LOCUS       NM_212483               1627 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus keratin 42 (Krt42), mRNA.
ACCESSION   NM_212483
VERSION     NM_212483.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1627)
  AUTHORS   Zieman,A.G., Poll,B.G., Ma,J. and Coulombe,P.A.
  TITLE     Altered keratinocyte differentiation is an early driver of keratin
            mutation-based palmoplantar keratoderma
  JOURNAL   Hum Mol Genet 28 (13), 2255-2270 (2019)
   PUBMED   31220272
REFERENCE   2  (bases 1 to 1627)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   3  (bases 1 to 1627)
  AUTHORS   Tong,X. and Coulombe,P.A.
  TITLE     A novel mouse type I intermediate filament gene, keratin 17n
            (K17n), exhibits preferred expression in nail tissue
  JOURNAL   J Invest Dermatol 122 (4), 965-970 (2004)
   PUBMED   15102087
REFERENCE   4  (bases 1 to 1627)
  AUTHORS   Hesse,M., Zimek,A., Weber,K. and Magin,T.M.
  TITLE     Comprehensive analysis of keratin gene clusters in humans and
            rodents
  JOURNAL   Eur J Cell Biol 83 (1), 19-26 (2004)
   PUBMED   15085952
REFERENCE   5  (bases 1 to 1627)
  AUTHORS   Mitsui,K., Tokuzawa,Y., Itoh,H., Segawa,K., Murakami,M.,
            Takahashi,K., Maruyama,M., Maeda,M. and Yamanaka,S.
  TITLE     The homeoprotein Nanog is required for maintenance of pluripotency
            in mouse epiblast and ES cells
  JOURNAL   Cell 113 (5), 631-642 (2003)
   PUBMED   12787504
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590873.17.
            
            On Jun 19, 2019 this sequence version replaced NM_212483.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY459292.1, BC112371.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-542               AL590873.17        166395-166936       c
            543-625             AL590873.17        164185-164267       c
            626-782             AL590873.17        163920-164076       c
            783-944             AL590873.17        162585-162746       c
            945-1070            AL590873.17        161914-162039       c
            1071-1291           AL590873.17        161463-161683       c
            1292-1341           AL590873.17        160279-160328       c
            1342-1627           AL590873.17        159867-160152       c
FEATURES             Location/Qualifiers
     source          1..1627
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.44 cM"
     gene            1..1627
                     /gene="Krt42"
                     /gene_synonym="2410039E07Rik; CK-42; ecat6; K17n; K42;
                     Ka22"
                     /note="keratin 42"
                     /db_xref="GeneID:68239"
                     /db_xref="MGI:MGI:1915489"
     exon            1..542
                     /gene="Krt42"
                     /gene_synonym="2410039E07Rik; CK-42; ecat6; K17n; K42;
                     Ka22"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1439
                     /gene="Krt42"
                     /gene_synonym="2410039E07Rik; CK-42; ecat6; K17n; K42;
                     Ka22"
                     /note="keratin 17n; type I keratin KA22; predicted
                     ortholog of type I keratin KA22; cytokeratin-42"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 42"
                     /protein_id="NP_997648.2"
                     /db_xref="CCDS:CCDS25416.1"
                     /db_xref="GeneID:68239"
                     /db_xref="MGI:MGI:1915489"
                     /translation="MASTTSVRQFSTSGSVKGLCAPGMGFSRMSSVRVGGACRAPSLL
                     GGGSCGNMSVTSSRFSAGLGGGYGGGYTCSLGGGFGSSFGVSDALLGGSEKETMQNLN
                     DRLATYLDRVRALEEANADLEVKIREWYKKQGPGPARDYSPYFKTIEDLRNKILAATI
                     DNASIVLQIDNARLAADDFRTKYETELNLRMSVEADINGLRRVLDELTLARADLEMQI
                     ESLKEELAYLRKNHEEEMNALRGQVGGDVNVEMDAAPGVDLSRILNEMRDQYEKMAEK
                     NRKDAEEWFFTKTEELNREVATNTEALQSSRTEITELRRSVQNLEIELQSQLSMKASL
                     ENSLAETEARYGAQLAQLQGLISSVEQQLCELRCDMERQNHEYQVLLDVKTRLEQEIA
                     TYRRLLEGEDAHLATQYSSSLASQPSREGMVTSRQVRTIVEEVQDGKVVSSREQVHRS
                     TH"
     exon            543..625
                     /gene="Krt42"
                     /gene_synonym="2410039E07Rik; CK-42; ecat6; K17n; K42;
                     Ka22"
                     /inference="alignment:Splign:2.1.0"
     exon            626..782
                     /gene="Krt42"
                     /gene_synonym="2410039E07Rik; CK-42; ecat6; K17n; K42;
                     Ka22"
                     /inference="alignment:Splign:2.1.0"
     exon            783..944
                     /gene="Krt42"
                     /gene_synonym="2410039E07Rik; CK-42; ecat6; K17n; K42;
                     Ka22"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1070
                     /gene="Krt42"
                     /gene_synonym="2410039E07Rik; CK-42; ecat6; K17n; K42;
                     Ka22"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1291
                     /gene="Krt42"
                     /gene_synonym="2410039E07Rik; CK-42; ecat6; K17n; K42;
                     Ka22"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1341
                     /gene="Krt42"
                     /gene_synonym="2410039E07Rik; CK-42; ecat6; K17n; K42;
                     Ka22"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1627
                     /gene="Krt42"
                     /gene_synonym="2410039E07Rik; CK-42; ecat6; K17n; K42;
                     Ka22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1600..1605
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt42"
                     /gene_synonym="2410039E07Rik; CK-42; ecat6; K17n; K42;
                     Ka22"
                     /note="hexamer: AATAAA"
     polyA_site      1622
                     /gene="Krt42"
                     /gene_synonym="2410039E07Rik; CK-42; ecat6; K17n; K42;
                     Ka22"
                     /note="major polyA site"
ORIGIN      
        1 agtctccctt cagcctggct ataaagggta gcccagggtc tccatctagt ccagaccctg
       61 ttgcttgacc tgaggataac atggcttcca ctaccagtgt ccgccagttt tcaacttctg
      121 gctccgttaa gggcctttgt gctcccggca tgggattctc ccggatgtcc tctgttcgtg
      181 ttgggggtgc ctgccgggct cccagcctct tgggaggtgg aagctgtggc aatatgtccg
      241 tcacctcctc ccgcttctca gcaggcttag gaggcggcta tggtggtggc tacacttgca
      301 gcctgggtgg gggctttggc tccagttttg gtgtgtcgga tgccctccta gggggcagtg
      361 agaaggagac catgcagaat cttaatgacc ggctggccac ctacttagac agggtgcgtg
      421 ccctggagga ggccaacgct gacctggagg tgaagatccg tgagtggtac aagaagcagg
      481 gccccggacc ggctcgtgac tacagcccct acttcaagac catagaggac ctgcggaaca
      541 agatcctggc agccacaatc gacaacgcca gcatcgtgct gcagattgac aacgctcgcc
      601 tggcagccga tgacttccgc accaagtacg agacagagct gaacctgcgc atgagcgtgg
      661 aggccgacat caatggcctg cgccgggtgc tggatgaact gaccctggcc agagccgacc
      721 tggaaatgca gatcgagagc ctgaaggagg agctggccta tctgaggaag aaccatgagg
      781 aggaaatgaa tgcccttcgt ggccaggtgg gcggggacgt caatgtggag atggacgccg
      841 cccccggtgt ggacctgagc cgcatcctga acgagatgcg ggatcagtat gagaagatgg
      901 cggagaagaa ccgcaaggat gctgaggaat ggttcttcac caagacagag gagctgaacc
      961 gagaagtggc caccaacacg gaggccctgc agagcagccg gacagagatc acggagctcc
     1021 gccgctctgt gcagaacctg gagattgagc tgcagtccca gctcagcatg aaagcatcac
     1081 tggagaacag cctggcagag acagaggcgc gctatggggc ccagctggcg cagctgcagg
     1141 gcctcattag cagtgtggaa cagcagctgt gtgagctgcg ttgtgacatg gaaaggcaga
     1201 atcatgagta ccaggtgctg ctggatgtga agacccgact ggagcaggag atcgccacct
     1261 accgccgtct gctggagggc gaggacgccc acctggctac tcaatactcc tcatccctgg
     1321 cttcgcagcc ctcccgagaa ggcatggtga ccagccgcca ggtgcgcacc attgtggagg
     1381 aagtccagga tggtaaggtg gtctcctcca gagagcaggt gcaccgctcc acccactgag
     1441 gcccctgtct gcgtatgata gcccaggccc aggaccttag gctgcagctc cctgcatcta
     1501 ctgccaagcc tgaactccta tgagctagct gttgccttct gtgtttgctt tgtgctgccc
     1561 cttacagaga ggccccttgg gttgacccca gaaattgcta ataaagcttt gaagaagtct
     1621 gatcctt
//
