LOCUS       NM_027574               1625 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus keratin 28 (Krt28), mRNA.
ACCESSION   NM_027574 XM_203344
VERSION     NM_027574.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1625)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1625)
  AUTHORS   Chen,A., Liao,S., Cheng,M., Ma,K., Wu,L., Lai,Y., Qiu,X., Yang,J.,
            Xu,J., Hao,S., Wang,X., Lu,H., Chen,X., Liu,X., Huang,X., Li,Z.,
            Hong,Y., Jiang,Y., Peng,J., Liu,S., Shen,M., Liu,C., Li,Q.,
            Yuan,Y., Wei,X., Zheng,H., Feng,W., Wang,Z., Liu,Y., Wang,Z.,
            Yang,Y., Xiang,H., Han,L., Qin,B., Guo,P., Lai,G.,
            Munoz-Canoves,P., Maxwell,P.H., Thiery,J.P., Wu,Q.F., Zhao,F.,
            Chen,B., Li,M., Dai,X., Wang,S., Kuang,H., Hui,J., Wang,L.,
            Fei,J.F., Wang,O., Wei,X., Lu,H., Wang,B., Liu,S., Gu,Y., Ni,M.,
            Zhang,W., Mu,F., Yin,Y., Yang,H., Lisby,M., Cornall,R.J.,
            Mulder,J., Uhlen,M., Esteban,M.A., Li,Y., Liu,L., Xu,X. and Wang,J.
  TITLE     Spatiotemporal transcriptomic atlas of mouse organogenesis using
            DNA nanoball-patterned arrays
  JOURNAL   Cell 185 (10), 1777-1792 (2022)
   PUBMED   35512705
REFERENCE   3  (bases 1 to 1625)
  AUTHORS   Fleger-Weckmann,A., Ustun,Y., Kloepper,J., Paus,R., Bloch,W.,
            Chen,Z.L., Wegner,J., Sorokin,L., Langbein,L., Eckes,B.,
            Zigrino,P., Krieg,T. and Nischt,R.
  TITLE     Deletion of the epidermis derived laminin gamma1 chain leads to
            defects in the regulation of late hair morphogenesis
  JOURNAL   Matrix Biol 56, 42-56 (2016)
   PUBMED   27234308
REFERENCE   4  (bases 1 to 1625)
  AUTHORS   Tanaka,S., Miura,I., Yoshiki,A., Kato,Y., Yokoyama,H., Shinogi,A.,
            Masuya,H., Wakana,S., Tamura,M. and Shiroishi,T.
  TITLE     Mutations in the helix termination motif of mouse type I IRS
            keratin genes impair the assembly of keratin intermediate filament
  JOURNAL   Genomics 90 (6), 703-711 (2007)
   PUBMED   17920809
REFERENCE   5  (bases 1 to 1625)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591165.17.
            
            On Dec 23, 2022 this sequence version replaced NM_027574.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK014642.1, SRR7345562.4352642.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164136, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-508               AL591165.17        14045-14552         c
            509-591             AL591165.17        13561-13643         c
            592-748             AL591165.17        12408-12564         c
            749-910             AL591165.17        10966-11127         c
            911-1036            AL591165.17        10760-10885         c
            1037-1254           AL591165.17        6473-6690           c
            1255-1310           AL591165.17        5091-5146           c
            1311-1625           AL591165.17        4520-4834           c
FEATURES             Location/Qualifiers
     source          1..1625
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 62.92 cM"
     gene            1..1625
                     /gene="Krt28"
                     /gene_synonym="4733401L19Rik; CK-28; K25D; K28; Krt25d"
                     /note="keratin 28"
                     /db_xref="GeneID:70843"
                     /db_xref="MGI:MGI:1918093"
     exon            1..508
                     /gene="Krt28"
                     /gene_synonym="4733401L19Rik; CK-28; K25D; K28; Krt25d"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1453
                     /gene="Krt28"
                     /gene_synonym="4733401L19Rik; CK-28; K25D; K28; Krt25d"
                     /note="keratin 25D; cytokeratin-28; type I inner root
                     sheath-specific keratin-K25irs4"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 28"
                     /protein_id="NP_081850.1"
                     /db_xref="CCDS:CCDS48906.1"
                     /db_xref="GeneID:70843"
                     /db_xref="MGI:MGI:1918093"
                     /translation="MSLRFSGGSRHVGIQSGSLRPPSGGAGFAGSSVAGGSVAGSGFS
                     WALGGTLGSAPGGSHATGALGNVSGVCFIGSEGGLLSGNEKVTMQNLNNRLASYLDNV
                     KALEEANSELERKIKTWHEKYGPGSCRGLDRDYSKYHLTIEDLKSKIISSTAANANII
                     LQIDNARLAADDFRLKYENELTLHQNVEADINGLRRVLDELTLCRTDQELQYESLSEE
                     MTYLKKNHEEEMKVLQCAAGGNVNVEMNAAPGVDLTVLLNNMRAEYEALAEQNRRDAE
                     AWFQEKSATLQQQISNDLGAATSARTELTELKRSLQTLEIELQSLSATKHSLECSLAE
                     TEGNYCSQLAQIQAQISALEEQLHQVRTETEGQKLEHEQLLDIKAHLEKEIETYCRLI
                     DGDENSCSVSKGFESGTSGNSPKDVSKTTLVKTVVEEIDQRGKVLSSRIHSIEEKMSK
                     MSNGKAEQRVPF"
     exon            509..591
                     /gene="Krt28"
                     /gene_synonym="4733401L19Rik; CK-28; K25D; K28; Krt25d"
                     /inference="alignment:Splign:2.1.0"
     exon            592..748
                     /gene="Krt28"
                     /gene_synonym="4733401L19Rik; CK-28; K25D; K28; Krt25d"
                     /inference="alignment:Splign:2.1.0"
     exon            749..910
                     /gene="Krt28"
                     /gene_synonym="4733401L19Rik; CK-28; K25D; K28; Krt25d"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1036
                     /gene="Krt28"
                     /gene_synonym="4733401L19Rik; CK-28; K25D; K28; Krt25d"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1254
                     /gene="Krt28"
                     /gene_synonym="4733401L19Rik; CK-28; K25D; K28; Krt25d"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1310
                     /gene="Krt28"
                     /gene_synonym="4733401L19Rik; CK-28; K25D; K28; Krt25d"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1625
                     /gene="Krt28"
                     /gene_synonym="4733401L19Rik; CK-28; K25D; K28; Krt25d"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1602..1607
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt28"
                     /gene_synonym="4733401L19Rik; CK-28; K25D; K28; Krt25d"
                     /note="hexamer: AATAAA"
     polyA_site      1625
                     /gene="Krt28"
                     /gene_synonym="4733401L19Rik; CK-28; K25D; K28; Krt25d"
                     /note="major polyA site"
ORIGIN      
        1 gaggttctgt acgcctttga aattacagct gcccacggac cagcggaacg tttggcttgg
       61 caccatgtct ctccggtttt ctggcggatc caggcacgtt ggcatacagt ccggatccct
      121 caggccgccc agcggaggcg caggctttgc tgggagcagc gtggctggcg gttcggttgc
      181 tggtagtgga ttttcttggg ctttgggagg gacactgggc agtgctcctg gtgggagcca
      241 tgccactggt gccctgggaa atgtctctgg tgtttgcttc atcggaagtg aagggggtct
      301 cctctctgga aacgagaagg tcaccatgca gaatcttaac aaccgcttgg cctcttacct
      361 ggataacgta aaagctctgg aggaggccaa ctctgagcta gagagaaaga tcaagacttg
      421 gcatgagaaa tacggaccgg gatcgtgccg tggacttgac cgtgactaca gcaagtatca
      481 tctaaccatt gaggacctga aaagcaagat catctcttcc acggctgcta atgctaatat
      541 aattctgcaa attgataacg ccagactggc cgcagacgat ttccgactaa agtatgaaaa
      601 cgaactcacc cttcaccaaa atgtcgaggc agacatcaat gggttgcggc gcgtccttga
      661 cgagctaacc ctctgcagaa cggaccaaga gctgcagtac gaatccctga gtgaggagat
      721 gacttatctc aagaagaacc acgaagagga aatgaaagtc ctgcagtgcg cagctggagg
      781 caacgtgaac gtggagatga acgcagcccc aggcgtggac ctcaccgtcc ttctgaacaa
      841 catgcgagca gagtacgagg ccctggctga gcagaaccgc agggacgccg aggcctggtt
      901 ccaagagaag agcgccacgc tgcagcagca gatctccaat gacttgggcg ccgccacctc
      961 agccaggacc gagctgacag agctgaaacg ctccctgcag accctggaga tcgagctgca
     1021 gtccctctca gctacgaaac actctctgga gtgctccctg gcggagaccg agggcaacta
     1081 ctgctcacag ctggctcaga tccaggctca gatcagcgcc ctggaggagc agctgcacca
     1141 ggtgaggacg gagaccgagg gccagaagct ggaacatgag cagctgctgg acatcaaggc
     1201 ccacctggag aaggagatcg agacctactg ccgcctcata gacggagacg agaattcctg
     1261 ctctgtctca aagggttttg aatctggaac ctcggggaat tcacccaaag atgtatccaa
     1321 aaccacactg gtgaagacgg tggttgaaga aatagatcag cgtgggaagg tgctgtcctc
     1381 caggatccac tccatcgagg aaaagatgtc taagatgagc aacggcaagg ctgagcagag
     1441 ggttcccttc tagctgccat gctaggggga tagagtaact tgggggcgga gcctaaatct
     1501 cagggagaat ggaaatgctt tcttctatta cagatgagga accttagaca aaatacctgt
     1561 tttcttagtg actttcaaag gatgctgggt gtttgtgtcc aaataaaata attgatggca
     1621 acaca
//
