LOCUS       NM_016880               1742 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus keratin 35 (Krt35), mRNA.
ACCESSION   NM_016880 XM_982341
VERSION     NM_016880.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1742)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1742)
  AUTHORS   Fleger-Weckmann,A., Ustun,Y., Kloepper,J., Paus,R., Bloch,W.,
            Chen,Z.L., Wegner,J., Sorokin,L., Langbein,L., Eckes,B.,
            Zigrino,P., Krieg,T. and Nischt,R.
  TITLE     Deletion of the epidermis derived laminin gamma1 chain leads to
            defects in the regulation of late hair morphogenesis
  JOURNAL   Matrix Biol 56, 42-56 (2016)
   PUBMED   27234308
REFERENCE   3  (bases 1 to 1742)
  AUTHORS   Nishiguchi,Y., Ohmoto,M., Koki,J., Enomoto,T., Kominami,R.,
            Matsumoto,I. and Hirota,J.
  TITLE     Bcl11b/Ctip2 is required for development of lingual papillae in
            mice
  JOURNAL   Dev Biol 416 (1), 98-110 (2016)
   PUBMED   27287879
REFERENCE   4  (bases 1 to 1742)
  AUTHORS   Kiso,M., Tanaka,S., Saba,R., Matsuda,S., Shimizu,A., Ohyama,M.,
            Okano,H.J., Shiroishi,T., Okano,H. and Saga,Y.
  TITLE     The disruption of Sox21-mediated hair shaft cuticle differentiation
            causes cyclic alopecia in mice
  JOURNAL   Proc Natl Acad Sci U S A 106 (23), 9292-9297 (2009)
   PUBMED   19470461
REFERENCE   5  (bases 1 to 1742)
  AUTHORS   Hwang,J., Mehrani,T., Millar,S.E. and Morasso,M.I.
  TITLE     Dlx3 is a crucial regulator of hair follicle differentiation and
            cycling
  JOURNAL   Development 135 (18), 3149-3159 (2008)
   PUBMED   18684741
REFERENCE   6  (bases 1 to 1742)
  AUTHORS   Gilon,M., Sher,N., Cohen,S. and Gat,U.
  TITLE     Transcriptional activation of a subset of hair keratin genes by the
            NF-kappaB effector p65/RelA
  JOURNAL   Differentiation 76 (5), 518-530 (2008)
   PUBMED   18021261
  REMARK    GeneRIF: Transfected human p65 induces transcriptional activation
            of mouse Ha5.
REFERENCE   7  (bases 1 to 1742)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   8  (bases 1 to 1742)
  AUTHORS   Wu,X., Quondamatteo,F., Lefever,T., Czuchra,A., Meyer,H.,
            Chrostek,A., Paus,R., Langbein,L. and Brakebusch,C.
  TITLE     Cdc42 controls progenitor cell differentiation and beta-catenin
            turnover in skin
  JOURNAL   Genes Dev 20 (5), 571-585 (2006)
   PUBMED   16510873
REFERENCE   9  (bases 1 to 1742)
  AUTHORS   Jonker,L., Kist,R., Aw,A., Wappler,I. and Peters,H.
  TITLE     Pax9 is required for filiform papilla development and suppresses
            skin-specific differentiation of the mammalian tongue epithelium
  JOURNAL   Mech Dev 121 (11), 1313-1322 (2004)
   PUBMED   15454262
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC100542.1.
            
            On May 27, 2009 this sequence version replaced NM_016880.1.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus to one that is more supported by the available
            transcript and conservation data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100542.1, AF020790.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN04095722
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1742              BC100542.1         1-1742
FEATURES             Location/Qualifiers
     source          1..1742
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.4 cM"
     gene            1..1742
                     /gene="Krt35"
                     /gene_synonym="Ha5; Krt1-24; Krtha5"
                     /note="keratin 35"
                     /db_xref="GeneID:53617"
                     /db_xref="MGI:MGI:1858899"
     exon            1..509
                     /gene="Krt35"
                     /gene_synonym="Ha5; Krt1-24; Krtha5"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1406
                     /gene="Krt35"
                     /gene_synonym="Ha5; Krt1-24; Krtha5"
                     /note="hair keratin acidic 5; K35; hair keratin, type I
                     Ha5; keratin complex 1, acidic, gene 24; keratin, hair,
                     acidic, 5; keratin complex 1, gene 24"
                     /codon_start=1
                     /product="keratin, type I cuticular Ha5"
                     /protein_id="NP_058576.2"
                     /db_xref="CCDS:CCDS25407.2"
                     /db_xref="GeneID:53617"
                     /db_xref="MGI:MGI:1858899"
                     /translation="MASKCLKASFSSGSLKSPGKAGGGSTRVSNMYSSSSCKLPSPSR
                     GARSFSVCSAGLGRGNYRVSSCLPALCLPTGGFATSYGTGGGWFGEGILTGNEKETMQ
                     SLNDRLASYLEKVRQLEQENASLESRIREWCEQQVPYMCPDYQSYFRTMEELQKKTLC
                     SKAENARLVVQIDNAKLAADDFRTKYETEVSLRQLVEADINGLRRILDDLTLCKADLE
                     AQVESLKEELLCLKKNHEEEVNSLRCQLGDRLNVEVDAAPPVDLNRVLDEMRCQYETL
                     VENNRRDAEDWYDTQTEELNQQVVSSSEQLQSCQSDIIELRRTVNSLEIELQAQQSMR
                     DALDSTLAETEGRYSSQLAQMQCMIGNVESQLGEIRADLERQNQEYQVLLDVRARLEC
                     EINTYRGLLESEDSKLPCNPCAPDYSSSKSCLPCLPAVSCSTGAARTTCSPRPVCVPC
                     PGGRF"
     exon            510..592
                     /gene="Krt35"
                     /gene_synonym="Ha5; Krt1-24; Krtha5"
                     /inference="alignment:Splign:2.1.0"
     exon            593..749
                     /gene="Krt35"
                     /gene_synonym="Ha5; Krt1-24; Krtha5"
                     /inference="alignment:Splign:2.1.0"
     exon            750..911
                     /gene="Krt35"
                     /gene_synonym="Ha5; Krt1-24; Krtha5"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1037
                     /gene="Krt35"
                     /gene_synonym="Ha5; Krt1-24; Krtha5"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1258
                     /gene="Krt35"
                     /gene_synonym="Ha5; Krt1-24; Krtha5"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1722
                     /gene="Krt35"
                     /gene_synonym="Ha5; Krt1-24; Krtha5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1695..1700
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt35"
                     /gene_synonym="Ha5; Krt1-24; Krtha5"
                     /note="hexamer: AATAAA"
     polyA_site      1720
                     /gene="Krt35"
                     /gene_synonym="Ha5; Krt1-24; Krtha5"
                     /note="major polyA site"
ORIGIN      
        1 ctcagagctc tactgcttac acctgggctg ctgtggccat ggcttccaaa tgcctcaagg
       61 ccagcttctc ctcaggatct ctgaagagcc cggggaaagc cggaggggga tccactcgcg
      121 tgtccaacat gtactccagc agctcttgca agctgcccag cccttcccgt ggagcccgga
      181 gtttctccgt gtgttccgct ggcctgggga gaggcaatta cagggtatcc agctgcctcc
      241 cagctctctg cctcccaacg ggaggctttg ccaccagcta cggcacgggt ggaggttggt
      301 ttggagaagg catcctcact ggtaatgaga aggagaccat gcagtccctg aatgaccgcc
      361 tggccagcta tctggagaag gtgcgccagc tggagcagga gaatgccagc ctggagagcc
      421 gaattcggga gtggtgtgag cagcaggtgc cctatatgtg ccccgattac cagtcttact
      481 tccggaccat ggaggagctc cagaagaaga ctctttgcag caaggcagag aacgccaggc
      541 tggtggtgca gattgacaat gccaagctgg ctgctgatga cttcaggacc aagtatgaga
      601 ctgaggtttc cctgcggcag ctggtggagg ctgacatcaa tggcctgcgc agaatcctgg
      661 atgatctgac tctgtgcaag gctgacctgg aagctcaggt ggagtctctg aaggaagaat
      721 tgctttgcct caagaagaac catgaggagg aagtgaactc actgcgctgc cagcttggcg
      781 atcggctcaa tgttgaggtg gatgctgctc cacccgttga cctgaaccgc gttctggatg
      841 agatgaggtg ccagtatgag accttggtgg agaataaccg gagggatgct gaagactggt
      901 atgacaccca gaccgaggaa ctgaaccagc aggttgtgtc cagctcagag cagctgcagt
      961 cctgccagtc ggacatcatt gagttgagac gcactgtcaa ctctctggag atagagctgc
     1021 aggcccagca gagcatgaga gatgctttgg actccaccct ggcagagaca gaaggccgct
     1081 acagctctca gctggctcag atgcagtgca tgatcggcaa tgtggagtcc cagcttggtg
     1141 agatccgggc tgacctggag cgtcagaacc aggagtacca ggtgctgctg gatgtccggg
     1201 ccaggctgga gtgtgagatc aacacgtaca ggggcctgct ggagagcgag gacagcaagc
     1261 ttccctgcaa cccgtgtgcc cctgactact cttcctccaa gtcatgcctc ccctgccttc
     1321 ctgcggtctc ctgcagcacg ggcgcagctc gtaccacctg cagcccccgc cctgtctgtg
     1381 tgccctgccc agggggccgg ttctgagagt aacgcatcca gagggtcaag gccgcggcct
     1441 ccagtcaatc tgactgttac agcgcaaatc tctctgttct ttctgggccc aggcccaatc
     1501 actgagaaga ttctctgcac ataaatgcct taaagtttct ttgaccctgt caactagggc
     1561 aggttgtcct ttaggccttg acgcctcatc atttcaacgg gctccagggt ctctgttctg
     1621 ggcctgctcc tttccttctg agtgtgtttt ccctaggttc tgaaatttaa tacagcgtat
     1681 ctgagggcgg gggcaataaa gccatttgct atggttccca gtaaaaaaaa aaaaaaaaaa
     1741 aa
//
