LOCUS       NM_010664               1400 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus keratin 18 (Krt18), mRNA.
ACCESSION   NM_010664
VERSION     NM_010664.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1400)
  AUTHORS   Ganjayi,M.S., Frank,S.W., Krauss,T.A., York,M.L., Bloch,R.J. and
            Baumann,C.W.
  TITLE     Skeletal muscle adaptations following eccentric contractions are
            not mediated by keratin 18
  JOURNAL   J Appl Physiol (1985) 137 (4), 903-909 (2024)
   PUBMED   39169838
  REMARK    GeneRIF: Skeletal muscle adaptations following eccentric
            contractions are not mediated by keratin 18.
REFERENCE   2  (bases 1 to 1400)
  AUTHORS   Grammer,C., Komorowska,J.A. and Swann,J.B.
  TITLE     Vhl safeguards thymic epithelial cell identity and thymopoietic
            capacity by constraining Hif1a activity during development
  JOURNAL   iScience 27 (7), 110258 (2024)
   PUBMED   39040069
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1400)
  AUTHORS   Liang,X., Qiu,X., Ma,Y., Xu,W., Chen,S., Zhang,P., Liu,M. and
            Lin,X.
  TITLE     KRT18 regulates trophoblast cell migration and invasion which are
            essential for embryo implantation
  JOURNAL   Reprod Biol Endocrinol 21 (1), 78 (2023)
   PUBMED   37620903
  REMARK    GeneRIF: KRT18 regulates trophoblast cell migration and invasion
            which are essential for embryo implantation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1400)
  AUTHORS   Tang,Y.C., Ponsin,K., Graham-Paquin,A.L., Luthold,C., Homsy,K.,
            Schindler,M., Tran,V., Cote,J.F., Bordeleau,F., Khadra,A. and
            Bouchard,M.
  TITLE     Coordination of non-professional efferocytosis and actomyosin
            contractility during epithelial tissue morphogenesis
  JOURNAL   Cell Rep 42 (3), 112202 (2023)
   PUBMED   36871220
REFERENCE   5  (bases 1 to 1400)
  AUTHORS   Feng,S., Wen,H., Liu,K., Xiong,M., Li,J., Gui,Y., Lv,C., Zhang,J.,
            Ma,X., Wang,X. and Yuan,S.
  TITLE     hnRNPH1 establishes Sertoli-germ cell crosstalk through cooperation
            with PTBP1 and AR, and is essential for male fertility in mice
  JOURNAL   Development 150 (3) (2023)
   PUBMED   36718792
REFERENCE   6  (bases 1 to 1400)
  AUTHORS   Schaart,G., Viebahn,C., Langmann,W. and Ramaekers,F.
  TITLE     Desmin and titin expression in early postimplantation mouse embryos
  JOURNAL   Development 107 (3), 585-596 (1989)
   PUBMED   2693040
REFERENCE   7  (bases 1 to 1400)
  AUTHORS   Kulesh,D.A., Cecena,G., Darmon,Y.M., Vasseur,M. and Oshima,R.G.
  TITLE     Posttranslational regulation of keratins: degradation of mouse and
            human keratins 18 and 8
  JOURNAL   Mol Cell Biol 9 (4), 1553-1565 (1989)
   PUBMED   2471065
REFERENCE   8  (bases 1 to 1400)
  AUTHORS   Ichinose,Y., Morita,T., Zhang,F.Y., Srimahasongcram,S.,
            Tondella,M.L., Matsumoto,M., Nozaki,M. and Matsushiro,A.
  TITLE     Nucleotide sequence and structure of the mouse cytokeratin endoB
            gene
  JOURNAL   Gene 70 (1), 85-95 (1988)
   PUBMED   2467843
REFERENCE   9  (bases 1 to 1400)
  AUTHORS   Oshima,R.G., Trevor,K., Shevinsky,L.H., Ryder,O.A. and Cecena,G.
  TITLE     Identification of the gene coding for the Endo B murine cytokeratin
            and its methylated, stable inactive state in mouse nonepithelial
            cells
  JOURNAL   Genes Dev 2 (5), 505-516 (1988)
   PUBMED   2454868
REFERENCE   10 (bases 1 to 1400)
  AUTHORS   Singer,P.A., Trevor,K. and Oshima,R.G.
  TITLE     Molecular cloning and characterization of the Endo B cytokeratin
            expressed in preimplantation mouse embryos
  JOURNAL   J Biol Chem 261 (2), 538-547 (1986)
   PUBMED   2416755
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CV561123.1, AK167469.1 and AW539037.2.
            
            On Jul 21, 2009 this sequence version replaced NM_010664.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M11686.1, AK167469.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                CV561123.1         4-24
            22-1395             AK167469.1         12-1385
            1396-1400           AW539037.2         1-5                 c
FEATURES             Location/Qualifiers
     source          1..1400
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.22 cM"
     gene            1..1400
                     /gene="Krt18"
                     /gene_synonym="CK18; K18; Krt1-18"
                     /note="keratin 18"
                     /db_xref="GeneID:16668"
                     /db_xref="MGI:MGI:96692"
     exon            1..459
                     /gene="Krt18"
                     /gene_synonym="CK18; K18; Krt1-18"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1335
                     /gene="Krt18"
                     /gene_synonym="CK18; K18; Krt1-18"
                     /note="cytokeratin-18; cytokeratin endo B; keratin D;
                     keratin complex 1, acidic, gene 18"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 18"
                     /protein_id="NP_034794.2"
                     /db_xref="CCDS:CCDS27869.1"
                     /db_xref="GeneID:16668"
                     /db_xref="MGI:MGI:96692"
                     /translation="MSFTTRSTTFSTNYRSLGSVRTPSQRVRPASSAASVYAGAGGSG
                     SRISVSRSVWGGSVGSAGLAGMGGIQTEKETMQDLNDRLASYLDKVKSLETENRRLES
                     KIREHLEKKGPQGVRDWGHYFKIIEDLRAQIFANSVDNARIVLQIDNARLAADDFRVK
                     YETELAMRQSVESDIHGLRKVVDDTNITRLQLETEIEALKEELLFMKKNHEEEVQGLE
                     AQIASSGLTVEVDAPKSQDLSKIMADIRAQYEALAQKNREELDKYWSQQIEESTTVVT
                     TKSAEIRDAETTLTELRRTLQTLEIDLDSMKNQNINLENSLGDVEARYKAQMEQLNGV
                     LLHLESELAQTRAEGQRQAQEYEALLNIKVKLEAEIATYRRLLEDGEDFSLNDALDSS
                     NSMQTVQKTTTRKIVDGRVVSETNDTRVLRH"
     exon            460..542
                     /gene="Krt18"
                     /gene_synonym="CK18; K18; Krt1-18"
                     /inference="alignment:Splign:2.1.0"
     exon            543..699
                     /gene="Krt18"
                     /gene_synonym="CK18; K18; Krt1-18"
                     /inference="alignment:Splign:2.1.0"
     exon            700..864
                     /gene="Krt18"
                     /gene_synonym="CK18; K18; Krt1-18"
                     /inference="alignment:Splign:2.1.0"
     exon            865..990
                     /gene="Krt18"
                     /gene_synonym="CK18; K18; Krt1-18"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1214
                     /gene="Krt18"
                     /gene_synonym="CK18; K18; Krt1-18"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1400
                     /gene="Krt18"
                     /gene_synonym="CK18; K18; Krt1-18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1373..1378
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt18"
                     /gene_synonym="CK18; K18; Krt1-18"
                     /note="hexamer: AATAAA"
     polyA_site      1396
                     /gene="Krt18"
                     /gene_synonym="CK18; K18; Krt1-18"
                     /note="major polyA site"
ORIGIN      
        1 ctgccaccct ccgcggcgga actcctgttc tggtctctcg cttcgctctc ctctccagac
       61 aagatgagct tcacaactcg ctccaccacc ttctccacca actaccggtc cctgggctct
      121 gtgcgaactc ccagccagcg ggtccggcct gccagcagcg cagccagcgt ctatgcaggt
      181 gctgggggct ccgggtcccg gatatccgtg tcccgctctg tctggggtgg ctctgtgggg
      241 tccgcaggcc tggcgggaat gggtggaatc cagaccgaga aggagaccat gcaagacctg
      301 aacgatcgcc tggccagcta cctagacaag gtgaagagcc tggaaactga gaacaggaga
      361 ctggagagca aaatccggga acatctggag aagaaggggc cccagggcgt cagagactgg
      421 ggccactact tcaagatcat cgaagacctg agggctcaga tctttgcgaa ttctgtggac
      481 aatgcccgca tcgtcttgca gatcgacaat gcccgccttg ccgccgatga ctttagagtc
      541 aagtatgaga cagaactagc catgcgccag tctgtggaga gcgacatcca tggactccgc
      601 aaggtggtag atgacaccaa catcacaagg ctgcagctgg agacagaaat cgaggcactc
      661 aaggaagaac ttctgttcat gaagaagaat catgaagagg aagtccaagg tctggaagcc
      721 cagattgcca gctctggatt gactgtggaa gtggatgccc ccaaatctca ggacctcagc
      781 aagatcatgg cggacatccg cgcccagtat gaagcgctgg ctcagaagaa ccgcgaggaa
      841 ctggacaagt actggtctca gcagattgag gagagtacca cagttgtcac caccaagtct
      901 gccgaaatca gggacgctga gaccacactc acggagctga gacgcaccct ccagaccttg
      961 gagattgact tggactccat gaaaaaccag aacatcaact tggagaacag cctcggggat
     1021 gtggaggccc gatacaaggc acagatggag cagctcaatg gggtccttct gcatctggag
     1081 tcagagctgg cacaaactcg ggcagagggc cagcgccagg cccaggaata tgaagccctc
     1141 ttgaacatca aggtgaagct tgaggcagag attgccacct accgccgctt gctggaggat
     1201 ggagaagatt tcagtctcaa cgatgccctg gactccagca actccatgca aactgtgcag
     1261 aagacaacta cccgtaagat cgtggatggc agagtggtgt ccgagactaa tgacaccaga
     1321 gttctgaggc actgaggcag agaaggaggg aacccctggg aactgaggga ccaataaaag
     1381 ttgagagctc actggacatc
//
