LOCUS       NM_033373               1570 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus keratin 23 (Krt23), mRNA.
ACCESSION   NM_033373 XM_904116
VERSION     NM_033373.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1570)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1570)
  AUTHORS   Xie,Z., Ma,X.H., Bai,Q.F., Tang,J., Sun,J.H., Jiang,F., Guo,W.,
            Wang,C.M., Yang,R., Wen,Y.C., Wang,F.Y., Chen,Y.X., Zhang,H.,
            He,D.Z., Kelley,M.W., Yang,S. and Zhang,W.J.
  TITLE     ZBTB20 is essential for cochlear maturation and hearing in mice
  JOURNAL   Proc Natl Acad Sci U S A 120 (24), e2220867120 (2023)
   PUBMED   37279265
REFERENCE   3  (bases 1 to 1570)
  AUTHORS   Saito,K., Michon,F., Yamada,A., Inuzuka,H., Yamaguchi,S.,
            Fukumoto,E., Yoshizaki,K., Nakamura,T., Arakaki,M., Chiba,Y.,
            Ishikawa,M., Okano,H., Thesleff,I. and Fukumoto,S.
  TITLE     Sox21 Regulates Anapc10 Expression and Determines the Fate of
            Ectodermal Organ
  JOURNAL   iScience 23 (7), 101329 (2020)
   PUBMED   32674056
REFERENCE   4  (bases 1 to 1570)
  AUTHORS   Kim,D., Brocker,C.N., Takahashi,S., Yagai,T., Kim,T., Xie,G.,
            Wang,H., Qu,A. and Gonzalez,F.J.
  TITLE     Keratin 23 Is a Peroxisome Proliferator-Activated Receptor
            Alpha-Dependent, MYC-Amplified Oncogene That Promotes Hepatocyte
            Proliferation
  JOURNAL   Hepatology 70 (1), 154-167 (2019)
   PUBMED   30697791
  REMARK    GeneRIF: PPARA and MYC bind to sites within the Krt23 promoter
REFERENCE   5  (bases 1 to 1570)
  AUTHORS   Pehrson,J.R., Changolkar,L.N., Costanzi,C. and Leu,N.A.
  TITLE     Mice without macroH2A histone variants
  JOURNAL   Mol Cell Biol 34 (24), 4523-4533 (2014)
   PUBMED   25312643
REFERENCE   6  (bases 1 to 1570)
  AUTHORS   Gerber,S.D., Amann,R., Wyder,S. and Trueb,B.
  TITLE     Comparison of the gene expression profiles from normal and Fgfrl1
            deficient mouse kidneys reveals downstream targets of Fgfrl1
            signaling
  JOURNAL   PLoS One 7 (3), e33457 (2012)
   PUBMED   22432025
REFERENCE   7  (bases 1 to 1570)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   8  (bases 1 to 1570)
  AUTHORS   Zhang,J.S., Wang,L., Huang,H., Nelson,M. and Smith,D.I.
  TITLE     Keratin 23 (K23), a novel acidic keratin, is highly induced by
            histone deacetylase inhibitors during differentiation of pancreatic
            cancer cells
  JOURNAL   Genes Chromosomes Cancer 30 (2), 123-135 (2001)
   PUBMED   11135429
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK036901.1 and AF102849.1.
            
            On Jul 5, 2018 this sequence version replaced NM_033373.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF102849.1, AK036954.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AK036901.1         6-15
            11-1570             AF102849.1         1-1560
FEATURES             Location/Qualifiers
     source          1..1570
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 62.92 cM"
     gene            1..1570
                     /gene="Krt23"
                     /gene_synonym="CK23; Haik1; K23; Krt1-23"
                     /note="keratin 23"
                     /db_xref="GeneID:94179"
                     /db_xref="MGI:MGI:2148866"
     exon            1..452
                     /gene="Krt23"
                     /gene_synonym="CK23; Haik1; K23; Krt1-23"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1325
                     /gene="Krt23"
                     /gene_synonym="CK23; Haik1; K23; Krt1-23"
                     /note="keratin complex 1, acidic, gene 23; cytokeratin-23;
                     type I intermediate filament cytokeratin"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 23"
                     /protein_id="NP_203537.1"
                     /db_xref="CCDS:CCDS25382.1"
                     /db_xref="GeneID:94179"
                     /db_xref="MGI:MGI:2148866"
                     /translation="MNSSHSFNQTYSASVHSLGSTRGRQGSCHRAPSVHGGAGGVRIS
                     LSFTTPGCLPPGGSWGSGRSSPLLGGNGKATMQNLNDRLATYLEKVRALEEANSKLET
                     RILRWHQEREPSHRKDYSQYEENISRLQEQIVDGKMANAHIVVLIDNARMAVDDFNLK
                     FENEHSLKKDLEIEVEGLRKTLDDLTIVTTDLEQEVEGMRKELILMKKRHEQEMEENH
                     LPSDFKVSVKVDTTPGEDLIKVLEDMRQEYELIIKKKHQELDTWFREQSAAMAQEVAS
                     PAPVQGNQSDIHELRRTFQALEIDLQAQHSRKTALENMLTETRARYSCRLQDMQQIIS
                     HYEEELIQLRQDLERQNNEHKVLLGIKTHLEKEIATYRRLLEGDTEGTMDGSESRLKG
                     SEASTIKAITQESVNGRIVLSQVNEIQKHI"
     exon            453..535
                     /gene="Krt23"
                     /gene_synonym="CK23; Haik1; K23; Krt1-23"
                     /inference="alignment:Splign:2.1.0"
     exon            536..692
                     /gene="Krt23"
                     /gene_synonym="CK23; Haik1; K23; Krt1-23"
                     /inference="alignment:Splign:2.1.0"
     exon            693..854
                     /gene="Krt23"
                     /gene_synonym="CK23; Haik1; K23; Krt1-23"
                     /inference="alignment:Splign:2.1.0"
     exon            855..977
                     /gene="Krt23"
                     /gene_synonym="CK23; Haik1; K23; Krt1-23"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1198
                     /gene="Krt23"
                     /gene_synonym="CK23; Haik1; K23; Krt1-23"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1230
                     /gene="Krt23"
                     /gene_synonym="CK23; Haik1; K23; Krt1-23"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1549
                     /gene="Krt23"
                     /gene_synonym="CK23; Haik1; K23; Krt1-23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1524..1529
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt23"
                     /gene_synonym="CK23; Haik1; K23; Krt1-23"
                     /note="hexamer: ATTAAA"
     polyA_site      1549
                     /gene="Krt23"
                     /gene_synonym="CK23; Haik1; K23; Krt1-23"
                     /note="major polyA site"
ORIGIN      
        1 cagtcctgtg agcgtcagag agctgagata gccctgctcc atacacagat gggaccatga
       61 actccagcca cagctttaac cagacctact cggcctctgt ccacagcctc ggaagcaccc
      121 gggggcggca ggggagctgc catcgggcac cgagtgtcca tggaggcgca gggggtgtcc
      181 gcatctccct ttccttcacc acgccaggct gcctgcctcc tggaggatca tgggggtctg
      241 gaagaagcag tcccctgcta ggtggcaatg gcaaggccac catgcagaat ctcaacgatc
      301 gcctggccac atatctggag aaggtgcggg ctctagagga ggctaactcg aagctggaaa
      361 cccgtatact aaggtggcat caggagagag aacccagcca cagaaaggat tattcccagt
      421 atgaggaaaa catcagccgc ctgcaggagc agatagtgga cggtaagatg gccaatgccc
      481 acattgtcgt gctcattgac aacgccagga tggcagtgga tgacttcaac ctgaagtttg
      541 aaaacgaaca ctcgttaaag aaagacttgg aaattgaagt tgagggcctc cgaaagacct
      601 tggatgatct gaccattgtc acaacagacc tggaacagga ggtggagggg atgaggaaag
      661 agctgatcct catgaagaaa cgccatgagc aggaaatgga ggagaatcac ttgccgagtg
      721 acttcaaggt cagtgtgaag gtggacacta ctccagggga agatctgatt aaggtcttgg
      781 aagatatgag gcaggaatac gagttaataa taaagaagaa acatcaagag ttggacacct
      841 ggttcagaga gcagtcagcc gccatggccc aggaagtggc cagtccagcg cctgtacagg
      901 gcaaccaaag tgatatccat gagctgagga gaacattcca ggccctagag attgacctgc
      961 aggcccagca cagcaggaaa accgctttgg aaaacatgct gacagagacc cgggctcgat
     1021 actcctgccg tctccaggac atgcagcaga tcatctccca ctacgaagaa gagctgattc
     1081 agctccgcca agacctggag cgtcagaaca atgaacacaa ggtgctgctg ggcatcaaaa
     1141 cccacctgga gaaggaaatc gccacctacc gccggctcct ggagggagac actgaaggga
     1201 cgatggatgg atctgagtca aggctgaaag gatctgaagc ttcaacgatc aaggccatca
     1261 ctcaagagag tgtcaatgga agaatcgttc tttctcaagt gaatgagatc caaaagcata
     1321 tatgaagcca aggagtttct gcctgttgta aaaaccacac tccccctatg gaaagtcttt
     1381 gtctccgcgc taatgggtga gtctcgacgg aaatccttgg agttttcaga ttcagaaact
     1441 tttctctata atggtctcac aggacttccc atgatgctct taatatattg ttggaatttt
     1501 tgagtgaaag aagaagttta taaattaaag ctctactctc ctgctctcaa aaaaaaaaaa
     1561 aaaaaaaaaa
//
