LOCUS       NM_008475               2147 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus keratin 4 (Krt4), mRNA.
ACCESSION   NM_008475
VERSION     NM_008475.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2147)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 2147)
  AUTHORS   Sunny,S.S., Lachova,J., Dupacova,N. and Kozmik,Z.
  TITLE     Multiple roles of Pax6 in postnatal cornea development
  JOURNAL   Dev Biol 491, 1-12 (2022)
   PUBMED   36049534
REFERENCE   3  (bases 1 to 2147)
  AUTHORS   Urbanek,M.E. and Zuo,J.
  TITLE     Genetic predisposition to tinnitus in the UK Biobank population
  JOURNAL   Sci Rep 11 (1), 18150 (2021)
   PUBMED   34518561
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2147)
  AUTHORS   Mevel,R., Steiner,I., Mason,S., Galbraith,L.C., Patel,R.,
            Fadlullah,M.Z., Ahmad,I., Leung,H.Y., Oliveira,P., Blyth,K.,
            Baena,E. and Lacaud,G.
  TITLE     RUNX1 marks a luminal castration-resistant lineage established at
            the onset of prostate development
  JOURNAL   Elife 9, e60225 (2020)
   PUBMED   33025905
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2147)
  AUTHORS   Guo,W., Li,L., He,J., Liu,Z., Han,M., Li,F., Xia,X., Zhang,X.,
            Zhu,Y., Wei,Y., Li,Y., Aji,R., Dai,H., Wei,H., Li,C., Chen,Y.,
            Chen,L. and Gao,D.
  TITLE     Single-cell transcriptomics identifies a distinct luminal
            progenitor cell type in distal prostate invagination tips
  JOURNAL   Nat Genet 52 (9), 908-918 (2020)
   PUBMED   32807988
REFERENCE   6  (bases 1 to 2147)
  AUTHORS   Kurpakus,M.A., Maniaci,M.T. and Esco,M.
  TITLE     Expression of keratins K12, K4 and K14 during development of ocular
            surface epithelium
  JOURNAL   Curr Eye Res 13 (11), 805-814 (1994)
   PUBMED   7531631
REFERENCE   7  (bases 1 to 2147)
  AUTHORS   Baribault,H. and Oshima,R.G.
  TITLE     Polarized and functional epithelia can form after the targeted
            inactivation of both mouse keratin 8 alleles
  JOURNAL   J Cell Biol 115 (6), 1675-1684 (1991)
   PUBMED   1721911
REFERENCE   8  (bases 1 to 2147)
  AUTHORS   Zhao,S.Y.
  TITLE     [Mouse type II cytokeratin genes CK-4 and CK-8 mapped on chromosome
            15]
  JOURNAL   Yi Chuan Xue Bao 18 (6), 490-494 (1991)
   PUBMED   1722687
REFERENCE   9  (bases 1 to 2147)
  AUTHORS   Morita,T., Tondella,M.L., Takemoto,Y., Hashido,K., Ichinose,Y.,
            Nozaki,M. and Matsushiro,A.
  TITLE     Nucleotide sequence of mouse EndoA cytokeratin cDNA reveals
            polypeptide characteristics of the type-II keratin subfamily
  JOURNAL   Gene 68 (1), 109-117 (1988)
   PUBMED   2464527
REFERENCE   10 (bases 1 to 2147)
  AUTHORS   Knapp,B., Rentrop,M., Schweizer,J. and Winter,H.
  TITLE     Nonepidermal members of the keratin multigene family: cDNA
            sequences and in situ localization of the mRNAs
  JOURNAL   Nucleic Acids Res 14 (2), 751-763 (1986)
   PUBMED   2418416
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY139439.1 and BC064008.1.
            
            On Mar 20, 2007 this sequence version replaced NM_008475.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064008.1, X03491.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-390               BY139439.1         2-391
            391-2147            BC064008.1         372-2128
FEATURES             Location/Qualifiers
     source          1..2147
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.13 cM"
     gene            1..2147
                     /gene="Krt4"
                     /gene_synonym="K4; Krt-2.4; Krt2-4"
                     /note="keratin 4"
                     /db_xref="GeneID:16682"
                     /db_xref="MGI:MGI:96701"
     exon            1..554
                     /gene="Krt4"
                     /gene_synonym="K4; Krt-2.4; Krt2-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1643
                     /gene="Krt4"
                     /gene_synonym="K4; Krt-2.4; Krt2-4"
                     /note="CK-4; cytokeratin-4; type-II keratin Kb4;
                     cytoskeletal 57 kDa keratin; 57kDa keratin; keratin
                     complex 2, basic, gene 4; 57kd keratin"
                     /codon_start=1
                     /product="keratin, type II cytoskeletal 4"
                     /protein_id="NP_032501.2"
                     /db_xref="CCDS:CCDS37222.1"
                     /db_xref="GeneID:16682"
                     /db_xref="MGI:MGI:96701"
                     /translation="MIARQSSVRGASRGFSSGSAIAGGVKRVAFSSGSMSGGAGRCSS
                     GGFGSRSLYNLGGHKSISMSVAGSCQGGGYGGAGGFGVGGYGAGFGAGGFGGGFGGSF
                     NGRGGPGFPVCPAGGIQEVTINQSLLTPLQVEIDPEIQKIRTAEREQIKTLNNKFASF
                     IDKVRFLEQQNKVLETKWNLLQQQTTTTSPKSLDPFFETYINALRKNLDTLSNDKGRL
                     QSELKMMQDSVEDFKTKYEEEINKRTAAENDFVVLKKDVDAAYMIKVELEAKMESLKD
                     EINFTRVLYEAELAQMQTHVSDTSVVLSMDNNRNLDLDGIIAEVRAQYEDIARKSKAE
                     VESWYQIKVQQLQMSADQHGDSLKTTKNEISELNRMIQRLRAEIENIKKQSQTLQASV
                     ADAEQRGELALKDAYSKRAELETALQKAKEDLARLLRDYQALMNVKLALDVEIATYRK
                     LLEGEECRMSGECKSAVSISVVGGSASIGGSGLGLGSGFCSGSGSGSGFGFGGGIYGG
                     SGSKITSSATITKRSPR"
     exon            555..769
                     /gene="Krt4"
                     /gene_synonym="K4; Krt-2.4; Krt2-4"
                     /inference="alignment:Splign:2.1.0"
     exon            770..830
                     /gene="Krt4"
                     /gene_synonym="K4; Krt-2.4; Krt2-4"
                     /inference="alignment:Splign:2.1.0"
     exon            831..926
                     /gene="Krt4"
                     /gene_synonym="K4; Krt-2.4; Krt2-4"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1091
                     /gene="Krt4"
                     /gene_synonym="K4; Krt-2.4; Krt2-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1217
                     /gene="Krt4"
                     /gene_synonym="K4; Krt-2.4; Krt2-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1438
                     /gene="Krt4"
                     /gene_synonym="K4; Krt-2.4; Krt2-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1473
                     /gene="Krt4"
                     /gene_synonym="K4; Krt-2.4; Krt2-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..2133
                     /gene="Krt4"
                     /gene_synonym="K4; Krt-2.4; Krt2-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2112..2117
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt4"
                     /gene_synonym="K4; Krt-2.4; Krt2-4"
                     /note="hexamer: AATAAA"
     polyA_site      2133
                     /gene="Krt4"
                     /gene_synonym="K4; Krt-2.4; Krt2-4"
                     /note="major polyA site"
ORIGIN      
        1 attcaggatc tggcctttgc ttcgcttctg ttctaagctc gttgcagctg cctcctctct
       61 cagccatgat cgccagacag tcaagtgtcc gcggagcctc ccggggcttt agcagtggct
      121 cagctattgc tggtggtgtc aagcgagtgg cctttagctc aggctccatg tctggcggtg
      181 cagggcgctg ctcttctggg ggcttcggca gcagaagtct ttacaacctc gggggtcaca
      241 agagtatctc catgagcgtg gctgggtcct gccaaggcgg cggctatggg ggtgccggag
      301 gcttcggcgt tggaggatac ggtgctgggt ttggtgccgg tggttttggc ggtggctttg
      361 gaggctcctt caacggtcga ggaggtcctg gcttcccagt ctgtcctgct ggaggtattc
      421 aggaagtcac catcaaccag agcctgctga cacctcttca ggtggagatt gacccagaga
      481 tccagaaaat ccgcacggcg gagcgtgagc agatcaagac cctcaacaac aaattcgcgt
      541 ccttcatcga taaggtgcga ttcttagagc aacagaacaa ggtcctggag accaaatgga
      601 acctcctcca gcagcagaca accaccacat ctcccaaaag cctggatcct ttctttgaga
      661 cttacatcaa cgccttgagg aagaacctgg acactttgag caatgacaaa ggtcgcctac
      721 agtcagagct aaagatgatg caggacagtg tggaggactt caagaccaag tatgaagagg
      781 agatcaacaa gcgtacagct gcagagaatg acttcgtggt cctcaagaaa gatgtggatg
      841 ctgcctacat gatcaaggtg gagttagagg ccaagatgga aagccttaag gatgagatca
      901 acttcacgag agtcctctat gaagcggagc tggcccagat gcagacacat gtctcagaca
      961 catctgtagt gctgtccatg gacaacaacc ggaacctgga cctggatggc atcatcgcag
     1021 aggtccgggc ccagtatgag gacattgcta ggaagagcaa ggctgaggtt gaatcctggt
     1081 accagatcaa ggtccagcag ctccagatgt cagctgacca acatggagat agcctgaaga
     1141 ccaccaagaa tgagatctca gaactcaaca ggatgatcca gaggctgcgg gcagagattg
     1201 agaacatcaa gaagcagagc cagactctgc aggcatctgt ggctgatgca gagcagcgtg
     1261 gagagctggc cctcaaagat gcctacagca aacgcgcaga actggagact gcactgcaga
     1321 aggccaagga ggacctggcc cggctgctga gggactacca ggctctcatg aacgtcaagc
     1381 tggccctgga tgtggagatt gccacctaca ggaagctgct ggagggcgag gagtgcagga
     1441 tgtctggaga atgcaagagt gctgtgagca tctcggtagt tggcggcagc gccagcattg
     1501 gcggcagtgg ccttggcctg ggtagcggtt tttgctccgg ttctggttct ggaagtggct
     1561 ttggatttgg tggtggcatt tatggcggtt ctggttccaa gatcacctct tccgccacca
     1621 tcaccaagag gtccccacga taggcgagac gggatcctga tggccctgag cccggcaggg
     1681 tcagccgttc ctgatatctc ctgtgcgatc ttcacttcac ctccagtctt cctggtgctc
     1741 atcttgttac tcttccccct ctgccttggt ccctcagttc caggacgatc ttcttggcca
     1801 tggtgtgacc tctgttctat tggaacctgg tagcttcttc tcaacttggg tcaagtggcc
     1861 ccccaccccc tgcatgggag gggtgtctga tttcacccca atggacagag gggatgaaga
     1921 gcagaaactc cttctgcaga tgtacactgt cactctcagc tcctctcgtc acaccggctt
     1981 ccacctgatc ctggagatct atgttctaca atgatgctca ttctccatca cctggcagca
     2041 acgggctctg ccaggtcaac aaggactgct tggtgtcccg tgcaaccctg ctcctctctc
     2101 tactcatccc caataaaatg cttttgtcat tcaaaaaaaa aaaaaaa
//
