LOCUS       NM_133730               2005 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus keratin 25 (Krt25), mRNA.
ACCESSION   NM_133730
VERSION     NM_133730.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2005)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2005)
  AUTHORS   Chen,G.D., Fatima,I., Xu,Q., Rozhkova,E., Fessing,M.Y.,
            Mardaryev,A.N., Sharov,A.A., Xu,G.L. and Botchkarev,V.A.
  TITLE     DNA dioxygenases Tet2/3 regulate gene promoter accessibility and
            chromatin topology in lineage-specific loci to control epithelial
            differentiation
  JOURNAL   Sci Adv 9 (2), eabo7605 (2023)
   PUBMED   36630508
REFERENCE   3  (bases 1 to 2005)
  AUTHORS   Tanaka,S., Miura,I., Yoshiki,A., Kato,Y., Yokoyama,H., Shinogi,A.,
            Masuya,H., Wakana,S., Tamura,M. and Shiroishi,T.
  TITLE     Mutations in the helix termination motif of mouse type I IRS
            keratin genes impair the assembly of keratin intermediate filament
  JOURNAL   Genomics 90 (6), 703-711 (2007)
   PUBMED   17920809
REFERENCE   4  (bases 1 to 2005)
  AUTHORS   Langbein,L., Rogers,M.A., Praetzel-Wunder,S., Helmke,B.,
            Schirmacher,P. and Schweizer,J.
  TITLE     K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4)
            represent the type I inner root sheath keratins of the human hair
            follicle
  JOURNAL   J Invest Dermatol 126 (11), 2377-2386 (2006)
   PUBMED   16874310
REFERENCE   5  (bases 1 to 2005)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   6  (bases 1 to 2005)
  AUTHORS   Masuya,H., Inoue,M., Wada,Y., Shimizu,A., Nagano,J., Kawai,A.,
            Inoue,A., Kagami,T., Hirayama,T., Yamaga,A., Kaneda,H.,
            Kobayashi,K., Minowa,O., Miura,I., Gondo,Y., Noda,T., Wakana,S. and
            Shiroishi,T.
  TITLE     Implementation of the modified-SHIRPA protocol for screening of
            dominant phenotypes in a large-scale ENU mutagenesis program
  JOURNAL   Mamm Genome 16 (11), 829-837 (2005)
   PUBMED   16284798
REFERENCE   7  (bases 1 to 2005)
  AUTHORS   Hesse,M., Zimek,A., Weber,K. and Magin,T.M.
  TITLE     Comprehensive analysis of keratin gene clusters in humans and
            rodents
  JOURNAL   Eur J Cell Biol 83 (1), 19-26 (2004)
   PUBMED   15085952
REFERENCE   8  (bases 1 to 2005)
  AUTHORS   Hogan,M.E., King,L.E. Jr. and Sundberg,J.P.
  TITLE     Defects of pelage hairs in 20 mouse mutations
  JOURNAL   J Invest Dermatol 104 (5 Suppl), 31S-32S (1995)
   PUBMED   7738386
REFERENCE   9  (bases 1 to 2005)
  AUTHORS   CARTER,T.C. and PHILLIPS,R.J.
  TITLE     The sex distribution of waved-2, shaker-2 and Rex in the house
            mouse
  JOURNAL   Z Indukt Abstamm Vererbungsl 85 (4), 564-578 (1953)
   PUBMED   13170359
REFERENCE   10 (bases 1 to 2005)
  AUTHORS   CARTER,T.C.
  TITLE     Wavy-coated mice: phenotypic interactions and linkage tests between
            rex and (a) waved-1, (b) waved-2
  JOURNAL   J Genet 50 (2), 268-276 (1951)
   PUBMED   24539708
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK014538.1, AI892703.1, AL590991.14 and CD774145.1.
            
            On Jul 3, 2018 this sequence version replaced NM_133730.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK014538.1, BC018391.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849382 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-769               AK014538.1         2-770
            770-884             AI892703.1         138-252
            885-1659            AK014538.1         885-1659
            1660-1868           AL590991.14        46507-46715
            1869-2005           CD774145.1         1-137               c
FEATURES             Location/Qualifiers
     source          1..2005
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 62.92 cM"
     gene            1..2005
                     /gene="Krt25"
                     /gene_synonym="4631426H08Rik; CK-25; K25; Ka38; Krt25a;
                     mIRSa1"
                     /note="keratin 25"
                     /db_xref="GeneID:70810"
                     /db_xref="MGI:MGI:1918060"
     exon            1..477
                     /gene="Krt25"
                     /gene_synonym="4631426H08Rik; CK-25; K25; Ka38; Krt25a;
                     mIRSa1"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1401
                     /gene="Krt25"
                     /gene_synonym="4631426H08Rik; CK-25; K25; Ka38; Krt25a;
                     mIRSa1"
                     /note="type I keratin KA38; cytokeratin-25; type I inner
                     root sheath-specific keratin-K25irs1; keratin 25A"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 25"
                     /protein_id="NP_598491.1"
                     /db_xref="CCDS:CCDS25377.1"
                     /db_xref="GeneID:70810"
                     /db_xref="MGI:MGI:1918060"
                     /translation="MSLRLSSGSRRSYARPSTGSLRGASFGAGNACGVAGIGSGFSCA
                     FGGSSTGGNTGVANSCAGFTVNEGGLLSGNEKVTMQNLNDRLASYLDNVQALQEANAD
                     LEQKIKGWYEKFGPGSCRGLDHDYSRYFPIIDDLKNQIITSTTSNANAVLQIDNARLT
                     ADDFRLKYENELALHQSVEADVNGLRRVLDEITLCRTDLEIQYETLSEELTYLKKNHK
                     EEMQALQCAAGGNVNVEMNAAPGVDLTVLLNNMRAEYEALAEQNRRDAEAWFQEKSAS
                     LQQQITEDVGATTSARNELTEMKRTLQTLEIELQSLLATKHSLECSLTETEGNYCTQL
                     AQIQAQISALEEQLHQVRTETEGQKLEYEQLLNVKAHLEKEIETYCLLIGGDEGACKS
                     SSYKSKDYGSGNAGNQIKDPVKAIVVKKVLEEVDQRSKILTTRLHSLEEKSQSN"
     exon            478..560
                     /gene="Krt25"
                     /gene_synonym="4631426H08Rik; CK-25; K25; Ka38; Krt25a;
                     mIRSa1"
                     /inference="alignment:Splign:2.1.0"
     exon            561..717
                     /gene="Krt25"
                     /gene_synonym="4631426H08Rik; CK-25; K25; Ka38; Krt25a;
                     mIRSa1"
                     /inference="alignment:Splign:2.1.0"
     exon            718..879
                     /gene="Krt25"
                     /gene_synonym="4631426H08Rik; CK-25; K25; Ka38; Krt25a;
                     mIRSa1"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1005
                     /gene="Krt25"
                     /gene_synonym="4631426H08Rik; CK-25; K25; Ka38; Krt25a;
                     mIRSa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1223
                     /gene="Krt25"
                     /gene_synonym="4631426H08Rik; CK-25; K25; Ka38; Krt25a;
                     mIRSa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1291
                     /gene="Krt25"
                     /gene_synonym="4631426H08Rik; CK-25; K25; Ka38; Krt25a;
                     mIRSa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1989
                     /gene="Krt25"
                     /gene_synonym="4631426H08Rik; CK-25; K25; Ka38; Krt25a;
                     mIRSa1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1638..1643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt25"
                     /gene_synonym="4631426H08Rik; CK-25; K25; Ka38; Krt25a;
                     mIRSa1"
                     /note="hexamer: AATAAA"
     polyA_site      1661
                     /gene="Krt25"
                     /gene_synonym="4631426H08Rik; CK-25; K25; Ka38; Krt25a;
                     mIRSa1"
                     /note="major polyA site"
ORIGIN      
        1 agaaggcact ctagtctgac tctcaagaac acagttcagc gacacgcttg ccctgagatc
       61 atgtctcttc gcctttccag tggatccagg aggtcctatg ctcgccccag cacagggtcg
      121 ctcaggggag ccagcttcgg agctggaaat gcatgtggcg tggcaggcat tggaagtggc
      181 ttctcctgcg ccttcggggg cagctccaca ggaggaaaca cgggggtggc caactcctgt
      241 gctggcttca ctgtgaatga gggggggctc ctctccggca atgagaaggt gaccatgcag
      301 aaccttaatg accgcctggc ctcctacctg gacaacgtgc aagcgctgca ggaggccaac
      361 gctgacctgg agcagaagat caagggctgg tatgaaaaat ttggacctgg gtcgtgccgc
      421 ggtctcgatc atgactacag tagatacttc cccatcattg atgatctaaa aaaccagatc
      481 atcacctcca ccaccagcaa cgccaacgct gtactgcaga ttgacaatgc caggctcacg
      541 gctgatgact tcagactcaa gtacgaaaac gagctggctc tccaccagag cgtagaggct
      601 gacgtcaacg ggctgcgcag agttctggat gaaatcaccc tgtgccgcac tgacctggag
      661 attcagtacg aaaccctgag cgaggagctg acctatctca agaagaacca caaagaggaa
      721 atgcaggctc tgcagtgcgc cgctggaggc aacgtgaacg tggagatgaa cgcagccccg
      781 ggcgtggacc tcaccgtcct gctgaacaac atgagagctg agtatgaggc cctggctgag
      841 cagaaccgca gggacgctga ggcctggttc caagagaaga gtgcttcgct gcagcagcag
      901 atcaccgagg acgtgggtgc caccacctca gccaggaatg agctcaccga aatgaagcga
      961 acgctccaaa ccctggagat tgaactgcag tctctcctgg ccacgaaaca ctctctggag
     1021 tgctccctga cggagaccga gggcaactac tgcacgcagc tggctcagat ccaggctcag
     1081 atcagcgccc tggaggagca gctgcaccag gtgaggacgg agaccgaggg ccagaagctg
     1141 gaatatgagc agctgctgaa tgtcaaggcc cacctggaga aggagatcga gacctactgc
     1201 ctcctcatag gaggagatga aggggcctgt aagtcttcga gttacaagtc taaagattat
     1261 ggatctggaa acgccggaaa ccaaatcaaa gatccagtca aagccatagt ggttaagaag
     1321 gttctagagg aggtggatca gcgcagcaag atactgacca ctaggctcca ctccctggaa
     1381 gagaaatctc aaagcaatta gcaaagatca tgagcaaaag aagaagaaga aaagcttcaa
     1441 agaagacaag gcatgcaatg tgtctgggaa atgagcaagc ctatggaaaa aaaaatgtct
     1501 gtcctgttgt cttctgttcc tttctccttc tgagccagca gcggcagaac tccccgtcca
     1561 tctggaggga agtcacttgc aaacgtgagg gctcacctga ttaccctaca gccatctgtc
     1621 agcatttctt tacagtcaat aaaccttcct tgagcaactt acccctactg gctgccactg
     1681 tcttgtcttt gaaaggtccg tggcagtgct gcagactgtg gacgcgtagc gactttggat
     1741 ttgtgtgacg tttatgcact aactaggagg tcggccccct cgggttttca caaggatttc
     1801 tagacaaggt cagagagaat aaaagtactt ccactgacac tttgacagaa gaaacttatt
     1861 tcctgtcacc attggtaaat gtgtgcctgg cgcattcttc atctgcaact gggaataaag
     1921 tgtttgtatt gaagtgaggt agacatccaa taatagtaat aaagtgatga agtactaact
     1981 ttacttcaaa aaaaaaaaaa aaaaa
//
