LOCUS       NM_001313957            1137 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus keratin 14 (Krt14), transcript variant 3, mRNA.
ACCESSION   NM_001313957 XM_006532330
VERSION     NM_001313957.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1137)
  AUTHORS   Hu,A., Pickup,M.E., Lawal,M.A., Patel,H.J. and Ahmed,M.I.
  TITLE     The involvement of Elf5 in regulating keratinocyte proliferation
            and differentiation processes in skin
  JOURNAL   PLoS One 20 (1), e0316134 (2025)
   PUBMED   39752333
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1137)
  AUTHORS   Liu,S., Li,Y., Huang,D., Liu,M., Zhang,X., Zhao,H., Liu,H., Li,Q.
            and Chen,Z.
  TITLE     Single-Cell RNA-Seq and Histological Analysis Reveals Dynamic Lrig1
            Expression During Salivary Gland Development
  JOURNAL   J Cell Physiol 240 (1), e31487 (2025)
   PUBMED   39587709
REFERENCE   3  (bases 1 to 1137)
  AUTHORS   Ghotbi,E., Tchegnon,E., Chen,Z., Li,S., Shipman,T., Wang,Y.,
            Raman,J., Zhang,Y., McKay,R.M., Liao,C.P. and Le,L.Q.
  TITLE     Transcription factor KROX20 marks epithelial stem cell ancestors
            for hair follicle formation
  JOURNAL   J Clin Invest 134 (23), e180160 (2024)
   PUBMED   39361422
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1137)
  AUTHORS   Olczak,A., Pieczonka,T.D., Lawicki,S., Lukaszyk,K.,
            Pulawska-Czub,A., Cambier,L. and Kobielak,K.
  TITLE     The overexpression of R-spondin 3 affects hair morphogenesis and
            hair development along with the formation and maturation of the
            hair follicle stem cells
  JOURNAL   Front Physiol 15, 1424077 (2024)
   PUBMED   39351282
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1137)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4.. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1137)
  AUTHORS   Gimenez-Conti,I.B., Lynch,M., Roop,D., Bhowmik,S., Majeski,P. and
            Conti,C.J.
  TITLE     Expression of keratins in mouse vaginal epithelium
  JOURNAL   Differentiation 56 (3), 143-151 (1994)
   PUBMED   7518402
REFERENCE   7  (bases 1 to 1137)
  AUTHORS   Bonifas,J.M., Bare,J.W., Lynch,E.D., Lebo,R.V. and Epstein,E.H. Jr.
  TITLE     Regional assignment of the human keratin 5 (KRT5) gene to
            chromosome 12q near D12S14 by PCR analysis of somatic cell hybrids
            and multicolor in situ hybridization
  JOURNAL   Genomics 13 (2), 452-454 (1992)
   PUBMED   1377166
REFERENCE   8  (bases 1 to 1137)
  AUTHORS   Correll,A.T., Webb,G.C., Ford,J.H., Rogers,G.E. and Powell,B.C.
  TITLE     Localization by in situ hybridization of a type I keratin
            intermediate filament gene (Krt-1.14) to band D of mouse chromosome
            11
  JOURNAL   Cytogenet Cell Genet 60 (3-4), 245-246 (1992)
   PUBMED   1380418
REFERENCE   9  (bases 1 to 1137)
  AUTHORS   Stoler,A., Kopan,R., Duvic,M. and Fuchs,E.
  TITLE     Use of monospecific antisera and cRNA probes to localize the major
            changes in keratin expression during normal and abnormal epidermal
            differentiation
  JOURNAL   J Cell Biol 107 (2), 427-446 (1988)
   PUBMED   2458356
REFERENCE   10 (bases 1 to 1137)
  AUTHORS   Knapp,B., Rentrop,M., Schweizer,J. and Winter,H.
  TITLE     Three cDNA sequences of mouse type I keratins. Cellular
            localization of the mRNAs in normal and hyperproliferative tissues
  JOURNAL   J Biol Chem 262 (2), 938-945 (1987)
   PUBMED   2433272
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590873.17, AA760592.1,
            AA499338.1, AA562488.1, AI893364.1 and AA612291.1.
            
            On Sep 15, 2015 this sequence version replaced XM_006532330.2.
            
            Summary: This gene encodes a member of the keratin family, the most
            diverse group of intermediate filaments. This gene product, a type
            I keratin, is usually found as a heterotetramer with two keratin 5
            molecules, a type II keratin. Together they form the cytoskeleton
            of epithelial cells. Three transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Sep
            2015].
            
            Transcript Variant: This variant (3) uses an alternate first exon
            in place of that of variant 1. This difference causes translation
            initiation at a downstream AUG and results in an isoform (3) with a
            shorter N-terminus compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003325.1, SRR17253011.10572074.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AL590873.17        102956-103015       c
            61-395              AA760592.1         195-529
            396-483             AA499338.1         216-303
            484-731             AA562488.1         187-434
            732-1053            AI893364.1         189-510
            1054-1137           AA612291.1         1-84                c
FEATURES             Location/Qualifiers
     source          1..1137
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.43 cM"
     gene            1..1137
                     /gene="Krt14"
                     /gene_synonym="CK-14; K14; Krt-1.14; Krt1-14"
                     /note="keratin 14"
                     /db_xref="GeneID:16664"
                     /db_xref="MGI:MGI:96688"
     exon            1..60
                     /gene="Krt14"
                     /gene_synonym="CK-14; K14; Krt-1.14; Krt1-14"
                     /inference="alignment:Splign:2.1.0"
     exon            61..143
                     /gene="Krt14"
                     /gene_synonym="CK-14; K14; Krt-1.14; Krt1-14"
                     /inference="alignment:Splign:2.1.0"
     exon            144..300
                     /gene="Krt14"
                     /gene_synonym="CK-14; K14; Krt-1.14; Krt1-14"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..972
                     /gene="Krt14"
                     /gene_synonym="CK-14; K14; Krt-1.14; Krt1-14"
                     /note="isoform 3 is encoded by transcript variant 3;
                     keratin, type I cytoskeletal 14; cytokeratin 14; keratin
                     complex 1, acidic, gene 14"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 14 isoform 3"
                     /protein_id="NP_001300886.1"
                     /db_xref="GeneID:16664"
                     /db_xref="MGI:MGI:96688"
                     /translation="MSVEADINGLRRVLDELTLARADLEMQIESLKEELAYLKKNHEE
                     EMASMRGQVGGDVNVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEEWFFSKTEEL
                     NREVATNSELVQSGKSEISELRRTMQNLEIELQSQLSMKASLENNLEETKGRYCMQLA
                     QIQEMIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLSSS
                     QFSSSSQFSSGSQSSRDVTSTNRQIRTKVMDVHDGKVVSTHEQVLRTKN"
     exon            301..462
                     /gene="Krt14"
                     /gene_synonym="CK-14; K14; Krt-1.14; Krt1-14"
                     /inference="alignment:Splign:2.1.0"
     exon            463..588
                     /gene="Krt14"
                     /gene_synonym="CK-14; K14; Krt-1.14; Krt1-14"
                     /inference="alignment:Splign:2.1.0"
     exon            589..809
                     /gene="Krt14"
                     /gene_synonym="CK-14; K14; Krt-1.14; Krt1-14"
                     /inference="alignment:Splign:2.1.0"
     exon            810..874
                     /gene="Krt14"
                     /gene_synonym="CK-14; K14; Krt-1.14; Krt1-14"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1122
                     /gene="Krt14"
                     /gene_synonym="CK-14; K14; Krt-1.14; Krt1-14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1094..1099
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt14"
                     /gene_synonym="CK-14; K14; Krt-1.14; Krt1-14"
                     /note="hexamer: AATAAA"
     polyA_site      1122
                     /gene="Krt14"
                     /gene_synonym="CK-14; K14; Krt-1.14; Krt1-14"
                     /note="major polyA site"
ORIGIN      
        1 aagctatgta gggattctta gggggacatt aaaatgccaa gccccatttt aggattatag
       61 atcctggcag ccaccgtgga caatgccaat gtcctcctgc agatcgacaa tgcccgcctg
      121 gctgccgatg acttccggac caagtttgag acggagcaga gcctgcgcat gagcgtggag
      181 gccgacatca atggcctgcg cagggtgctg gatgagctga ccctggccag agccgacctg
      241 gagatgcaga ttgagagcct caaggaggag ctggcctacc tgaagaagaa ccacgaggag
      301 gaaatggcct ccatgagagg ccaggtgggt ggagacgtca atgtggagat ggacgccgcc
      361 cctggtgtgg acctgagccg catcctgaac gagatgcggg atcagtacga gaagatggcg
      421 gagaagaacc gcaaggatgc tgaggaatgg ttcttcagca agacagagga gctgaaccgc
      481 gaggtggcca ccaacagcga gctggtgcag agcggcaaga gtgagatttc tgagctccgg
      541 cgcaccatgc agaacctgga gatcgagctg cagtcccagc tcagcatgaa agcatccctg
      601 gagaataacc tggaggagac caaaggccgt tactgcatgc agctggccca gatccaggag
      661 atgatcggca gtgtggagga gcagctggct cagctgcgct gcgagatgga gcagcagaac
      721 caggagtaca aaatcctgct ggatgtgaag acaaggctgg agcaggagat cgccacctac
      781 cgccgtctgc tggagggaga ggacgcccac ctttcatctt cccaattctc ctcatcctct
      841 caattctcct ctggctctca gtcatccaga gatgtgacct ccaccaaccg ccagatccgc
      901 accaaggtca tggatgtgca cgatggcaag gtggtctcca cccacgagca ggtcctgcgc
      961 accaagaact aaagctgcta catgctgctc aggcttagga ggctcctgcg tggacgcaga
     1021 tactgctgga agagcccctg tattgtccct ataggcttca ctctttactt gacccttgtc
     1081 cttcctggca agcaataaag cttctttttc tgagttgcac aaaaaaaaaa aaaaaaa
//
