LOCUS       NP_001028349             594 aa            linear   ROD 27-APR-2025
DEFINITION  keratin, type II cytoskeletal 2 oral [Mus musculus].
ACCESSION   NP_001028349 XP_128174 XP_921946
VERSION     NP_001028349.1
DBSOURCE    REFSEQ: accession NM_001033177.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 594)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 594)
  AUTHORS   Nelke,C., Muntefering,T., Cengiz,D., Theissen,L., Dobelmann,V.,
            Schroeter,C.B., Block,H., Preusse,C., Michels,A.P.E.,
            Lichtenberg,S., Pawlitzki,M., Pfeuffer,S., Huntemann,N.,
            Zarbock,A., Briese,T., Kittl,C., Dittmayer,C., Budde,T.,
            Lundberg,I.E., Stenzel,W., Meuth,S.G. and Ruck,T.
  TITLE     K2P2.1 is a regulator of inflammatory cell responses in idiopathic
            inflammatory myopathies
  JOURNAL   J Autoimmun 142, 103136 (2024)
   PUBMED   37935063
  REMARK    GeneRIF: K2P2.1 is a regulator of inflammatory cell responses in
            idiopathic inflammatory myopathies.
REFERENCE   3  (residues 1 to 594)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 594)
  AUTHORS   Sequeira,I., Neves,J.F., Carrero,D., Peng,Q., Palasz,N.,
            Liakath-Ali,K., Lord,G.M., Morgan,P.R., Lombardi,G. and Watt,F.M.
  TITLE     Immunomodulatory role of Keratin 76 in oral and gastric cancer
  JOURNAL   Nat Commun 9 (1), 3437 (2018)
   PUBMED   30143634
  REMARK    GeneRIF: Data shows that immunomodulatory role of Keratin 76 in
            oral and gastric cancer.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 594)
  AUTHORS   DiTommaso,T., Jones,L.K., Cottle,D.L., Gerdin,A.K., Vancollie,V.E.,
            Watt,F.M., Ramirez-Solis,R., Bradley,A., Steel,K.P., Sundberg,J.P.,
            White,J.K. and Smyth,I.M.
  CONSRTM   WTSI Mouse Genetics Program
  TITLE     Identification of genes important for cutaneous function revealed
            by a large scale reverse genetic screen in the mouse
  JOURNAL   PLoS Genet 10 (10), e1004705 (2014)
   PUBMED   25340873
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 594)
  AUTHORS   DiTommaso,T., Cottle,D.L., Pearson,H.B., Schluter,H., Kaur,P.,
            Humbert,P.O. and Smyth,I.M.
  TITLE     Keratin 76 is required for tight junction function and maintenance
            of the skin barrier
  JOURNAL   PLoS Genet 10 (10), e1004706 (2014)
   PUBMED   25340345
  REMARK    GeneRIF: We further demonstrate that KRT76 interacts with CLDN1 and
            propose that this interaction is necessary to correctly position
            CLDN1 in tight junctions.
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 594)
  AUTHORS   Liakath-Ali,K., Vancollie,V.E., Heath,E., Smedley,D.P., Estabel,J.,
            Sunter,D., Ditommaso,T., White,J.K., Ramirez-Solis,R., Smyth,I.,
            Steel,K.P. and Watt,F.M.
  TITLE     Novel skin phenotypes revealed by a genome-wide mouse reverse
            genetic screen
  JOURNAL   Nat Commun 5, 3540 (2014)
   PUBMED   24721909
  REMARK    Publication Status: Online-Only
REFERENCE   8  (residues 1 to 594)
  AUTHORS   Ambatipudi,S., Bhosale,P.G., Heath,E., Pandey,M., Kumar,G.,
            Kane,S., Patil,A., Maru,G.B., Desai,R.S., Watt,F.M. and
            Mahimkar,M.B.
  TITLE     Downregulation of keratin 76 expression during oral carcinogenesis
            of human, hamster and mouse
  JOURNAL   PLoS One 8 (7), e70688 (2013)
   PUBMED   23936238
  REMARK    Publication Status: Online-Only
REFERENCE   9  (residues 1 to 594)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK137676.1.
            
            On or before Jan 26, 2006 this sequence version replaced
            XP_128174.1, XP_921946.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137676.1, AK036802.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..594
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.1 cM"
     Protein         1..594
                     /product="keratin, type II cytoskeletal 2 oral"
                     /note="K76; type-II keratin Kb9"
                     /calculated_mol_wt=62714
     Region          1..164
                     /region_name="Head. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UV17.1)"
     Region          16..161
                     /region_name="Keratin_2_head"
                     /note="Keratin type II head; pfam16208"
                     /db_xref="CDD:465068"
     Site            85
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q6IFZ6; propagated from
                     UniProtKB/Swiss-Prot (Q3UV17.1)"
     Site            104
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q6IFZ6; propagated from
                     UniProtKB/Swiss-Prot (Q3UV17.1)"
     Region          164..479
                     /region_name="Filament"
                     /note="Intermediate filament protein; pfam00038"
                     /db_xref="CDD:459643"
     Region          165..200
                     /region_name="Coil 1A. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UV17.1)"
     Region          201..221
                     /region_name="Linker 1. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UV17.1)"
     Region          222..313
                     /region_name="Coil 1B. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UV17.1)"
     Region          314..337
                     /region_name="Linker 12. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UV17.1)"
     Region          338..476
                     /region_name="Coil 2. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UV17.1)"
     Region          477..594
                     /region_name="Tail. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UV17.1)"
     Region          497..594
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3UV17.1)"
     Site            541
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q6IFZ6; propagated from
                     UniProtKB/Swiss-Prot (Q3UV17.1)"
     CDS             1..594
                     /gene="Krt76"
                     /gene_synonym="2310001L23Rik"
                     /coded_by="NM_001033177.2:62..1846"
                     /db_xref="CCDS:CCDS27866.1"
                     /db_xref="GeneID:77055"
                     /db_xref="MGI:MGI:1924305"
ORIGIN      
        1 msrqackksf scgsqgfsgh savvsgssrs scvarsgaas ggacgfrsga gslgshslys
       61 lggsksisis vaaggsragg fsggrsscgs gfgsgyggsl ggsrgmgagf ggpsgfggag
      121 gfgrpgsfgp gscpggiqev tinqsllqpl nveidpqigq vkaqereqik tlnnkfasfi
      181 dkvrfleqqn kvletkwell qqqtirsgsg pqnlepffes yisclrkqld sllgakgsle
      241 gelksmqdlv edfkkkyeee inrrtaaene fvglkkdvdg afmnkvelqa kvdsltdein
      301 flrtlydmel sqiqshvsdt svvlsmdnnr cldldsiiae vkaqyediaq kskaeaealy
      361 qtklgelqtt agrhgddlrs tkseimdlnr miqrlraeie nvkkqntnmq tsiaeaeqrg
      421 eralkdadtk fqdlqvalqk akedmarllk eyqelmnvkl aldveiatyr kllegeecrl
      481 sgefqnavsi svvsnvtsts ssgsfrgtgg snyggdssgr sggssssssr gsssrgssgs
      541 rlgsggsisv sqqrmgfnsg gsqtsvgssy ksgrggsssv qfsqttsssq qrsk
//
