LOCUS       NM_133357               3268 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus keratin 75 (Krt75), mRNA.
ACCESSION   NM_133357
VERSION     NM_133357.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3268)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3268)
  AUTHORS   Deshmukh,R., Vasquez,B., Bhogadi,L., Gabe,C.M., Lukashova,L.,
            Verdelis,K., Morasso,M.I. and Beniash,E.
  TITLE     Elucidating the role of keratin 75 in enamel using Krt75tm1Der
            knock-in mouse model
  JOURNAL   Front Physiol 13, 1102553 (2022)
   PUBMED   36620220
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3268)
  AUTHORS   Denkena,J., Zaisser,A., Merz,B., Klinger,B., Kuhl,D., Bluthgen,N.
            and Hermey,G.
  TITLE     Neuronal activity regulates alternative exon usage
  JOURNAL   Mol Brain 13 (1), 148 (2020)
   PUBMED   33172478
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3268)
  AUTHORS   Yang,X., Yamazaki,H., Yamakoshi,Y., Duverger,O., Morasso,M.I. and
            Beniash,E.
  TITLE     Trafficking and secretion of keratin 75 by ameloblasts in vivo
  JOURNAL   J Biol Chem 294 (48), 18475-18487 (2019)
   PUBMED   31628189
  REMARK    GeneRIF: Results indicate that keratin 75 (K75), a cytosolic
            protein lacking a signal sequence, is secreted into the forming
            enamel matrix utilizing portions of the conventional endoplasmic
            reticulum (ER)-Golgi secretory pathway.
REFERENCE   5  (bases 1 to 3268)
  AUTHORS   Fleger-Weckmann,A., Ustun,Y., Kloepper,J., Paus,R., Bloch,W.,
            Chen,Z.L., Wegner,J., Sorokin,L., Langbein,L., Eckes,B.,
            Zigrino,P., Krieg,T. and Nischt,R.
  TITLE     Deletion of the epidermis derived laminin gamma1 chain leads to
            defects in the regulation of late hair morphogenesis
  JOURNAL   Matrix Biol 56, 42-56 (2016)
   PUBMED   27234308
REFERENCE   6  (bases 1 to 3268)
  AUTHORS   Chen,J., Jaeger,K., Den,Z., Koch,P.J., Sundberg,J.P. and Roop,D.R.
  TITLE     Mice expressing a mutant Krt75 (K6hf) allele develop hair and nail
            defects resembling pachyonychia congenita
  JOURNAL   J Invest Dermatol 128 (2), 270-279 (2008)
   PUBMED   17851587
  REMARK    GeneRIF: Mice expressing mutant form of Krt75 developed hair and
            nail defects resembling pachyonychia congenita
REFERENCE   7  (bases 1 to 3268)
  AUTHORS   Gu,L.H. and Coulombe,P.A.
  TITLE     Keratin expression provides novel insight into the morphogenesis
            and function of the companion layer in hair follicles
  JOURNAL   J Invest Dermatol 127 (5), 1061-1073 (2007)
   PUBMED   17170733
  REMARK    GeneRIF: mK6a and mK75 thus exhibit temporally distinct, and
            spatially opposed, expression patterns in the companion layer (Cl)
            during postnatal anagen.
REFERENCE   8  (bases 1 to 3268)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   9  (bases 1 to 3268)
  AUTHORS   Adolphe,C., Hetherington,R., Ellis,T. and Wainwright,B.
  TITLE     Patched1 functions as a gatekeeper by promoting cell cycle
            progression
  JOURNAL   Cancer Res 66 (4), 2081-2088 (2006)
   PUBMED   16489008
REFERENCE   10 (bases 1 to 3268)
  AUTHORS   Poirier,C., Yoshiki,A., Fujiwara,K., Guenet,J.L. and Kusakabe,M.
  TITLE     Hague (Hag). A new mouse hair mutation with an unstable
            semidominant allele
  JOURNAL   Genetics 162 (2), 831-840 (2002)
   PUBMED   12399393
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC120787.14
            and AC103674.10.
            
            On May 1, 2007 this sequence version replaced NM_133357.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028972.1, BC137935.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN04095723
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-574               AC120787.14        136884-137457
            575-789             AC120787.14        137952-138166
            790-850             AC120787.14        139084-139144
            851-946             AC103674.10        142255-142350       c
            947-1111            AC103674.10        141394-141558       c
            1112-1237           AC103674.10        139523-139648       c
            1238-1458           AC103674.10        139178-139398       c
            1459-1493           AC103674.10        137474-137508       c
            1494-3268           AC103674.10        134577-136351       c
FEATURES             Location/Qualifiers
     source          1..3268
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.91 cM"
     gene            1..3268
                     /gene="Krt75"
                     /gene_synonym="4732468K03Rik; K6hf; Krt2-6hf; Krtcap1"
                     /note="keratin 75"
                     /db_xref="GeneID:109052"
                     /db_xref="MGI:MGI:1923500"
     exon            1..574
                     /gene="Krt75"
                     /gene_synonym="4732468K03Rik; K6hf; Krt2-6hf; Krtcap1"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1729
                     /gene="Krt75"
                     /gene_synonym="4732468K03Rik; K6hf; Krt2-6hf; Krtcap1"
                     /note="keratinocyte associated protein 1; cytokeratin
                     KRT2-6HF; K75; CK-75; mK6hf; cytokeratin-75; type II
                     keratin-K6hf; type-II keratin Kb18; keratin-6 hair
                     follicle; keratin 75 activity-regulated"
                     /codon_start=1
                     /product="keratin, type II cytoskeletal 75"
                     /protein_id="NP_579935.1"
                     /db_xref="CCDS:CCDS27856.1"
                     /db_xref="GeneID:109052"
                     /db_xref="MGI:MGI:1923500"
                     /translation="MSRQSTITFHSGSRRGFSTASATTPTAGRSRFSSVSVARSSGNS
                     GGLGRISGIGSGFGSRSLYNLGGTRRVSIGGCAGSGFRGGFGGRTSSGFGGSSGFAYG
                     GGIGGGFGGPGFSVCPSGGIQEVTVNQSLLTPLNLQIDPTIQRVRKEEREQIKTLNNK
                     FASFIDKVRFLEQQNKVLETKWNLLQEQGSRTVRQNLEPFFDTYVNDLRRQLDGITAE
                     RGRLDAELRNMQEVVEDFKVRYEDEINKRAAAENEFVGLKKDVDSAYMNKVELEAKVD
                     SLTDQINFYRMIYEAELSQMQNQVSDTSVVLSMDNNRSLDLDSIIAEVKAQYEDIANR
                     SRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEISEMNRMIQRLRSEIDAVKKQCSSL
                     QTAISDAEQRGELALKDARAKLMELEDALQKAKQDMARLLREYQELMNVKLALDVEIA
                     TYRKLLEGEECRLSGEGVSPVNISVVTSTVSSGYGGGANIGGGSLGLGGNSGYSFTTS
                     GGHSLGTGLGGSGFTTTSSRGPVGSGSSIKFVSSTSSRKSYKH"
     exon            575..789
                     /gene="Krt75"
                     /gene_synonym="4732468K03Rik; K6hf; Krt2-6hf; Krtcap1"
                     /inference="alignment:Splign:2.1.0"
     exon            790..850
                     /gene="Krt75"
                     /gene_synonym="4732468K03Rik; K6hf; Krt2-6hf; Krtcap1"
                     /inference="alignment:Splign:2.1.0"
     exon            851..946
                     /gene="Krt75"
                     /gene_synonym="4732468K03Rik; K6hf; Krt2-6hf; Krtcap1"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1111
                     /gene="Krt75"
                     /gene_synonym="4732468K03Rik; K6hf; Krt2-6hf; Krtcap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1237
                     /gene="Krt75"
                     /gene_synonym="4732468K03Rik; K6hf; Krt2-6hf; Krtcap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1458
                     /gene="Krt75"
                     /gene_synonym="4732468K03Rik; K6hf; Krt2-6hf; Krtcap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1493
                     /gene="Krt75"
                     /gene_synonym="4732468K03Rik; K6hf; Krt2-6hf; Krtcap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..3268
                     /gene="Krt75"
                     /gene_synonym="4732468K03Rik; K6hf; Krt2-6hf; Krtcap1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2188..2193
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt75"
                     /gene_synonym="4732468K03Rik; K6hf; Krt2-6hf; Krtcap1"
                     /note="hexamer: ATTAAA"
     polyA_site      2217
                     /gene="Krt75"
                     /gene_synonym="4732468K03Rik; K6hf; Krt2-6hf; Krtcap1"
                     /note="major polyA site"
ORIGIN      
        1 gcctggcttc tctatcccct tcacgaatct acgaatctac ctcggagctc ctgtgctgcc
       61 ttcttcgccc atcatgtccc ggcaatccac catcaccttc cactccggca gccgcagggg
      121 cttcagcaca gcctcagcca ccacacctac ggctggacgc tcccgcttca gctccgtgtc
      181 tgtggcccgc tcctcaggaa acagtggggg actgggcagg atcagtggta ttggttctgg
      241 ctttggaagc cgcagcctct acaacctagg ggggacccgg cgggtctcca ttggtggctg
      301 tgctggcagt ggcttcaggg gtggctttgg tggcaggact agcagtggct ttgggggcag
      361 cagtggcttt gcttatggag gtggcattgg agggggcttt ggtggccctg gcttctctgt
      421 ctgtccctct ggaggcattc aggaagttac tgtcaaccag agcctcctga ctcccctcaa
      481 cctgcaaatc gaccccacta tccagcgggt gcggaaagaa gaacgggagc agatcaagac
      541 tctgaacaac aagttcgcct ccttcattga caaggtacgc ttcctggagc agcagaacaa
      601 ggtcctggag accaagtgga atctcctgca ggagcagggc tctaggacag tcagacagaa
      661 cctggagcct ttcttcgata catatgtcaa tgacctccgc cggcagctgg atggcatcac
      721 agctgaaaga ggcagactgg atgctgaact gaggaacatg caggaggttg tagaagactt
      781 caaagtcagg tatgaagacg aaattaacaa gcgtgcggct gccgagaatg agttcgtggg
      841 cctgaaaaag gacgtagaca gtgcctacat gaacaaggtg gagctggaag cgaaggtcga
      901 ctctctgact gaccagatca acttctaccg gatgatctat gaggcagagc tgtctcagat
      961 gcagaaccag gtgagtgaca cctctgtggt cctctccatg gacaacaacc gcagcctgga
     1021 cctggacagc atcatcgccg aggtcaaggc ccagtacgag gacattgcca accgaagccg
     1081 ggcagaggct gagtcctggt accagacgaa gtatgaggag ctgcaggtga ccgcaggccg
     1141 gcatggtgat gacctccgca acaccaaaca agagatttca gagatgaacc ggatgatcca
     1201 gaggctcaga tctgagattg atgccgtcaa gaagcagtgc tccagcttac aaactgctat
     1261 ctctgacgct gagcagcgtg gagagctagc tctcaaggat gcccgggcca agctgatgga
     1321 gcttgaagat gccctacaga aagccaagca ggacatggcc aggttgcttc gagagtacca
     1381 ggaactcatg aacgtcaaac tggccttgga tgtggagatc gccacctaca ggaagctgct
     1441 ggaaggcgag gagtgcaggc tgagcggaga gggagtttcc ccagtgaaca tctctgtggt
     1501 cacttctacg gtttccagtg gctatggcgg tggtgccaac attggaggtg gaagcctggg
     1561 tcttggtggg aacagtggct actccttcac gaccagtggt gggcacagcc tgggcacagg
     1621 tctgggaggc tctggcttta ccaccaccag cagccggggc ccagtgggca gtggctccag
     1681 catcaagttt gtctccagca catcatccag aaagagttac aagcactgag gtggccagca
     1741 ggcagtctcc cttgccactg ctccgatgcc tctttacact tataactgga tgcctggggc
     1801 ccatctctca tatcctcttc acaatagcac ccttcccagc agccagggat cctggtatcc
     1861 tggctaaacc cattccctgg cctatggcag cctcctgaca gccctaggct gctcctggta
     1921 cttctttgtg ctagacacac agacccaaag ctcatgtccc tccaaagttc acaataaatg
     1981 gatctgccag ggcatggcat ctgcaaacac ccccagacat ctacaaatgc cccttcagta
     2041 ccacctgccc ctttcctcca ggtgcagcaa tggaggagtc cgtgtctccc aggccatcct
     2101 caatgccagg ctgccttgtc cttctctggc tgcttataaa ctaccagcta gagtcaaagc
     2161 tcctctgttt ccacctggaa tgtgcctatt aaatgcatgt gtcatgtgtt tggctcagtc
     2221 ctctgtgtgc agtgctgatg agcctggagc aactccgact ttcaggcagc cccagccagt
     2281 gttattccat acaagcagta ctcaaggcac agcagctctt gccccttcca gaggagctgg
     2341 aggggagata gagaaggggg gagcatggga agggcagcag accaatagtc ttcctcctct
     2401 agcggctcca actctttgga atgcttgttt gggaagtccc aacccctggg cagagccctg
     2461 cccagcctcc tgctctgtat gtcatgcagg gtgaggctat accctcccca aatcagcctg
     2521 tgttcctggg acagcgctga cgtaagatgg gtggtcaagg cactggccag caaaggagcc
     2581 gattgttccc tgacagcttc aaacttgtag acctgagcag agaaataaca gagcaggaga
     2641 ggagttaaaa gtcagcccgg aggccaagga gcaaatgagc ccataattgc aagacaggga
     2701 gacacccagg aagctcctca ttcctcagtt tatagtctcc tggacccctc ccctcaggac
     2761 ctagggggat gatgggacta atcaatgaat gggatcgagg tgtttggtca gggtgggctt
     2821 gtcacatagg attactgata ggagctgcca atcagaaaac cacccacgct cagaaaggag
     2881 ttctatcata ggagtcagaa gggagggatg tgaaataaga gaccggaagt atagaatggt
     2941 tgagggtaac agtttcagag tagacaggaa aaactgtgca aataattgcc aaattcacta
     3001 gctaagacca gggaggaaag aagaggatgg gaatgtgggg ggaacctcag actacttctt
     3061 aggaaggacc agagacatca ctttcccctg ctatgtgaag cacagggatt ctgggcacac
     3121 agcccaatca gacactgggt tctagtgttg tctccaggat tccctggcca tgtgacctgt
     3181 gtgacaatgg ttgcaggaag aaaccaaggg caaaaacatc caatgttgga aggtaaactg
     3241 ttagagtttg tctcccatga tactgctc
//
