LOCUS       NM_008471               1396 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus keratin 19 (Krt19), transcript variant 1, mRNA.
ACCESSION   NM_008471
VERSION     NM_008471.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1396)
  AUTHORS   Defamie,V., Aliar,K., Sarkar,S., Vyas,F., Shetty,R., Reddy
            Narala,S., Fang,H., Saw,S., Tharmapalan,P., Sanchez,O., Knox,J.J.,
            Waterhouse,P.D. and Khokha,R.
  TITLE     Metalloproteinase inhibitors regulate biliary progenitor cells
            through sDLK1 in organoid models of liver injury
  JOURNAL   J Clin Invest 135 (3), e164997 (2024)
   PUBMED   39699962
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1396)
  AUTHORS   Thowfeequ,S., Fiorentino,J., Hu,D., Solovey,M., Ruane,S.,
            Whitehead,M., Zhou,F., Godwin,J., Mateo-Otero,Y.,
            Vanhaesebroeck,B., Scialdone,A. and Srinivas,S.
  TITLE     An integrated approach identifies the molecular underpinnings of
            murine anterior visceral endoderm migration
  JOURNAL   Dev Cell 59 (17), 2347-2363 (2024)
   PUBMED   38843837
REFERENCE   3  (bases 1 to 1396)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1396)
  AUTHORS   Xu,J., Deng,Y. and Li,G.
  TITLE     Keratin 19 (Krt19) is a novel marker gene for epicardial cells
  JOURNAL   Front Genet 15, 1385867 (2024)
   PUBMED   38831775
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1396)
  AUTHORS   Wrynn,T., Min,S., Horeth,E., Osinski,J., Sinha,S. and Romano,R.A.
  TITLE     DeltaNp63 regulates Sfrp1 expression to direct salivary gland
            branching morphogenesis
  JOURNAL   PLoS One 19 (5), e0301082 (2024)
   PUBMED   38722977
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1396)
  AUTHORS   Nozaki,M., Mori,M. and Matsushiro,A.
  TITLE     The complete sequence of the gene encoding mouse cytokeratin 15
  JOURNAL   Gene 138 (1-2), 197-200 (1994)
   PUBMED   7510260
REFERENCE   7  (bases 1 to 1396)
  AUTHORS   Correll,A.T., Webb,G.C., Ford,J.H., Rogers,G.E. and Powell,B.C.
  TITLE     Localization by in situ hybridization of a type I keratin
            intermediate filament gene (Krt-1.14) to band D of mouse chromosome
            11
  JOURNAL   Cytogenet Cell Genet 60 (3-4), 245-246 (1992)
   PUBMED   1380418
REFERENCE   8  (bases 1 to 1396)
  AUTHORS   Lussier,M., Filion,M., Compton,J.G., Nadeau,J.H., Lapointe,L. and
            Royal,A.
  TITLE     The mouse keratin 19-encoding gene: sequence, structure and
            chromosomal assignment
  JOURNAL   Gene 95 (2), 203-213 (1990)
   PUBMED   1701153
REFERENCE   9  (bases 1 to 1396)
  AUTHORS   Lussier,M., Ouellet,T., Lampron,C., Lapointe,L. and Royal,A.
  TITLE     Mouse keratin 19: complete amino acid sequence and gene expression
            during development
  JOURNAL   Gene 85 (2), 435-444 (1989)
   PUBMED   2483396
REFERENCE   10 (bases 1 to 1396)
  AUTHORS   Ichinose,Y., Hashido,K., Miyamoto,H., Nagata,T., Nozaki,M.,
            Morita,T. and Matsushiro,A.
  TITLE     Molecular cloning and characterization of cDNA encoding mouse
            cytokeratin no. 19
  JOURNAL   Gene 80 (2), 315-323 (1989)
   PUBMED   2479589
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590873.17 and AB472075.1.
            
            On Sep 16, 2015 this sequence version replaced NM_008471.2.
            
            Summary: The protein encoded by this gene is a member of the
            keratin family. The keratins are intermediate filament proteins
            responsible for the structural integrity of epithelial cells and
            are subdivided into cytokeratins and hair keratins. The type I
            cytokeratins consist of acidic proteins which are arranged in pairs
            of heterotypic keratin chains. Unlike its related family members,
            this smallest known acidic cytokeratin is not paired with a basic
            cytokeratin in epithelial cells. It is specifically expressed in
            the periderm, the transiently superficial layer that envelopes the
            developing epidermis. Two transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Sep
            2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB472075.1, BC085304.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AL590873.17        42905-42911         c
            8-1396              AB472075.1         1-1389
FEATURES             Location/Qualifiers
     source          1..1396
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.42 cM"
     gene            1..1396
                     /gene="Krt19"
                     /gene_synonym="CK-19; EndoC; K19; Krt-1.19; Krt1-19"
                     /note="keratin 19"
                     /db_xref="GeneID:16669"
                     /db_xref="MGI:MGI:96693"
     exon            1..496
                     /gene="Krt19"
                     /gene_synonym="CK-19; EndoC; K19; Krt-1.19; Krt1-19"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..1279
                     /gene="Krt19"
                     /gene_synonym="CK-19; EndoC; K19; Krt-1.19; Krt1-19"
                     /note="isoform 1 is encoded by transcript variant 1;
                     keratin, type I cytoskeletal 19; keratin complex 1,
                     acidic, gene 19; cytokeratin 19"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 19 isoform 1"
                     /protein_id="NP_032497.1"
                     /db_xref="CCDS:CCDS25411.1"
                     /db_xref="GeneID:16669"
                     /db_xref="MGI:MGI:96693"
                     /translation="MTSYSYRQTSAMSSFGGTGGGSVRIGSGGVFRAPSIHGGSGGRG
                     VSVSSTRFVTSSSGSYGGVRGGSFSGTLAVSDGLLSGNEKITMQNLNDRLASYLDKVR
                     ALEQANGELEVKIRDWYQKQGPGPSRDYNHYFKTIEDLRDKILGATIDNSKIVLQIDN
                     ARLAADDFRTKFETEHALRLSVEADINGLRRVLDELTLARTDLEMQIESLKEELAYLK
                     KNHEEEITALRSQVGGQVSVEVDSTPGVDLAKILSEMRSQYEIMAEKNRKDAEATYLA
                     RIEELNTQVAVHSEQIQISKTEVTDLRRTLQGLEIELQSQLSMKAALEGTLAETEARY
                     GVQLSQIQSVISGFEAQLSDVRADIERQNQEYKQLMDIKSRLEQEIATYRSLLEGQEA
                     HYNNLPTPKAI"
     exon            497..579
                     /gene="Krt19"
                     /gene_synonym="CK-19; EndoC; K19; Krt-1.19; Krt1-19"
                     /inference="alignment:Splign:2.1.0"
     exon            580..736
                     /gene="Krt19"
                     /gene_synonym="CK-19; EndoC; K19; Krt-1.19; Krt1-19"
                     /inference="alignment:Splign:2.1.0"
     exon            737..898
                     /gene="Krt19"
                     /gene_synonym="CK-19; EndoC; K19; Krt-1.19; Krt1-19"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1024
                     /gene="Krt19"
                     /gene_synonym="CK-19; EndoC; K19; Krt-1.19; Krt1-19"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1382
                     /gene="Krt19"
                     /gene_synonym="CK-19; EndoC; K19; Krt-1.19; Krt1-19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1357..1362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt19"
                     /gene_synonym="CK-19; EndoC; K19; Krt-1.19; Krt1-19"
                     /note="hexamer: AATAAA"
     polyA_site      1382
                     /gene="Krt19"
                     /gene_synonym="CK-19; EndoC; K19; Krt-1.19; Krt1-19"
                     /note="major polyA site"
ORIGIN      
        1 tcctcctgcg gccagcagtt ctcagacctg cgtccctttt tccttcgctc tggtctccct
       61 cctcatcatg acttcctata gctatcgcca gacctcagct atgtcttcct ttgggggtac
      121 gggcgggggt tcagtacgca ttgggtcagg gggtgttttc cgcgcaccca gcatccacgg
      181 gggctcaggt ggccgcggcg tgtccgtgtc ctccacccgc ttcgtgacct cgtcctccgg
      241 gagctatggc ggagtccgcg gtggaagttt tagtgggacc ctggctgtgt ctgatgggct
      301 gctgtctggc aatgagaaga tcaccatgca aaacctcaat gatcgtctcg cctcctactt
      361 ggacaaggtg cgcgccctag agcaggccaa tggcgagctg gaggtgaaga tccgcgactg
      421 gtaccagaag cagggacccg gaccctcccg agattacaac cactacttta agaccatcga
      481 ggacttgcgc gacaagattc ttggtgccac cattgacaac tccaagattg tcctacagat
      541 tgacaatgct cgcctggctg cagatgactt cagaaccaag tttgagacag aacacgcctt
      601 gcgtctgagc gtggaggccg acatcaacgg cctgcgccgg gtgctggatg agctgactct
      661 ggccaggact gacctggaga tgcagattga gagcctgaag gaggagctgg cctacctgaa
      721 gaagaaccat gaggaggaaa ttactgccct gaggagccag gtgggtggcc aggtcagtgt
      781 ggaggtggat tccactcccg gtgtcgacct agccaagatc ctgagtgaga tgagaagtca
      841 gtatgagatc atggccgaga agaaccggaa ggatgctgaa gccacctacc ttgctcggat
      901 tgaggagctg aacacccagg tcgccgtcca ctctgagcag atccagataa gcaagaccga
      961 agtcacggac cttcgacgga ccctccaggg ccttgagatt gagctgcagt cccagctcag
     1021 catgaaagct gccctggaag gcacgctggc agagacggag gcccgttatg gagtccagct
     1081 gtcacagatc cagagcgtga tcagcggttt tgaagcccag ctgagcgacg tgcgtgccga
     1141 catagagcgc cagaaccagg agtataagca gctcatggac atcaagtcca ggctggagca
     1201 ggagatcgcc acctaccgca gcctgctgga gggccaggaa gcccactaca acaatctgcc
     1261 cacccccaag gccatctgag ctaccagcga gactcccctg ggaaggggcc tgactggggt
     1321 gataaaagtt tactctaacc cctccctcga cttgtcaata aaactatcct ccaagggaaa
     1381 aaaaaaaaaa aaaaaa
//
