LOCUS       NM_010659               1581 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus keratin 31 (Krt31), mRNA.
ACCESSION   NM_010659
VERSION     NM_010659.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1581)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1581)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1581)
  AUTHORS   Donati,G., Proserpio,V., Lichtenberger,B.M., Natsuga,K.,
            Sinclair,R., Fujiwara,H. and Watt,F.M.
  TITLE     Epidermal Wnt/beta-catenin signaling regulates adipocyte
            differentiation via secretion of adipogenic factors
  JOURNAL   Proc Natl Acad Sci U S A 111 (15), E1501-E1509 (2014)
   PUBMED   24706781
REFERENCE   4  (bases 1 to 1581)
  AUTHORS   Sotiropoulou,P.A., Karambelas,A.E., Debaugnies,M., Candi,A.,
            Bouwman,P., Moers,V., Revenco,T., Rocha,A.S., Sekiguchi,K.,
            Jonkers,J. and Blanpain,C.
  TITLE     BRCA1 deficiency in skin epidermis leads to selective loss of hair
            follicle stem cells and their progeny
  JOURNAL   Genes Dev 27 (1), 39-51 (2013)
   PUBMED   23271346
REFERENCE   5  (bases 1 to 1581)
  AUTHORS   Woo,S.H., Baba,Y., Franco,A.M., Lumpkin,E.A. and Owens,D.M.
  TITLE     Excitatory glutamate is essential for development and maintenance
            of the piloneural mechanoreceptor
  JOURNAL   Development 139 (4), 740-748 (2012)
   PUBMED   22241839
REFERENCE   6  (bases 1 to 1581)
  AUTHORS   Sato,H., Koide,T., Sagai,T., Ishiguro,S.I., Tamai,M., Saitou,N. and
            Shiroishi,T.
  TITLE     The genomic organization of type I keratin genes in mice
  JOURNAL   Genomics 56 (3), 303-309 (1999)
   PUBMED   10087197
REFERENCE   7  (bases 1 to 1581)
  AUTHORS   Chiang,C., Swan,R.Z., Grachtchouk,M., Bolinger,M., Litingtung,Y.,
            Robertson,E.K., Cooper,M.K., Gaffield,W., Westphal,H., Beachy,P.A.
            and Dlugosz,A.A.
  TITLE     Essential role for Sonic hedgehog during hair follicle
            morphogenesis
  JOURNAL   Dev Biol 205 (1), 1-9 (1999)
   PUBMED   9882493
REFERENCE   8  (bases 1 to 1581)
  AUTHORS   Magin,T.M.
  TITLE     Lessons from keratin transgenic and knockout mice
  JOURNAL   Subcell Biochem 31, 141-172 (1998)
   PUBMED   9932492
  REMARK    Review article
REFERENCE   9  (bases 1 to 1581)
  AUTHORS   Kaytes,P.S., McNab,A.R., Rea,T.J., Groppi,V., Kawabe,T.T.,
            Buhl,A.E., Bertolino,A.P., Hatzenbuhler,N.T. and Vogeli,G.
  TITLE     Hair-specific keratins: characterization and expression of a mouse
            type I keratin gene
  JOURNAL   J Invest Dermatol 97 (5), 835-842 (1991)
   PUBMED   1717610
REFERENCE   10 (bases 1 to 1581)
  AUTHORS   Bertolino,A.P., Checkla,D.M., Notterman,R., Sklaver,I.,
            Schiff,T.A., Freedberg,I.M. and DiDona,G.J.
  TITLE     Cloning and characterization of a mouse type I hair keratin cDNA
  JOURNAL   J Invest Dermatol 91 (6), 541-546 (1988)
   PUBMED   2461417
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL592545.10.
            
            On Apr 27, 2007 this sequence version replaced NM_010659.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN04095722,
                              SAMN04095723 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-417               AL592545.10        123598-124014       c
            418-500             AL592545.10        123328-123410       c
            501-657             AL592545.10        122903-123059       c
            658-819             AL592545.10        121803-121964       c
            820-945             AL592545.10        121581-121706       c
            946-1166            AL592545.10        121132-121352       c
            1167-1581           AL592545.10        120109-120523       c
FEATURES             Location/Qualifiers
     source          1..1581
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.39 cM"
     gene            1..1581
                     /gene="Krt31"
                     /gene_synonym="Ha1; Kha1; Krt1-1; MKHA-1"
                     /note="keratin 31"
                     /db_xref="GeneID:16660"
                     /db_xref="MGI:MGI:1309993"
     exon            1..417
                     /gene="Krt31"
                     /gene_synonym="Ha1; Kha1; Krt1-1; MKHA-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1320
                     /gene="Krt31"
                     /gene_synonym="Ha1; Kha1; Krt1-1; MKHA-1"
                     /note="K31; HKA-1; hair keratin, type I Ha1; keratin
                     complex 1, gene 1; keratin complex 1, acidic, gene 1"
                     /codon_start=1
                     /product="keratin, type I cuticular Ha1"
                     /protein_id="NP_034789.2"
                     /db_xref="CCDS:CCDS25405.1"
                     /db_xref="GeneID:16660"
                     /db_xref="MGI:MGI:1309993"
                     /translation="MPYNCCLPALSCRTSCSSRPCVPPSCHGCTLPGACNIPANVGNC
                     NWFCEGSFNGNEKETMQFLNDRLASYMEKVRQLERENAELECRIQERNQQQDPLVCPA
                     YQAYFRTIEELQQKILCSKSENARLVVQIDNAKLAADDFRTKYETELGLRQLVESDIN
                     GLRRILDELTLCKSDLEAQVESLKEELLCLKRNHEEEVNTLRCQLGDRLNVEVDAAPT
                     VDLNRVLNETRCQYEAMVETNRREVEEWFTTQTEELNKQVVSSSEQLQSCQAEIIELR
                     RTVNALEIELQAQHCMRNSLENTLTESEARYSSQLSQVQCLITNVESQLGEIRADLER
                     QNQEYQVLLDVKARLECEINTYRGLLESEDCKLPCNPCATSNACGKPIGPCVSNPCVP
                     CPPPAPCTPCVPRPRCGPCNSFVR"
     exon            418..500
                     /gene="Krt31"
                     /gene_synonym="Ha1; Kha1; Krt1-1; MKHA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            501..657
                     /gene="Krt31"
                     /gene_synonym="Ha1; Kha1; Krt1-1; MKHA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            658..819
                     /gene="Krt31"
                     /gene_synonym="Ha1; Kha1; Krt1-1; MKHA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            820..945
                     /gene="Krt31"
                     /gene_synonym="Ha1; Kha1; Krt1-1; MKHA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1166
                     /gene="Krt31"
                     /gene_synonym="Ha1; Kha1; Krt1-1; MKHA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1581
                     /gene="Krt31"
                     /gene_synonym="Ha1; Kha1; Krt1-1; MKHA-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagctctga ggcttggaga attcacaccg agtcttcagc caggtacctc tctccctccc
       61 tccagcacca tgccatacaa ttgctgcctg ccggccctga gctgccgcac cagctgctcc
      121 tcccggccct gtgtgccccc cagctgccat ggctgcaccc tgcctggggc ctgcaacatc
      181 cccgccaatg tgggcaactg caattggttc tgtgagggct ccttcaatgg caatgagaag
      241 gagaccatgc agttcctgaa tgaccgcctg gcctcctata tggagaaggt gaggcagctg
      301 gagagagaga atgcagagct ggaatgtagg atccaggaga ggaaccagca gcaggacccc
      361 ctggtgtgtc ctgcctacca ggcctacttc aggaccattg aggagttgca gcagaagatc
      421 ctgtgcagca aatcagagaa tgccaggttg gtggtgcaga tagataatgc caagctggct
      481 gcagacgact tcaggaccaa gtatgagaca gagctcggtc tgcggcagct ggtagagtca
      541 gacatcaacg gcctgcgaag gatcttggat gagctgaccc tgtgcaagtc tgacctggag
      601 gcgcaggtgg agtccctgaa ggaggagctg ctgtgtctca agaggaacca tgaagaggaa
      661 gtcaacaccc tacgctgcca gcttggagac cgcctcaacg tggaggtgga cgctgctccc
      721 accgtggacc tgaaccgtgt gctcaacgag accaggtgtc agtacgaggc catggtggaa
      781 accaaccgcc gggaagtgga ggaatggttc accacacaga cagaggagct gaacaagcag
      841 gtggtgtcca gctcagagca gctgcagtcc tgccaagccg agatcatcga gctgagacgc
      901 acagtcaacg ccctggagat cgagctgcag gcccagcact gcatgagaaa ctctctggag
      961 aacaccctga cagagagtga ggctcgctac agctctcagc tgtcccaggt gcagtgcctg
     1021 atcaccaacg tggagtccca gcttggtgag atccgggctg acctggagcg tcagaaccag
     1081 gagtaccagg tgctgctgga tgtcaaggcc cggctggagt gtgagatcaa cacgtatagg
     1141 ggcctgctgg agagcgagga ctgcaagcta ccttgcaacc cctgtgccac aagcaatgca
     1201 tgcggcaagc ccattgggcc ctgcgtctcc aatccctgtg tcccctgccc accccctgcc
     1261 ccttgcacac cttgtgtccc acgtccccgc tgtgggccat gcaactcctt tgtacgctag
     1321 aacctggggg atgtcaacag agcaaggaca ctgggcttag cactccagat ggctgacctg
     1381 gttctggttc cacaaaaaca gacgtaaaac ccacaaacct aatggccaga gcatctctgg
     1441 gatgacagtc ccagaatctg tgtcttcagc cactgcaccc tcctccaggc cattctctgc
     1501 ctgcctccta ttcttcattg gactgctcag aggactctga agtgccagtg gccctccctt
     1561 gtaatctccc aataaacatt t
//
