LOCUS       NM_213728               2025 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus keratin 72 (Krt72), mRNA.
ACCESSION   NM_213728 XM_128271
VERSION     NM_213728.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2025)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2025)
  AUTHORS   Sardella,C., Winkler,C., Quignodon,L., Hardman,J.A., Toffoli,B.,
            Giordano Attianese,G.M.P., Hundt,J.E., Michalik,L., Vinson,C.R.,
            Paus,R., Desvergne,B. and Gilardi,F.
  TITLE     Delayed Hair Follicle Morphogenesis and Hair Follicle Dystrophy in
            a Lipoatrophy Mouse Model of Pparg Total Deletion
  JOURNAL   J Invest Dermatol 138 (3), 500-510 (2018)
   PUBMED   28964716
REFERENCE   3  (bases 1 to 2025)
  AUTHORS   Leilei,Y., Bing,L., Yang,L., Shaoxia,W., Yuan,X., Dongping,W.,
            Huahu,Y., Shichen,S., Guangzhou,Z., Ruiyun,P., Lin,Z. and
            Wenlong,L.
  TITLE     iRhom2 mutation leads to aberrant hair follicle differentiation in
            mice
  JOURNAL   PLoS One 9 (12), e115114 (2014)
   PUBMED   25546423
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2025)
  AUTHORS   Blanco,S., Kurowski,A., Nichols,J., Watt,F.M., Benitah,S.A. and
            Frye,M.
  TITLE     The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells
            to differentiate
  JOURNAL   PLoS Genet 7 (12), e1002403 (2011)
   PUBMED   22144916
REFERENCE   5  (bases 1 to 2025)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   6  (bases 1 to 2025)
  AUTHORS   Wu,X., Quondamatteo,F., Lefever,T., Czuchra,A., Meyer,H.,
            Chrostek,A., Paus,R., Langbein,L. and Brakebusch,C.
  TITLE     Cdc42 controls progenitor cell differentiation and beta-catenin
            turnover in skin
  JOURNAL   Genes Dev 20 (5), 571-585 (2006)
   PUBMED   16510873
REFERENCE   7  (bases 1 to 2025)
  AUTHORS   Hesse,M., Zimek,A., Weber,K. and Magin,T.M.
  TITLE     Comprehensive analysis of keratin gene clusters in humans and
            rodents
  JOURNAL   Eur J Cell Biol 83 (1), 19-26 (2004)
   PUBMED   15085952
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104862.15, BK001584.1 and AA717861.1.
            
            On Jul 12, 2018 this sequence version replaced NM_213728.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK001584.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN04095721
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AC104862.15        81565-81626         c
            63-1625             BK001584.1         1-1563
            1626-2025           AA717861.1         1-400               c
FEATURES             Location/Qualifiers
     source          1..2025
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.02 cM"
     gene            1..2025
                     /gene="Krt72"
                     /gene_synonym="CK-72; K6irs2; K72; Krt2-35; Krt72-ps"
                     /note="keratin 72"
                     /db_xref="GeneID:105866"
                     /db_xref="MGI:MGI:2146034"
     exon            1..515
                     /gene="Krt72"
                     /gene_synonym="CK-72; K6irs2; K72; Krt2-35; Krt72-ps"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1625
                     /gene="Krt72"
                     /gene_synonym="CK-72; K6irs2; K72; Krt2-35; Krt72-ps"
                     /note="type-II keratin Kb35; keratin complex 2, basic,
                     gene 35; cytokeratin-72; type II inner root
                     sheath-specific keratin-K6irs2; keratin 72, pseudogene"
                     /codon_start=1
                     /product="keratin, type II cytoskeletal 72"
                     /protein_id="NP_998893.1"
                     /db_xref="CCDS:CCDS27863.1"
                     /db_xref="GeneID:105866"
                     /db_xref="MGI:MGI:2146034"
                     /translation="MSRQLTLYPGAERLGFSGCSAVISGRLSGSHASVRAGVKGAAFG
                     SRSLFCVGGGRRLALSSAGRSGGFTLGHGGASGGRPGGFVGTVFGSAGLGPTCPSVCP
                     PGGIPQVVVNKSLLAPLNVELDPEIQKVRAQEREQIKALNNKFASFIDKVRFLEQQNQ
                     VLETKWELLQQLDLNNSKRSLEPVHESYISNLQKQLEILSGDRVRLDSELRNMREVVE
                     DCKKRYEVEINRRTAAENEFVVLKKDVDAAYMNKVELQAKVDSLTDDIKFFKVLFEGE
                     IAQMQSHISDTSVILSMDNNRQLDLDSILAEVRAQYEEIAVKSKAETENMYQCKIQEL
                     QATAGQHGDDLKHTKSEITEINRLIQRIHSEIGNMKKQCSNLETAIADAEQRGDCALK
                     DARAKLDQLEGALQQAKEELARMLREHQELMNVKLALDMEIATYRKLLESEESRMAGE
                     YPNSVSISVISSTNAGPGGAGFSVGFGASSSYNYRPLALEVKTKGSCGSELKDPPAKT
                     SGSSGTTKKTSR"
     exon            516..730
                     /gene="Krt72"
                     /gene_synonym="CK-72; K6irs2; K72; Krt2-35; Krt72-ps"
                     /inference="alignment:Splign:2.1.0"
     exon            731..791
                     /gene="Krt72"
                     /gene_synonym="CK-72; K6irs2; K72; Krt2-35; Krt72-ps"
                     /inference="alignment:Splign:2.1.0"
     exon            792..887
                     /gene="Krt72"
                     /gene_synonym="CK-72; K6irs2; K72; Krt2-35; Krt72-ps"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1052
                     /gene="Krt72"
                     /gene_synonym="CK-72; K6irs2; K72; Krt2-35; Krt72-ps"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1178
                     /gene="Krt72"
                     /gene_synonym="CK-72; K6irs2; K72; Krt2-35; Krt72-ps"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1399
                     /gene="Krt72"
                     /gene_synonym="CK-72; K6irs2; K72; Krt2-35; Krt72-ps"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1434
                     /gene="Krt72"
                     /gene_synonym="CK-72; K6irs2; K72; Krt2-35; Krt72-ps"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..2013
                     /gene="Krt72"
                     /gene_synonym="CK-72; K6irs2; K72; Krt2-35; Krt72-ps"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1992..1997
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt72"
                     /gene_synonym="CK-72; K6irs2; K72; Krt2-35; Krt72-ps"
                     /note="hexamer: AATAAA"
     polyA_site      2011
                     /gene="Krt72"
                     /gene_synonym="CK-72; K6irs2; K72; Krt2-35; Krt72-ps"
                     /note="major polyA site"
ORIGIN      
        1 agctgtatcc gtgccccagg cctgcctgct gccgtcctgc cagtccttgc ccgctgccag
       61 ccatgagccg ccagttgacc ctctatcccg gagctgagcg cctgggtttc agtggctgct
      121 ctgcggtcat ctcaggcagg ctcagtggca gtcacgcctc ggtccgagct ggagtcaagg
      181 gagcagcatt tgggagcaga agcctgttct gtgtgggggg aggccggcgg ctggcgttga
      241 gctctgcagg gcgaagtggt ggcttcacgc tgggccacgg aggggcgagc ggtgggcggc
      301 ctgggggctt cgtgggcacc gtcttcggca gcgcgggact ggggcccaca tgcccatcag
      361 tgtgccctcc cggtggcatc ccccaggttg tcgtcaacaa gagccttctg gccccactca
      421 atgtggagct ggacccggag atccagaagg tgcgggcaca agagagggag cagatcaagg
      481 ctctgaacaa caagtttgcc tccttcattg acaaggtccg cttcttggag caacagaacc
      541 aggtactgga gaccaagtgg gagctgctgc agcagctgga cctaaacaac tccaagagga
      601 gcctggagcc tgtgcatgag agttacatca gcaacctgca gaagcagctg gagatcctgt
      661 ctggggatag ggtgaggctg gactcagagc tgaggaacat gagggaagtg gtggaggact
      721 gcaagaagag gtacgaggtg gagattaaca gacgcacggc tgccgagaac gagttcgtgg
      781 tgctgaagaa ggatgtggac gcagcttaca tgaacaaggt ggagctccag gccaaggtgg
      841 actccttgac agatgacatc aaattcttca aggttctctt tgaaggggag atagctcaga
      901 tgcagtccca catcagcgac acatccgtca ttctctccat ggacaataac cggcagctgg
      961 acctggacag catcctcgct gaggttcgag cccagtatga ggagattgct gtgaagagca
     1021 aggcagagac ggagaacatg taccagtgta agatccagga gctgcaggcc actgcaggcc
     1081 aacacgggga tgacctcaaa cacaccaagt ctgagatcac agagatcaac aggctgatcc
     1141 agaggatcca ttcagagata ggaaacatga agaagcagtg ctccaacctg gagacggcca
     1201 ttgctgacgc tgaacagaga ggtgactgtg ctctcaagga tgcccgggcc aagctggacc
     1261 agctggaggg agccctgcag caggccaagg aggagctggc ccggatgctg cgtgagcatc
     1321 aggagctcat gaatgtcaag ctcgccctgg acatggagat cgccacctac aggaagcttc
     1381 tggagagcga ggagagccgg atggctggtg aatacccaaa ttctgtgagc atttctgtca
     1441 ttagcagtac caatgcagga ccaggaggtg ctggcttcag tgtgggcttt ggtgcctcga
     1501 gcagttacaa ctatagacct ctggccctgg aggtgaagac caagggtagc tgtggcagcg
     1561 agctcaagga tcctccggcc aaaacctcag gcagcagcgg tacaaccaaa aagacctcca
     1621 gatgacagac aggggcagtg ttgtaagcag aaggctgtgg accccatgtt cctgttctct
     1681 tcccttgggt ccctttctaa gtcaggaagc aagcgttttc tccatcactg aaatcccaac
     1741 tattctccca gccctgtttc cctggcacag ggaactatcg ggtaggagaa ggccagccag
     1801 tcacatgctc tatcccactc tcttcttact ggatagctgc ccccacacag agatgaagca
     1861 ggggcccgag atatgtccct gaagccaact gctagcccct ctgtttgtgt cttcctccag
     1921 ccttccctat caagagggcc tttcctgttg tcctctgatg gggattctgt ctagctctct
     1981 gcctctcttg caataaacaa ttgatggatg ccaaaaaaaa aaaaa
//
