LOCUS       NM_023256               1948 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus keratin 20 (Krt20), mRNA.
ACCESSION   NM_023256
VERSION     NM_023256.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1948)
  AUTHORS   Liu,C.Y., Girish,N., Gomez,M.L., Kalski,M., Bernard,J.K.,
            Simons,B.D. and Polk,D.B.
  TITLE     Wound-healing plasticity enables clonal expansion of founder
            progenitor cells in colitis
  JOURNAL   Dev Cell 58 (21), 2309-2325 (2023)
   PUBMED   37652012
REFERENCE   2  (bases 1 to 1948)
  AUTHORS   Guo,C., Zhang,Y., Tan,R., Tang,Z., Lam,C.M., Ye,X., Wang,Z. and
            Li,X.
  TITLE     Arid1a regulates bladder urothelium formation and maintenance
  JOURNAL   Dev Biol 485, 61-69 (2022)
   PUBMED   35283102
REFERENCE   3  (bases 1 to 1948)
  AUTHORS   Ohara,T.E., Colonna,M. and Stappenbeck,T.S.
  TITLE     Adaptive differentiation promotes intestinal villus recovery
  JOURNAL   Dev Cell 57 (2), 166-179 (2022)
   PUBMED   35016013
REFERENCE   4  (bases 1 to 1948)
  AUTHORS   Kim,E., Choi,S., Kang,B., Kong,J., Kim,Y., Yoon,W.H., Lee,H.R.,
            Kim,S., Kim,H.M., Lee,H., Yang,C., Lee,Y.J., Kang,M., Roh,T.Y.,
            Jung,S., Kim,S., Ku,J.H. and Shin,K.
  TITLE     Creation of bladder assembloids mimicking tissue regeneration and
            cancer
  JOURNAL   Nature 588 (7839), 664-669 (2020)
   PUBMED   33328632
REFERENCE   5  (bases 1 to 1948)
  AUTHORS   Yu,Z., Mannik,J., Soto,A., Lin,K.K. and Andersen,B.
  TITLE     The epidermal differentiation-associated Grainyhead gene Get1/Grhl3
            also regulates urothelial differentiation
  JOURNAL   EMBO J 28 (13), 1890-1903 (2009)
   PUBMED   19494835
REFERENCE   6  (bases 1 to 1948)
  AUTHORS   Erman,A., Veranic,P., Psenicnik,M. and Jezernik,K.
  TITLE     Superficial cell differentiation during embryonic and postnatal
            development of mouse urothelium
  JOURNAL   Tissue Cell 38 (5), 293-301 (2006)
   PUBMED   16973199
REFERENCE   7  (bases 1 to 1948)
  AUTHORS   Schweizer,J., Bowden,P.E., Coulombe,P.A., Langbein,L., Lane,E.B.,
            Magin,T.M., Maltais,L., Omary,M.B., Parry,D.A., Rogers,M.A. and
            Wright,M.W.
  TITLE     New consensus nomenclature for mammalian keratins
  JOURNAL   J Cell Biol 174 (2), 169-174 (2006)
   PUBMED   16831889
REFERENCE   8  (bases 1 to 1948)
  AUTHORS   Zhou,Q., Cadrin,M., Herrmann,H., Chen,C.H., Chalkley,R.J.,
            Burlingame,A.L. and Omary,M.B.
  TITLE     Keratin 20 serine 13 phosphorylation is a stress and intestinal
            goblet cell marker
  JOURNAL   J Biol Chem 281 (24), 16453-16461 (2006)
   PUBMED   16608857
  REMARK    GeneRIF: K20 Ser(13) is a highly dynamic protein kinase C-related
            phosphorylation site that is induced during apoptosis and tissue
            injury
REFERENCE   9  (bases 1 to 1948)
  AUTHORS   Drori,S., Girnun,G.D., Tou,L., Szwaya,J.D., Mueller,E., Xia,K.,
            Shivdasani,R.A. and Spiegelman,B.M.
  TITLE     Hic-5 regulates an epithelial program mediated by PPARgamma
  JOURNAL   Genes Dev 19 (3), 362-375 (2005)
   PUBMED   15687259
  REMARK    Erratum:[Genes Dev. 2005 Apr 1;19(7):875. Kia, Xia [corrected to
            Xia, Kai]]
REFERENCE   10 (bases 1 to 1948)
  AUTHORS   Zhou,Q., Toivola,D.M., Feng,N., Greenberg,H.B., Franke,W.W. and
            Omary,M.B.
  TITLE     Keratin 20 helps maintain intermediate filament organization in
            intestinal epithelia
  JOURNAL   Mol Biol Cell 14 (7), 2959-2971 (2003)
   PUBMED   12857878
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK018567.1 and AL591165.17.
            
            On Dec 2, 2015 this sequence version replaced NM_023256.1.
            
            Summary: This gene encodes a member of the keratin protein family
            and is found within a cluster of cytokeratin genes on chromosome
            11. Keratins are cytoskeletal proteins that are preferentially
            expressed in epithelial cells. The encoded protein may help
            maintain intermediate filament organization in intestinal
            epithelium. Phosphorylation of this protein may also influence
            mucin secretion in the small intestine. [provided by RefSeq, Dec
            2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK018567.1, BC057172.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1930              AK018567.1         1-1930
            1931-1948           AL591165.17        68034-68051         c
FEATURES             Location/Qualifiers
     source          1..1948
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 62.92 cM"
     gene            1..1948
                     /gene="Krt20"
                     /gene_synonym="9030623C06Rik; Ck-20; Ck20; K20; Krt21"
                     /note="keratin 20"
                     /db_xref="GeneID:66809"
                     /db_xref="MGI:MGI:1914059"
     exon            1..467
                     /gene="Krt20"
                     /gene_synonym="9030623C06Rik; Ck-20; Ck20; K20; Krt21"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1352
                     /gene="Krt20"
                     /gene_synonym="9030623C06Rik; Ck-20; Ck20; K20; Krt21"
                     /note="cytokeratin 20"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 20"
                     /protein_id="NP_075745.1"
                     /db_xref="CCDS:CCDS25381.1"
                     /db_xref="GeneID:66809"
                     /db_xref="MGI:MGI:1914059"
                     /translation="MDFSRQSFHRSLSSSSQGPALSMSGSLYRKGTVQRLGAAPSVYG
                     GAGGHGTRISVSKAVMSYGGDLSNGSDLFGGNGKLAMQNLNDRLANYLEKVRSLEQSN
                     SRLEAQIKQWYETNAPSTIRDYSSYYAQIKELQNQVKDAQVQNAQCVLRIDNAKLAAE
                     DFRLKFETERGMRIAVEADLQGLSKVYDNLTLQKTDLEIQIEELNKDLALLKKEHQEE
                     VEVLRRQLGNNVNVEVDAAPGLNLGEIMNEMRQRYEVLAQKNLQEAKEQFERQSQTLQ
                     QQVTVNTEELKGFEVQVTELRRTYQNLEIELQSHLSMKESLERNLEDVKARYASQLAA
                     IQEMLSSLEAQLMQIRSDTERQNQEHNILLDIKTRLEQEIATYRRLLEGEDIKTTEYQ
                     LSTLEMKDIKKTRKIKTVVEEVVDGKVVSSEVKEIEESV"
     exon            468..550
                     /gene="Krt20"
                     /gene_synonym="9030623C06Rik; Ck-20; Ck20; K20; Krt21"
                     /inference="alignment:Splign:2.1.0"
     exon            551..707
                     /gene="Krt20"
                     /gene_synonym="9030623C06Rik; Ck-20; Ck20; K20; Krt21"
                     /inference="alignment:Splign:2.1.0"
     exon            708..869
                     /gene="Krt20"
                     /gene_synonym="9030623C06Rik; Ck-20; Ck20; K20; Krt21"
                     /inference="alignment:Splign:2.1.0"
     exon            870..995
                     /gene="Krt20"
                     /gene_synonym="9030623C06Rik; Ck-20; Ck20; K20; Krt21"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1216
                     /gene="Krt20"
                     /gene_synonym="9030623C06Rik; Ck-20; Ck20; K20; Krt21"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1254
                     /gene="Krt20"
                     /gene_synonym="9030623C06Rik; Ck-20; Ck20; K20; Krt21"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1948
                     /gene="Krt20"
                     /gene_synonym="9030623C06Rik; Ck-20; Ck20; K20; Krt21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1894..1899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt20"
                     /gene_synonym="9030623C06Rik; Ck-20; Ck20; K20; Krt21"
                     /note="hexamer: AATAAA"
     regulatory      1910..1915
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt20"
                     /gene_synonym="9030623C06Rik; Ck-20; Ck20; K20; Krt21"
                     /note="hexamer: ATTAAA"
     polyA_site      1915
                     /gene="Krt20"
                     /gene_synonym="9030623C06Rik; Ck-20; Ck20; K20; Krt21"
                     /note="major polyA site"
     polyA_site      1934
                     /gene="Krt20"
                     /gene_synonym="9030623C06Rik; Ck-20; Ck20; K20; Krt21"
ORIGIN      
        1 gacagacagg ctgtgctcca agtccaggct acaggcgttg cctccctaca tcccagatgg
       61 atttcagtcg tcaaagtttt caccgaagtc tgagttcctc ctcacaaggc ccagcactca
      121 gcatgagtgg ctcgctgtat aggaagggga ctgtgcagcg tctgggggct gcacccagcg
      181 tctatggtgg ggctggaggc catggcactc gcatctctgt ctccaaagcc gtaatgagct
      241 acgggggtga tctctccaac ggatcggacc tgtttggggg caatgggaaa ctggcaatgc
      301 agaacctgaa cgacagattg gcaaactacc tagaaaaagt gcgctccctg gagcaatcca
      361 attccagact tgaagcccag atcaagcagt ggtacgaaac caacgcgccg agcaccatcc
      421 gagactatag ctcctactac gcacagatta aagagctgca aaatcaggtt aaggatgctc
      481 aagtacaaaa tgcccagtgc gtcctgcgaa ttgacaatgc taagctggct gcagaggact
      541 tcagattgaa gtttgagact gagaggggaa tgcgtatagc tgtggaagct gatctccaag
      601 gcctgagcaa agtttatgat aatctgactc ttcaaaagac agacttggaa attcagattg
      661 aagaactgaa caaggacctg gccctcctca aaaaggaaca tcaagaggaa gttgaggttc
      721 ttcgccggca gctgggcaac aatgtcaacg tggaggtgga tgctgctcca ggcctgaacc
      781 tgggagagat catgaatgag atgagacaga gatatgaagt cctggcccag aagaacctgc
      841 aagaggccaa agaacagttc gagagacaga gtcaaactct gcagcaacaa gtcacagtga
      901 acacggagga gctgaaagga ttcgaggttc aagtcacgga gctgagacgc acctaccaga
      961 acctggagat agagttgcag tcccacctca gcatgaaaga gtctctggag cgcaacctag
     1021 aggacgtcaa ggctcgttac gccagccagt tggcagccat ccaggagatg ctgagctccc
     1081 tggaggccca actgatgcag atcaggagtg acacagaacg ccagaaccaa gaacacaaca
     1141 tccttctcga cataaagacc cggcttgagc aggagatcgc cacctaccgc cgccttctgg
     1201 agggagaaga tataaaaact acagaatacc agctgagcac tttggaaatg aaggatatca
     1261 agaaaaccag gaagattaag acggtcgtgg aagaagtggt agacggcaag gtcgtgtcct
     1321 ctgaagtcaa ggagatagaa gagagtgtct aaccagctgt caaagggagg ctgctccagc
     1381 tgtggcccgc tgaagacaac actgtgtagt ggctttaaag tgtgtgtggg ggggggggag
     1441 tctatttatc aagctgtgta attaaatata aatggttcac tccagggagc tgtaaagggc
     1501 aagattaaac ccagcacaat cgtcctcatt gcaaggcaca tccatcacag accagttcag
     1561 gtagagtaaa gcattggagg agttcaagca aagagcaaat aaaccgctct cctttggggt
     1621 cttgtttttc ttgtttctga attgctaaaa gccccgttag tgaacgggtt ctccagggag
     1681 gcaacttccc agttaatctc attgtctcct tgctgccttt aagcctttcc tgatgtctcc
     1741 cactgcctct caaaactcaa cttagtcttt gaataattta aaacaaactc caatcacaaa
     1801 tgctgaggag aataagaaca cagcacaagg tgattgacat ggggttcagt taagagcaaa
     1861 actagcctgg atgggaatgt gtcttcgtct cataataaac tgcttaacca ttaaaggtgg
     1921 ctttatttgg tgaatctgga gtataaaa
//
