LOCUS       NM_010663               1579 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus keratin 17 (Krt17), mRNA.
ACCESSION   NM_010663
VERSION     NM_010663.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1579)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 1579)
  AUTHORS   Xu,L., Tan,C., Barr,J., Talaba,N., Verheyden,J., Chin,J.S.,
            Gaboyan,S., Kasaraneni,N., Elgamal,R.M., Gaulton,K.J., Lin,G.,
            Afshar,K., Golts,E., Meier,A., Crotty Alexander,L.E., Borok,Z.,
            Shen,Y., Chung,W.K., McCulley,D.J. and Sun,X.
  TITLE     Context-dependent roles of mitochondrial LONP1 in orchestrating the
            balance between airway progenitor versus progeny cells
  JOURNAL   Cell Stem Cell 31 (10), 1465-1483 (2024)
   PUBMED   39181129
REFERENCE   3  (bases 1 to 1579)
  AUTHORS   Xu,Y., Cohen,E., Johnson,C.N., Parent,C.A. and Coulombe,P.A.
  TITLE     Repeated stress to the skin amplifies neutrophil infiltration in a
            keratin 17- and PKCalpha-dependent manner
  JOURNAL   PLoS Biol 22 (8), e3002779 (2024)
   PUBMED   39159283
  REMARK    GeneRIF: Repeated stress to the skin amplifies neutrophil
            infiltration in a keratin 17- and PKCalpha-dependent manner.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1579)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 1579)
  AUTHORS   Luo,Y., Pang,B., Hao,J., Li,Q., Qiao,P., Zhang,C., Bai,Y., Xiao,C.,
            Chen,J., Zhi,D., Liu,Y., Dang,E., Wang,G. and Li,B.
  TITLE     Keratin 17 covalently binds to alpha-enolase and exacerbates
            proliferation of keratinocytes in psoriasis
  JOURNAL   Int J Biol Sci 19 (11), 3395-3411 (2023)
   PUBMED   37497003
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1579)
  AUTHORS   Sato,H., Koide,T., Sagai,T., Ishiguro,S.I., Tamai,M., Saitou,N. and
            Shiroishi,T.
  TITLE     The genomic organization of type I keratin genes in mice
  JOURNAL   Genomics 56 (3), 303-309 (1999)
   PUBMED   10087197
REFERENCE   7  (bases 1 to 1579)
  AUTHORS   Chiang,C., Swan,R.Z., Grachtchouk,M., Bolinger,M., Litingtung,Y.,
            Robertson,E.K., Cooper,M.K., Gaffield,W., Westphal,H., Beachy,P.A.
            and Dlugosz,A.A.
  TITLE     Essential role for Sonic hedgehog during hair follicle
            morphogenesis
  JOURNAL   Dev Biol 205 (1), 1-9 (1999)
   PUBMED   9882493
REFERENCE   8  (bases 1 to 1579)
  AUTHORS   McGowan,K.M. and Coulombe,P.A.
  TITLE     Onset of keratin 17 expression coincides with the definition of
            major epithelial lineages during skin development
  JOURNAL   J Cell Biol 143 (2), 469-486 (1998)
   PUBMED   9786956
REFERENCE   9  (bases 1 to 1579)
  AUTHORS   Knapp,B., Rentrop,M., Schweizer,J. and Winter,H.
  TITLE     Three cDNA sequences of mouse type I keratins. Cellular
            localization of the mRNAs in normal and hyperproliferative tissues
  JOURNAL   J Biol Chem 262 (2), 938-945 (1987)
   PUBMED   2433272
REFERENCE   10 (bases 1 to 1579)
  AUTHORS   Steinert,P.M., Rice,R.H., Roop,D.R., Trus,B.L. and Steven,A.C.
  TITLE     Complete amino acid sequence of a mouse epidermal keratin subunit
            and implications for the structure of intermediate filaments
  JOURNAL   Nature 302 (5911), 794-800 (1983)
   PUBMED   6188955
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590873.17, BC132454.1,
            EH104192.1 and EH105154.1.
            
            On Sep 16, 2015 this sequence version replaced NM_010663.2.
            
            Summary: The protein encoded by this gene is a member of the type I
            keratin gene family. The keratins are intermediate filament
            proteins responsible for the structural integrity of epithelial
            cells and are subdivided into cytokeratins and hair keratins. The
            encoded protein is a cytokeratin required for the normal growth of
            hair follicles and may act in psoriasis as an immunopathogenic
            autoantigen. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032161.2, AB013608.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AL590873.17        158010-158014       c
            6-1458              BC132454.1         1-1453
            1459-1550           EH104192.1         222-313
            1551-1579           EH105154.1         22-50               c
FEATURES             Location/Qualifiers
     source          1..1579
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.44 cM"
     gene            1..1579
                     /gene="Krt17"
                     /gene_synonym="K17; Krt1-17"
                     /note="keratin 17"
                     /db_xref="GeneID:16667"
                     /db_xref="MGI:MGI:96691"
     exon            1..496
                     /gene="Krt17"
                     /gene_synonym="K17; Krt1-17"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1366
                     /gene="Krt17"
                     /gene_synonym="K17; Krt1-17"
                     /note="CK-17; cytokeratin-17; keratin complex 1, acidic,
                     gene 17"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 17"
                     /protein_id="NP_034793.1"
                     /db_xref="CCDS:CCDS25415.1"
                     /db_xref="GeneID:16667"
                     /db_xref="MGI:MGI:96691"
                     /translation="MTTTIRQFTSSSSIKGSSGLGGGSSRTSCRLSGSLGAGSCRLGS
                     ASGLGSALGSNSYSSCYSFGTGSGYGGNFGGVDGLLAGGEKATMQNLNDRLASYLDKV
                     RALEEANTELEVKIRDWYQKQAPGPARDYSAYYHTIEDLKNKILVATVDNASILLQID
                     NARLAADDFRTKFETEQALRMSVEADINGLRRVLDELTLARADLEMQIENLKEELAYL
                     KKNHEEEMNALRGQVGGEINVEMDAAPGVDLSRILSEMRDQYEKMAEKNRKDAEDWFF
                     SKTEELNREVATNSELVQSGKSEISELRRTMQALEIELQSQLSMKASLEGSLAETENR
                     YCVQLSQIQGLIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGED
                     AHLTQYKPKEPVTTRQVRTIVEEVQDGKVISSREQVHQTTR"
     exon            497..579
                     /gene="Krt17"
                     /gene_synonym="K17; Krt1-17"
                     /inference="alignment:Splign:2.1.0"
     exon            580..736
                     /gene="Krt17"
                     /gene_synonym="K17; Krt1-17"
                     /inference="alignment:Splign:2.1.0"
     exon            737..898
                     /gene="Krt17"
                     /gene_synonym="K17; Krt1-17"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1024
                     /gene="Krt17"
                     /gene_synonym="K17; Krt1-17"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1245
                     /gene="Krt17"
                     /gene_synonym="K17; Krt1-17"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1271
                     /gene="Krt17"
                     /gene_synonym="K17; Krt1-17"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1553
                     /gene="Krt17"
                     /gene_synonym="K17; Krt1-17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1480..1485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt17"
                     /gene_synonym="K17; Krt1-17"
                     /note="hexamer: ATTAAA"
     polyA_site      1500
                     /gene="Krt17"
                     /gene_synonym="K17; Krt1-17"
                     /note="major polyA site"
     regulatory      1531..1536
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt17"
                     /gene_synonym="K17; Krt1-17"
                     /note="hexamer: AATAAA"
     polyA_site      1553
                     /gene="Krt17"
                     /gene_synonym="K17; Krt1-17"
ORIGIN      
        1 acgcatcttg gcgcctctct tcctcccaag ccctccagct ccacatccgt tgcccgctgc
       61 caccatgacc accaccatcc gccagtttac ctcctccagc tctatcaagg gctcctctgg
      121 cctgggtgga ggttcatctc ggacctcctg ccgactgtct ggcagcctgg gtgcaggctc
      181 ctgcaggctg gggtcagcta gtggcctggg tagtgctctt gggagcaaca gttattccag
      241 ctgctacagc tttggcactg gcagtggtta tggaggcaac tttgggggtg tcgatgggct
      301 gctggctgga ggggagaagg ccaccatgca gaacctcaat gaccgcctgg cctcctacct
      361 ggacaaggtg cgtgccctgg aagaggccaa cactgagctg gaggtgaaga tccgagattg
      421 gtaccagaag caggccccgg ggccagccag agactacagc gcttattacc ataccattga
      481 ggatctgaag aacaagatcc ttgtggccac cgtggacaat gccagcatcc tgctccagat
      541 tgacaatgct cgtctggcag ccgatgactt ccgtaccaag tttgagacag agcaggctct
      601 gcgcatgagc gtggaggccg acatcaatgg cctgcgccgg gtgctggatg agctgaccct
      661 ggccagagcc gacctggaga tgcagattga gaatctcaag gaggagctgg cctacctgaa
      721 gaagaaccac gaggaggaga tgaatgctct gagaggccag gtgggcggcg aaatcaacgt
      781 ggagatggat gccgctcccg gtgtggacct gagccgcatc ctgtcagaga tgcgtgatca
      841 gtacgagaag atggcggaga agaaccgcaa ggatgccgaa gactggttct tcagcaagac
      901 cgaggagctg aaccgcgagg tggccaccaa cagcgagctg gtgcagagcg gcaagagcga
      961 gatctccgag ctcaggcgca ccatgcaggc cctggagatt gagctgcagt cccagctcag
     1021 catgaaagca tctctggagg gcagcctggc agagacagag aaccgctact gcgtgcagct
     1081 gtctcagatc caggggctga tcggcagtgt ggaggagcag ctggctcagc tgcgctgcga
     1141 gatggagcag cagaaccagg agtacaagat cctgctggat gtgaagacaa ggctggagca
     1201 ggagatcgcc acctaccgcc gtctgctgga gggagaggat gcccacctga ctcagtacaa
     1261 gccaaaagaa cctgtgacca cccgccaggt gcgcaccatt gtggaagaag ttcaggatgg
     1321 caaggtcatc tcatcccggg aacaggtgca ccagaccacc cgttaaggac tcagctcctt
     1381 ccgcccagtt ccccgaggct gcagagaggc agcttccctc tccgctccgg catcaccctc
     1441 ctgctacagc ctctccccag cattcctatg cttgagacca ttaaagcttg ctgacctgaa
     1501 gtgaactgtg gcctttgttc tgaacactga aataaatgac catggtgaca ataaaaaaaa
     1561 aaaaaaaaaa aaaaaaaaa
//
