LOCUS       NM_001174099            1666 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus keratin 36 (Krt36), mRNA.
ACCESSION   NM_001174099
VERSION     NM_001174099.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1666)
  AUTHORS   Yu,X., Xu,B., Gao,T., Fu,X., Jiang,B., Zhou,N., Gao,W., Wu,T.,
            Shen,C., Huang,X., Wu,Y. and Zheng,B.
  TITLE     E3 ubiquitin ligase RNF187 promotes growth of spermatogonia via
            lysine 48-linked polyubiquitination-mediated degradation of
            KRT36/KRT84
  JOURNAL   FASEB J 37 (10), e23217 (2023)
   PUBMED   37738023
  REMARK    GeneRIF: E3 ubiquitin ligase RNF187 promotes growth of
            spermatogonia via lysine 48-linked polyubiquitination-mediated
            degradation of KRT36/KRT84.
REFERENCE   2  (bases 1 to 1666)
  AUTHORS   Xu,M., Horrell,J., Snitow,M., Cui,J., Gochnauer,H., Syrett,C.M.,
            Kallish,S., Seykora,J.T., Liu,F., Gaillard,D., Katz,J.P.,
            Kaestner,K.H., Levin,B., Mansfield,C., Douglas,J.E., Cowart,B.J.,
            Tordoff,M., Liu,F., Zhu,X., Barlow,L.A., Rubin,A.I., McGrath,J.A.,
            Morrisey,E.E., Chu,E.Y. and Millar,S.E.
  TITLE     WNT10A mutation causes ectodermal dysplasia by impairing progenitor
            cell proliferation and KLF4-mediated differentiation
  JOURNAL   Nat Commun 8, 15397 (2017)
   PUBMED   28589954
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1666)
  AUTHORS   Kawasaki,M., Kawasaki,K., Oommen,S., Blackburn,J., Watanabe,M.,
            Nagai,T., Kitamura,A., Maeda,T., Liu,B., Schmidt-Ullrich,R.,
            Akiyama,T., Inoue,J., Hammond,N.L., Sharpe,P.T. and Ohazama,A.
  TITLE     Regional regulation of Filiform tongue papillae development by
            Ikkalpha/Irf6
  JOURNAL   Dev Dyn 245 (9), 937-946 (2016)
   PUBMED   27302476
REFERENCE   4  (bases 1 to 1666)
  AUTHORS   Harrow,J.L., Steward,C.A., Frankish,A., Gilbert,J.G.,
            Gonzalez,J.M., Loveland,J.E., Mudge,J., Sheppard,D., Thomas,M.,
            Trevanion,S. and Wilming,L.G.
  TITLE     The Vertebrate Genome Annotation browser 10 years on
  JOURNAL   Nucleic Acids Res 42 (Database issue), D771-D779 (2014)
   PUBMED   24316575
REFERENCE   5  (bases 1 to 1666)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   6  (bases 1 to 1666)
  AUTHORS   Jonker,L., Kist,R., Aw,A., Wappler,I. and Peters,H.
  TITLE     Pax9 is required for filiform papilla development and suppresses
            skin-specific differentiation of the mammalian tongue epithelium
  JOURNAL   Mech Dev 121 (11), 1313-1322 (2004)
   PUBMED   15454262
REFERENCE   7  (bases 1 to 1666)
  AUTHORS   Tobiasch,E., Winter,H. and Schweizer,J.
  TITLE     Structural features and sites of expression of a new murine 65 kD
            and 48 kD hair-related keratin pair, associated with a special type
            of parakeratotic epithelial differentiation
  JOURNAL   Differentiation 50 (3), 163-178 (1992)
   PUBMED   1385239
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590873.17 and AL662808.12.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on mouse and homologous human transcript
            alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849375,
                              SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-489               AL590873.17        2123-2611           c
            490-572             AL662808.12        37327-37409         c
            573-729             AL662808.12        36944-37100         c
            730-891             AL662808.12        36287-36448         c
            892-1017            AL662808.12        36069-36194         c
            1018-1238           AL662808.12        35701-35921         c
            1239-1666           AL662808.12        34910-35337         c
FEATURES             Location/Qualifiers
     source          1..1666
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.41 cM"
     gene            1..1666
                     /gene="Krt36"
                     /gene_synonym="HRa-1; K36; Krt1-22; Krt1-5; MHRa-1"
                     /note="keratin 36"
                     /db_xref="GeneID:16673"
                     /db_xref="MGI:MGI:109364"
     exon            1..489
                     /gene="Krt36"
                     /gene_synonym="HRa-1; K36; Krt1-22; Krt1-5; MHRa-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1452
                     /gene="Krt36"
                     /gene_synonym="HRa-1; K36; Krt1-22; Krt1-5; MHRa-1"
                     /note="type I keratin 48 kDa (MHRa-1); keratin-5; keratin
                     complex 1, acidic, gene 5"
                     /codon_start=1
                     /product="keratin, type I cuticular Ha6"
                     /protein_id="NP_001167570.1"
                     /db_xref="CCDS:CCDS48929.1"
                     /db_xref="GeneID:16673"
                     /db_xref="MGI:MGI:109364"
                     /translation="MATQICTPTFSAGSAKGLCGTSGSFSRISSIHSMGSCRAPSLVG
                     TVGSVSSFRTGFSGPGSCLPGSYLSSGCHSSGFAGSGGWFCEGAFNGNEKATMQILND
                     RLANYLEKVRQLEQENTQLECRIREWYECQIPYICPDYQSYFKTAEELQQKILLTKSE
                     NARLILQIDNAKLAADDFRTKYETELSLRQLVEADINGLRRILDELTLCKADLEAQVE
                     SLKEELLCLKRNHEEEVNALRSQLGDRLNVEVDAAPPVDLNKILDDMRCQYETLVENN
                     RRDVEAWFNTQTEELNQQVVSSSEQLQCCQTEIIELRRTVNSLEIELQAQQSMRNSLE
                     STLAETEARYSSQLGQMQCLITNVESQLAEIRCDLERQNHEYQVLLDVKARLESEIAT
                     YRRLLDGEDCKLPAHPCSTECKPAVRVPYIPSTTCTPAGPCTPAGPCTPAPQVSTQIR
                     TITEEIRDGRVISSREHVVPRAM"
     exon            490..572
                     /gene="Krt36"
                     /gene_synonym="HRa-1; K36; Krt1-22; Krt1-5; MHRa-1"
                     /inference="alignment:Splign:2.1.0"
     exon            573..729
                     /gene="Krt36"
                     /gene_synonym="HRa-1; K36; Krt1-22; Krt1-5; MHRa-1"
                     /inference="alignment:Splign:2.1.0"
     exon            730..891
                     /gene="Krt36"
                     /gene_synonym="HRa-1; K36; Krt1-22; Krt1-5; MHRa-1"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1017
                     /gene="Krt36"
                     /gene_synonym="HRa-1; K36; Krt1-22; Krt1-5; MHRa-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1238
                     /gene="Krt36"
                     /gene_synonym="HRa-1; K36; Krt1-22; Krt1-5; MHRa-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1666
                     /gene="Krt36"
                     /gene_synonym="HRa-1; K36; Krt1-22; Krt1-5; MHRa-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1640..1645
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt36"
                     /gene_synonym="HRa-1; K36; Krt1-22; Krt1-5; MHRa-1"
                     /note="hexamer: AATAAA"
     polyA_site      1666
                     /gene="Krt36"
                     /gene_synonym="HRa-1; K36; Krt1-22; Krt1-5; MHRa-1"
                     /note="major polyA site"
ORIGIN      
        1 acctattcag caaccttcct cgctagcatc atggccaccc agatctgcac cccgaccttc
       61 tctgctgggt ctgccaaggg cctctgtggc acttcaggga gcttctctcg gatatcttcc
      121 atccattcca tgggctcctg cagggccccc agtttggttg gcactgtggg gtccgtgtcc
      181 tccttcagga caggcttctc tggccctggg agctgcttgc caggctccta cctgtcctct
      241 gggtgccact cctctggctt tgctgggagc gggggatggt tctgcgaggg cgccttcaat
      301 ggcaacgaga aggcgaccat gcagatcttg aatgaccgac tggccaacta cctggagaag
      361 gtgcggcagc tggagcagga gaacacacag ctggagtgcc gcatccgaga gtggtacgag
      421 tgtcagatcc catacatctg cccggactac cagtcctact tcaagactgc tgaggagttg
      481 cagcagaaga tcctgctgac caagtctgag aatgccaggc tgatattaca aattgacaat
      541 gccaagctgg ctgctgatga cttccggacc aagtatgaga cggagttgtc cctgcgacag
      601 ctggtagagg ctgacatcaa tggtctacgc cggatcttgg atgagctgac cttgtgtaag
      661 gctgacctgg aggcacaggt tgagtccctg aaggaggagc tgctgtgtct caagaggaac
      721 catgaagagg aagtcaatgc cctccgttcc cagcttgggg accgactgaa tgtggaggtg
      781 gatgctgctc ccccagtgga tctcaacaag atactggatg acatgcgatg ccagtatgag
      841 acgctggtgg agaataaccg tagagatgtg gaggcttggt tcaacactca gaccgaggag
      901 ctgaaccagc aggtggtatc cagctcagag cagctgcagt gttgccagac agagatcatt
      961 gagctgagac gcacagtcaa ctccctggag atcgagctgc aggctcaaca gagcatgagg
     1021 aattctctgg aatctaccct ggctgagaca gaggcccgct acagctccca gctgggccag
     1081 atgcagtgcc tgatcaccaa cgtggaatcc cagctggctg agattcgttg tgacctggag
     1141 cggcagaacc atgagtatca ggtgttactg gatgtcaagg cccggctgga gtcagagatt
     1201 gccacctacc gtcgcctgct ggatggggag gactgcaagc ttcctgccca cccttgttcc
     1261 acggaatgca agcctgctgt aagagtacct tatatccctt ctacaacctg cactccagct
     1321 gggccctgca ccccagctgg gccctgcacc ccagctcctc aagtcagcac ccagatccgg
     1381 accatcaccg aggagatcag ggatggaaga gtcatctcct ccagggagca cgtggtgccc
     1441 cgggcaatgt gagcagccac cagaggggcc taggccacag gaaggaggac accttgtggt
     1501 tcttggcagc taaatgatct tgcacttctc tagggccctc cttgcttagc aggtttttct
     1561 actcaaattc atctattgtt tctggtctta actgtgcttt ttacgccatg caaaaccagg
     1621 ttcccctgga aatattccca ataaagtgtt ctcttggcat agcaaa
//
