LOCUS       NM_001033177            2312 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus keratin 76 (Krt76), mRNA.
ACCESSION   NM_001033177 XM_128174 XM_916853
VERSION     NM_001033177.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2312)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2312)
  AUTHORS   Nelke,C., Muntefering,T., Cengiz,D., Theissen,L., Dobelmann,V.,
            Schroeter,C.B., Block,H., Preusse,C., Michels,A.P.E.,
            Lichtenberg,S., Pawlitzki,M., Pfeuffer,S., Huntemann,N.,
            Zarbock,A., Briese,T., Kittl,C., Dittmayer,C., Budde,T.,
            Lundberg,I.E., Stenzel,W., Meuth,S.G. and Ruck,T.
  TITLE     K2P2.1 is a regulator of inflammatory cell responses in idiopathic
            inflammatory myopathies
  JOURNAL   J Autoimmun 142, 103136 (2024)
   PUBMED   37935063
  REMARK    GeneRIF: K2P2.1 is a regulator of inflammatory cell responses in
            idiopathic inflammatory myopathies.
REFERENCE   3  (bases 1 to 2312)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2312)
  AUTHORS   Sequeira,I., Neves,J.F., Carrero,D., Peng,Q., Palasz,N.,
            Liakath-Ali,K., Lord,G.M., Morgan,P.R., Lombardi,G. and Watt,F.M.
  TITLE     Immunomodulatory role of Keratin 76 in oral and gastric cancer
  JOURNAL   Nat Commun 9 (1), 3437 (2018)
   PUBMED   30143634
  REMARK    GeneRIF: Data shows that immunomodulatory role of Keratin 76 in
            oral and gastric cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2312)
  AUTHORS   DiTommaso,T., Jones,L.K., Cottle,D.L., Gerdin,A.K., Vancollie,V.E.,
            Watt,F.M., Ramirez-Solis,R., Bradley,A., Steel,K.P., Sundberg,J.P.,
            White,J.K. and Smyth,I.M.
  CONSRTM   WTSI Mouse Genetics Program
  TITLE     Identification of genes important for cutaneous function revealed
            by a large scale reverse genetic screen in the mouse
  JOURNAL   PLoS Genet 10 (10), e1004705 (2014)
   PUBMED   25340873
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2312)
  AUTHORS   DiTommaso,T., Cottle,D.L., Pearson,H.B., Schluter,H., Kaur,P.,
            Humbert,P.O. and Smyth,I.M.
  TITLE     Keratin 76 is required for tight junction function and maintenance
            of the skin barrier
  JOURNAL   PLoS Genet 10 (10), e1004706 (2014)
   PUBMED   25340345
  REMARK    GeneRIF: We further demonstrate that KRT76 interacts with CLDN1 and
            propose that this interaction is necessary to correctly position
            CLDN1 in tight junctions.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2312)
  AUTHORS   Liakath-Ali,K., Vancollie,V.E., Heath,E., Smedley,D.P., Estabel,J.,
            Sunter,D., Ditommaso,T., White,J.K., Ramirez-Solis,R., Smyth,I.,
            Steel,K.P. and Watt,F.M.
  TITLE     Novel skin phenotypes revealed by a genome-wide mouse reverse
            genetic screen
  JOURNAL   Nat Commun 5, 3540 (2014)
   PUBMED   24721909
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2312)
  AUTHORS   Ambatipudi,S., Bhosale,P.G., Heath,E., Pandey,M., Kumar,G.,
            Kane,S., Patil,A., Maru,G.B., Desai,R.S., Watt,F.M. and
            Mahimkar,M.B.
  TITLE     Downregulation of keratin 76 expression during oral carcinogenesis
            of human, hamster and mouse
  JOURNAL   PLoS One 8 (7), e70688 (2013)
   PUBMED   23936238
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2312)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK137676.1.
            
            On Apr 6, 2007 this sequence version replaced NM_001033177.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137676.1, AK036802.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2312              AK137676.1         2-2313
FEATURES             Location/Qualifiers
     source          1..2312
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.1 cM"
     gene            1..2312
                     /gene="Krt76"
                     /gene_synonym="2310001L23Rik"
                     /note="keratin 76"
                     /db_xref="GeneID:77055"
                     /db_xref="MGI:MGI:1924305"
     exon            1..607
                     /gene="Krt76"
                     /gene_synonym="2310001L23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            608..828
                     /gene="Krt76"
                     /gene_synonym="2310001L23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            829..889
                     /gene="Krt76"
                     /gene_synonym="2310001L23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            890..985
                     /gene="Krt76"
                     /gene_synonym="2310001L23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1150
                     /gene="Krt76"
                     /gene_synonym="2310001L23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1276
                     /gene="Krt76"
                     /gene_synonym="2310001L23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1497
                     /gene="Krt76"
                     /gene_synonym="2310001L23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1532
                     /gene="Krt76"
                     /gene_synonym="2310001L23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..2312
                     /gene="Krt76"
                     /gene_synonym="2310001L23Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2312
                     /gene="Krt76"
                     /gene_synonym="2310001L23Rik"
                     /note="putative"
ORIGIN      
        1 atcctctcct cagccctttg ctctgctaag ttactgctag ctcactgcca cactcctcac
       61 tatgagcaga caagcctgca agaaatcctt cagttgtggg agccagggct tctctggcca
      121 ctcagctgtg gtatctggca gcagcaggag cagctgtgtg gctcgctctg gggcagccag
      181 tggaggggct tgtgggttcc ggagcggagc aggtagcctt ggcagtcaca gcctctacag
      241 cctgggtggc agtaagagta tttctatcag cgtggcggct ggtggctccc gggctggtgg
      301 cttcagtgga gggcgtagca gctgtggcag tggctttgga agtggctatg gaggtagcct
      361 tggtggtagt agaggaatgg gagctggctt tgggggccct tctggatttg ggggagctgg
      421 tggctttggt aggcctggta gctttggccc tggtagctgc cctggtggaa tccaggaagt
      481 gaccatcaac cagagcctcc tgcagcccct caatgtagag attgaccccc agattgggca
      541 agtgaaggcc caggagcgtg aacagatcaa gaccctcaac aacaagtttg cttccttcat
      601 cgacaaggtg cgcttcctgg agcagcagaa caaggtcctg gagaccaagt gggagctgct
      661 gcagcagcag accatacgct ctggctcagg accccagaac ctggaacctt tctttgaatc
      721 ctacatcagc tgcctgcgca agcagttaga ttcacttctg ggggcgaagg ggagcctgga
      781 gggagagctg aagagcatgc aagacctggt agaagacttc aaaaagaagt atgaagagga
      841 gatcaacagg cgtactgctg cagagaatga atttgtaggg ctgaagaagg atgtagatgg
      901 agctttcatg aacaaagtgg agctgcaggc taaagtggac agtctgacag atgaaatcaa
      961 ctttctgagg actctctacg acatggagct gtcccagata cagagtcatg tcagtgacac
     1021 atctgtggtc ctgtccatgg acaacaaccg ctgcctggac ctggacagca tcatcgctga
     1081 ggtcaaggcc cagtatgagg acattgccca gaagagtaag gctgaggctg aggccctgta
     1141 ccagaccaag cttggggagt tacagaccac agctggcagg catggtgatg acctgaggag
     1201 caccaagagc gagatcatgg atctcaacag gatgatccag agactgcgag cggagattga
     1261 gaatgtcaag aagcagaaca ccaacatgca gacatccatt gcagaggctg aacagcgtgg
     1321 tgagcgggcc ctcaaggatg cagataccaa attccaagac ttgcaggttg ctctgcagaa
     1381 ggccaaggag gacatggccc ggctgctgaa ggagtaccag gagctcatga atgtcaagct
     1441 ggccctggat gtggagatcg ccacctacag gaagctactg gagggcgagg agtgcaggtt
     1501 gtctggagag tttcagaatg ctgtgagcat ttcagtggtc agcaatgtta ccagcacaag
     1561 cagcagcgga agcttcagag ggaccggtgg cagtaactac ggaggggata gcagtggcag
     1621 aagcggcggc agcagcagca gcagcagcag aggcagcagc agcagaggca gcagtgggag
     1681 cagacttggc agtggaggca gcatctccgt gagccagcag agaatgggct ttaactctgg
     1741 tggcagccag acctcagtag gcagcagcta caagtctggc agaggaggca gcagcagtgt
     1801 tcagttctct cagaccacca gttcaagcca gcaacgctcc aagtgatctt caggggcaaa
     1861 gcatccacac cctcctgctt tccctgcctc agcctgcaat ggcatctgct cccaacttct
     1921 tggcatcaac aggtgcacag ttcaaccctg ctttaactca agttccttgg agaaggggcc
     1981 gaacttcttt gctcctatat ctttaagtct tctcttaggt cagggtagtc caactactag
     2041 tctgggatga tggcgctcct agagaagagc ctgtggtgaa tctgaaatgt ggtcagcagt
     2101 accagaggct aggccttccc aagctttcta gtctagccta gtccattctg tccatctgtc
     2161 actcacaggt gaaactgttt ccaaactgtt ggttctcatg ggactctcct gacagctggc
     2221 tcatctatcc ccttaaaacc tcctgagctc tgggtctttt gcttatgaaa agttatattc
     2281 tcttttctca ataaatttgc agtgtgcttc at
//
