LOCUS       NM_001159374            1716 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Mus musculus keratin 32 (Krt32), mRNA.
ACCESSION   NM_001159374
VERSION     NM_001159374.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1716)
  AUTHORS   Shi,P., Chen,W., Lyu,X., Wang,Z., Li,W., Jia,F., Zheng,C., Liu,T.,
            Wang,C., Zhang,Y., Mi,Z., Sun,Y., Chen,X., Chen,S., Zhou,G.,
            Liu,Y., Lin,Y., Bai,F., Sun,Q., Ogese,M.O., Yu,Q., Liu,J., Liu,H.
            and Zhang,F.
  TITLE     Loss-of-function mutations in Keratin 32 gene disrupt skin immune
            homeostasis in pityriasis rubra pilaris
  JOURNAL   Nat Commun 15 (1), 6259 (2024)
   PUBMED   39048559
  REMARK    GeneRIF: Loss-of-function mutations in Keratin 32 gene disrupt skin
            immune homeostasis in pityriasis rubra pilaris.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1716)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1716)
  AUTHORS   Saito,K., Michon,F., Yamada,A., Inuzuka,H., Yamaguchi,S.,
            Fukumoto,E., Yoshizaki,K., Nakamura,T., Arakaki,M., Chiba,Y.,
            Ishikawa,M., Okano,H., Thesleff,I. and Fukumoto,S.
  TITLE     Sox21 Regulates Anapc10 Expression and Determines the Fate of
            Ectodermal Organ
  JOURNAL   iScience 23 (7), 101329 (2020)
   PUBMED   32674056
REFERENCE   4  (bases 1 to 1716)
  AUTHORS   Sardella,C., Winkler,C., Quignodon,L., Hardman,J.A., Toffoli,B.,
            Giordano Attianese,G.M.P., Hundt,J.E., Michalik,L., Vinson,C.R.,
            Paus,R., Desvergne,B. and Gilardi,F.
  TITLE     Delayed Hair Follicle Morphogenesis and Hair Follicle Dystrophy in
            a Lipoatrophy Mouse Model of Pparg Total Deletion
  JOURNAL   J Invest Dermatol 138 (3), 500-510 (2018)
   PUBMED   28964716
REFERENCE   5  (bases 1 to 1716)
  AUTHORS   Kiso,M., Tanaka,S., Saba,R., Matsuda,S., Shimizu,A., Ohyama,M.,
            Okano,H.J., Shiroishi,T., Okano,H. and Saga,Y.
  TITLE     The disruption of Sox21-mediated hair shaft cuticle differentiation
            causes cyclic alopecia in mice
  JOURNAL   Proc Natl Acad Sci U S A 106 (23), 9292-9297 (2009)
   PUBMED   19470461
REFERENCE   6  (bases 1 to 1716)
  AUTHORS   Pershouse,M., Li,J., Yang,C., Su,H., Brundage,E., Di,W.,
            Biggs,P.J., Bradley,A. and Chinault,A.C.
  TITLE     BAC contig from a 3-cM region of mouse chromosome 11 surrounding
            Brca1
  JOURNAL   Genomics 69 (1), 139-142 (2000)
   PUBMED   11013085
REFERENCE   7  (bases 1 to 1716)
  AUTHORS   Meier,N., Dear,T.N. and Boehm,T.
  TITLE     Whn and mHa3 are components of the genetic hierarchy controlling
            hair follicle differentiation
  JOURNAL   Mech Dev 89 (1-2), 215-221 (1999)
   PUBMED   10559501
REFERENCE   8  (bases 1 to 1716)
  AUTHORS   Talbot,D., Loring,J. and Schorle,H.
  TITLE     Spatiotemporal expression pattern of keratins in skin of
            AP-2alpha-deficient mice
  JOURNAL   J Invest Dermatol 113 (5), 816-820 (1999)
   PUBMED   10571739
  REMARK    Erratum:[J Invest Dermatol 2000 Mar;114(3):609. Lorgin J [corrected
            to Loring J]]
REFERENCE   9  (bases 1 to 1716)
  AUTHORS   Sato,H., Koide,T., Sagai,T., Ishiguro,S.I., Tamai,M., Saitou,N. and
            Shiroishi,T.
  TITLE     The genomic organization of type I keratin genes in mice
  JOURNAL   Genomics 56 (3), 303-309 (1999)
   PUBMED   10087197
REFERENCE   10 (bases 1 to 1716)
  AUTHORS   Winter,H., Siry,P., Tobiasch,E. and Schweizer,J.
  TITLE     Sequence and expression of murine type I hair keratins mHa2 and
            mHa3
  JOURNAL   Exp Cell Res 212 (2), 190-200 (1994)
   PUBMED   7514534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL662808.12.
            
            On Feb 20, 2019 this sequence version replaced NM_001159374.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X75649.1, BC117553.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-526               AL662808.12        20642-21167         c
            527-609             AL662808.12        19571-19653         c
            610-766             AL662808.12        19248-19404         c
            767-928             AL662808.12        17823-17984         c
            929-1054            AL662808.12        17615-17740         c
            1055-1275           AL662808.12        16786-17006         c
            1276-1716           AL662808.12        13746-14186         c
FEATURES             Location/Qualifiers
     source          1..1716
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.4 cM"
     gene            1..1716
                     /gene="Krt32"
                     /gene_synonym="Ha3; Hka2; K32; Krt1-2; Krtha2"
                     /note="keratin 32"
                     /db_xref="GeneID:16670"
                     /db_xref="MGI:MGI:1309995"
     exon            1..526
                     /gene="Krt32"
                     /gene_synonym="Ha3; Hka2; K32; Krt1-2; Krtha2"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1405
                     /gene="Krt32"
                     /gene_synonym="Ha3; Hka2; K32; Krt1-2; Krtha2"
                     /note="hair keratin, type I Ha2; keratin complex 1,
                     acidic, gene 2"
                     /codon_start=1
                     /product="keratin, type I cuticular Ha2"
                     /protein_id="NP_001152846.2"
                     /db_xref="CCDS:CCDS56805.1"
                     /db_xref="GeneID:16670"
                     /db_xref="MGI:MGI:1309995"
                     /translation="MPSSCCVTNTSSASLKSSARPSSVCSSNMGSRSELCLGYVCQPL
                     QCMPSVCMPTTYRPASCLSKTYLSSSCQPSNRRPTGCISSSMGTYGLFCEGAFNGNEK
                     ETMQVLNDRLANYLEKVRQLEKENAELEGKIQDVYQGQVLTMCPDYQSYFQTIEELQQ
                     KVLCTKAENARMIVHIDNAKLAADDFRTKYETELALRQLVEADTNGLRRILDELTLNK
                     ADLEAQVESLKEELLCLKRNHEEEVGVLRQQLGDRLNIEVDAAPPVDLTRMLEEMRCQ
                     YETMVETNHRDVEEWFNMQMEELNKQVATSSEQLQSYQSDIIDLRRTVNTLEIELQAQ
                     HSLRDSLENTLGETEGRFTSQLSQMQCMITNVESQLSDIRCDLERQNQEYKVLLDVKA
                     RLECEIDTYRGLLESEDSKLPCNPCSTPSCQPCAPSPGVSRTVCVPHTVCVPCSPCLQ
                     TRY"
     exon            527..609
                     /gene="Krt32"
                     /gene_synonym="Ha3; Hka2; K32; Krt1-2; Krtha2"
                     /inference="alignment:Splign:2.1.0"
     exon            610..766
                     /gene="Krt32"
                     /gene_synonym="Ha3; Hka2; K32; Krt1-2; Krtha2"
                     /inference="alignment:Splign:2.1.0"
     exon            767..928
                     /gene="Krt32"
                     /gene_synonym="Ha3; Hka2; K32; Krt1-2; Krtha2"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1054
                     /gene="Krt32"
                     /gene_synonym="Ha3; Hka2; K32; Krt1-2; Krtha2"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1275
                     /gene="Krt32"
                     /gene_synonym="Ha3; Hka2; K32; Krt1-2; Krtha2"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1716
                     /gene="Krt32"
                     /gene_synonym="Ha3; Hka2; K32; Krt1-2; Krtha2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1687..1692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt32"
                     /gene_synonym="Ha3; Hka2; K32; Krt1-2; Krtha2"
                     /note="hexamer: AATAAA"
     polyA_site      1705
                     /gene="Krt32"
                     /gene_synonym="Ha3; Hka2; K32; Krt1-2; Krtha2"
                     /note="major polyA site"
ORIGIN      
        1 gtagagatcc agggaactgc tggggggaaa ggacttcctt agcatgccat ccagctgctg
       61 tgtcaccaac acctcatcag catctctcaa gagctcggca cggccttcct ccgtctgttc
      121 cagtaacatg ggcagcaggt ccgagctgtg cctgggttat gtctgccagc cgctgcagtg
      181 catgccctct gtctgcatgc cgaccaccta caggccagcc agctgccttt ctaagaccta
      241 cttgtccagc tcttgccaac ccagcaaccg ccggccaacg ggttgcatct ctagctccat
      301 ggggacctat ggcctgttct gtgagggtgc cttcaatggc aatgagaaag agaccatgca
      361 ggtcctgaat gaccgtctgg ccaactacct ggagaaggtg aggcagctgg agaaagagaa
      421 tgcagagctg gagggcaaga tccaagatgt ctaccagggg caggtgctga ccatgtgtcc
      481 tgactaccag tcctacttcc agaccatcga agagctgcag caaaaggttc tgtgcaccaa
      541 ggctgagaat gcaagaatga tcgtgcacat cgacaatgcc aagctggctg cagatgactt
      601 cagaaccaag tatgaaacag agctggccct aagacagctg gtagaagcag acaccaatgg
      661 cctgcgcagg atcctggatg agctaaccct taataaggct gatctagagg ctcaagtaga
      721 gtccctgaag gaggaacttc tgtgcctcaa gaggaaccat gaagaggaag ttggtgtcct
      781 tcgacaacag ctcggggacc gccttaacat tgaggtagat gctgcacctc ccgtggacct
      841 aaccaggatg ctggaggaga tgagatgtca gtatgagacc atggtggaaa ccaaccacag
      901 ggacgtggag gaatggttca atatgcagat ggaggagctt aacaagcagg tggccacaag
      961 ctctgagcag cttcagagct accaatcaga catcattgac ctgagacgaa cagtcaatac
     1021 tctggagata gaactgcagg ctcagcacag cctgagagac tccctggaaa acacgctggg
     1081 ggagacagag ggccgcttca cctcccagct gtcccagatg caatgcatga tcaccaatgt
     1141 ggagtcccag ctgtctgaca tccgctgtga cctggagaga cagaaccaag agtacaaggt
     1201 gttgctggat gtcaaggccc ggctggagtg tgagattgac acgtacaggg gcctgctgga
     1261 gagtgaggac agcaagctac cctgtaaccc ttgctccact ccctcctgcc agccttgtgc
     1321 accctctcct ggggtatccc gcaccgtctg tgtgccccac actgtttgtg tgccttgttc
     1381 accctgccta cagacccgct actgaagcct ctgagcatct ctcagtgtgt gagtcccaga
     1441 gggacctgag ttctctggcc tggtgcctcg tcacaccaag tctgaccaca atcctgagac
     1501 caagacaaga gtgtggccag cttagttggc cctgaccaga accaggaagt ggacactagc
     1561 aacatgtcct gataatacat tgcttcagcg ctgcctcctc tatttccttg ggtagaaggt
     1621 tctctttggt ggtgtttctg gttgtctctg ctttctcaga gtgcatgtgt tttcggctaa
     1681 actgcgaata aaacttaatt cagtggcctg ccttgc
//
