LOCUS       NM_027563               1609 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus keratin 34 (Krt34), mRNA.
ACCESSION   NM_027563
VERSION     NM_027563.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1609)
  AUTHORS   Defamie,V., Aliar,K., Sarkar,S., Vyas,F., Shetty,R., Reddy
            Narala,S., Fang,H., Saw,S., Tharmapalan,P., Sanchez,O., Knox,J.J.,
            Waterhouse,P.D. and Khokha,R.
  TITLE     Metalloproteinase inhibitors regulate biliary progenitor cells
            through sDLK1 in organoid models of liver injury
  JOURNAL   J Clin Invest 135 (3), e164997 (2024)
   PUBMED   39699962
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1609)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1609)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   4  (bases 1 to 1609)
  AUTHORS   Wu,X., Quondamatteo,F., Lefever,T., Czuchra,A., Meyer,H.,
            Chrostek,A., Paus,R., Langbein,L. and Brakebusch,C.
  TITLE     Cdc42 controls progenitor cell differentiation and beta-catenin
            turnover in skin
  JOURNAL   Genes Dev 20 (5), 571-585 (2006)
   PUBMED   16510873
REFERENCE   5  (bases 1 to 1609)
  AUTHORS   Zhang,H., Hara,M., Seki,K., Fukuda,K. and Nishida,T.
  TITLE     Eyelid fusion and epithelial differentiation at the ocular surface
            during mouse embryonic development
  JOURNAL   Jpn J Ophthalmol 49 (3), 195-204 (2005)
   PUBMED   15944823
REFERENCE   6  (bases 1 to 1609)
  AUTHORS   Meier,N., Dear,T.N. and Boehm,T.
  TITLE     Whn and mHa3 are components of the genetic hierarchy controlling
            hair follicle differentiation
  JOURNAL   Mech Dev 89 (1-2), 215-221 (1999)
   PUBMED   10559501
REFERENCE   7  (bases 1 to 1609)
  AUTHORS   Sato,H., Koide,T., Sagai,T., Ishiguro,S.I., Tamai,M., Saitou,N. and
            Shiroishi,T.
  TITLE     The genomic organization of type I keratin genes in mice
  JOURNAL   Genomics 56 (3), 303-309 (1999)
   PUBMED   10087197
REFERENCE   8  (bases 1 to 1609)
  AUTHORS   Winter,H., Siry,P., Tobiasch,E. and Schweizer,J.
  TITLE     Sequence and expression of murine type I hair keratins mHa2 and
            mHa3
  JOURNAL   Exp Cell Res 212 (2), 190-200 (1994)
   PUBMED   7514534
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK014631.1, AA755053.1 and
            AL592545.10.
            
            On Sep 16, 2015 this sequence version replaced NM_027563.3.
            
            Summary: The protein encoded by this gene is a member of the
            keratin gene family. As a type I hair keratin, it is an acidic
            protein which heterodimerizes with type II keratins to form hair
            and nails. [provided by RefSeq, Sep 2015].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK014631.1, BC125446.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN04095723 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1445              AK014631.1         3-1447
            1446-1604           AA755053.1         24-182              c
            1605-1609           AL592545.10        110810-110814       c
FEATURES             Location/Qualifiers
     source          1..1609
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.38 cM"
     gene            1..1609
                     /gene="Krt34"
                     /gene_synonym="4733401E01Rik; Ha2; K34; Krt1-4"
                     /note="keratin 34"
                     /db_xref="GeneID:16672"
                     /db_xref="MGI:MGI:1309994"
     exon            1..406
                     /gene="Krt34"
                     /gene_synonym="4733401E01Rik; Ha2; K34; Krt1-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1237
                     /gene="Krt34"
                     /gene_synonym="4733401E01Rik; Ha2; K34; Krt1-4"
                     /note="hair keratin, type I Ha4; keratin complex 1,
                     acidic, gene 4"
                     /codon_start=1
                     /product="keratin, type I cuticular Ha4"
                     /protein_id="NP_081839.1"
                     /db_xref="CCDS:CCDS25404.1"
                     /db_xref="GeneID:16672"
                     /db_xref="MGI:MGI:1309994"
                     /translation="MSCESCLPALSCRTSCSSRPCVPPSCHGCTLPGACNIPANVGNC
                     NWFCEGSFNGNEKETMQFLNDRLASYMEKVRQLERENAELECRIQERNQQQDPLVCPA
                     YQAYFRTIEELQQKILCAKSENARLVVQIDNAKLASDDFRTKYQTELSMRQLVEADIN
                     SLRRILDELTLCKSDLEAQVESLREELLCLKKNHEEEVNTLRCQLGDRLNVEVDAAPT
                     VDLNRVLNETRCQYEALVETNRREVEEWFTTQSEELNKQVVSSSEQLQSCQAEIIELR
                     RTVNALEIELQAQHCMRNSLENTLTESEARYSSQLSQVQCLITNVESQLGEIRADLER
                     QNQEYQVLLDVRARLECEINTYRSLLESEDCNLPCNPCATTNASGSCCGPCGSSKRCC
                     "
     exon            407..489
                     /gene="Krt34"
                     /gene_synonym="4733401E01Rik; Ha2; K34; Krt1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            490..646
                     /gene="Krt34"
                     /gene_synonym="4733401E01Rik; Ha2; K34; Krt1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            647..808
                     /gene="Krt34"
                     /gene_synonym="4733401E01Rik; Ha2; K34; Krt1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            809..934
                     /gene="Krt34"
                     /gene_synonym="4733401E01Rik; Ha2; K34; Krt1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1155
                     /gene="Krt34"
                     /gene_synonym="4733401E01Rik; Ha2; K34; Krt1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1609
                     /gene="Krt34"
                     /gene_synonym="4733401E01Rik; Ha2; K34; Krt1-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1581..1586
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt34"
                     /gene_synonym="4733401E01Rik; Ha2; K34; Krt1-4"
                     /note="hexamer: AATAAA"
     polyA_site      1609
                     /gene="Krt34"
                     /gene_synonym="4733401E01Rik; Ha2; K34; Krt1-4"
                     /note="major polyA site"
ORIGIN      
        1 aaacctcacc cagacctacc tgcagcagct cactgctccc atcacttctc cccaaaccat
       61 gtcctgtgag tcttgcctgc ccgccctgag ctgccgcacc agctgctcct cccggccctg
      121 cgtgcccccc agctgccatg gctgcaccct gcccggggcc tgcaacatcc ccgccaatgt
      181 gggcaactgc aattggttct gtgagggctc cttcaatggc aatgagaagg agaccatgca
      241 gttcctgaat gaccgcctgg cctcctatat ggagaaggtg aggcagctgg agagagagaa
      301 tgcagagctg gaatgtagga tccaggagag gaaccagcag caggaccccc tggtgtgtcc
      361 tgcctaccag gcctacttca ggaccattga ggagctgcag cagaagattc tgtgtgctaa
      421 gtctgagaac gccaggctgg tcgtgcagat cgacaatgcc aagctggcct ctgatgactt
      481 caggaccaag taccagactg agctgtccat gaggcagctg gtggaggctg acatcaacag
      541 cctgcgcagg atcctggatg agctgaccct ctgcaagtct gacttggagg ctcaggtgga
      601 gtctctgagg gaggagctgc tgtgcctcaa gaagaaccac gaggaggaag tcaacaccct
      661 gcgctgccag cttggagacc gcctcaacgt ggaggtggac gctgctccca ccgtggacct
      721 gaaccgagtg ctcaacgaga ccaggtgtca gtacgaggcc ctggtggaaa ccaaccgccg
      781 ggaagtggag gaatggttca ccacacagtc agaggagctg aacaagcagg tggtgtccag
      841 ctcagagcag ctacagtcct gccaggctga gatcatcgag ctaagacgca cagtcaacgc
      901 cctggagatc gagctgcagg cccagcactg catgagaaac tctctggaga acaccctgac
      961 agagagtgag gctcgctaca gctctcagct gtcccaggtg cagtgcctga tcaccaacgt
     1021 ggagtctcag cttggtgaga tccgggctga cctggagcgt cagaaccagg agtaccaggt
     1081 gctgctggat gtccgggcca ggctggagtg tgagatcaac acgtacagga gcctgctgga
     1141 gagcgaggac tgcaacctcc cctgcaaccc atgcgccacc accaatgcta gtggcagttg
     1201 ctgtggacct tgcggcagct caaagcgttg ctgttaactg aactgattcc cttttgaaga
     1261 tgtcgatgaa gtcatttagt tcaaatgcag gaacggtcaa acccaggccc ctcctttgca
     1321 aggatttccg ttgtcactaa gaaacgtcat cgtgacaact gtgattttta gatgaggatg
     1381 agctttcctg aaccagcaac ttcctgtcca actccttcag ttgaaggttg agtgtctttt
     1441 ctgctcaggt gtcacatgtc tgccaacgga actccgtgag attggcatag agggcggttc
     1501 ctgtacatgc ctccatttcc tgccttcctt tcttcttggt gattctctgg aatgcaagga
     1561 ggcagcttca tccacctccc aataaacttt atttctctgg catagtaaa
//
