LOCUS       NM_027011               2205 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus keratin 5 (Krt5), mRNA.
ACCESSION   NM_027011
VERSION     NM_027011.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2205)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 2205)
  AUTHORS   Warren,R., Klinkhammer,K., Lyu,H., Knopp,J., Yuan,T., Yao,C.,
            Stripp,B. and De Langhe,S.P.
  TITLE     Cell competition drives bronchiolization and pulmonary fibrosis
  JOURNAL   Nat Commun 15 (1), 10624 (2024)
   PUBMED   39639058
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2205)
  AUTHORS   Xu,L., Tan,C., Barr,J., Talaba,N., Verheyden,J., Chin,J.S.,
            Gaboyan,S., Kasaraneni,N., Elgamal,R.M., Gaulton,K.J., Lin,G.,
            Afshar,K., Golts,E., Meier,A., Crotty Alexander,L.E., Borok,Z.,
            Shen,Y., Chung,W.K., McCulley,D.J. and Sun,X.
  TITLE     Context-dependent roles of mitochondrial LONP1 in orchestrating the
            balance between airway progenitor versus progeny cells
  JOURNAL   Cell Stem Cell 31 (10), 1465-1483 (2024)
   PUBMED   39181129
REFERENCE   4  (bases 1 to 2205)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2205)
  AUTHORS   Deng,Z., Carpinelli,M.R., Butt,T., Magor,G.W., Zhao,P.,
            Gillinder,K.R., Perkins,A.C. and Jane,S.M.
  TITLE     Single-cell transcriptomics reveals the cellular identity of a
            novel progenitor population crucial for murine neural tube closure
  JOURNAL   Heliyon 10 (17), e37259 (2024)
   PUBMED   39296075
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2205)
  AUTHORS   Morasso,M.I., Markova,N.G. and Sargent,T.D.
  TITLE     Regulation of epidermal differentiation by a Distal-less
            homeodomain gene
  JOURNAL   J Cell Biol 135 (6 Pt 2), 1879-1887 (1996)
   PUBMED   8991098
REFERENCE   7  (bases 1 to 2205)
  AUTHORS   Dowling,J., Yu,Q.C. and Fuchs,E.
  TITLE     Beta4 integrin is required for hemidesmosome formation, cell
            adhesion and cell survival
  JOURNAL   J Cell Biol 134 (2), 559-572 (1996)
   PUBMED   8707838
REFERENCE   8  (bases 1 to 2205)
  AUTHORS   Byrne,C., Tainsky,M. and Fuchs,E.
  TITLE     Programming gene expression in developing epidermis
  JOURNAL   Development 120 (9), 2369-2383 (1994)
   PUBMED   7525178
REFERENCE   9  (bases 1 to 2205)
  AUTHORS   Kartasova,T., Roop,D.R., Holbrook,K.A. and Yuspa,S.H.
  TITLE     Mouse differentiation-specific keratins 1 and 10 require a
            preexisting keratin scaffold to form a filament network
  JOURNAL   J Cell Biol 120 (5), 1251-1261 (1993)
   PUBMED   7679677
REFERENCE   10 (bases 1 to 2205)
  AUTHORS   Stoler,A., Kopan,R., Duvic,M. and Fuchs,E.
  TITLE     Use of monospecific antisera and cRNA probes to localize the major
            changes in keratin expression during normal and abnormal epidermal
            differentiation
  JOURNAL   J Cell Biol 107 (2), 427-446 (1988)
   PUBMED   2458356
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104862.15 and AC120787.14.
            
            On Jul 12, 2018 this sequence version replaced NM_027011.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC108361.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-632               AC104862.15        7380-8011           c
            633-847             AC104862.15        6635-6849           c
            848-859             AC104862.15        5894-5905           c
            860-908             AC120787.14        1-49
            909-1004            AC120787.14        157-252
            1005-1169           AC120787.14        373-537
            1170-1295           AC120787.14        910-1035
            1296-1516           AC120787.14        1692-1912
            1517-1551           AC120787.14        2637-2671
            1552-2205           AC120787.14        3066-3719
FEATURES             Location/Qualifiers
     source          1..2205
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.98 cM"
     gene            1..2205
                     /gene="Krt5"
                     /gene_synonym="3300001P10Rik; CK5; K5; Krt2-5; Tfip8"
                     /note="keratin 5"
                     /db_xref="GeneID:110308"
                     /db_xref="MGI:MGI:96702"
     exon            1..632
                     /gene="Krt5"
                     /gene_synonym="3300001P10Rik; CK5; K5; Krt2-5; Tfip8"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1838
                     /gene="Krt5"
                     /gene_synonym="3300001P10Rik; CK5; K5; Krt2-5; Tfip8"
                     /note="cytokeratin 5; 58 kDa cytokeratin; type-II keratin
                     Kb5; keratin complex 2, basic, gene 5; tuftelin
                     interacting protein 8"
                     /codon_start=1
                     /product="keratin, type II cytoskeletal 5"
                     /protein_id="NP_081287.1"
                     /db_xref="CCDS:CCDS27861.1"
                     /db_xref="GeneID:110308"
                     /db_xref="MGI:MGI:96702"
                     /translation="MSRQSSVSFRSGGSRSFSAASAITPSVSRTSFSSVSRSGGGGGG
                     RISLGGACGAGGYGSRSLYNVGGSKRISYSSGGGSFRNQFGAGGFGFGGGAGSGFGFG
                     GGAGSGFGFGGGAGFGGGYGGAGFPVCPPGGIQEVTVNQNLLTPLNLQIDPTIQRVRT
                     EEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWALLQEQGTKTIKQNLDPLFEQYIN
                     NLRRQLDGVLGERGRLDSELRNMQDLVEDYKNKYEDEINKRTTAENEFVMLKKDVDAA
                     YMNKVELEARVDALMDEINFMKMFFDAELSQMQTHVSDTSVVLSMDNNRSLDLDSIIA
                     EVKAQYEDIANRSRTEAESWYQTKYEELQQTAGRHGDDLRNTKHEISEMNRMIQRLRS
                     EIDNVKKQCANLQNAIAEAEQRGELALKDARNKLTELEEALQKAKQDMARLLREYQEL
                     MNTKLALDVEIATYRKLLEGEECRLSGEGVGPVNISVVTNSVSSGYGGGSSIGVGSGF
                     GGGLGSGFAGGLGPRFTRGGGGLGLGSGLSVGGSGFSAGSSQGGMSFGSGGGSGSSVK
                     FVSTTSSSRRSFKS"
     exon            633..847
                     /gene="Krt5"
                     /gene_synonym="3300001P10Rik; CK5; K5; Krt2-5; Tfip8"
                     /inference="alignment:Splign:2.1.0"
     exon            848..908
                     /gene="Krt5"
                     /gene_synonym="3300001P10Rik; CK5; K5; Krt2-5; Tfip8"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1004
                     /gene="Krt5"
                     /gene_synonym="3300001P10Rik; CK5; K5; Krt2-5; Tfip8"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1169
                     /gene="Krt5"
                     /gene_synonym="3300001P10Rik; CK5; K5; Krt2-5; Tfip8"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1295
                     /gene="Krt5"
                     /gene_synonym="3300001P10Rik; CK5; K5; Krt2-5; Tfip8"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1516
                     /gene="Krt5"
                     /gene_synonym="3300001P10Rik; CK5; K5; Krt2-5; Tfip8"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1551
                     /gene="Krt5"
                     /gene_synonym="3300001P10Rik; CK5; K5; Krt2-5; Tfip8"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..2205
                     /gene="Krt5"
                     /gene_synonym="3300001P10Rik; CK5; K5; Krt2-5; Tfip8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2184..2189
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt5"
                     /gene_synonym="3300001P10Rik; CK5; K5; Krt2-5; Tfip8"
                     /note="hexamer: AATAAA"
     polyA_site      2204
                     /gene="Krt5"
                     /gene_synonym="3300001P10Rik; CK5; K5; Krt2-5; Tfip8"
                     /note="major polyA site"
ORIGIN      
        1 acagagccac ccacagcgtc ctgttgaacg ccgctgacct cgccagcacc tccccaccac
       61 cagcgcccag tgttcttgct cctccaggaa ccatcatgtc tcgccagtcc agtgtgtcct
      121 tccgaagtgg gggcagccgc tctttcagcg ccgcctctgc catcacccca tctgtctctc
      181 gtacgagctt cagctcggtg tcccgcagtg gtggtggtgg tggtggcagg atcagccttg
      241 ggggtgcttg tggagccggg ggctatggca gccggagcct gtacaatgtg gggggctcca
      301 aaaggatatc ctacagttct ggcggaggca gcttcaggaa ccaatttggt gctggtggct
      361 ttggctttgg aggaggagcc ggcagtggat ttggttttgg tggtggagct ggtagtggct
      421 ttggcttcgg tggtggagct ggctttggtg gtggctatgg gggagctggc ttcccggtgt
      481 gcccacctgg aggcatccaa gaggtcaccg ttaaccagaa cctcctcacc cctctgaacc
      541 tgcaaatcga ccccaccatc cagcgggtca ggactgagga gagggagcag atcaagaccc
      601 tcaacaacaa gtttgcctcc ttcatcgaca aggtgcggtt cctggagcag cagaacaagg
      661 tcctggacac caagtgggcc ctgctgcagg agcagggcac caagaccata aagcagaacc
      721 tggatccgtt gtttgaacag tacattaaca acctccgtag acagctggac ggggttctgg
      781 gggagagggg ccgcctggac tcagagctga ggaacatgca ggacctggtg gaggactaca
      841 agaacaagta tgaggatgag atcaacaagc gtaccacggc tgagaatgag tttgtgatgt
      901 tgaagaagga tgtggatgct gcctacatga acaaggtgga gctggaggcc agggtcgatg
      961 ccctgatgga cgagatcaac ttcatgaaga tgttctttga tgcggagctg tcccagatgc
     1021 agacacacgt ctctgacaca tctgtggtcc tttccatgga caacaaccgc agcctggacc
     1081 tggacagcat catcgctgag gtcaaggccc agtacgagga cattgccaac cgcagccgaa
     1141 cagaggctga gtcctggtac cagaccaagt atgaggagct gcaacagaca gctggccgtc
     1201 atggcgatga ccttcgaaac accaagcacg agatctctga gatgaaccga atgatccaga
     1261 ggctgagatc tgaaattgac aacgtcaaga agcagtgtgc caacctccag aacgccattg
     1321 ctgaagctga gcaacgcggg gagctggctc tcaaagatgc cagaaacaag ctgacagagc
     1381 tggaggaggc cctgcagaag gccaagcagg acatggccag gctgctgcgg gagtaccagg
     1441 agctcatgaa caccaagctg gctctggacg tggagatcgc cacctacagg aagctgctgg
     1501 agggcgagga gtgcaggctg agtggggaag gagttggacc agtcaacatc tctgtcgtta
     1561 caaacagtgt ctcttctggc tacggaggag gcagcagcat tggtgttggc agtggctttg
     1621 gcggtggcct tggcagcggc tttgctggtg gccttggccc acgcttcacc aggggtggtg
     1681 ggggtcttgg tttgggtagc gggctaagtg tggggggctc tggcttcagt gcaggcagca
     1741 gtcaaggagg catgagcttc ggcagtggtg gtggcagcgg ctccagtgtc aaatttgtct
     1801 ccaccacctc ctcctcccgg aggagcttca agagctaaga agagcctgct gcaagaccct
     1861 ggtcctcacg ggcagccccg ggcccacaga gactgcttct tttaggcagt ctcccaggcc
     1921 acgtttcctt tttctggaga gtagtctaga ccatgcctgc tgcagaacca catgctttgg
     1981 ttcccggaag ggaacgaatc ccaacctctg gcctccccat ggctcagttc tacatttgtg
     2041 ttgcacgtca gcacctatac atgttctttg gtgacccaga ccccaaaatg ttgcagaatg
     2101 taagccacca aagcagaacc ccatccctac ccagataccc acctaaattc tgtcctggtt
     2161 ctgacttcct ccagagtctg tccaataaaa tgcttttata ataag
//
