LOCUS       NM_016958               1675 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus keratin 14 (Krt14), transcript variant 1, mRNA.
ACCESSION   NM_016958
VERSION     NM_016958.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1675)
  AUTHORS   Hu,A., Pickup,M.E., Lawal,M.A., Patel,H.J. and Ahmed,M.I.
  TITLE     The involvement of Elf5 in regulating keratinocyte proliferation
            and differentiation processes in skin
  JOURNAL   PLoS One 20 (1), e0316134 (2025)
   PUBMED   39752333
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1675)
  AUTHORS   Liu,S., Li,Y., Huang,D., Liu,M., Zhang,X., Zhao,H., Liu,H., Li,Q.
            and Chen,Z.
  TITLE     Single-Cell RNA-Seq and Histological Analysis Reveals Dynamic Lrig1
            Expression During Salivary Gland Development
  JOURNAL   J Cell Physiol 240 (1), e31487 (2025)
   PUBMED   39587709
REFERENCE   3  (bases 1 to 1675)
  AUTHORS   Ghotbi,E., Tchegnon,E., Chen,Z., Li,S., Shipman,T., Wang,Y.,
            Raman,J., Zhang,Y., McKay,R.M., Liao,C.P. and Le,L.Q.
  TITLE     Transcription factor KROX20 marks epithelial stem cell ancestors
            for hair follicle formation
  JOURNAL   J Clin Invest 134 (23), e180160 (2024)
   PUBMED   39361422
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1675)
  AUTHORS   Olczak,A., Pieczonka,T.D., Lawicki,S., Lukaszyk,K.,
            Pulawska-Czub,A., Cambier,L. and Kobielak,K.
  TITLE     The overexpression of R-spondin 3 affects hair morphogenesis and
            hair development along with the formation and maturation of the
            hair follicle stem cells
  JOURNAL   Front Physiol 15, 1424077 (2024)
   PUBMED   39351282
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1675)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4.. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1675)
  AUTHORS   Gimenez-Conti,I.B., Lynch,M., Roop,D., Bhowmik,S., Majeski,P. and
            Conti,C.J.
  TITLE     Expression of keratins in mouse vaginal epithelium
  JOURNAL   Differentiation 56 (3), 143-151 (1994)
   PUBMED   7518402
REFERENCE   7  (bases 1 to 1675)
  AUTHORS   Bonifas,J.M., Bare,J.W., Lynch,E.D., Lebo,R.V. and Epstein,E.H. Jr.
  TITLE     Regional assignment of the human keratin 5 (KRT5) gene to
            chromosome 12q near D12S14 by PCR analysis of somatic cell hybrids
            and multicolor in situ hybridization
  JOURNAL   Genomics 13 (2), 452-454 (1992)
   PUBMED   1377166
REFERENCE   8  (bases 1 to 1675)
  AUTHORS   Correll,A.T., Webb,G.C., Ford,J.H., Rogers,G.E. and Powell,B.C.
  TITLE     Localization by in situ hybridization of a type I keratin
            intermediate filament gene (Krt-1.14) to band D of mouse chromosome
            11
  JOURNAL   Cytogenet Cell Genet 60 (3-4), 245-246 (1992)
   PUBMED   1380418
REFERENCE   9  (bases 1 to 1675)
  AUTHORS   Stoler,A., Kopan,R., Duvic,M. and Fuchs,E.
  TITLE     Use of monospecific antisera and cRNA probes to localize the major
            changes in keratin expression during normal and abnormal epidermal
            differentiation
  JOURNAL   J Cell Biol 107 (2), 427-446 (1988)
   PUBMED   2458356
REFERENCE   10 (bases 1 to 1675)
  AUTHORS   Knapp,B., Rentrop,M., Schweizer,J. and Winter,H.
  TITLE     Three cDNA sequences of mouse type I keratins. Cellular
            localization of the mRNAs in normal and hyperproliferative tissues
  JOURNAL   J Biol Chem 262 (2), 938-945 (1987)
   PUBMED   2433272
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590873.17, AA760592.1,
            AA499338.1, AA562488.1, AI893364.1 and AA612291.1.
            
            On Sep 15, 2015 this sequence version replaced NM_016958.1.
            
            Summary: This gene encodes a member of the keratin family, the most
            diverse group of intermediate filaments. This gene product, a type
            I keratin, is usually found as a heterotetramer with two keratin 5
            molecules, a type II keratin. Together they form the cytoskeleton
            of epithelial cells. Three transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Sep
            2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011074.1, SRR13948564.3773758.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-404               AL590873.17        104092-104495       c
            405-933             AA760592.1         1-529
            934-1021            AA499338.1         216-303
            1022-1269           AA562488.1         187-434
            1270-1591           AI893364.1         189-510
            1592-1675           AA612291.1         1-84                c
FEATURES             Location/Qualifiers
     source          1..1675
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.43 cM"
     gene            1..1675
                     /gene="Krt14"
                     /gene_synonym="CK-14; K14; Krt-1.14; Krt1-14"
                     /note="keratin 14"
                     /db_xref="GeneID:16664"
                     /db_xref="MGI:MGI:96688"
     exon            1..598
                     /gene="Krt14"
                     /gene_synonym="CK-14; K14; Krt-1.14; Krt1-14"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..1510
                     /gene="Krt14"
                     /gene_synonym="CK-14; K14; Krt-1.14; Krt1-14"
                     /note="isoform 1 is encoded by transcript variant 1;
                     keratin, type I cytoskeletal 14; cytokeratin 14; keratin
                     complex 1, acidic, gene 14"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 14 isoform 1"
                     /protein_id="NP_058654.1"
                     /db_xref="CCDS:CCDS25413.1"
                     /db_xref="GeneID:16664"
                     /db_xref="MGI:MGI:96688"
                     /translation="MATCSRQFTSSSSMKGSCGIGGGSSRMSSILAGGSCRAPSTYGG
                     MSVTSSRFSSGGACGIGGGYGGSFSSSSFGGGLGSGFGGRFDGFGGGFGGGLGGGFGG
                     GLGGGLGGGIGDGLLVGSEKVTMQNLNDRLATYLDKVRALEEANTELEVKIRDWYQRQ
                     RPTEIKDYSPYFKTIEDLKSKILAATVDNANVLLQIDNARLAADDFRTKFETEQSLRM
                     SVEADINGLRRVLDELTLARADLEMQIESLKEELAYLKKNHEEEMASMRGQVGGDVNV
                     EMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEEWFFSKTEELNREVATNSELVQSGK
                     SEISELRRTMQNLEIELQSQLSMKASLENNLEETKGRYCMQLAQIQEMIGSVEEQLAQ
                     LRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLSSSQFSSSSQFSSGSQSS
                     RDVTSTNRQIRTKVMDVHDGKVVSTHEQVLRTKN"
     exon            599..681
                     /gene="Krt14"
                     /gene_synonym="CK-14; K14; Krt-1.14; Krt1-14"
                     /inference="alignment:Splign:2.1.0"
     exon            682..838
                     /gene="Krt14"
                     /gene_synonym="CK-14; K14; Krt-1.14; Krt1-14"
                     /inference="alignment:Splign:2.1.0"
     exon            839..1000
                     /gene="Krt14"
                     /gene_synonym="CK-14; K14; Krt-1.14; Krt1-14"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1126
                     /gene="Krt14"
                     /gene_synonym="CK-14; K14; Krt-1.14; Krt1-14"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1347
                     /gene="Krt14"
                     /gene_synonym="CK-14; K14; Krt-1.14; Krt1-14"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1412
                     /gene="Krt14"
                     /gene_synonym="CK-14; K14; Krt-1.14; Krt1-14"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1660
                     /gene="Krt14"
                     /gene_synonym="CK-14; K14; Krt-1.14; Krt1-14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1632..1637
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt14"
                     /gene_synonym="CK-14; K14; Krt-1.14; Krt1-14"
                     /note="hexamer: AATAAA"
     polyA_site      1660
                     /gene="Krt14"
                     /gene_synonym="CK-14; K14; Krt-1.14; Krt1-14"
                     /note="major polyA site"
ORIGIN      
        1 gctctctctt ctctctgccg actcactcgc tcacttgctc acctctctca aagccatggc
       61 cacctgcagc cgccagttca cctcctccag ctccatgaag ggctcttgtg gtatcggtgg
      121 tggctctagc cgcatgtcct ccatcctggc tggaggatcc tgccgggctc ccagcaccta
      181 cgggggcatg tcggttacct cctctcgctt ctcctctggg ggagcctgtg ggattggagg
      241 tggctatggt gggagcttca gcagcagcag ttttggtgga ggacttggta gtggatttgg
      301 tggtcgattt gatggatttg gtggtggttt tggtggtggt cttggtggtg gttttggtgg
      361 tggtcttggt ggtggtcttg gcggtggtat tggtgatggg ctcctggtgg gcagtgagaa
      421 agtgaccatg cagaacctca atgaccgcct ggccacctac ctggacaagg tgcgtgccct
      481 ggaagaggcc aacactgaac tggaggtgaa gattcgggac tggtaccaga ggcagcggcc
      541 cactgagatc aaagactaca gcccctactt caagaccatc gaggacctga agagcaagat
      601 cctggcagcc accgtggaca atgccaatgt cctcctgcag atcgacaatg cccgcctggc
      661 tgccgatgac ttccggacca agtttgagac ggagcagagc ctgcgcatga gcgtggaggc
      721 cgacatcaat ggcctgcgca gggtgctgga tgagctgacc ctggccagag ccgacctgga
      781 gatgcagatt gagagcctca aggaggagct ggcctacctg aagaagaacc acgaggagga
      841 aatggcctcc atgagaggcc aggtgggtgg agacgtcaat gtggagatgg acgccgcccc
      901 tggtgtggac ctgagccgca tcctgaacga gatgcgggat cagtacgaga agatggcgga
      961 gaagaaccgc aaggatgctg aggaatggtt cttcagcaag acagaggagc tgaaccgcga
     1021 ggtggccacc aacagcgagc tggtgcagag cggcaagagt gagatttctg agctccggcg
     1081 caccatgcag aacctggaga tcgagctgca gtcccagctc agcatgaaag catccctgga
     1141 gaataacctg gaggagacca aaggccgtta ctgcatgcag ctggcccaga tccaggagat
     1201 gatcggcagt gtggaggagc agctggctca gctgcgctgc gagatggagc agcagaacca
     1261 ggagtacaaa atcctgctgg atgtgaagac aaggctggag caggagatcg ccacctaccg
     1321 ccgtctgctg gagggagagg acgcccacct ttcatcttcc caattctcct catcctctca
     1381 attctcctct ggctctcagt catccagaga tgtgacctcc accaaccgcc agatccgcac
     1441 caaggtcatg gatgtgcacg atggcaaggt ggtctccacc cacgagcagg tcctgcgcac
     1501 caagaactaa agctgctaca tgctgctcag gcttaggagg ctcctgcgtg gacgcagata
     1561 ctgctggaag agcccctgta ttgtccctat aggcttcact ctttacttga cccttgtcct
     1621 tcctggcaag caataaagct tctttttctg agttgcacaa aaaaaaaaaa aaaaa
//
