LOCUS       NM_008476               2287 bp    mRNA    linear   ROD 27-JUN-2023
DEFINITION  Mus musculus keratin 6A (Krt6a), mRNA.
ACCESSION   NM_008476
VERSION     NM_008476.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2287)
  AUTHORS   Butera A, Agostini M, Cassandri M, De Nicola F, Fanciulli M,
            D'Ambrosio L, Falasca L, Nardacci R, Wang L, Piacentini M, Knight
            RA, Jia W, Sun Q, Shi Y, Wang Y, Candi E and Melino G.
  TITLE     ZFP750 affects the cutaneous barrier through regulating lipid
            metabolism
  JOURNAL   Sci Adv 9 (17), eadg5423 (2023)
   PUBMED   37115925
REFERENCE   2  (bases 1 to 2287)
  AUTHORS   Saroya G, Hu J, Hu M, Panaretos C, Mann J, Kim S, Bush JO and
            Kaartinen V.
  TITLE     Periderm Fate during Palatogenesis: TGF-beta and Periderm
            Dedifferentiation
  JOURNAL   J Dent Res 102 (4), 459-466 (2023)
   PUBMED   36751050
REFERENCE   3  (bases 1 to 2287)
  AUTHORS   Cai S, Si N, Wang Y and Yin N.
  TITLE     Transcriptomic analysis of the upper lip and primary palate
            development in mice
  JOURNAL   Front Genet 13, 1039850 (2023)
   PUBMED   36685938
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2287)
  AUTHORS   Teng T, Teng CS, Kaartinen V and Bush JO.
  TITLE     A unique form of collective epithelial migration is crucial for
            tissue fusion in the secondary palate and can overcome loss of
            epithelial apoptosis
  JOURNAL   Development 149 (10) (2022)
   PUBMED   35593401
REFERENCE   5  (bases 1 to 2287)
  AUTHORS   Damen M, Wirtz L, Soroka E, Khatif H, Kukat C, Simons BD and Bazzi
            H.
  TITLE     High proliferation and delamination during skin epidermal
            stratification
  JOURNAL   Nat Commun 12 (1), 3227 (2021)
   PUBMED   34050161
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2287)
  AUTHORS   Wojcik SM, Imakado S, Seki T, Longley MA, Petherbridge L, Bundman
            DS, Bickenbach JR, Rothnagel JA and Roop DR.
  TITLE     Expression of MK6a dominant-negative and C-terminal mutant
            transgenes in mice has distinct phenotypic consequences in the
            epidermis and hair follicle
  JOURNAL   Differentiation 65 (2), 97-112 (1999)
   PUBMED   10550543
REFERENCE   7  (bases 1 to 2287)
  AUTHORS   Takahashi K, Yan B, Yamanishi K, Imamura S and Coulombe PA.
  TITLE     The two functional keratin 6 genes of mouse are differentially
            regulated and evolved independently from their human orthologs
  JOURNAL   Genomics 53 (2), 170-183 (1998)
   PUBMED   9790766
REFERENCE   8  (bases 1 to 2287)
  AUTHORS   Takahashi K, Paladini RD and Coulombe PA.
  TITLE     Cloning and characterization of multiple human genes and cDNAs
            encoding highly related type II keratin 6 isoforms
  JOURNAL   J Biol Chem 270 (31), 18581-18592 (1995)
   PUBMED   7543104
REFERENCE   9  (bases 1 to 2287)
  AUTHORS   Finch J, Andrews K, Krieg P, Furstenberger G, Slaga T, Ootsuyama A,
            Tanooka H and Bowden GT.
  TITLE     Identification of a cloned sequence activated during multi-stage
            carcinogenesis in mouse skin
  JOURNAL   Carcinogenesis 12 (8), 1519-1522 (1991)
   PUBMED   1713533
REFERENCE   10 (bases 1 to 2287)
  AUTHORS   Steinert,P.M., Parry,D.A., Racoosin,E.L., Idler,W.W., Steven,A.C.,
            Trus,B.L. and Roop,D.R.
  TITLE     The complete cDNA and deduced amino acid sequence of a type II
            mouse epidermal keratin of 60,000 Da: analysis of sequence
            differences between type I and type II keratins
  JOURNAL   Proc Natl Acad Sci U S A 81 (18), 5709-5713 (1984)
   PUBMED   6207530
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC080820.1.
            
            [WARNING] On Jan 26, 2024 this sequence was replaced by
            NM_008476.4.
            
            On Oct 24, 2004 this sequence version replaced NM_008476.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC080820.1, AK009394.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2287
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.97 cM"
     gene            1..2287
                     /gene="Krt6a"
                     /gene_synonym="2310016L08Rik; CK-6A; K6A; K6[a]; Krt2-6a;
                     Krt2-6c; MK6a; mK6[a]"
                     /note="keratin 6A"
                     /db_xref="GeneID:16687"
                     /db_xref="MGI:MGI:1100845"
     exon            1..564
                     /gene="Krt6a"
                     /gene_synonym="2310016L08Rik; CK-6A; K6A; K6[a]; Krt2-6a;
                     Krt2-6c; MK6a; mK6[a]"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1719
                     /gene="Krt6a"
                     /gene_synonym="2310016L08Rik; CK-6A; K6A; K6[a]; Krt2-6a;
                     Krt2-6c; MK6a; mK6[a]"
                     /note="cytokeratin-6A; keratin-6-alpha; keratin complex 2,
                     basic, gene 6a; keratin complex 2, basic, gene 6c; 60-kDa
                     keratin; K6-alpha; mK6-alpha"
                     /codon_start=1
                     /product="keratin, type II cytoskeletal 6A"
                     /protein_id="NP_032502.3"
                     /db_xref="CCDS:CCDS27860.1"
                     /db_xref="GeneID:16687"
                     /db_xref="MGI:MGI:1100845"
                     /translation="MSTKTTIKSQTSHRGYSASSARVPGLNRSGFSSVSVCRSRGSGG
                     SSAMCGGAGFGSRSLYGVGSSKRISIGGGSCGIGGGYGSRFGGSFGIGGGAGSGFGFG
                     GGAGFGGGYGGAGFPVCPPGGIQEVTINQSLLTPLNLQIDPTIQRVRTEEREQIKTLN
                     NKFASFIDKVRFLEQQNKVLDTKWALLQEQGTKTVRQNLEPMFEQYISNLRRQLDSII
                     GERGRLDSELRNMQDTVEDYKSKYEDEINKRTAAENEFVTLKKDVDAAYMNKVELQAK
                     ADSLTDDINFLRALYEAELSQMQTHISDTSVVLSMDNNRSLDLDSIIAEVKAQYEDIA
                     QRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEIAEINRMIQRLRSEIDHVKKQCA
                     NLQAAIADAEQRGEMALKDARGKLEGLEDALQKAKQDMARLLKEYQELMNVKLALDVE
                     IATYRKLLEGEECRLNGEGVGPVNISVVQSTVSSGYGSAGGASSSLGLGGGSSYSYSS
                     SHGLGGGFSAGSGRAIGGGLSSSGGLSSSTIKYTTTSSSKKSYRQ"
     exon            565..779
                     /gene="Krt6a"
                     /gene_synonym="2310016L08Rik; CK-6A; K6A; K6[a]; Krt2-6a;
                     Krt2-6c; MK6a; mK6[a]"
                     /inference="alignment:Splign:2.1.0"
     exon            780..840
                     /gene="Krt6a"
                     /gene_synonym="2310016L08Rik; CK-6A; K6A; K6[a]; Krt2-6a;
                     Krt2-6c; MK6a; mK6[a]"
                     /inference="alignment:Splign:2.1.0"
     exon            841..936
                     /gene="Krt6a"
                     /gene_synonym="2310016L08Rik; CK-6A; K6A; K6[a]; Krt2-6a;
                     Krt2-6c; MK6a; mK6[a]"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1101
                     /gene="Krt6a"
                     /gene_synonym="2310016L08Rik; CK-6A; K6A; K6[a]; Krt2-6a;
                     Krt2-6c; MK6a; mK6[a]"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1227
                     /gene="Krt6a"
                     /gene_synonym="2310016L08Rik; CK-6A; K6A; K6[a]; Krt2-6a;
                     Krt2-6c; MK6a; mK6[a]"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1448
                     /gene="Krt6a"
                     /gene_synonym="2310016L08Rik; CK-6A; K6A; K6[a]; Krt2-6a;
                     Krt2-6c; MK6a; mK6[a]"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1483
                     /gene="Krt6a"
                     /gene_synonym="2310016L08Rik; CK-6A; K6A; K6[a]; Krt2-6a;
                     Krt2-6c; MK6a; mK6[a]"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..2258
                     /gene="Krt6a"
                     /gene_synonym="2310016L08Rik; CK-6A; K6A; K6[a]; Krt2-6a;
                     Krt2-6c; MK6a; mK6[a]"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcttcagct ctgccctgcc gtttctctac ttcccagcct tctcatctcc aggaaccatg
       61 tctaccaaaa ccaccatcaa aagtcaaacc agccaccgtg gctacagtgc cagctcagcc
      121 agagtgcctg ggctcaaccg ctctggcttc agcagtgtgt ccgtgtgccg ctcccggggc
      181 agcggtggct ccagtgcaat gtgtggagga gctggctttg gcagcaggag cctctatggt
      241 gtggggagct ccaagaggat ctccatcgga gggggcagct gtggcattgg aggaggctat
      301 ggcagccgat ttggaggaag cttcggcatt ggaggtggag ctggtagtgg ctttggcttc
      361 ggtggtggag ctggctttgg tggtggctat gggggagctg gcttcccggt gtgcccacct
      421 ggaggcatcc aagaggtcac catcaaccag agcctcctca cacccctgaa cctgcaaatt
      481 gaccccacca tccagcgggt caggactgag gagagggagc agatcaagac cctcaacaac
      541 aagtttgcct ccttcatcga caaggtgcgg ttcctggagc agcagaacaa ggtcctggac
      601 accaagtggg ccctgctgca agagcagggc accaagaccg tgaggcagaa cctggagcct
      661 atgtttgagc agtacatcag caacctccgc agacagctgg acagcatcat tggagagagg
      721 ggtcgcctgg actcagagct gaggaacatg caggacacag tggaggacta caagagcaaa
      781 tatgaagatg aaatcaacaa gcgcacagca gcagagaatg aattcgtgac cctgaagaag
      841 gatgtagatg ctgcctacat gaacaaagtt gaactgcaag ccaaggcaga cagtctaaca
      901 gatgatatca acttcttgag agctctctat gaagcagaac tgtctcagat gcaaactcac
      961 atctcagaca catctgtggt cctctccatg gacaacaacc gtagcctgga cctggacagc
     1021 atcatcgctg aggtcaaggc ccagtatgag gacattgctc agagaagtcg ggctgaagct
     1081 gagtcctggt accagactaa atatgaggag ctgcaggtca cagctggcag acatggggac
     1141 gacctacgca acaccaagca ggagattgct gagatcaacc gcatgatcca gaggctgaga
     1201 tctgagatcg accacgttaa gaagcagtgt gccaacctgc aagctgctat tgctgatgct
     1261 gagcaacgtg gggagatggc cctgaaggat gccaggggca agctggaagg gctggaggat
     1321 gccctgcaga aggccaaaca ggacatggcc aggctgctga aggagtacca ggaactcatg
     1381 aatgtcaagc tggccctgga tgtggaaatt gccacctaca ggaagctgct ggaaggagag
     1441 gagtgcaggt tgaatggtga aggtgttgga ccagtcaaca tctctgtggt gcagtccacc
     1501 gtgtccagcg gctatggcag tgccgggggt gccagcagca gcttaggcct gggtggaggc
     1561 agcagctact cctatagcag cagccatggc cttggaggtg gcttcagtgc tggcagtggc
     1621 agagccatcg gaggtggcct cagctcttct ggtggcctca gctcttctac catcaaatac
     1681 accaccacct cctccagcaa gaagagctac aggcagtgaa ttctgtcacc aagagcttgt
     1741 ctctggtccc agatgtcatg gctgcagaat cccgtgctca gagccccgag ttcaggggct
     1801 tctcctccct ggaccccacc tctgctccct tcttgggact gaggaggctg tgtcattttg
     1861 ctcatatttc tgtccccatg ggtccccact gctcatctct ttatagtcat cctgtgagct
     1921 tacatcacaa ttcactcaca tttggtgctt catgttgtat ttggttgcca ggctcctgcc
     1981 tccctacctc tgtctctgag gctgcctgtg acagggtgtt tccgacacct tcatttttga
     2041 aatcattgtc tgggtcctac tcaagtaatg agcagctccc tgtgagtttc taatggcctg
     2101 agaaacccca tctctcaaca tcataaccct ccctgtcagt aactgtgact gccccgtcac
     2161 tggtcctgtg atgtaagttt ctgctcatgt gatgtctttg ctttccttga tgctcttggc
     2221 ttcctcgtaa tttctaaata aagcaggttt atacataaaa aaaaaaaaaa aaaaaaaaaa
     2281 aaaaaaa
//
