LOCUS       NM_019956               2193 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus keratin 71 (Krt71), mRNA.
ACCESSION   NM_019956
VERSION     NM_019956.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2193)
  AUTHORS   Zhang,T., Yao,H., Wang,H. and Sui,T.
  TITLE     Development of Woolly Hair and Hairlessness in a CRISPR-Engineered
            Mutant Mouse Model with KRT71 Mutations
  JOURNAL   Cells 12 (13), 1781 (2023)
   PUBMED   37443815
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2193)
  AUTHORS   Noto,M., Noguchi,N., Ishimura,A., Kiyonari,H., Abe,T., Suzuki,T.,
            Hasunuma,N., Taira,M., Manabe,M. and Osada,S.I.
  TITLE     Sox13 is a novel early marker for hair follicle development
  JOURNAL   Biochem Biophys Res Commun 509 (4), 862-868 (2019)
   PUBMED   30638933
REFERENCE   3  (bases 1 to 2193)
  AUTHORS   Fairfield,H., Srivastava,A., Ananda,G., Liu,R., Kircher,M.,
            Lakshminarayana,A., Harris,B.S., Karst,S.Y., Dionne,L.A.,
            Kane,C.C., Curtain,M., Berry,M.L., Ward-Bailey,P.F., Greenstein,I.,
            Byers,C., Czechanski,A., Sharp,J., Palmer,K., Gudis,P., Martin,W.,
            Tadenev,A., Bogdanik,L., Pratt,C.H., Chang,B., Schroeder,D.G.,
            Cox,G.A., Cliften,P., Milbrandt,J., Murray,S., Burgess,R.,
            Bergstrom,D.E., Donahue,L.R., Hamamy,H., Masri,A., Santoni,F.A.,
            Makrythanasis,P., Antonarakis,S.E., Shendure,J. and Reinholdt,L.G.
  TITLE     Exome sequencing reveals pathogenic mutations in 91 strains of mice
            with Mendelian disorders
  JOURNAL   Genome Res 25 (7), 948-957 (2015)
   PUBMED   25917818
REFERENCE   4  (bases 1 to 2193)
  AUTHORS   Leilei,Y., Bing,L., Yang,L., Shaoxia,W., Yuan,X., Dongping,W.,
            Huahu,Y., Shichen,S., Guangzhou,Z., Ruiyun,P., Lin,Z. and
            Wenlong,L.
  TITLE     iRhom2 mutation leads to aberrant hair follicle differentiation in
            mice
  JOURNAL   PLoS One 9 (12), e115114 (2014)
   PUBMED   25546423
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2193)
  AUTHORS   Sotiropoulou,P.A., Karambelas,A.E., Debaugnies,M., Candi,A.,
            Bouwman,P., Moers,V., Revenco,T., Rocha,A.S., Sekiguchi,K.,
            Jonkers,J. and Blanpain,C.
  TITLE     BRCA1 deficiency in skin epidermis leads to selective loss of hair
            follicle stem cells and their progeny
  JOURNAL   Genes Dev 27 (1), 39-51 (2013)
   PUBMED   23271346
REFERENCE   6  (bases 1 to 2193)
  AUTHORS   Noebels,J.L., Qiao,X., Bronson,R.T., Spencer,C. and Davisson,M.T.
  TITLE     Stargazer: a new neurological mutant on chromosome 15 in the mouse
            with prolonged cortical seizures
  JOURNAL   Epilepsy Res 7 (2), 129-135 (1990)
   PUBMED   2289471
  REMARK    Erratum:[Epilepsy Res 1992 Mar;11(1):72]
REFERENCE   7  (bases 1 to 2193)
  AUTHORS   Davisson,M.T., Roderick,T.H., Akeson,E.C., Hawes,N.L. and
            Sweet,H.O.
  TITLE     The hairy ears (Eh) mutation is closely associated with a
            chromosomal rearrangement in mouse chromosome 15
  JOURNAL   Genet Res 56 (2-3), 167-178 (1990)
   PUBMED   2272507
REFERENCE   8  (bases 1 to 2193)
  AUTHORS   Beier,D.R., Morton,C.C., Leder,A., Wallace,R. and Leder,P.
  TITLE     Perinatal lethality (ple): a mutation caused by integration of a
            transgene into distal mouse chromosome 15
  JOURNAL   Genomics 4 (4), 498-504 (1989)
   PUBMED   2744761
REFERENCE   9  (bases 1 to 2193)
  AUTHORS   Horton,C.E. Jr., Davisson,M.T., Jacobs,J.B., Bernstein,G.T.,
            Retik,A.B. and Mandell,J.
  TITLE     Congenital progressive hydronephrosis in mice: a new recessive
            mutation
  JOURNAL   J Urol 140 (5 Pt 2), 1310-1315 (1988)
   PUBMED   3184310
REFERENCE   10 (bases 1 to 2193)
  AUTHORS   Teicher,L.S. and Caspari,E.W.
  TITLE     The genetics of blind--a lethal factor in mice
  JOURNAL   J Hered 69 (2), 86-90 (1978)
   PUBMED   670679
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB033744.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB033744.1, AB100413.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN04095721
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2193
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.0 cM"
     gene            1..2193
                     /gene="Krt71"
                     /gene_synonym="Ca; Cal4; Cu; Krt2-6g; mK6irs; mK6irs1"
                     /note="keratin 71"
                     /db_xref="GeneID:56735"
                     /db_xref="MGI:MGI:1861586"
     exon            1..495
                     /gene="Krt71"
                     /gene_synonym="Ca; Cal4; Cu; Krt2-6g; mK6irs; mK6irs1"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1626
                     /gene="Krt71"
                     /gene_synonym="Ca; Cal4; Cu; Krt2-6g; mK6irs; mK6irs1"
                     /note="K6G; K71; CK-6G; CK-71; keratin-6G; cytokeratin-6G;
                     cytokeratin-71; mK6irs1/Krt2-6g; type-II keratin Kb34;
                     type II inner root sheath-specific keratin-K6irs1; keratin
                     complex 2, basic, gene 6g; keratin complex 2, gene 6g;
                     caracul"
                     /codon_start=1
                     /product="keratin, type II cytoskeletal 71"
                     /protein_id="NP_064340.1"
                     /db_xref="CCDS:CCDS27862.1"
                     /db_xref="GeneID:56735"
                     /db_xref="MGI:MGI:1861586"
                     /translation="MSRQFTCKSGASNRGFSGCSAVLSGGSSSSYRAGGKGLSGGFGS
                     RSLYSLGGGRSITLNMASGSGKNGGFGFGRNRASGFAGSIFGSVALGPVCPAVCPPGG
                     IHQVTVNESLLAPLNVELDPEIQKVRAQEREQIKALNNKFASFIDKVRFLEQQNQVLQ
                     TKWELLQQLDLNNCKNNLEPILEGHISNMRKQLETLSGDRVRLDSELRNVRDVVEDYK
                     KKYEEEINRRTAAENEFVLLKKDVDAAYANKVELQAKVDTMDQDIKFFKCLFEAEMAQ
                     IQSHISDMSVILSMDNNRNLDLDSIIDEVRAQYEEIALKSKAEAEALYQTKFQELQLA
                     AGRHGDDLKNTKNEITELTRFIQRLRSEIENAKKQASNLETAIADAEQRGDSALKDAR
                     AKLDELEGALHQAKEELARMLREYQELMSLKLALDMEIATYRKLLESEECRMSGEYSS
                     PVSISIISSTSGSGGYGFRPSTVSGGYVANSTSCISGVCSVRGGENRSRGSASDYKDT
                     LTKGSSLSTPSKKGGR"
     exon            496..710
                     /gene="Krt71"
                     /gene_synonym="Ca; Cal4; Cu; Krt2-6g; mK6irs; mK6irs1"
                     /inference="alignment:Splign:2.1.0"
     exon            711..771
                     /gene="Krt71"
                     /gene_synonym="Ca; Cal4; Cu; Krt2-6g; mK6irs; mK6irs1"
                     /inference="alignment:Splign:2.1.0"
     exon            772..867
                     /gene="Krt71"
                     /gene_synonym="Ca; Cal4; Cu; Krt2-6g; mK6irs; mK6irs1"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1032
                     /gene="Krt71"
                     /gene_synonym="Ca; Cal4; Cu; Krt2-6g; mK6irs; mK6irs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1158
                     /gene="Krt71"
                     /gene_synonym="Ca; Cal4; Cu; Krt2-6g; mK6irs; mK6irs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1379
                     /gene="Krt71"
                     /gene_synonym="Ca; Cal4; Cu; Krt2-6g; mK6irs; mK6irs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1414
                     /gene="Krt71"
                     /gene_synonym="Ca; Cal4; Cu; Krt2-6g; mK6irs; mK6irs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..2174
                     /gene="Krt71"
                     /gene_synonym="Ca; Cal4; Cu; Krt2-6g; mK6irs; mK6irs1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttcgtggga atctaccttc ctcctgcacc tttactccat cctctaccaa catgagccgc
       61 caattcacct gcaagtctgg agccagcaac aggggcttca gtggttgctc cgcagtgctc
      121 tctgggggaa gctcatcctc ctaccgggca ggaggcaaag ggctcagcgg gggctttggc
      181 agtcggagtc tctacagcct gggaggtggc aggagcatca ctcttaacat ggctagtggc
      241 agcgggaaga acggaggttt tggatttggc cggaaccgag ccagtggctt tgccggaagt
      301 atctttggca gtgtggccct ggggcccgtg tgccctgctg tgtgcccgcc tggcggtatc
      361 catcaggtca cagtcaatga aagccttctg gccccactca atgtggagct ggaccctgag
      421 atccagaagg tgcgcgcaca ggagcgggag cagatcaagg ctctgaacaa caagtttgcc
      481 tccttcattg acaaggtgcg cttcttggag cagcagaacc aggtgctgca gaccaagtgg
      541 gagctgctgc agcagctgga cctgaacaac tgcaagaaca acctggaacc catccttgag
      601 ggccacatca gcaacatgcg gaagcagctg gagacgctgt ctggggacag agtgaggctg
      661 gactctgagc tgaggaatgt gcgtgacgtg gtggaggact acaagaagaa gtatgaggag
      721 gagatcaacc ggcggacagc tgcagagaat gagtttgtgc tgctgaagaa ggacgtggat
      781 gcggcttatg ccaacaaggt ggaactgcag gccaaggtgg acaccatgga ccaggacatc
      841 aaattcttca agtgtctgtt cgaagccgag atggctcaga tccagtccca catcagcgac
      901 atgtccgtca tcctgtccat ggacaacaac aggaacctgg acctggacag catcatcgat
      961 gaggttcgcg ctcagtatga ggagattgcc ctgaagagca aggctgaagc tgaggccctg
     1021 taccagacca agttccagga gctgcagctg gcagctggtc gccatggaga tgacctcaaa
     1081 aacaccaaaa atgaaatcac tgagctgacc cggttcatcc agagactccg ctcagagatt
     1141 gagaacgcaa agaagcaggc ttctaaccta gagacagcca tcgctgatgc cgagcagcga
     1201 ggtgacagtg ccctcaagga tgcccgggcc aagctggatg agctggaggg tgccctgcac
     1261 caggccaagg aggagctggc caggatgctg cgtgaatatc aggagctcat gagcctaaag
     1321 ttggccctgg acatggagat cgccacctac cgcaaacttc tggagagcga ggagtgcagg
     1381 atgtccggag aatactcttc ccccgtcagc atctccatta tcagcagcac cagtggcagt
     1441 ggaggctatg gcttccggcc cagcacagtc agcggtggct acgtggccaa tagcactagc
     1501 tgcatctctg gagtgtgcag tgtccgtggt ggggagaaca ggagcagagg tagtgccagc
     1561 gactacaagg ataccctaac aaagggctcc agtctgagca ccccctccaa gaaaggtggc
     1621 cgatgagagg gcttcttgtg acctcgatcc ctcagcaccc tctgtgccct agcctgttgt
     1681 ccccctccct actcccttat atcattcctg ggcccctaga tgtgtcctca gctaacctcc
     1741 ttctctctcc aagtgttctg agcctgggta gctctgggct accatgtggt gcacttctga
     1801 cagacaccag gggtttctaa gcttcagctc aggtccagcc tgtcccttcc accagccttt
     1861 gcctccgtcc tcaccacact acctggtttc ttgggtctcc atctgggctt cctcgtctgc
     1921 tgagcttttg tcccagctcc tgtgtacaac acaagctaga gctgtaccca agaagaagac
     1981 taacagaaaa ccaactcaga gttgggagcc caccccaccc cggcacagtc tcgttttgag
     2041 tggaaccact cagagtaaag ggactctgtc ttcactttct tgaacccaga accagggaaa
     2101 atgggacagc cttggcttct cttgtattct tttaagccct ccctgttgca ttctcaataa
     2161 acagcacaat ctgaaaaaaa aaaaaaaaaa aaa
//
