LOCUS       NM_010668               2629 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus keratin 2 (Krt2), mRNA.
ACCESSION   NM_010668
VERSION     NM_010668.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2629)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2629)
  AUTHORS   Butera,A., Agostini,M., Cassandri,M., De Nicola,F., Fanciulli,M.,
            D'Ambrosio,L., Falasca,L., Nardacci,R., Wang,L., Piacentini,M.,
            Knight,R.A., Jia,W., Sun,Q., Shi,Y., Wang,Y., Candi,E. and
            Melino,G.
  TITLE     ZFP750 affects the cutaneous barrier through regulating lipid
            metabolism
  JOURNAL   Sci Adv 9 (17), eadg5423 (2023)
   PUBMED   37115925
REFERENCE   3  (bases 1 to 2629)
  AUTHORS   Zieman,A.G., Poll,B.G., Ma,J. and Coulombe,P.A.
  TITLE     Altered keratinocyte differentiation is an early driver of keratin
            mutation-based palmoplantar keratoderma
  JOURNAL   Hum Mol Genet 28 (13), 2255-2270 (2019)
   PUBMED   31220272
REFERENCE   4  (bases 1 to 2629)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 2629)
  AUTHORS   Fischer,H., Langbein,L., Reichelt,J., Buchberger,M., Tschachler,E.
            and Eckhart,L.
  TITLE     Keratins K2 and K10 are essential for the epidermal integrity of
            plantar skin
  JOURNAL   J Dermatol Sci 81 (1), 10-16 (2016)
   PUBMED   26603179
  REMARK    GeneRIF: This study demonstrates that the loss of the main
            cytoskeletal components of plantar epidermis, i.e. K2 and K10, can
            be only partly compensated by the upregulation of other keratins.
REFERENCE   6  (bases 1 to 2629)
  AUTHORS   Poirier,C., Yoshiki,A., Fujiwara,K., Guenet,J.L. and Kusakabe,M.
  TITLE     Hague (Hag). A new mouse hair mutation with an unstable
            semidominant allele
  JOURNAL   Genetics 162 (2), 831-840 (2002)
   PUBMED   12399393
REFERENCE   7  (bases 1 to 2629)
  AUTHORS   McGowan,K. and Coulombe,P.A.
  TITLE     The wound repair-associated keratins 6, 16, and 17. Insights into
            the role of intermediate filaments in specifying keratinocyte
            cytoarchitecture
  JOURNAL   Subcell Biochem 31, 173-204 (1998)
   PUBMED   9932493
  REMARK    Review article
REFERENCE   8  (bases 1 to 2629)
  AUTHORS   Reichelt,J., Bauer,C., Porter,R., Lane,E. and Magin,V.
  TITLE     Out of balance: consequences of a partial keratin 10 knockout
  JOURNAL   J Cell Sci 110 (Pt 18), 2175-2186 (1997)
   PUBMED   9378767
REFERENCE   9  (bases 1 to 2629)
  AUTHORS   Herzog,F., Winter,H. and Schweizer,J.
  TITLE     The large type II 70-kDa keratin of mouse epidermis is the ortholog
            of human keratin K2e
  JOURNAL   J Invest Dermatol 102 (2), 165-170 (1994)
   PUBMED   7508961
REFERENCE   10 (bases 1 to 2629)
  AUTHORS   Rentrop,M., Nischt,R., Knapp,B., Schweizer,J. and Winter,H.
  TITLE     An unusual type-II 70-kilodalton keratin protein of mouse epidermis
            exhibiting postnatal body-site specificity and sensitivity to
            hyperproliferation
  JOURNAL   Differentiation 34 (3), 189-200 (1987)
   PUBMED   2448177
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK161098.1, AK161078.1 and BE945724.1.
            
            On Feb 6, 2007 this sequence version replaced NM_010668.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132476.1, AK161078.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2205              AK161098.1         3-2207
            2206-2610           AK161078.1         2205-2609
            2611-2629           BE945724.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..2629
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.03 cM"
     gene            1..2629
                     /gene="Krt2"
                     /gene_synonym="Krt2-17; Krt2-2; Krt2e"
                     /note="keratin 2"
                     /db_xref="GeneID:16681"
                     /db_xref="MGI:MGI:96699"
     exon            1..716
                     /gene="Krt2"
                     /gene_synonym="Krt2-17; Krt2-2; Krt2e"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..2192
                     /gene="Krt2"
                     /gene_synonym="Krt2-17; Krt2-2; Krt2e"
                     /note="K2e; CK-2e; keratin-2e; cytokeratin-2e; type-II
                     keratin Kb2; epithelial keratin-2e; keratin complex 2,
                     gene 17; keratin complex 2, basic, gene 17; keratin 2
                     epidermis"
                     /codon_start=1
                     /product="keratin, type II cytoskeletal 2 epidermal"
                     /protein_id="NP_034798.2"
                     /db_xref="CCDS:CCDS37220.1"
                     /db_xref="GeneID:16681"
                     /db_xref="MGI:MGI:96699"
                     /translation="MSCQISCRSRRGGGGGGGGGFRGFSSGSAVVSGGSRRSNTSFSC
                     ISRHGGGRGGSGGGGFGSQSLVGLGGYKSISSSVAGNSGGYGGSSFGGSSGFGGGRGF
                     GGGQGFGGSGGFGGGSGFGGGQGFGGGSRFGGGSGFGGGGFGGGSFGGGRFGGGPGGF
                     GGPGGFPGGGIHEVSVNQSLLQPLDVKVDPEIQNVKSQEREQIKTLNNKFASFIDKVR
                     FLEQQNQVLRTKWELLQQLDVGSRTTNLDPIFQAYIGMLKKQVDRLSAERTSQESELN
                     NMQDLVEDFKKKYEDEINKRTSAENDFVTIKKDVDSCYMDKTELQARLDILAQEVNFL
                     RTLYDAELSQLQQDVTDTNVILSMDNNRNLDLDSIIAEVQNQYEMIAHKSKAESEELY
                     HSKYEELQVTAVKHGDSLKEIKMEISELNRTIQRLQGEISHVKKQCKGVQDSIADAEQ
                     RGEHAIKDARGKLTDLEEALQQCREDLARLLRDYQELMNTKLSLDVEIATYRKLLEGE
                     ECRMSGDFSDNVSVSITSSTISSSVASKTGFGSGGQSSGGRGSYGGRGGGGGGGSTYG
                     SGGRSSGSRGSGSGSGGGGYSSGGGSRGGSGGGYGSGGGSRGGSGGGYGSGGGSGSGG
                     GYSSGGGSRGGSGGGGVSSGGGSRGGSSSGGGSRGGSSSGGGGYSSGGGSRGGSSSGG
                     AGSSSEKGGSGSGEGCGSGVTFSFR"
     exon            717..931
                     /gene="Krt2"
                     /gene_synonym="Krt2-17; Krt2-2; Krt2e"
                     /inference="alignment:Splign:2.1.0"
     exon            932..992
                     /gene="Krt2"
                     /gene_synonym="Krt2-17; Krt2-2; Krt2e"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1088
                     /gene="Krt2"
                     /gene_synonym="Krt2-17; Krt2-2; Krt2e"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1253
                     /gene="Krt2"
                     /gene_synonym="Krt2-17; Krt2-2; Krt2e"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1379
                     /gene="Krt2"
                     /gene_synonym="Krt2-17; Krt2-2; Krt2e"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1600
                     /gene="Krt2"
                     /gene_synonym="Krt2-17; Krt2-2; Krt2e"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1635
                     /gene="Krt2"
                     /gene_synonym="Krt2-17; Krt2-2; Krt2e"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..2613
                     /gene="Krt2"
                     /gene_synonym="Krt2-17; Krt2-2; Krt2e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2592..2597
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt2"
                     /gene_synonym="Krt2-17; Krt2-2; Krt2e"
                     /note="hexamer: AATAAA"
     polyA_site      2613
                     /gene="Krt2"
                     /gene_synonym="Krt2-17; Krt2-2; Krt2e"
                     /note="major polyA site"
ORIGIN      
        1 agcacacttt ggtctccagc ctcggatctg ctcaggaata ttcactcgtc ttgctgagca
       61 aaaacatcat gagttgccag atctcctgca ggtcccgaag aggaggaggc ggcggcggag
      121 gcggcggatt caggggcttc agtagcggtt cagctgtggt ctctggaggg agccggagat
      181 caaataccag cttctcctgc ataagccgcc acggtggtgg cagaggaggc tctggtggag
      241 gtggctttgg tagtcagagt cttgttggcc tcggcgggta caagagcatc tctagtagcg
      301 tggctggcaa cagtggtggc tacggtggca gcagctttgg aggcagcagt ggctttggag
      361 gaggccgagg atttggaggt ggccaaggat ttggaggcag cggtggcttc ggaggtggct
      421 ctggctttgg aggaggccaa ggatttggag gtggcagccg ctttggaggt ggcagcggct
      481 tcggaggtgg tggatttggc ggaggcagtt ttggcggagg ccgatttgga ggtggccctg
      541 gaggttttgg gggccctgga ggattccctg gtggaggtat ccatgaagtg tctgtcaatc
      601 agagcctctt gcagcctctt gatgttaaag tagacccaga gattcagaac gtgaagtctc
      661 aggagcggga gcagatcaaa accctcaaca acaaatttgc ctctttcatt gacaaggtgc
      721 gattcctgga gcagcagaac caggtgttgc ggaccaaatg ggaactcctg cagcagttgg
      781 atgtaggcag ccgcaccaca aacctggacc ccatcttcca ggcctacata ggcatgctca
      841 agaagcaagt ggacaggctt tctgcagaaa ggacctcaca ggagtcagag ctgaacaaca
      901 tgcaggatct cgtggaagac tttaagaaga agtacgagga tgagatcaac aagcgcacgt
      961 ctgcggagaa tgattttgtg accattaaaa aggatgtgga cagttgctac atggacaaga
     1021 cagagctgca ggccaggctg gacatactag cacaggaagt caacttcctg agaacactct
     1081 acgatgcgga actgtcccag ctacagcagg atgtcaccga caccaatgtc atcctgtcca
     1141 tggacaacaa ccggaacctt gacctggaca gcatcattgc tgaggttcag aatcaatacg
     1201 agatgatcgc ccataagagc aaggctgagt cagaggagct gtaccacagc aagtatgaag
     1261 aactccaggt cactgctgtg aaacacgggg acagcttgaa agagatcaag atggaaatca
     1321 gcgagttgaa ccgcacaatc cagaggctgc aaggggagat atcacatgtg aagaagcagt
     1381 gtaagggtgt acaagactcc attgcagatg cagagcagcg tggagagcat gccatcaaag
     1441 atgccagggg caagctcact gacctggagg aggccctaca acagtgccga gaggacctgg
     1501 cccggctact gagggactac caggagctca tgaacaccaa gctgtccctg gatgtggaga
     1561 ttgccaccta caggaagctg ctggaggggg aagagtgcag gatgtctgga gacttcagcg
     1621 acaacgtgtc tgtgtccatc acaagcagca ccatctcctc atctgtggca tctaagactg
     1681 gcttcggctc tgggggtcaa agttctggag gaagagggtc ttatggagga cgaggaggag
     1741 gaggaggagg aggaagcacc tatggctctg gaggcagaag ctctggctcc agaggatctg
     1801 gatccggatc tggaggagga ggatacagct ctggaggagg ttccagggga ggatctggag
     1861 gaggatatgg ctctggagga ggctccaggg gaggatctgg aggaggatac ggctctggag
     1921 gtggctccgg ctctggagga ggatacagct ctggaggagg ctccagggga ggatctggag
     1981 gaggaggagt cagctctgga ggaggctcta gaggaggctc cagctctgga ggaggctcca
     2041 gaggtggctc cagctctggt gggggaggat atagttctgg aggaggctcc agaggtggct
     2101 ccagctcagg aggagcagga tctagctctg aaaagggagg ttctgggtca ggggaaggtt
     2161 gtggctcagg tgtgaccttc tcctttagat agagatatgt cttttctctc tactcttgga
     2221 ttccagaatg tcagctgtta tctctgtatc tctaactctg attaacccca atatttgtaa
     2281 tccacctgat gtgatttttt gtttttgaga tggggggtga taaaagatgt ctcttagcaa
     2341 ttagagccag agatactgtg ttctgggaaa gaatctgcat tgtccaagtg tgtcttcaag
     2401 ccgttgtccc actcccgcct ctcgcattgt ttacctggca tccctcccag atggcgatgt
     2461 gctgaggacc ccagggtagc ctccctattc tacccccaac agtggtctaa ggaactatgc
     2521 tttttttttt tttgtacata gcctcttgaa tggactctgc tttctgagtg ttggggtctg
     2581 ggtctctgca taataaactt catttgcaat tgaaaaaaaa aaaaaaaaa
//
