LOCUS       NM_001039666            2132 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus keratin 40 (Krt40), transcript variant 1, mRNA.
ACCESSION   NM_001039666 XM_484076
VERSION     NM_001039666.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2132)
  AUTHORS   Wang,Q., Zeng,S., Liang,Y., Zhou,R. and Wang,D.
  TITLE     ASH2L Mediates Epidermal Differentiation and Hair Follicle
            Morphogenesis through H3K4me3 Modification
  JOURNAL   J Invest Dermatol 144 (11), 2406-2416 (2024)
   PUBMED   38582368
REFERENCE   2  (bases 1 to 2132)
  AUTHORS   Ghotbi,E., Tchegnon,E., Chen,Z., Li,S., Shipman,T., Wang,Y.,
            Raman,J., Zhang,Y., McKay,R.M., Liao,C.P. and Le,L.Q.
  TITLE     Transcription factor KROX20 marks epithelial stem cell ancestors
            for hair follicle formation
  JOURNAL   J Clin Invest 134 (23), e180160 (2024)
   PUBMED   39361422
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2132)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2132)
  AUTHORS   Dauber,K.L., Perdigoto,C.N., Valdes,V.J., Santoriello,F.J.,
            Cohen,I. and Ezhkova,E.
  TITLE     Dissecting the Roles of Polycomb Repressive Complex 2 Subunits in
            the Control of Skin Development
  JOURNAL   J Invest Dermatol 136 (8), 1647-1655 (2016)
   PUBMED   26994968
REFERENCE   5  (bases 1 to 2132)
  AUTHORS   Yang,N., Li,L., Eguether,T., Sundberg,J.P., Pazour,G.J. and Chen,J.
  TITLE     Intraflagellar transport 27 is essential for hedgehog signaling but
            dispensable for ciliogenesis during hair follicle morphogenesis
  JOURNAL   Development 142 (12), 2194-2202 (2015)
   PUBMED   26023097
  REMARK    Erratum:[Development. 2015 Aug 15;142(16):2860. doi:
            10.1242/dev.128751.. PMID: 26286943]
REFERENCE   6  (bases 1 to 2132)
  AUTHORS   Tsai,S.Y., Sennett,R., Rezza,A., Clavel,C., Grisanti,L., Zemla,R.,
            Najam,S. and Rendl,M.
  TITLE     Wnt/beta-catenin signaling in dermal condensates is required for
            hair follicle formation
  JOURNAL   Dev Biol 385 (2), 179-188 (2014)
   PUBMED   24309208
REFERENCE   7  (bases 1 to 2132)
  AUTHORS   Wang,D., Zhang,Z., O'Loughlin,E., Wang,L., Fan,X., Lai,E.C. and
            Yi,R.
  TITLE     MicroRNA-205 controls neonatal expansion of skin stem cells by
            modulating the PI(3)K pathway
  JOURNAL   Nat Cell Biol 15 (10), 1153-1163 (2013)
   PUBMED   23974039
REFERENCE   8  (bases 1 to 2132)
  AUTHORS   Folgueras,A.R., Guo,X., Pasolli,H.A., Stokes,N., Polak,L., Zheng,D.
            and Fuchs,E.
  TITLE     Architectural niche organization by LHX2 is linked to hair follicle
            stem cell function
  JOURNAL   Cell Stem Cell 13 (3), 314-327 (2013)
   PUBMED   24012369
REFERENCE   9  (bases 1 to 2132)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   10 (bases 1 to 2132)
  AUTHORS   Hesse,M., Zimek,A., Weber,K. and Magin,T.M.
  TITLE     Comprehensive analysis of keratin gene clusters in humans and
            rodents
  JOURNAL   Eur J Cell Biol 83 (1), 19-26 (2004)
   PUBMED   15085952
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591417.9.
            
            On Jun 21, 2019 this sequence version replaced NM_001039666.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC119522.2, BK004023.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-509               AL591417.9         69567-70075
            510-592             AL591417.9         71046-71128
            593-749             AL591417.9         71434-71590
            750-911             AL591417.9         72553-72714
            912-1037            AL591417.9         72790-72915
            1038-1258           AL591417.9         74016-74236
            1259-2132           AL591417.9         75179-76052
FEATURES             Location/Qualifiers
     source          1..2132
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 62.92 cM"
     gene            1..2132
                     /gene="Krt40"
                     /gene_synonym="CK-40; K40"
                     /note="keratin 40"
                     /db_xref="GeneID:406221"
                     /db_xref="MGI:MGI:3629968"
     exon            1..509
                     /gene="Krt40"
                     /gene_synonym="CK-40; K40"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1382
                     /gene="Krt40"
                     /gene_synonym="CK-40; K40"
                     /note="isoform 1 is encoded by transcript variant 1;
                     keratin, type I cytoskeletal 40; cytokeratin-40"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 40 isoform 1"
                     /protein_id="NP_001034755.1"
                     /db_xref="CCDS:CCDS36307.1"
                     /db_xref="GeneID:406221"
                     /db_xref="MGI:MGI:3629968"
                     /translation="MASDGSPSCCSSEPCAGASGCATASFCPTNTTCLPNTCSTSRCQ
                     TPSFLCRASLPACCLSPCYLAGGCNSPCLVGSCAWCEEGSFNSNEKETMQFLNDRLAS
                     YLERVRSLEENNAELECRIREQCEPNAPLVCPDYQRYFDTIEELQQKILCTKAENSRL
                     AVQVDNCKLAADDFRSKYESELSLRQLVENDITGLRGILGELTLCKSDLEAHVESMKD
                     DLICLKKGHEEEVNLLREQLGDRLSVELDTAPTVDLNKVLDEMRCQYERVLANNRRDA
                     EEWFAAQTEELNQQQKSSAEQLEGCQTEMLELKRKANTLEIELQAQQTLTESLECTVA
                     ETEAQYSTQLAQMQCLIDSVEHQLAEIRCDLERQNQEYQVLLDTKARLECEINTYRGL
                     LEKEDSRLPCNPGSGAPMPNSTCEPCSNSMCEPCSAYVICTVENCCA"
     exon            510..592
                     /gene="Krt40"
                     /gene_synonym="CK-40; K40"
                     /inference="alignment:Splign:2.1.0"
     exon            593..749
                     /gene="Krt40"
                     /gene_synonym="CK-40; K40"
                     /inference="alignment:Splign:2.1.0"
     exon            750..911
                     /gene="Krt40"
                     /gene_synonym="CK-40; K40"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1037
                     /gene="Krt40"
                     /gene_synonym="CK-40; K40"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1258
                     /gene="Krt40"
                     /gene_synonym="CK-40; K40"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..2132
                     /gene="Krt40"
                     /gene_synonym="CK-40; K40"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacctttgg agactaggcg agaccgaagc aatactacat cctgtctgtt ccttctcaga
       61 agatggcttc cgatggctcc cctagctgct gctcttctga gccctgtgca ggggcttccg
      121 gctgcgcaac tgcctcattc tgccccacca acacaacttg cctccccaac acctgttcca
      181 catccagatg tcaaacccca agcttcctct gcagggcttc cctcccagcc tgttgcctct
      241 caccgtgcta cttggctggt ggctgtaaca gtccttgcct ggtggggagc tgtgcatggt
      301 gtgaggaagg atcgttcaac agtaatgaga aggagaccat gcagttcctg aatgaccgcc
      361 tggccagcta tctggagagg gtgagaagcc tggaagagaa caacgcagag ctggagtgca
      421 ggatccgaga gcaatgcgag cccaatgccc ctctggtctg ccccgattat cagcggtact
      481 tcgacaccat tgaagaactc caacaaaaga tattgtgcac aaaggcagag aattctagac
      541 ttgccgttca ggtggacaac tgcaaactgg ctgctgatga tttcaggtca aaatatgaga
      601 gcgaactgtc cctgcgccag ctggtggaga acgacatcac tggccttcgt gggatcctgg
      661 gtgaactgac cctgtgcaag tcagatctag aggcccacgt ggagtctatg aaagatgatc
      721 tgatttgcct taagaaaggc catgaagagg aggtcaacct gcttcgtgag cagcttggcg
      781 atcggctcag cgtggagctg gacactgccc ccactgtgga cctcaacaag gtcctggatg
      841 agatgcgatg tcaatacgag agggtgctgg ccaacaaccg cagggatgca gaggagtggt
      901 tcgctgctca gacagaagag ctgaaccagc agcagaagtc cagcgcggag cagttggagg
      961 gctgccagac tgagatgttg gagttgaagc gcaaggccaa cactctggaa attgagctcc
     1021 aggcgcagca aaccctgacg gagtctctgg agtgtactgt ggcagaaacc gaggcccagt
     1081 acagcacaca actggcccaa atgcagtgcc taattgacag tgtggagcac cagctggctg
     1141 agatccgctg tgacctggag cgtcagaacc aggagtacca ggtgctgctg gacaccaagg
     1201 cccggctgga gtgtgagatc aacacgtaca ggggcctgct ggagaaggag gacagcagac
     1261 tcccctgcaa tccaggctcc ggagcaccca tgccgaacag cacatgtgag ccgtgttcaa
     1321 acagcatgtg tgagccgtgt tcagcctatg tgatttgcac agttgaaaac tgctgtgcat
     1381 gacaattaaa tctccagcac gctggatgaa aatcaaaact gctcaagaaa gaagtccaga
     1441 cctgatcctg gctacaccca accttgagac acagatctgt cccggagtca ggacctcaaa
     1501 catgctccac ccagtgcaga aacagatcta ctgggatttc agatcctgaa aatctgcact
     1561 aagcatcccg ggtctgttga tcatagcttc tgccttaagc ttgcttttgg tattctagaa
     1621 gcccatgaag ccttcttgct aatctccaaa taaaacttgt ttcacttctt tagggtggta
     1681 aatacagttt agtggtcaat ggccttggct ataataggca tttaacagaa gagaagttgt
     1741 ctaaacccag gactgtagtt tcaatttgcc taacaccagt ctgaaaatat ctttactcct
     1801 caaacagatt aaataatcca tgagaaatgt tgcatatata aaatgatgga tgactgcatc
     1861 tttctcagaa ataaattaac atgtatttta tgtttaattc tcgatgaata aggttctcct
     1921 atttttaaca tttgcatatt aaggggaaat atacagttcc ggcccacaaa tggccaatat
     1981 ttagaaggga cttctaattt tcattcttat aattggtttt ctacataggg ataattatac
     2041 ttaacaattt atacagtttc atattctttt cacttatgtt accaaagcac tttaatccca
     2101 acttaaaaga aaacattttc tgtactcaac at
//
