LOCUS       NM_008469               1720 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus keratin 15 (Krt15), mRNA.
ACCESSION   NM_008469
VERSION     NM_008469.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1720)
  AUTHORS   Hu,A., Pickup,M.E., Lawal,M.A., Patel,H.J. and Ahmed,M.I.
  TITLE     The involvement of Elf5 in regulating keratinocyte proliferation
            and differentiation processes in skin
  JOURNAL   PLoS One 20 (1), e0316134 (2025)
   PUBMED   39752333
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1720)
  AUTHORS   Ghotbi,E., Tchegnon,E., Chen,Z., Li,S., Shipman,T., Wang,Y.,
            Raman,J., Zhang,Y., McKay,R.M., Liao,C.P. and Le,L.Q.
  TITLE     Transcription factor KROX20 marks epithelial stem cell ancestors
            for hair follicle formation
  JOURNAL   J Clin Invest 134 (23), e180160 (2024)
   PUBMED   39361422
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1720)
  AUTHORS   Olczak,A., Pieczonka,T.D., Lawicki,S., Lukaszyk,K.,
            Pulawska-Czub,A., Cambier,L. and Kobielak,K.
  TITLE     The overexpression of R-spondin 3 affects hair morphogenesis and
            hair development along with the formation and maturation of the
            hair follicle stem cells
  JOURNAL   Front Physiol 15, 1424077 (2024)
   PUBMED   39351282
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1720)
  AUTHORS   Zhu,W., Han,L., Wu,Y., Tong,L., He,L., Wang,Q., Yan,Y., Pan,T.,
            Shen,J., Song,Y., Shen,Y., Zhu,Q. and Zhou,J.
  TITLE     Keratin 15 protects against cigarette smoke-induced epithelial
            mesenchymal transformation by MMP-9
  JOURNAL   Respir Res 24 (1), 297 (2023)
   PUBMED   38007424
  REMARK    GeneRIF: Keratin 15 protects against cigarette smoke-induced
            epithelial mesenchymal transformation by MMP-9.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1720)
  AUTHORS   Ievlev,V., Lynch,T.J., Freischlag,K.W., Gries,C.B., Shah,A.,
            Pai,A.C., Ahlers,B.A., Park,S., Engelhardt,J.F. and Parekh,K.R.
  TITLE     Krt14 and Krt15 differentially regulate regenerative properties and
            differentiation potential of airway basal cells
  JOURNAL   JCI Insight 8 (2), e162041 (2023)
   PUBMED   36512409
  REMARK    GeneRIF: Krt14 and Krt15 differentially regulate regenerative
            properties and differentiation potential of airway basal cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1720)
  AUTHORS   Talbot,D., Loring,J. and Schorle,H.
  TITLE     Spatiotemporal expression pattern of keratins in skin of
            AP-2alpha-deficient mice
  JOURNAL   J Invest Dermatol 113 (5), 816-820 (1999)
   PUBMED   10571739
  REMARK    Erratum:[J Invest Dermatol 2000 Mar;114(3):609. Lorgin J [corrected
            to Loring J]]
REFERENCE   7  (bases 1 to 1720)
  AUTHORS   Sato,H., Koide,T., Sagai,T., Ishiguro,S.I., Tamai,M., Saitou,N. and
            Shiroishi,T.
  TITLE     The genomic organization of type I keratin genes in mice
  JOURNAL   Genomics 56 (3), 303-309 (1999)
   PUBMED   10087197
REFERENCE   8  (bases 1 to 1720)
  AUTHORS   Lloyd,C., Yu,Q.C., Cheng,J., Turksen,K., Degenstein,L., Hutton,E.
            and Fuchs,E.
  TITLE     The basal keratin network of stratified squamous epithelia:
            defining K15 function in the absence of K14
  JOURNAL   J Cell Biol 129 (5), 1329-1344 (1995)
   PUBMED   7539810
REFERENCE   9  (bases 1 to 1720)
  AUTHORS   Filion,M., Sarafian,V., Lussier,M., Belanger,C., Lapointe,L. and
            Royal,A.
  TITLE     Arrangement of a cluster of three mouse type I keratin genes
            expressed sequentially during esophageal-type epithelial cell
            differentiation
  JOURNAL   Genomics 24 (2), 303-310 (1994)
   PUBMED   7535287
REFERENCE   10 (bases 1 to 1720)
  AUTHORS   Nozaki,M., Mori,M. and Matsushiro,A.
  TITLE     The complete sequence of the gene encoding mouse cytokeratin 15
  JOURNAL   Gene 138 (1-2), 197-200 (1994)
   PUBMED   7510260
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY107287.1, BY061070.1, CN456368.1, CA451823.1 and BY436080.1.
            
            On Apr 15, 2009 this sequence version replaced NM_008469.1.
            
            CCDS Note: The coding region has been updated to represent an
            alternative terminal exon splice site that is more supported by the
            available transcript and protein data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057934.1, SRR5189673.134426.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-336               BY107287.1         2-337
            337-365             BY061070.1         338-366
            366-1109            CN456368.1         1-744
            1110-1711           CA451823.1         117-718
            1712-1720           BY436080.1         399-407
FEATURES             Location/Qualifiers
     source          1..1720
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.41 cM"
     gene            1..1720
                     /gene="Krt15"
                     /gene_synonym="K15; Krt1-15"
                     /note="keratin 15"
                     /db_xref="GeneID:16665"
                     /db_xref="MGI:MGI:96689"
     exon            1..568
                     /gene="Krt15"
                     /gene_synonym="K15; Krt1-15"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1462
                     /gene="Krt15"
                     /gene_synonym="K15; Krt1-15"
                     /note="CK-15; cytokeratin-15; keratin complex 1, acidic,
                     gene 15"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 15"
                     /protein_id="NP_032495.2"
                     /db_xref="CCDS:CCDS25410.2"
                     /db_xref="GeneID:16665"
                     /db_xref="MGI:MGI:96689"
                     /translation="MATTFLQTSSTFGGSSTRGASLRAGGGSFGGGSLYGGGGSRSIS
                     ASSARFVSSGAGGGFGGGMSCGFGGGFGGGFGGGFGGGFGDFGGGDGGLLSGNEKVTM
                     QNLNDRLASYLDKVRALEQANTELEVKIRDWYQKQSPASPDRDYSHYFKTMEEIRDKI
                     LAATIDNSRVVLEIDNARLAADDFRLKYENELTLRQGVEADINGLRRVLDELTLARTD
                     LEMQIEQLNEELAYLKKNHEEEMKEFSSQLAGQVNVEMDAAPGVDLTRMLAEMREQYE
                     AIAEKNRRDVEAWFFSKTEELNKEVASNTEMIQTSKTEITDLRRTLQGLEIELQSQLS
                     MKAGLENSLAEVECRYATQLQQIQGVITGLETQLSELRCEMEAQNQEYNMLLDIKTRL
                     EQEIATYRNLLEGQDAKMAGIGVREVSLGGSSGGGGSSSSSSNFHISVEESVDGKVVS
                     SRKREI"
     exon            569..651
                     /gene="Krt15"
                     /gene_synonym="K15; Krt1-15"
                     /inference="alignment:Splign:2.1.0"
     exon            652..808
                     /gene="Krt15"
                     /gene_synonym="K15; Krt1-15"
                     /inference="alignment:Splign:2.1.0"
     exon            809..970
                     /gene="Krt15"
                     /gene_synonym="K15; Krt1-15"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1096
                     /gene="Krt15"
                     /gene_synonym="K15; Krt1-15"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1317
                     /gene="Krt15"
                     /gene_synonym="K15; Krt1-15"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1343
                     /gene="Krt15"
                     /gene_synonym="K15; Krt1-15"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1720
                     /gene="Krt15"
                     /gene_synonym="K15; Krt1-15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1688..1693
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt15"
                     /gene_synonym="K15; Krt1-15"
                     /note="hexamer: AATAAA"
     polyA_site      1720
                     /gene="Krt15"
                     /gene_synonym="K15; Krt1-15"
                     /note="major polyA site"
ORIGIN      
        1 aggcactgca ggctgctttc agtccagctc agacactctt gctagagtct ctcctgcttg
       61 ctagggacag gaaggcacag gctgcctgac catggccacc acattcttgc aaacgtcttc
      121 cacttttgga ggcagctcta cccgaggggc ttccctccgt gctgggggag gcagctttgg
      181 tggagggagt ctctatgggg gaggtggaag ccgaagtatc tctgcttctt ctgctaggtt
      241 tgtctcctcg ggggcaggag ggggctttgg gggtggcatg agttgtggct ttggtggtgg
      301 ttttggtgga ggctttggtg ggggttttgg cggtggcttc ggtgattttg gtggtggcga
      361 tggaggtctc ctctctggca atgagaaggt gaccatgcag aaccttaatg accgcctggc
      421 ctcctacctg gacaaggtgc gtgccctaga gcaggccaac actgagctgg aggtgaagat
      481 ccgagattgg taccagaagc agagcccagc cagtccagat cgggactaca gccattactt
      541 taagaccatg gaagagatcc gggacaaaat tctggctgcc accattgaca actcgcgcgt
      601 tgtcctggag attgacaatg ccaggctggc ggcggacgac ttcaggctca agtatgagaa
      661 tgagctgacc ctgcgtcagg gcgtggaggc cgacatcaac gggctgcgcc gggtgctgga
      721 tgagctgacc ctggccagga ccgacctgga gatgcagatt gagcagctga acgaggagct
      781 ggcttacctg aagaagaacc atgaggagga gatgaaggaa ttcagcagtc aactggctgg
      841 ccaggtcaat gtggaaatgg acgcagcacc cggggtggac ctgacccgca tgctggcaga
      901 gatgagggag cagtatgaag ctattgcaga gaaaaaccgt cgggatgtag aggcctggtt
      961 cttcagtaag actgaagagc tgaacaagga ggtggcgtct aacacagaaa tgatccagac
     1021 cagcaagacg gagatcacag acctgagacg gaccctgcag gggctagaga ttgagttgca
     1081 gtctcagctc agcatgaaag ccgggctgga gaactctctg gcagaggtgg agtgccgcta
     1141 tgccacacag ctgcagcaga tccagggggt cattaccggt ctggagactc agctgagtga
     1201 gctccgctgt gagatggagg ctcagaacca ggagtacaac atgctgctgg acatcaagac
     1261 tcggctggaa caggagatcg ccacttaccg gaacctgctc gagggccagg atgctaagat
     1321 ggctggtatt ggtgtcagag aagtatccct gggaggaagc agcggtggcg gtggcagcag
     1381 tagcagcagc agcaatttcc atatcagtgt ggaggaatca gtggatggaa aagtggtttc
     1441 ttcccgtaag agagaaatct aagtgtctgg tgcaggagag aacaaccttg ccttcccctg
     1501 ctctccctgg gctgagagag gcactggaca tagaggctgg gaaaacaggc tccagtccgt
     1561 gccttagagg atctctctgc tttccagttt gtggttctgc atgctcttcc tattgtagct
     1621 ttctcggctt ccttctgagt gtagcggtgt aggaagcaat agatctttgt atggcggctg
     1681 ttccttcaat aaagaatcat gtttcttttt acaaatgcca
//
