contribute to skin phenotype of
            mouse embryos lacking the Hsp90 co-chaperone p23
  JOURNAL   PLoS One 12 (6), e0180035 (2017)
   PUBMED   28650975
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2940)
  AUTHORS   Boix,J., Carceller,E., Sevilla,L.M., Marcos-Garces,V. and Perez,P.
  TITLE     The mineralocorticoid receptor plays a transient role in mouse skin
            development
  JOURNAL   Exp Dermatol 25 (1), 69-71 (2016)
   PUBMED   26268211
REFERENCE   4  (bases 1 to 2940)
  AUTHORS   Kumar,V., Bouameur,J.E., Bar,J., Rice,R.H., Hornig-Do,H.T.,
            Roop,D.R., Schwarz,N., Brodesser,S., Thiering,S., Leube,R.E.,
            Wiesner,R.J., Vijayaraj,P., Brazel,C.B., Heller,S., Binder,H.,
            Loffler-Wirth,H., Seibel,P. and Magin,T.M.
  TITLE     A keratin scaffold regulates epidermal barrier formation,
            mitochondrial lipid composition, and activity
  JOURNAL   J Cell Biol 211 (5), 1057-1075 (2015)
   PUBMED   26644517
  REMARK    Erratum:[J Cell Biol. 2016 Mar 28;212(7):877. doi:
            10.1083/jcb.20140414703042016c.. PMID: 27002167]
REFERENCE   5  (bases 1 to 2940)
  AUTHORS   Bebee,T.W., Park,J.W., Sheridan,K.I., Warzecha,C.C., Cieply,B.W.,
            Rohacek,A.M., Xing,Y. and Carstens,R.P.
  TITLE     The splicing regulators Esrp1 and Esrp2 direct an epithelial
            splicing program essential for mammalian development
  JOURNAL   Elife 4, e08954 (2015)
   PUBMED   26371508
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2940)
  AUTHORS   Kunisada,M., Cui,C.Y., Piao,Y., Ko,M.S. and Schlessinger,D.
  TITLE     Requirement for Shh and Fox family genes at different stages in
            sweat gland development
  JOURNAL   Hum Mol Genet 18 (10), 1769-1778 (2009)
   PUBMED   19270025
REFERENCE   7  (bases 1 to 2940)
  AUTHORS   Bazzi,H., Fantauzzo,K.A., Richardson,G.D., Jahoda,C.A. and
            Christiano,A.M.
  TITLE     Transcriptional profiling of developing mouse epidermis reveals
            novel patterns of coordinated gene expression
  JOURNAL   Dev Dyn 236 (4), 961-970 (2007)
   PUBMED   17330888
  REMARK    GeneRIF: Krt77 is the highest expressed gene among keratins in
            epidermis embryonic development.
REFERENCE   8  (bases 1 to 2940)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   9  (bases 1 to 2940)
  AUTHORS   Senshu,T., Ishida-Yamamoto,A., Takahashi,H. and Iizuka,H.
  TITLE     Prediction of a coding sequence for a novel type II keratin from
            N-terminal sequences of mouse epidermal proteins site-specifically
            deiminated in embryonic development
  JOURNAL   J Dermatol Sci 37 (1), 41-48 (2005)
   PUBMED   15619433
  REMARK    GeneRIF: sequence of novel type II keratin site-specifically
            deiminated in embryonic mouse epidermis.
REFERENCE   10 (bases 1 to 2940)
  AUTHORS   Hesse,M., Zimek,A., Weber,K. and Magin,T.M.
  TITLE     Comprehensive analysis of keratin gene clusters in humans and
            rodents
  JOURNAL   Eur J Cell Biol 83 (1), 19-26 (2004)
   PUBMED   15085952
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132513.1, BK003993.1, AC104862.15 and AA880500.1.
            
            On Jul 12, 2018 this sequence version replaced NM_001003667.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132513.1, BC107395.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                AK132513.1         2-88
            88-1806             BK003993.1         1-1719
            1807-2773           AC104862.15        153995-154961       c
            2774-2940           AA880500.1         1-167               c
FEATURES             Location/Qualifiers
     source          1..2940
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.08 cM"
     gene            1..2940
                     /gene="Krt77"
                     /gene_synonym="4732484G22Rik; CK-1B; K1emb; K77; Krt239;
                     mK1b"
                     /note="keratin 77"
                     /db_xref="GeneID:406220"
                     /db_xref="MGI:MGI:3588209"
     exon            1..639
                     /gene="Krt77"
                     /gene_synonym="4732484G22Rik; CK-1B; K1emb; K77; Krt239;
                     mK1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1806
                     /gene="Krt77"
                     /gene_synonym="4732484G22Rik; CK-1B; K1emb; K77; Krt239;
                     mK1b"
                     /note="keratin 1b; keratin complex 2, basic, gene 39; type
                     II keratin Kb39; type-II intermediate filament protein;
                     embryonic type II keratin 1; cytokeratin-1B"
                     /codon_start=1
                     /product="keratin, type II cytoskeletal 1b"
                     /protein_id="NP_001003667.1"
                     /db_xref="CCDS:CCDS27865.1"
                     /db_xref="GeneID:406220"
                     /db_xref="MGI:MGI:3588209"
                     /translation="MSRQFSSQSAFSSRSRRAYSSRSSSGFGGGRQALVSVSQSRRYG
                     GDYGGGFSSRSLYSLGGSKSIFGNLVGRSASGFCQSRGPGGGFGGGIGGGIGGGRGFG
                     GGGFGGGYGGGGRFGGGFGGAGFGFGGFGPSYPPGGIHEVTINQSLLEPLHLEVDPEI
                     QRVKTQEREQIKTLNNKFASFIDKVRFLEQQNQVLQTKWELLQQVNTSTRTSSLEPVF
                     EEFISQLQRQVDVLTTEQLRQNTEIRNMQDVVEDYKNKYEDEINKRTNAENDFVVLKK
                     DVDAAFMGKSDLQSKVDTLYGEINFLKYLFDTELSQIQTHVSDTNVILSMDNNRSLDL
                     DSIIDAVRAQYEIIAQKSKDEAEALYQTKYQELQITAGKHGDDLKNSKMEISELNRNI
                     QRLRAEIANIKKQVEGMHGLISDAEERGERALQNAKQKLQDMEEALQQAKEDLAKLLR
                     DYQAMLGAKLSLDVEIATYRQLLEGEESRMSGALQSQVSISVQSSQVTIGGGGGGSGS
                     YSGSSRGGGGGGGGTGSRGGGGGGGGSSYVSSSRSATKYGSGGGSSRTQILQTSTHSS
                     RRHVVE"
     exon            640..854
                     /gene="Krt77"
                     /gene_synonym="4732484G22Rik; CK-1B; K1emb; K77; Krt239;
                     mK1b"
                     /inference="alignment:Splign:2.1.0"
     exon            855..915
                     /gene="Krt77"
                     /gene_synonym="4732484G22Rik; CK-1B; K1emb; K77; Krt239;
                     mK1b"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1011
                     /gene="Krt77"
                     /gene_synonym="4732484G22Rik; CK-1B; K1emb; K77; Krt239;
                     mK1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1176
                     /gene="Krt77"
                     /gene_synonym="4732484G22Rik; CK-1B; K1emb; K77; Krt239;
                     mK1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1302
                     /gene="Krt77"
                     /gene_synonym="4732484G22Rik; CK-1B; K1emb; K77; Krt239;
                     mK1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1523
                     /gene="Krt77"
                     /gene_synonym="4732484G22Rik; CK-1B; K1emb; K77; Krt239;
                     mK1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1558
                     /gene="Krt77"
                     /gene_synonym="4732484G22Rik; CK-1B; K1emb; K77; Krt239;
                     mK1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..2931
                     /gene="Krt77"
                     /gene_synonym="4732484G22Rik; CK-1B; K1emb; K77; Krt239;
                     mK1b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2907..2912
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt77"
                     /gene_synonym="4732484G22Rik; CK-1B; K1emb; K77; Krt239;
                     mK1b"
                     /note="hexamer: AATAAA"
     polyA_site      2929
                     /gene="Krt77"
                     /gene_synonym="4732484G22Rik; CK-1B; K1emb; K77; Krt239;
                     mK1b"
                     /note="major polyA site"
ORIGIN      
        1 aagagagtcg cagctccctc agtccctgct ctctgcctgc tttcagctga gtccttgcta
       61 ccagtgcttc tggttgccct agcaaccatg agccgccagt ttagttctca gtctgcattt
      121 agctcgagga gcaggagggc ctatagctcc aggtcttcat caggctttgg aggtgggaga
      181 caggctctgg tgtctgtgag tcagtcgagg aggtatggcg gtgattatgg tggtgggttc
      241 agttccagga gtctctacag tctgggtggt agtaaaagca tctttgggaa cctagtggga
      301 cgaagtgcca gtggtttctg ccagagtaga gggccaggag gaggatttgg aggaggaatc
      361 ggaggaggaa ttggaggagg aagaggcttt ggtggaggtg gctttggtgg tggctatggc
      421 ggaggtggca gatttggagg tggttttggg ggtgctggat ttggatttgg gggcttcggt
      481 ccttcttatc ctcccggggg catccatgag gtgactatta accagagtct cctggagccc
      541 cttcacctgg aggtggatcc tgaaattcag agggtcaaga cccaggagcg ggaacagatc
      601 aagaccctca acaacaagtt tgcctccttc attgacaagg tgcggttcct ggagcagcag
      661 aaccaggtgc tacagacaaa atgggagctg ctgcagcagg tgaacacctc cacccggacc
      721 agcagcctgg agccagtctt cgaggagttc atcagtcagc tgcagaggca ggtggatgtt
      781 ctgaccaccg agcagttgcg ccagaacacg gagatcagga acatgcagga tgtcgtggag
      841 gactacaaga acaagtatga ggatgaaatc aacaagcgga ccaatgcaga aaatgacttt
      901 gttgttctga agaaggacgt ggatgctgct ttcatgggca aatcagactt gcagtccaaa
      961 gtagacacac tgtatgggga gatcaacttc ctgaaatatc tatttgatac ggagctgtcc
     1021 cagatacaaa cccacgtcag tgataccaat gtcatcttgt caatggacaa taaccgctcc
     1081 ctggacctgg acagcatcat cgatgccgta cgagcccagt atgaaataat tgcacagaag
     1141 agcaaagatg aggctgaggc cctgtaccag accaagtacc aggagctgca gattacagct
     1201 gggaaacacg gagacgacct gaagaatagc aagatggaga tctcagagct caaccgtaac
     1261 atccagaggc tgcgggcaga gatcgccaat atcaagaagc aggtcgaagg gatgcacgga
     1321 ttgatttctg atgcggagga gagaggagaa agggctctcc agaacgccaa gcagaagctg
     1381 caagacatgg aagaggccct ccagcaggct aaggaggatc tggccaagct gctgagagac
     1441 taccaggcaa tgctgggtgc caagctgtcc ttggacgtag agatcgccac ctaccgccag
     1501 cttttggagg gcgaggagag caggatgtcg ggggcgctgc agagtcaagt gagcatctcg
     1561 gtgcagagta gccaggtgac cattggcggc ggtggcggcg gctcaggaag ttacagcggc
     1621 agctcccgcg gaggcggtgg tggcggcgga ggaactggct cccgcggcgg cggcggcggc
     1681 ggcggcggca gtagttacgt ctccagcagc agaagcgcca ctaaatatgg cagcggcggc
     1741 ggctcctccc gcactcagat cctgcagacc tccacccaca gctcgcgtag gcacgtggtg
     1801 gagtagcggc caagtccttg cacttctaca gccttcttcc ccaatccctc ccgggctccc
     1861 tcacctatct tttcccaatg ggtctcagca agtttccagg tgacgacact cagactctag
     1921 gagagaaaga gacagacaca tgctcacata cgcacctccc tgctggtctt gtcactgtcc
     1981 taatcctcat gggctttgcc cagcaactaa gaaaaagaac tcggtgaaca aacttcacta
     2041 tgagcctcag tcccaggtcc ctgttcctaa actggacagt tcagtaaata ttaagtcccc
     2101 gcgcggcggc ctaccgaaat ccctattgca aggcaagctt gcttagtgag ggggacatct
     2161 gagccaacag ccttcgggac cctttgctct gtaggctcat gctggttcac catgacagca
     2221 agggtaggtt tgttgttctg agtacctgtg ggacaagcct gtgccgactt gtgtcattca
     2281 ctggttaaca gttgatatgg agacttaagg aagactgtcc ttagcagtgg gtgtggatag
     2341 gatagggtgg ttaatcaagt tctgtttctg tcccatcccc ttccagcaac ccccctgcat
     2401 ttagagccgc ccattccctg ctgagaactg ctcaaatgcc gggcacctgt ggggcagcgc
     2461 tgctccttgc aaatgtctgg gtctggggaa tgagagttgc tgacttgggt tgatccagcc
     2521 ttatgcaaat ctggaaatgc aaacaactca agttctcagt tcatcccttc tgctctctga
     2581 ttccgagtac cctgtcagac tttgtctcct aatttaaagt ttaatttaca gttctatcag
     2641 aaatacttga gctgtgctga gggggcagga agaggaaagt tccagccaat gaagagtcac
     2701 gagagggaat gtgcctttgc ttcgcgttcc ggagacccct tgacttgctt gcctagtccc
     2761 tacaaccgct gagttgataa ttctgtccgg gagagcttct ctgcaggggc tgctgggtaa
     2821 tgcttgtgac ctcatttcct ggttggaagc tgaactctga agggcttggc agttctgttt
     2881 ttttcttttt ttcttttttc tcctacaata aatttctctg tgatctccat aaaaaaaaaa
//
