LOCUS       NM_010669               2241 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus keratin 6B (Krt6b), mRNA.
ACCESSION   NM_010669
VERSION     NM_010669.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2241)
  AUTHORS   Butera,A., Agostini,M., Cassandri,M., De Nicola,F., Fanciulli,M.,
            D'Ambrosio,L., Falasca,L., Nardacci,R., Wang,L., Piacentini,M.,
            Knight,R.A., Jia,W., Sun,Q., Shi,Y., Wang,Y., Candi,E. and
            Melino,G.
  TITLE     ZFP750 affects the cutaneous barrier through regulating lipid
            metabolism
  JOURNAL   Sci Adv 9 (17), eadg5423 (2023)
   PUBMED   37115925
REFERENCE   2  (bases 1 to 2241)
  AUTHORS   Steen,K., Chen,D., Wang,F., Majumdar,R., Chen,S., Kumar,S.,
            Lombard,D.B., Weigert,R., Zieman,A.G., Parent,C.A. and
            Coulombe,P.A.
  TITLE     A role for keratins in supporting mitochondrial organization and
            function in skin keratinocytes
  JOURNAL   Mol Biol Cell 31 (11), 1103-1111 (2020)
   PUBMED   32213122
REFERENCE   3  (bases 1 to 2241)
  AUTHORS   Wang,F., Chen,S., Liu,H.B., Parent,C.A. and Coulombe,P.A.
  TITLE     Keratin 6 regulates collective keratinocyte migration by altering
            cell-cell and cell-matrix adhesion
  JOURNAL   J Cell Biol 217 (12), 4314-4330 (2018)
   PUBMED   30389720
  REMARK    GeneRIF: These findings reveal that K6a/K6b modulate keratinocyte
            migration by regulating cell-matrix and cell-cell adhesion and
            highlight a role for keratins in collective cell migration.
REFERENCE   4  (bases 1 to 2241)
  AUTHORS   Bebee,T.W., Park,J.W., Sheridan,K.I., Warzecha,C.C., Cieply,B.W.,
            Rohacek,A.M., Xing,Y. and Carstens,R.P.
  TITLE     The splicing regulators Esrp1 and Esrp2 direct an epithelial
            splicing program essential for mammalian development
  JOURNAL   Elife 4, e08954 (2015)
   PUBMED   26371508
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2241)
  AUTHORS   Cui,C.Y., Klar,J., Georgii-Heming,P., Frojmark,A.S., Baig,S.M.,
            Schlessinger,D. and Dahl,N.
  TITLE     Frizzled6 deficiency disrupts the differentiation process of nail
            development
  JOURNAL   J Invest Dermatol 133 (8), 1990-1997 (2013)
   PUBMED   23439395
REFERENCE   6  (bases 1 to 2241)
  AUTHORS   Wojcik,S.M., Longley,M.A. and Roop,D.R.
  TITLE     Discovery of a novel murine keratin 6 (K6) isoform explains the
            absence of hair and nail defects in mice deficient for K6a and K6b
  JOURNAL   J Cell Biol 154 (3), 619-630 (2001)
   PUBMED   11489919
REFERENCE   7  (bases 1 to 2241)
  AUTHORS   Mazzalupo,S. and Coulombe,P.A.
  TITLE     A reporter transgene based on a human keratin 6 gene promoter is
            specifically expressed in the periderm of mouse embryos
  JOURNAL   Mech Dev 100 (1), 65-69 (2001)
   PUBMED   11118885
REFERENCE   8  (bases 1 to 2241)
  AUTHORS   Wong,P., Colucci-Guyon,E., Takahashi,K., Gu,C., Babinet,C. and
            Coulombe,P.A.
  TITLE     Introducing a null mutation in the mouse K6alpha and K6beta genes
            reveals their essential structural role in the oral mucosa
  JOURNAL   J Cell Biol 150 (4), 921-928 (2000)
   PUBMED   10953016
REFERENCE   9  (bases 1 to 2241)
  AUTHORS   Rothnagel,J.A., Seki,T., Ogo,M., Longley,M.A., Wojcik,S.M.,
            Bundman,D.S., Bickenbach,J.R. and Roop,D.R.
  TITLE     The mouse keratin 6 isoforms are differentially expressed in the
            hair follicle, footpad, tongue and activated epidermis
  JOURNAL   Differentiation 65 (2), 119-130 (1999)
   PUBMED   10550545
REFERENCE   10 (bases 1 to 2241)
  AUTHORS   Takahashi,K., Yan,B., Yamanishi,K., Imamura,S. and Coulombe,P.A.
  TITLE     The two functional keratin 6 genes of mouse are differentially
            regulated and evolved independently from their human orthologs
  JOURNAL   Genomics 53 (2), 170-183 (1998)
   PUBMED   9790766
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120787.14.
            
            On Feb 13, 2019 this sequence version replaced NM_010669.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137688.1, BC124556.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-577               AC120787.14        30495-31071
            578-792             AC120787.14        31638-31852
            793-853             AC120787.14        32175-32235
            854-949             AC120787.14        32393-32488
            950-1114            AC120787.14        32615-32779
            1115-1240           AC120787.14        33196-33321
            1241-1461           AC120787.14        33462-33682
            1462-1496           AC120787.14        33890-33924
            1497-2241           AC120787.14        34021-34765
FEATURES             Location/Qualifiers
     source          1..2241
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.97 cM"
     gene            1..2241
                     /gene="Krt6b"
                     /gene_synonym="Krt2-6b; mK6[b]"
                     /note="keratin 6B"
                     /db_xref="GeneID:16688"
                     /db_xref="MGI:MGI:1333768"
     exon            1..577
                     /gene="Krt6b"
                     /gene_synonym="Krt2-6b; mK6[b]"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..1735
                     /gene="Krt6b"
                     /gene_synonym="Krt2-6b; mK6[b]"
                     /note="K6B; CK-6B; mK6-beta; cytokeratin-6B;
                     keratin-6-beta; keratin complex 2, basic, gene 6b"
                     /codon_start=1
                     /product="keratin, type II cytoskeletal 6B"
                     /protein_id="NP_034799.2"
                     /db_xref="CCDS:CCDS27859.1"
                     /db_xref="GeneID:16688"
                     /db_xref="MGI:MGI:1333768"
                     /translation="MSTKTTIKSQTSHRGYSASSARVPGLNRSGFSSVSVCRSRGSGG
                     SSAMCGGAGFGSRSLYGVGSSKRISIGGGSCGIGGGYGSRFGGSFGIGGGAGSGFGFG
                     GGVGFGGGYGGAGFPVCPPGGIQEVTINQNLLTPLNVQIDPTIQRVRTEEREQIKTLN
                     NKFASFIDKVRFLEQQNKVLDTKWALLQEQGTKTVRQNLEPMFEQYISNLRRQLDSII
                     GERGRLDSELRNMQDTVEDYKSKYEDEINKRTKAENEFVTVKKDVDAAYMTKVELQAK
                     ADSLADEINFLRVIYEAELSQMQTHISDTSVVLSMDNNRSLDLDSIIAEVKAQYEDIA
                     QRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEIAEINRMIQRLRSEIDHVKKQCA
                     NLQAAIADAEQRGEMALKDARGKLEGLEDALQKAKQEMARLLKEYQELMNVKLALDVE
                     IATYRKLLEGEECRLNGEGVGPVNISVVQSTVSSGYGSAGGASSSLGLGGSSSYSYGS
                     SHGLGGGFSAGSGRAIGGGLSSSGGLSSSTIKYTTSASSSRKSYRH"
     exon            578..792
                     /gene="Krt6b"
                     /gene_synonym="Krt2-6b; mK6[b]"
                     /inference="alignment:Splign:2.1.0"
     exon            793..853
                     /gene="Krt6b"
                     /gene_synonym="Krt2-6b; mK6[b]"
                     /inference="alignment:Splign:2.1.0"
     exon            854..949
                     /gene="Krt6b"
                     /gene_synonym="Krt2-6b; mK6[b]"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1114
                     /gene="Krt6b"
                     /gene_synonym="Krt2-6b; mK6[b]"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1240
                     /gene="Krt6b"
                     /gene_synonym="Krt2-6b; mK6[b]"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1461
                     /gene="Krt6b"
                     /gene_synonym="Krt2-6b; mK6[b]"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1496
                     /gene="Krt6b"
                     /gene_synonym="Krt2-6b; mK6[b]"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..2241
                     /gene="Krt6b"
                     /gene_synonym="Krt2-6b; mK6[b]"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2217..2222
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt6b"
                     /gene_synonym="Krt2-6b; mK6[b]"
                     /note="hexamer: AATAAA"
     polyA_site      2238
                     /gene="Krt6b"
                     /gene_synonym="Krt2-6b; mK6[b]"
                     /note="major polyA site"
ORIGIN      
        1 acactcatct gttcagctct gccctgccat ttctaaactt ctcatctgct gctcctcagc
       61 tcacggaacc atgtctacca aaaccaccat caagagtcaa actagccacc gtggctacag
      121 tgccagctca gccagagtgc ctgggctcaa ccgctctggc ttcagcagtg tgtccgtgtg
      181 ccgctcccgg ggcagcggtg gctccagtgc aatgtgtgga ggagctggct ttggcagcag
      241 gagcctctat ggtgtgggga gctccaagag gatctccatc ggagggggca gctgtggcat
      301 tggaggaggc tatggcagcc gatttggagg aagcttcggc attggaggtg gagctggtag
      361 tggctttggc ttcggtggtg gagttggctt tggtggtggc tatggcggag ctggcttccc
      421 ggtgtgcccc cctggaggca tccaagaggt caccatcaac cagaacctcc tcacccctct
      481 gaacgtgcaa atcgacccca ccatccagcg ggtcaggact gaggagaggg agcagatcaa
      541 gaccctcaac aacaagtttg cctccttcat cgacaaggtc cggttcctgg agcagcagaa
      601 caaggtcctg gacaccaagt gggccctgct gcaagagcag ggcaccaaga ccgtgaggca
      661 gaacctggag cctatgtttg agcagtacat cagcaacctc cgcagacagc tggacagcat
      721 cattggagag aggggtcgcc tggactcaga gctgaggaac atgcaggaca cagtggagga
      781 ctacaagagc aaatatgaag atgaaatcaa caagcgtaca aaagcagaga atgaatttgt
      841 aaccgtgaaa aaggatgtag atgctgccta catgaccaag gttgaactgc aagccaaggc
      901 agatagtctt gcagacgaga tcaacttcct gagagttatt tatgaggcag aactgtctca
      961 gatgcaaact cacatctcag acacatctgt ggtcctctcc atggacaaca accgtagcct
     1021 ggacctggac agcatcatcg ctgaggtcaa ggcccagtat gaggacattg ctcagagaag
     1081 tcgggctgaa gctgagtcct ggtaccagac taaatatgag gagctgcagg tcacagctgg
     1141 cagacatggg gacgacctgc gcaacaccaa gcaggagatt gctgagatca accgcatgat
     1201 ccagaggctg agatctgaga tcgaccacgt taagaagcag tgtgccaacc tgcaagctgc
     1261 tattgctgat gctgagcaac gtggggagat ggccctgaag gatgccaggg gcaagctgga
     1321 agggctggag gatgccctgc agaaggccaa acaggaaatg gccaggctgc tgaaggagta
     1381 ccaggaactc atgaatgtca agctggccct ggatgtggaa attgccacct acaggaagct
     1441 gctggaagga gaggagtgca ggttgaatgg tgaaggtgtt ggaccagtca acatctctgt
     1501 ggtgcagtcc accgtgtcca gcggctatgg cagtgccggg ggtgccagca gcagcttagg
     1561 cctgggtgga agcagcagct actcctatgg cagcagccat ggccttggag gtggcttcag
     1621 tgctggcagt ggcagagcca tcggaggtgg cctcagctct tctggtggcc tcagctcttc
     1681 caccatcaaa tacaccacca gcgcctcctc cagcaggaag agctacaggc actgaaatcc
     1741 caactaccag agcttgttgc agaccccaga taccctggct gcagtgccct gtgtacgggg
     1801 tcgtgttttc actgaacctc cacctctgct gtctgcttct gtctgaggag gctgtgtcct
     1861 ctcgcttctc tttttgtctg cttgggatct cactgctcac tttttgagcc atcctctgag
     1921 ctcacatcac gattcacaca catttggtgc ttcatgctgt atttgggttt ccaggctcct
     1981 ccctccctac ctctgtctct gagttgcctg gtaaagtgtg tgtcagtcct cttcattcta
     2041 gaaatgattg tctgggtctt actaaagaaa tgaacaactc ccttctagtt tccaatggcc
     2101 tgggaaaccc catttttcaa cctcataaac cttcctgtca gtacttgtga caacacagtc
     2161 attagtcctg tgctcacatg atgccatctc tgctctttgt ttccttgtaa ttgctaaata
     2221 aagcagattt ataaaaagta a
//
