LOCUS       NM_172946               3166 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus keratin 222 (Krt222), transcript variant 1, mRNA.
ACCESSION   NM_172946
VERSION     NM_172946.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3166)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB850745.1, AK031954.1 and BC079890.1.
            
            On Mar 29, 2018 this sequence version replaced NM_172946.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.255979.1, AK031954.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                BB850745.1         2-81
            81-2815             AK031954.1         2-2736
            2816-3166           BC079890.1         2730-3080
FEATURES             Location/Qualifiers
     source          1..3166
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 62.92 cM"
     gene            1..3166
                     /gene="Krt222"
                     /gene_synonym="6330509G02Rik"
                     /note="keratin 222"
                     /db_xref="GeneID:268481"
                     /db_xref="MGI:MGI:2442728"
     exon            1..205
                     /gene="Krt222"
                     /gene_synonym="6330509G02Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..994
                     /gene="Krt222"
                     /gene_synonym="6330509G02Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     keratin-like protein KRT222"
                     /codon_start=1
                     /product="keratin-like protein KRT222 isoform 1"
                     /protein_id="NP_766534.1"
                     /db_xref="CCDS:CCDS25375.1"
                     /db_xref="GeneID:268481"
                     /db_xref="MGI:MGI:2442728"
                     /translation="MELSQLLNEIRANYEQLLTRNQIETVLSTRIQLEEDITKKMDKD
                     GEALKAAQAELKEARRQCHHLQVEIESLHAVERGLENSLQASEQHYQMQLQDLESVIG
                     RLERELQEVRRGIERQLREHEMLLNTKMRLEQEIATYRRLLEQEEIRYYGCIQGEKKE
                     EKPTKSKVGFLLPSAIINEISFSTKVSQKYENENMETVTKQAVVNRDVKESAEAHGTI
                     QTEKVDEVIKEWEGSFFKDNPRLRKKSVSLRFDLHLAATDEGCLESRQDNLPDIEVRL
                     IMRRSCSIPSIKPPPGTN"
     exon            206..334
                     /gene="Krt222"
                     /gene_synonym="6330509G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            335..555
                     /gene="Krt222"
                     /gene_synonym="6330509G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            556..632
                     /gene="Krt222"
                     /gene_synonym="6330509G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            633..765
                     /gene="Krt222"
                     /gene_synonym="6330509G02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            766..3152
                     /gene="Krt222"
                     /gene_synonym="6330509G02Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1621..1626
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt222"
                     /gene_synonym="6330509G02Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1640
                     /gene="Krt222"
                     /gene_synonym="6330509G02Rik"
                     /note="major polyA site"
     regulatory      3129..3134
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt222"
                     /gene_synonym="6330509G02Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3152
                     /gene="Krt222"
                     /gene_synonym="6330509G02Rik"
                     /note="major polyA site"
ORIGIN      
        1 aaggctctgc ggggctgtct gctctggcga cgcaggcagg gcaggctctg ccgcagcggc
       61 tcatcccatc gctaaggtcc agttagccaa ggtggaggat gggaaaagaa tggagctgtc
      121 ccagctcctc aatgagatca gggcaaacta tgaacagctc ctcaccagaa atcagataga
      181 gacggtgttg tcgacgcgga tccagctaga ggaagatata accaaaaaaa tggacaagga
      241 tggggaagct ctgaaggcag ctcaggctga actcaaggag gcccgccggc agtgccacca
      301 cctgcaagtg gaaatcgagt ctctccacgc tgtggaaagg ggccttgaga actccctgca
      361 ggccagtgag cagcattatc agatgcagct gcaagatctg gagtcagtga ttggcagact
      421 ggagagggag ctgcaggaag tgaggcgtgg catcgagagg cagcttcgag agcacgagat
      481 gcttctcaac acgaagatga ggctggagca ggaaatagcc acgtaccgcc gcctgctaga
      541 acaggaagaa atcagatatt atggttgtat ccaaggagag aaaaaagaag aaaagcctac
      601 caagagtaaa gttggctttc ttctcccctc agccattata aatgaaatct ccttttcaac
      661 aaaagtctcc caaaagtatg aaaatgaaaa tatggagaca gtgaccaaac aggcagtagt
      721 gaacagagac gtgaaggaga gcgcggaggc ccacggcacc attcagacag agaaagtgga
      781 tgaagttata aaagaatggg aaggttcatt ctttaaagat aaccctcgac tgaggaaaaa
      841 gtccgtctct ctccggtttg atctccatct agcagccacg gatgagggct gtttagagag
      901 tagacaagat aatctgccag atatcgaagt cagacttatc atgagaagat cctgcagtat
      961 tccctccatc aaacccccac caggaaccaa ctaacccaga gagagtgttt agcaagggca
     1021 ccaggatgga cctatgtagg ccatacagac ccccagtccc aagtgtaagt tattttacat
     1081 ggatagatag tgttaagatg ctgtgggctc tggctctctt cagagaacac ataagtaaga
     1141 gatgctgcag ctaggactcc aaagatgagc aggggttttt tgctgttttg ttttgttttg
     1201 ttttttgaga ggggctgctt aaaaataaat cagaaatcca gtgtggattc tgttttattt
     1261 gtcatctaaa tagtctttat tctggcgagc tttatcagag actttaagta ttaaggtggc
     1321 ttcattaagc ctgtaatttt cctcaaaagc taaacatccc aaggaaaaca aaatagcttg
     1381 tttgaaaact gaagagctac ggtgagttac tctccgtggt ttcaggacca gctgaaccta
     1441 gaatgttcca cttctaaaaa ggcagcagtt aggaacaaac tgtttaagga gcagactcag
     1501 tattcactta ggactttccc ttttgagaca atcatttgaa ccctgggaat gacgaagtgt
     1561 tccatccatg agcgattctg aatggactgt agagcactct ccaaggcaat tttgattatt
     1621 aataaaattg ggttactcta tatctttatc ttaaagcttt ttaaaaatca gtatcgggag
     1681 agttagtttg ttgaaagtta aaggttgtac acacacacac acacacacac ccggacatac
     1741 acacactcca gctgtacaaa ccttttaaag cacattgaga ttgtggtgaa tccagttacc
     1801 aggacagtta cccagctgct caccatctgc aaaatgaagt gtgagtagcg tgtgctatgg
     1861 gcctgagagg aaagagtcta tgaactcaga gaaatagtcc ttgcagtcat ttctgtgagc
     1921 taacagcata gtactgctat ctgagctaag agtgcctgca gaacttgatt ttaaattgtt
     1981 caaactgtaa taaatagaga tgtaaaatat atttgtgaat aagtgaaaaa ttgttgcaaa
     2041 gttgttttct ggttttgttt ttaattgtta ttatttactt gctatacata tatgcttgca
     2101 ccccagaagg agggcatcag atctcatgac agatggttgt gagccaccat gtggttactg
     2161 ggaattgaac tcaggacctc tagaagagca gccactgctc ttaacctctg agccatctct
     2221 ctagccccat tgcaaagttt gttttgtttt ttaaaaaaca acctaaattt gtttaatgca
     2281 ggtacattta ctttgagacc ttaaatagta gatatctgtt ttacgacatt tagatatttt
     2341 aggctttttt tttcctaaac aacaacaaat aaggagtaca aaccattggc cactgttctt
     2401 tgttctcagc tcaagtatca tctaagggct acagctatat tagcatttta gtggggcctt
     2461 caaagcccac cctcctctcc ccctccctcc ctctccacat gtgtgtatat atgttgacta
     2521 gtaaatatgc tttagccaca aggaacttac attagttagc ttttagtgta atccagaggt
     2581 ttaacgttcc cctttttcat tactccaggt tgccttcagc ctgactcact ctagttagtg
     2641 agtaaaaatg aacgatgctg ttcttcaatg ttacaacagc atattaagca cttattcttg
     2701 aataagcgcc tgacctaaaa ttgcatccta cacattaaat gtttctttca ggctgggggt
     2761 accgcaaggt ggcagaactt cacctagcac ataggaggca ctgggtctgg acctcaggga
     2821 aaaaaaaaag ggagggggag tattcatcat taaatgctgc tactttatta aagctttgac
     2881 tgcaatcata ttagccattg tactggttac tgcattatgc aacaacaatt acgataaagc
     2941 gatacattta gtgcaatcta ctgcagtgtt gggactgggc attgtgaatt aacagcttgc
     3001 tagagaagtt ccactgtgtg gctattctgt gtgtaacatg cagtacttga atttgtaaat
     3061 gagttttgtt tgctttgagg cattttaaaa tcagaatatg aatttaccaa agtaaatgat
     3121 gccaccataa taaaaaaaaa tttaaacatg aaaaaaaaaa aaaaaa
//
