LOCUS       NM_010662               1674 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus keratin 13 (Krt13), transcript variant 1, mRNA.
ACCESSION   NM_010662
VERSION     NM_010662.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1674)
  AUTHORS   Xu,L., Tan,C., Barr,J., Talaba,N., Verheyden,J., Chin,J.S.,
            Gaboyan,S., Kasaraneni,N., Elgamal,R.M., Gaulton,K.J., Lin,G.,
            Afshar,K., Golts,E., Meier,A., Alexander,L.E.C., Borok,Z., Shen,Y.,
            Chung,W.K., McCulley,D.J. and Sun,X.
  TITLE     Context-dependent roles of mitochondrial LONP1 in orchestrating the
            balance between airway progenitor versus progeny cells
  JOURNAL   Cell Stem Cell 31 (10), 1465-1483 (2024)
   PUBMED   39181129
REFERENCE   2  (bases 1 to 1674)
  AUTHORS   Zhou,Y., Yang,Y., Guo,L., Qian,J., Ge,J., Sinner,D., Ding,H.,
            Califano,A. and Cardoso,W.V.
  TITLE     Airway basal cells show regionally distinct potential to undergo
            metaplastic differentiation
  JOURNAL   Elife 11, e80083 (2022)
   PUBMED   36178196
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1674)
  AUTHORS   Shi,M., Wan,J., Wang,H. and Yu,H.
  TITLE     Cytokeratin 13 promotes radiotherapy sensitivity of nasopharyngeal
            carcinoma by downregulating the MEK/ERK pathway
  JOURNAL   IUBMB Life 74 (6), 543-553 (2022)
   PUBMED   35426961
  REMARK    GeneRIF: Cytokeratin 13 promotes radiotherapy sensitivity of
            nasopharyngeal carcinoma by downregulating the MEK/ERK pathway.
REFERENCE   4  (bases 1 to 1674)
  AUTHORS   DeLaForest,A., Kohlnhofer,B.M., Franklin,O.D., Stavniichuk,R.,
            Thompson,C.A., Pulakanti,K., Rao,S. and Battle,M.A.
  TITLE     GATA4 Controls Epithelial Morphogenesis in the Developing Stomach
            to Promote Establishment of Glandular Columnar Epithelium
  JOURNAL   Cell Mol Gastroenterol Hepatol 12 (4), 1391-1413 (2021)
   PUBMED   34111600
REFERENCE   5  (bases 1 to 1674)
  AUTHORS   Simonson,L., Vold,S., Mowers,C., Massey,R.J., Ong,I.M.,
            Longley,B.J. and Chang,H.
  TITLE     Keratin 13 deficiency causes white sponge nevus in mice
  JOURNAL   Dev Biol 468 (1-2), 146-153 (2020)
   PUBMED   32758484
  REMARK    GeneRIF: Keratin 13 deficiency causes white sponge nevus in mice.
REFERENCE   6  (bases 1 to 1674)
  AUTHORS   Winter,H., Fink,P. and Schweizer,J.
  TITLE     Retinoic acid-induced normal and tumor-associated aberrant
            expression of the murine keratin K13 gene does not involve a
            promotor sequence with striking homology to a natural retinoic acid
            responsive element
  JOURNAL   Carcinogenesis 15 (11), 2653-2656 (1994)
   PUBMED   7525098
REFERENCE   7  (bases 1 to 1674)
  AUTHORS   Gimenez-Conti,I.B., Lynch,M., Roop,D., Bhowmik,S., Majeski,P. and
            Conti,C.J.
  TITLE     Expression of keratins in mouse vaginal epithelium
  JOURNAL   Differentiation 56 (3), 143-151 (1994)
   PUBMED   7518402
REFERENCE   8  (bases 1 to 1674)
  AUTHORS   Correll,A.T., Webb,G.C., Ford,J.H., Rogers,G.E. and Powell,B.C.
  TITLE     Localization by in situ hybridization of a type I keratin
            intermediate filament gene (Krt-1.14) to band D of mouse chromosome
            11
  JOURNAL   Cytogenet Cell Genet 60 (3-4), 245-246 (1992)
   PUBMED   1380418
REFERENCE   9  (bases 1 to 1674)
  AUTHORS   Winter,H., Rentrop,M., Nischt,R. and Schweizer,J.
  TITLE     Tissue-specific expression of murine keratin K13 in internal
            stratified squamous epithelia and its aberrant expression during
            two-stage mouse skin carcinogenesis is associated with the
            methylation state of a distinct CpG site in the remote 5'-flanking
            region of the gene
  JOURNAL   Differentiation 43 (2), 105-114 (1990)
   PUBMED   1695590
REFERENCE   10 (bases 1 to 1674)
  AUTHORS   Knapp,B., Rentrop,M., Schweizer,J. and Winter,H.
  TITLE     Nonepidermal members of the keratin multigene family: cDNA
            sequences and in situ localization of the mRNAs
  JOURNAL   Nucleic Acids Res 14 (2), 751-763 (1986)
   PUBMED   2418416
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK132640.1 and EH100895.1.
            
            On Sep 15, 2015 this sequence version replaced NM_010662.1.
            
            Summary: The protein encoded by this gene is a member of the
            keratin gene family. The keratins are intermediate filament
            proteins responsible for the structural integrity of epithelial
            cells and are subdivided into cytokeratins and hair keratins. Most
            of the type I cytokeratins consist of acidic proteins which are
            arranged in pairs of heterotypic keratin chains. This type I
            cytokeratin is paired with keratin 4 and expressed in the
            suprabasal layers of non-cornified stratified epithelia. Two
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132640.1, AK004635.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1649              AK132640.1         2-1650
            1650-1674           EH100895.1         6-30                c
FEATURES             Location/Qualifiers
     source          1..1674
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.41 cM"
     gene            1..1674
                     /gene="Krt13"
                     /gene_synonym="CK13; K13; Krt-1.13; Krt1-13"
                     /note="keratin 13"
                     /db_xref="GeneID:16663"
                     /db_xref="MGI:MGI:101925"
     exon            1..542
                     /gene="Krt13"
                     /gene_synonym="CK13; K13; Krt-1.13; Krt1-13"
                     /inference="alignment:Splign:2.1.0"
     exon            543..625
                     /gene="Krt13"
                     /gene_synonym="CK13; K13; Krt-1.13; Krt1-13"
                     /inference="alignment:Splign:2.1.0"
     exon            626..782
                     /gene="Krt13"
                     /gene_synonym="CK13; K13; Krt-1.13; Krt1-13"
                     /inference="alignment:Splign:2.1.0"
     exon            783..944
                     /gene="Krt13"
                     /gene_synonym="CK13; K13; Krt-1.13; Krt1-13"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1070
                     /gene="Krt13"
                     /gene_synonym="CK13; K13; Krt-1.13; Krt1-13"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1291
                     /gene="Krt13"
                     /gene_synonym="CK13; K13; Krt-1.13; Krt1-13"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1314
                     /gene="Krt13"
                     /gene_synonym="CK13; K13; Krt-1.13; Krt1-13"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1654
                     /gene="Krt13"
                     /gene_synonym="CK13; K13; Krt-1.13; Krt1-13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1629..1634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt13"
                     /gene_synonym="CK13; K13; Krt-1.13; Krt1-13"
                     /note="hexamer: AATAAA"
     polyA_site      1654
                     /gene="Krt13"
                     /gene_synonym="CK13; K13; Krt-1.13; Krt1-13"
                     /note="major polyA site"
ORIGIN      
        1 atagtcttct cttggccttg gtcaagttca gctcctgtct gctctctctc tctcaccttc
       61 ttgctcccac catgagctgc cgcttccaga gttcctccat gagctatgga ggtggtttcg
      121 gagctggttc ttgccagctt ggaggaggcc gtaatatctc ctcctgctca tctcggtttg
      181 tcactggagg gtcagctgga ggctatggag ggggcatgag ctgtggcttt ggtggaggag
      241 ctggtggtgg ctttggaggt ggctttggag gtggctttgg aggtagctat ggcggaggtt
      301 ttggcggtgg ctttggtgac ttcggaggtg tcgatggtgg cctcctctct ggcaacgaga
      361 agatcaccat gcagaacctc aatgaccgcc tggccagcta cctggataag gtgcgcgcct
      421 tggaggcagc caatgccgac ctggaggtga agattcgtga ctggcatctg aaacagagcc
      481 cagctagtcc agagcgggac tacagtgctt attataagac catcgaggag ctccggatca
      541 agattctgga agccaccacg gacaacaacc ggatcatcct ggagattgac aatgccaggc
      601 tggctgcaga tgacttcagg ctcaagtacg aaaatgagct gaccttgcgc cagagcgtgg
      661 aggccgacat caacggcctg cgcagggtgc tggatgagct gactctggct aagactgacc
      721 tggaaatgca gattgagagc ctgaatgaag aactggctta cctgaagaag aaccacgaag
      781 aggagatgaa ggaattcagc aaccaggtag taggccaggt caatgtggag atggacgcca
      841 cccctggcat tgatctgacc cgtgtgctgg ctgagatgag ggagcagtat gaagccctgg
      901 cagagaagaa tcggagggat gctgaggaat ggttccagac caagagtgca gagctgaaca
      961 aggaagtatc ctccaacgct gaaatgatcc agaccagcaa gacagagatc acagaactca
     1021 ggcgcacact ccagggcctg gagattgagc tgcagtccca gctgagcatg aaagccggcc
     1081 tggaaagtac gttggcagag acagagtgcc gctacgccct gcagctgcaa cagatccagg
     1141 ggctcatcag cagcatcgag gctcagctga gcgagctccg aagtgagatg gagtgccaga
     1201 accaggaata caagatgctg ttggacatca aaacaaggct ggaacaggag atcgccacct
     1261 accgcagcct gctagagggc caggatgcta agatgaccgg cttcaactcc ggaggaaata
     1321 acactactac ctccaacggg tccccctcct ccaattccgg tcgcccagat ttccgaaagt
     1381 attaactcag cctggcgtcc cttccctggc cttcagcagc cacaggagga gagctgatgt
     1441 cgcctgtagg atgagaggac tgcaggatgt gatgcccagt cccattgtcc cccccaggac
     1501 ccatggctct gacaagccct gagggtgggc ccttccccat ctcttctgat tggaatcttt
     1561 cttctcccta ccccattctc tctattcttt ggcttctcag tgtctctaca acaaagaata
     1621 gatgattcaa taaagtttct tgattttctg caaaaaaaaa aaaaaaaaaa aaaa
//
