LOCUS       NM_010666               1570 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus keratin 27 (Krt27), mRNA.
ACCESSION   NM_010666
VERSION     NM_010666.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1570)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1570)
  AUTHORS   Cao,R., Takechi,M., Wang,X., Furutera,T., Nojiri,T., Koyabu,D. and
            Li,J.
  TITLE     Temporal and regulatory dynamics of the inner ear transcriptome
            during development in mice
  JOURNAL   Sci Rep 12 (1), 21196 (2022)
   PUBMED   36476755
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1570)
  AUTHORS   Fairfield,H., Srivastava,A., Ananda,G., Liu,R., Kircher,M.,
            Lakshminarayana,A., Harris,B.S., Karst,S.Y., Dionne,L.A.,
            Kane,C.C., Curtain,M., Berry,M.L., Ward-Bailey,P.F., Greenstein,I.,
            Byers,C., Czechanski,A., Sharp,J., Palmer,K., Gudis,P., Martin,W.,
            Tadenev,A., Bogdanik,L., Pratt,C.H., Chang,B., Schroeder,D.G.,
            Cox,G.A., Cliften,P., Milbrandt,J., Murray,S., Burgess,R.,
            Bergstrom,D.E., Donahue,L.R., Hamamy,H., Masri,A., Santoni,F.A.,
            Makrythanasis,P., Antonarakis,S.E., Shendure,J. and Reinholdt,L.G.
  TITLE     Exome sequencing reveals pathogenic mutations in 91 strains of mice
            with Mendelian disorders
  JOURNAL   Genome Res 25 (7), 948-957 (2015)
   PUBMED   25917818
REFERENCE   4  (bases 1 to 1570)
  AUTHORS   Tanaka,S., Miura,I., Yoshiki,A., Kato,Y., Yokoyama,H., Shinogi,A.,
            Masuya,H., Wakana,S., Tamura,M. and Shiroishi,T.
  TITLE     Mutations in the helix termination motif of mouse type I IRS
            keratin genes impair the assembly of keratin intermediate filament
  JOURNAL   Genomics 90 (6), 703-711 (2007)
   PUBMED   17920809
REFERENCE   5  (bases 1 to 1570)
  AUTHORS   Langbein,L., Rogers,M.A., Praetzel-Wunder,S., Helmke,B.,
            Schirmacher,P. and Schweizer,J.
  TITLE     K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4)
            represent the type I inner root sheath keratins of the human hair
            follicle
  JOURNAL   J Invest Dermatol 126 (11), 2377-2386 (2006)
   PUBMED   16874310
REFERENCE   6  (bases 1 to 1570)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   7  (bases 1 to 1570)
  AUTHORS   Runkel,F., Marquardt,A., Stoeger,C., Kochmann,E., Simon,D.,
            Kohnke,B., Korthaus,D., Wattler,F., Fuchs,H., Hrabe de Angelis,M.,
            Stumm,G., Nehls,M., Wattler,S., Franz,T. and Augustin,M.
  TITLE     The dominant alopecia phenotypes Bareskin, Rex-denuded, and Reduced
            Coat 2 are caused by mutations in gasdermin 3
  JOURNAL   Genomics 84 (5), 824-835 (2004)
   PUBMED   15475261
REFERENCE   8  (bases 1 to 1570)
  AUTHORS   Sato,H., Koide,T., Sagai,T., Ishiguro,S.I., Tamai,M., Saitou,N. and
            Shiroishi,T.
  TITLE     The genomic organization of type I keratin genes in mice
  JOURNAL   Genomics 56 (3), 303-309 (1999)
   PUBMED   10087197
REFERENCE   9  (bases 1 to 1570)
  AUTHORS   Gruneberg,H.
  TITLE     Exocrine glands and the Chievitz organ of some mouse mutants
  JOURNAL   J Embryol Exp Morphol 25 (2), 247-261 (1971)
   PUBMED   5088022
REFERENCE   10 (bases 1 to 1570)
  AUTHORS   Batchelor,A.L., Phillips,R.J. and Searle,A.G.
  TITLE     A comparison of the mutagenic effectiveness of chronic neutron- and
            gamma-irradiation of mouse spermatogonia
  JOURNAL   Mutat Res 3 (3), 218-229 (1966)
   PUBMED   5962396
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590991.14, AK077384.1 and
            AA756799.1.
            
            On Sep 16, 2015 this sequence version replaced NM_010666.1.
            
            Summary: This gene encodes a member of the type I (acidic) keratin
            family, which belongs to the superfamily of intermediate filament
            (IF) proteins. Keratins are heteropolymeric structural proteins
            which form the intermediate filament. These filaments, along with
            actin microfilaments and microtubules, compose the cytoskeleton of
            epithelial cells. The mouse type I keratin genes are clustered in a
            region of chromosome 11. The encoded protein is involved in the
            formation of intermediate filaments in the inner root sheath.
            [provided by RefSeq, Sep 2015].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC140997.1, AB013607.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN04095721, SAMN04095722
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AL590991.14        11234-11247
            15-115              AK077384.1         2-102
            116-1554            AK077384.1         104-1542
            1555-1570           AA756799.1         1-16                c
FEATURES             Location/Qualifiers
     source          1..1570
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 62.92 cM"
     gene            1..1570
                     /gene="Krt27"
                     /gene_synonym="CK-27; Krt1-c29; mIRSa3.1; stpm"
                     /note="keratin 27"
                     /db_xref="GeneID:16675"
                     /db_xref="MGI:MGI:1339999"
     exon            1..459
                     /gene="Krt27"
                     /gene_synonym="CK-27; Krt1-c29; mIRSa3.1; stpm"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1392
                     /gene="Krt27"
                     /gene_synonym="CK-27; Krt1-c29; mIRSa3.1; stpm"
                     /note="cytokeratin-27; type I inner root sheath-specific
                     keratin-K25irs3; keratin complex-1, acidic, gene C29;
                     keratin complex-1, gene C29"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 27"
                     /protein_id="NP_034796.1"
                     /db_xref="CCDS:CCDS25379.1"
                     /db_xref="GeneID:16675"
                     /db_xref="MGI:MGI:1339999"
                     /translation="MSVRFSSASRRLGSVRLSSAGAALGAGNACGVPGIGSGFSCAFG
                     GSSLAGGLGMGGASCGAFTANEHGLLSGNEKVTMQNLNDRLASYLENVQALEEANADL
                     EQKIKDWYEKFGPGSCRGLDHDYSRYFPIIDDLRTQIISATAHNANIILQNDNARLTA
                     DDFRMKYENELALHQSVDADINGLRRVLDELTLCRTDLEVQLETLSEELAYLKKNHEE
                     EMQALQCAAGGNVNVEMNAAPGVDLTVLLNNMRAEYEALAEQNRRDAEAWFQEKSASL
                     QQQISDDAGATTSARNELTEMKRTLQTLEIELQSLLAMKHSLECSLTETEGNYCTQLA
                     QIQAQISALEEQLHQVRTETEGQKLEYEQLLNVKAHLEKEIETYCRLIDGDEGSCVKA
                     KGQGRPGNQTKDSPKTAIVKTVVEELDPRGKVLSSRVHTLEEKSTKVNKTEQRIPS"
     exon            460..542
                     /gene="Krt27"
                     /gene_synonym="CK-27; Krt1-c29; mIRSa3.1; stpm"
                     /inference="alignment:Splign:2.1.0"
     exon            543..699
                     /gene="Krt27"
                     /gene_synonym="CK-27; Krt1-c29; mIRSa3.1; stpm"
                     /inference="alignment:Splign:2.1.0"
     exon            700..861
                     /gene="Krt27"
                     /gene_synonym="CK-27; Krt1-c29; mIRSa3.1; stpm"
                     /inference="alignment:Splign:2.1.0"
     exon            862..987
                     /gene="Krt27"
                     /gene_synonym="CK-27; Krt1-c29; mIRSa3.1; stpm"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1205
                     /gene="Krt27"
                     /gene_synonym="CK-27; Krt1-c29; mIRSa3.1; stpm"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1255
                     /gene="Krt27"
                     /gene_synonym="CK-27; Krt1-c29; mIRSa3.1; stpm"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1564
                     /gene="Krt27"
                     /gene_synonym="CK-27; Krt1-c29; mIRSa3.1; stpm"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1539..1544
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt27"
                     /gene_synonym="CK-27; Krt1-c29; mIRSa3.1; stpm"
                     /note="hexamer: AATAAA"
     polyA_site      1564
                     /gene="Krt27"
                     /gene_synonym="CK-27; Krt1-c29; mIRSa3.1; stpm"
                     /note="major polyA site"
ORIGIN      
        1 agccagggac attcaccgtt ggggcagcac tgcagagtga tcaccatgtc cgttcgcttt
       61 tcttccgcat ccagacggct gggctctgtg aggctctcca gcgcgggagc agccttgggg
      121 gctggaaacg catgcggagt gccgggcatc ggaagcggct tctcctgcgc ctttgggggc
      181 agttcattgg caggggggct cggtatgggc ggtgcttctt gtggggcctt cacagcgaat
      241 gagcacggcc tcctctccgg caatgagaag gtcaccatgc agaaccttaa tgaccgcctg
      301 gcctcctacc tggagaacgt gcaagcactg gaggaggcca atgctgacct ggagcagaag
      361 atcaaggact ggtatgaaaa atttggacct gggtcgtgcc gcggtctcga tcatgactac
      421 agtagatact tccccatcat tgatgacctc aggacccaga tcatctctgc aactgcacac
      481 aacgccaaca tcatcctgca aaatgacaac gcaagactga cggcggatga cttcagaatg
      541 aagtatgaga atgaactggc actccaccag agcgtcgatg ctgacatcaa tggcttgcgg
      601 agggtcctgg atgagctgac cctgtgcaga accgaccttg aggtccagct ggaaacactc
      661 agtgaggagc tggcatacct caagaagaac cacgaggagg aaatgcaggc tctgcagtgc
      721 gccgctggag gcaacgtgaa cgtggagatg aacgcagccc cgggcgtgga cctcaccgtc
      781 ctgctgaaca acatgagagc cgagtacgag gccctggctg agcagaaccg tagggacgcc
      841 gaggcctggt tccaagagaa gagcgcctcc ctgcagcagc agatttcaga cgatgctgga
      901 gccaccacct cagccaggaa cgaacttaca gagatgaaac ggactctcca aaccctggag
      961 atagagctac agtccctctt agccatgaaa cactctctgg agtgctccct gacggagacc
     1021 gagggcaact actgcacgca gctggctcag atccaggctc agatcagcgc cctggaggag
     1081 cagctgcacc aagtgaggac ggagacggag ggccagaagc tggaatatga gcagctgctg
     1141 aatgtcaagg cccacctgga gaaggagatc gagacctact gccgcctcat agatggagac
     1201 gagggctctt gtgttaaggc aaaaggccaa ggaagacccg gaaatcagac aaaagattcg
     1261 cctaaaactg ccatcgttaa aactgtcgtg gaagagttag acccccgtgg caaggttctc
     1321 tcctccagag ttcacaccct ggaagagaaa tccaccaaag tcaacaagac cgagcagagg
     1381 atcccttctt gaactccgcc tctaaagcag acggctctag tttcaaatac caaatctaaa
     1441 tgcttttcct acgttatgtt tctgcttctc tccagtgagc cgagatgagc tcctaataga
     1501 ttagtgacat tctttgactt tctctctggt gatgcttcaa taaacgtctt cctgttgcaa
     1561 gttaaaaaaa
//
