LOCUS       NM_033073               1602 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Mus musculus keratin 7 (Krt7), mRNA.
ACCESSION   NM_033073
VERSION     NM_033073.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1602)
  AUTHORS   Wrynn,T., Min,S., Horeth,E., Osinski,J., Sinha,S. and Romano,R.A.
  TITLE     DeltaNp63 regulates Sfrp1 expression to direct salivary gland
            branching morphogenesis
  JOURNAL   PLoS One 19 (5), e0301082 (2024)
   PUBMED   38722977
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1602)
  AUTHORS   Kumar,N., Prakash,P.G., Wentland,C., Kurian,S.M., Jethva,G.,
            Brinkmann,V., Mollenkopf,H.J., Krammer,T., Toussaint,C.,
            Saliba,A.E., Biebl,M., Jurgensen,C., Wiedenmann,B., Meyer,T.F.,
            Gurumurthy,R.K. and Chumduri,C.
  TITLE     Decoding spatiotemporal transcriptional dynamics and epithelial
            fibroblast crosstalk during gastroesophageal junction development
            through single cell analysis
  JOURNAL   Nat Commun 15 (1), 3064 (2024)
   PUBMED   38594232
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1602)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1602)
  AUTHORS   Liu,C.Y., Girish,N., Gomez,M.L., Kalski,M., Bernard,J.K.,
            Simons,B.D. and Polk,D.B.
  TITLE     Wound-healing plasticity enables clonal expansion of founder
            progenitor cells in colitis
  JOURNAL   Dev Cell 58 (21), 2309-2325 (2023)
   PUBMED   37652012
REFERENCE   5  (bases 1 to 1602)
  AUTHORS   He,Q., Zuo,Z., Song,K., Wang,W., Yu,L., Tang,Z., Hu,S., Li,L.,
            Luo,H., Chen,Z., Liu,J., Lin,B., Luo,J., Jiang,Y., Huang,Q. and
            Guo,X.
  TITLE     Keratin7 and Desmoplakin are involved in acute lung injury induced
            by sepsis through RAGE
  JOURNAL   Int Immunopharmacol 124 (Pt A), 110867 (2023)
   PUBMED   37660597
  REMARK    GeneRIF: Keratin7 and Desmoplakin are involved in acute lung injury
            induced by sepsis through RAGE.
REFERENCE   6  (bases 1 to 1602)
  AUTHORS   Tamai,Y., Ishikawa,T., Bosl,M.R., Mori,M., Nozaki,M., Baribault,H.,
            Oshima,R.G. and Taketo,M.M.
  TITLE     Cytokeratins 8 and 19 in the mouse placental development
  JOURNAL   J Cell Biol 151 (3), 563-572 (2000)
   PUBMED   11062258
REFERENCE   7  (bases 1 to 1602)
  AUTHORS   Hesse,M., Franz,T., Tamai,Y., Taketo,M.M. and Magin,T.M.
  TITLE     Targeted deletion of keratins 18 and 19 leads to trophoblast
            fragility and early embryonic lethality
  JOURNAL   EMBO J 19 (19), 5060-5070 (2000)
   PUBMED   11013209
REFERENCE   8  (bases 1 to 1602)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   9  (bases 1 to 1602)
  AUTHORS   Zhong,J., Edelhoff,S., Disteche,C. and Braun,R.E.
  TITLE     The gene encoding PRBP, the mouse homolog of human TRBP, maps to
            distal chromosome 15
  JOURNAL   Mamm Genome 9 (5), 413-414 (1998)
   PUBMED   9545508
REFERENCE   10 (bases 1 to 1602)
  AUTHORS   Su,L., Morgan,P.R. and Lane,E.B.
  TITLE     Protein and mRNA expression of simple epithelial keratins in
            normal, dysplastic, and malignant oral epithelia
  JOURNAL   Am J Pathol 145 (6), 1349-1357 (1994)
   PUBMED   7527618
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157583.9, AK146914.1 and BU755120.1.
            
            On Aug 26, 2009 this sequence version replaced NM_033073.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF509888.1, AK002434.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AC157583.9         135892-135913
            23-1576             AK146914.1         1-1554
            1577-1602           BU755120.1         1-26                c
FEATURES             Location/Qualifiers
     source          1..1602
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.88 cM"
     gene            1..1602
                     /gene="Krt7"
                     /gene_synonym="D15Wsu77e; K7; Krt2-7"
                     /note="keratin 7"
                     /db_xref="GeneID:110310"
                     /db_xref="MGI:MGI:96704"
     exon            1..377
                     /gene="Krt7"
                     /gene_synonym="D15Wsu77e; K7; Krt2-7"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..1445
                     /gene="Krt7"
                     /gene_synonym="D15Wsu77e; K7; Krt2-7"
                     /note="CK-7; cytokeratin-7; type-II keratin Kb7; keratin
                     complex 2, basic, gene 7; sarcolectin; Cytokeratin 7"
                     /codon_start=1
                     /product="keratin, type II cytoskeletal 7"
                     /protein_id="NP_149064.1"
                     /db_xref="CCDS:CCDS27851.1"
                     /db_xref="GeneID:110310"
                     /db_xref="MGI:MGI:96704"
                     /translation="MSIHFSSRSTAYPGRGAQVRLSSGRASFGSRSLYGLGSSRPRVA
                     VRSAYGGPVGAGIREITINQSLLAPLSVDIDPTIQQVRQEEREQIKTLNNKFASFIDK
                     VRFLEQQNKMLETKWALLQEQKSAKSSQLPRIFEAQIAGLRQQLETLQLDGGRLEVEL
                     RNMQDVVEDFKNKYEEEINRRTAAENEFVLLKKDVDAAYTNKVELEAKADSLQDEINF
                     LKTLHETELAELQSQISDTSVVLSMDNSRSLDLDGIIADVKAQYEEMANHSRAEAEAW
                     YQTKFETLQAQAGKHGDDLRNTRNEIAEMNRSIQRLQAEIDTLKNQRAKLESSIAEAE
                     EQGELAIKDAHAKQGELEAALQKAKQDVARQLREYQELLNTKLALDIEIATYRKLLEG
                     EESRLSGDGMGPVNISVVNSTGGNGGKLIFGGTMGSNALSFSGGPGALRAYSIKTTST
                     TRRGTHN"
     exon            378..589
                     /gene="Krt7"
                     /gene_synonym="D15Wsu77e; K7; Krt2-7"
                     /inference="alignment:Splign:2.1.0"
     exon            590..650
                     /gene="Krt7"
                     /gene_synonym="D15Wsu77e; K7; Krt2-7"
                     /inference="alignment:Splign:2.1.0"
     exon            651..746
                     /gene="Krt7"
                     /gene_synonym="D15Wsu77e; K7; Krt2-7"
                     /inference="alignment:Splign:2.1.0"
     exon            747..911
                     /gene="Krt7"
                     /gene_synonym="D15Wsu77e; K7; Krt2-7"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1037
                     /gene="Krt7"
                     /gene_synonym="D15Wsu77e; K7; Krt2-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1258
                     /gene="Krt7"
                     /gene_synonym="D15Wsu77e; K7; Krt2-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1293
                     /gene="Krt7"
                     /gene_synonym="D15Wsu77e; K7; Krt2-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1586
                     /gene="Krt7"
                     /gene_synonym="D15Wsu77e; K7; Krt2-7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1552..1557
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt7"
                     /gene_synonym="D15Wsu77e; K7; Krt2-7"
                     /note="hexamer: AATAAA"
     polyA_site      1573
                     /gene="Krt7"
                     /gene_synonym="D15Wsu77e; K7; Krt2-7"
                     /note="major polyA site"
ORIGIN      
        1 gtcgcagact gcctgaggtc agggagttcg cgctgctcct cgcctcgtcc agccagctgt
       61 gtccagccgc tatgtccatc cacttcagct ctcgctccac tgcttacccg ggccgcgggg
      121 ctcaggtgcg cctgagctcg ggccgcgcca gcttcggcag caggagcctc tatggcctgg
      181 gctcatcaag gcctcgtgtg gccgtgcgct ccgcttatgg gggcccggtg ggcgctggca
      241 tccgcgagat caccatcaat cagagcttgc tggcgccgct gagtgtggac atcgatccca
      301 ccatccagca ggtgcgccag gaggagcgcg agcagatcaa gaccctcaac aacaaattcg
      361 cctccttcat cgacaaggta cgcttcctgg aacagcagaa caagatgctg gagaccaagt
      421 gggcgctgct gcaggaacag aagtcagcca agagcagcca gcttccccga atctttgagg
      481 ctcagattgc tgggctgagg cagcagctcg agacactgca gctggatggg ggccgcctgg
      541 aggtggaact gcggaacatg caggatgtgg tggaagattt caagaataag tatgaagagg
      601 agatcaaccg acgcacggct gctgagaatg agtttgtgtt gctgaagaag gatgtggatg
      661 ccgcctacac gaacaaggtg gagttggagg ccaaggcgga cagtctgcag gatgagatca
      721 acttcctcaa gacccttcac gagacagagt tagcagagct gcagtcgcag atctcagaca
      781 catctgtggt gctgtccatg gacaacagcc gctccctgga cttggatggt atcattgctg
      841 acgtcaaagc ccagtatgag gagatggcca accacagccg ggcagaggct gaagcttggt
      901 accagaccaa gtttgagaca ctccaggccc aggctgggaa gcacggggat gacctccgca
      961 acacccggaa tgagattgcg gagatgaacc gctctatcca gaggctgcag gcagagattg
     1021 acaccttgaa gaaccagcgt gccaagttag agtccagcat cgcagaggct gaggaacaag
     1081 gggagctggc aatcaaggat gctcatgcta agcaggggga gctggaggct gccctgcaga
     1141 aggccaagca ggatgtggcc cggcaacttc gagagtacca ggagctcctg aacaccaagc
     1201 tggcgctgga cattgagatc gccacctacc gcaagctgct ggagggcgag gagagccggt
     1261 tgtctggaga cggaatggga cctgtgaata tctctgttgt gaattccact gggggcaatg
     1321 gtggcaagct tatcttcgga ggaaccatgg gaagcaatgc tctgagcttc agtgggggac
     1381 ccggagccct cagggcctat tccatcaaga ccacatctac tacccgcagg ggcacccaca
     1441 attgagcaca tacaaccaag ctgtgggctt ggagagaccc cccataccct tttgtccatc
     1501 tcatgtccct gtcccgagcc tggaagatag tctgaaactg ctgttggctt taataaaggg
     1561 cctctctgag agagctgcat cggctaaaaa aaaaaaaaaa aa
//
