LOCUS       NM_212485               2186 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus keratin 73 (Krt73), mRNA.
ACCESSION   NM_212485 XM_128282
VERSION     NM_212485.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2186)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   2  (bases 1 to 2186)
  AUTHORS   Wu,X., Quondamatteo,F., Lefever,T., Czuchra,A., Meyer,H.,
            Chrostek,A., Paus,R., Langbein,L. and Brakebusch,C.
  TITLE     Cdc42 controls progenitor cell differentiation and beta-catenin
            turnover in skin
  JOURNAL   Genes Dev 20 (5), 571-585 (2006)
   PUBMED   16510873
REFERENCE   3  (bases 1 to 2186)
  AUTHORS   Hesse,M., Zimek,A., Weber,K. and Magin,T.M.
  TITLE     Comprehensive analysis of keratin gene clusters in humans and
            rodents
  JOURNAL   Eur J Cell Biol 83 (1), 19-26 (2004)
   PUBMED   15085952
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104862.15.
            
            On Jul 12, 2018 this sequence version replaced NM_212485.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067067.1, BK003988.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-507               AC104862.15        96960-97466         c
            508-722             AC104862.15        95818-96032         c
            723-783             AC104862.15        95007-95067         c
            784-879             AC104862.15        94426-94521         c
            880-1044            AC104862.15        93877-94041         c
            1045-1170           AC104862.15        91449-91574         c
            1171-1391           AC104862.15        90882-91102         c
            1392-1426           AC104862.15        89917-89951         c
            1427-2186           AC104862.15        88410-89169         c
FEATURES             Location/Qualifiers
     source          1..2186
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.03 cM"
     gene            1..2186
                     /gene="Krt73"
                     /gene_synonym="CK-73; K73; Kb36"
                     /note="keratin 73"
                     /db_xref="GeneID:223915"
                     /db_xref="MGI:MGI:3607712"
     exon            1..507
                     /gene="Krt73"
                     /gene_synonym="CK-73; K73; Kb36"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1683
                     /gene="Krt73"
                     /gene_synonym="CK-73; K73; Kb36"
                     /note="type II keratin Kb36; cytokeratin-73; type II inner
                     root sheath-specific keratin-K6irs3"
                     /codon_start=1
                     /product="keratin, type II cytoskeletal 73"
                     /protein_id="NP_997650.1"
                     /db_xref="CCDS:CCDS27864.1"
                     /db_xref="GeneID:223915"
                     /db_xref="MGI:MGI:3607712"
                     /translation="MNRQFTCKPGVANRGFSGCSAVLSGGSSSSYRAAGKGLSGGFSS
                     RSLYSLRSPRSISFNVASSSGRTGGYGFGRNRASGFAGSMFGSGALGPSNPSLCLPGG
                     IHQVTVNKSLLAPLNVELDPEIQKVRAQEREQIKALNNKFASFIDKVRFLEQQNQVLQ
                     TKWELLQQLDLSNCRRNLEPVYEAHISSLQKQLDSLSGDRVRLDSELRGMRDAVEDCK
                     KRYEEEINKRTTAENEFVVLKKDVDAAYMSKVELQAKVDALDGEIKFLKCLYEGEITQ
                     MQSHISDTSVVLSMDNNRNLDLDSIIAEVRAQYEDIALKSKAEAEMVYQTKFQELQLA
                     AGRHGDDLKHTRNEISELTRLIQRLRSEIESVKKQCSNLETAIADAEQRGDCALKDAR
                     AKLDELERALHQAKEELARMLREHQELMSMKLALDIEIATYRKLLEGEECRMSGEHTS
                     AVSISVISSSAPGTVGAGTSFGFSSAGTYGYRQSSVAGGYGILSGGCVTGSGNCSPRG
                     DTKNRLGSASEFKEVSGKTLALGSPSKKTMR"
     exon            508..722
                     /gene="Krt73"
                     /gene_synonym="CK-73; K73; Kb36"
                     /inference="alignment:Splign:2.1.0"
     exon            723..783
                     /gene="Krt73"
                     /gene_synonym="CK-73; K73; Kb36"
                     /inference="alignment:Splign:2.1.0"
     exon            784..879
                     /gene="Krt73"
                     /gene_synonym="CK-73; K73; Kb36"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1044
                     /gene="Krt73"
                     /gene_synonym="CK-73; K73; Kb36"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1170
                     /gene="Krt73"
                     /gene_synonym="CK-73; K73; Kb36"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1391
                     /gene="Krt73"
                     /gene_synonym="CK-73; K73; Kb36"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1426
                     /gene="Krt73"
                     /gene_synonym="CK-73; K73; Kb36"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..2186
                     /gene="Krt73"
                     /gene_synonym="CK-73; K73; Kb36"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2163..2168
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt73"
                     /gene_synonym="CK-73; K73; Kb36"
                     /note="hexamer: AATAAA"
     polyA_site      2182
                     /gene="Krt73"
                     /gene_synonym="CK-73; K73; Kb36"
                     /note="major polyA site"
ORIGIN      
        1 ggaacagtca gtctcttggc gaaggcttgt gtcttgtctc attctgtctg tggcttcttc
       61 aggatgaatc gccaattcac ctgcaaacct ggagttgcca acaggggctt cagcggctgc
      121 tcagctgtgc tctccggagg cagctcatcc tcttaccggg cagccggcaa agggctcagt
      181 ggaggcttca gcagtcggag cctctacagc ctgaggagtc ccaggagcat ctccttcaat
      241 gtggctagca gcagcgggcg cacaggggga tatgggtttg gccggaatcg ggccagtggc
      301 tttgctggca gtatgtttgg cagtggggct ctggggcctt caaatccatc cttgtgcctg
      361 cctggaggca tccaccaggt aacagtcaat aaaagcctcc tggctcctct caatgtggag
      421 ctggacccgg agatccagaa ggtgcgcgcc caggagcggg agcagatcaa ggctctgaac
      481 aacaaattcg cctccttcat cgacaaggtg cgcttcttgg agcagcagaa ccaggtgctg
      541 cagaccaagt gggagctgct gcagcagctg gacctgagca actgcaggag gaacctggag
      601 cctgtttatg aggcccacat cagcagcctg caaaagcagc tggattcgct atctggggac
      661 agggtgaggc tggactcgga gctgaggggc atgcgggatg cagtggagga ctgcaagaag
      721 aggtatgaag aagaaataaa caagcgtaca actgctgaga atgaatttgt agtgcttaag
      781 aaggatgtgg atgccgcata catgagcaag gtggagcttc aggccaaggt ggacgccctg
      841 gatggagaga tcaaattcct caagtgtctg tatgaggggg agattactca gatgcagtcc
      901 cacataagtg acacctctgt ggtcctgtcc atggacaaca accgcaacct ggacctggac
      961 agcatcatcg ctgaggtccg agctcagtac gaggacattg ccctgaagag caaggcagag
     1021 gctgagatgg tgtaccagac caagttccaa gagctgcagc tggcagctgg ccggcacgga
     1081 gatgacctca agcacaccag gaatgagatc tctgagttga cccggctcat ccagagactg
     1141 cgatcagaaa tcgagagtgt gaagaagcaa tgttccaatc tagagacagc cattgctgat
     1201 gctgagcagc gaggtgactg tgccctcaag gatgcccggg ccaagctgga tgagctggag
     1261 agagccctgc accaggctaa ggaggagctg gcccggatgc tgcgtgagca ccaggagctg
     1321 atgagtatga agctggccct ggacattgag atcgccacct accgcaagct gctggagggg
     1381 gaggagtgca ggatgtctgg agaacacacc agtgctgtga gcatttctgt catcagtagt
     1441 tccgcacctg ggacagtcgg tgcggggacc agtttcggat tcagtagcgc tgggacctat
     1501 ggctaccggc agagctctgt cgctgggggc tatggcatac tgtcaggggg ctgtgtcact
     1561 ggtagtggga actgcagccc ccgtggagat accaagaaca gactgggtag tgcaagtgaa
     1621 tttaaggagg tttcgggaaa gaccttggct ttgggctcac cctcaaagaa aaccatgaga
     1681 taaattgaca gccaatcccc catttctgcc gagctttggt tttctctgga ctctcttcca
     1741 ggaactcctc ctgttttatt taccattgct cacattttac ctttctttgt tgtcaacgtg
     1801 gccttatcat caaaccctct gcctttatta accacaccag gattctaggg ttgacattat
     1861 ctcatgcatc tttctgcccc agtgtgaagg gactacttct tagccttcca cacattcatg
     1921 aggacttgcc tgcctgcccc cttgcagcct ctatgttgtc ctcctgctgc ttatgatagt
     1981 ctgggtgcaa gagacttgaa gtgtgttgat ggacattcct gcaagaacca acccagcatg
     2041 gatcaagcac ctggcaccgt tgtatctggc ataaatctct tgttatagga ctgggggtcc
     2101 ccatccattc tggaccttgc ttaggttcca gctctctgct cctgtacccc actaataaaa
     2161 taaataaata tgtataaaat aaggtc
//
