LOCUS       NM_010661               1854 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus keratin 12 (Krt12), mRNA.
ACCESSION   NM_010661 XM_905213
VERSION     NM_010661.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1854)
  AUTHORS   Sunny,S.S., Lachova,J., Kasparek,P., Palkova,M., Spoutil,F.,
            Prochazka,J., Sedlacek,R., Liskova,P. and Kozmik,Z.
  TITLE     Ovol2 promoter mutations in mice and human illuminate
            species-specific phenotypic divergence
  JOURNAL   Hum Mol Genet 33 (6), 491-500 (2024)
   PUBMED   37971355
REFERENCE   2  (bases 1 to 1854)
  AUTHORS   Abu-Romman,A., Scholand,K.K., Pal-Ghosh,S., Yu,Z., Kelagere,Y.,
            Yazdanpanah,G., Kao,W.W., Coulson-Thomas,V.J., Stepp,M.A. and de
            Paiva,C.S.
  TITLE     Conditional deletion of CD25 in the corneal epithelium reveals sex
            differences in barrier disruption
  JOURNAL   Ocul Surf 30, 57-72 (2023)
   PUBMED   37516317
REFERENCE   3  (bases 1 to 1854)
  AUTHORS   Liang,W., Huang,L., Whelchel,A., Yuan,T., Ma,X., Cheng,R.,
            Takahashi,Y., Karamichos,D. and Ma,J.X.
  TITLE     Peroxisome proliferator-activated receptor-alpha (PPARalpha)
            regulates wound healing and mitochondrial metabolism in the cornea
  JOURNAL   Proc Natl Acad Sci U S A 120 (13), e2217576120 (2023)
   PUBMED   36943878
REFERENCE   4  (bases 1 to 1854)
  AUTHORS   Lin,Y., Liu,Q., Li,L., Yang,R., Ye,J., Yang,S., Luo,G.,
            Reinach,P.S. and Yan,D.
  TITLE     Sirt1 Regulates Corneal Epithelial Migration by Deacetylating
            Cortactin
  JOURNAL   Invest Ophthalmol Vis Sci 63 (12), 14 (2022)
   PUBMED   36350618
REFERENCE   5  (bases 1 to 1854)
  AUTHORS   Sunny,S.S., Lachova,J., Dupacova,N. and Kozmik,Z.
  TITLE     Multiple roles of Pax6 in postnatal cornea development
  JOURNAL   Dev Biol 491, 1-12 (2022)
   PUBMED   36049534
REFERENCE   6  (bases 1 to 1854)
  AUTHORS   Kao,W.W., Liu,C.Y., Converse,R.L., Shiraishi,A., Kao,C.W.,
            Ishizaki,M., Doetschman,T. and Duffy,J.
  TITLE     Keratin 12-deficient mice have fragile corneal epithelia
  JOURNAL   Invest Ophthalmol Vis Sci 37 (13), 2572-2584 (1996)
   PUBMED   8977471
REFERENCE   7  (bases 1 to 1854)
  AUTHORS   Moyer,P.D., Kaufman,A.H., Zhang,Z., Kao,C.W., Spaulding,A.G. and
            Kao,W.W.
  TITLE     Conjunctival epithelial cells can resurface denuded cornea, but do
            not transdifferentiate to express cornea-specific keratin 12
            following removal of limbal epithelium in mouse
  JOURNAL   Differentiation 60 (1), 31-38 (1996)
   PUBMED   8935926
REFERENCE   8  (bases 1 to 1854)
  AUTHORS   Kurpakus,M.A., Maniaci,M.T. and Esco,M.
  TITLE     Expression of keratins K12, K4 and K14 during development of ocular
            surface epithelium
  JOURNAL   Curr Eye Res 13 (11), 805-814 (1994)
   PUBMED   7531631
REFERENCE   9  (bases 1 to 1854)
  AUTHORS   Liu,C.Y., Zhu,G., Converse,R., Kao,C.W., Nakamura,H., Tseng,S.C.,
            Mui,M.M., Seyer,J., Justice,M.J., Stech,M.E. et al.
  TITLE     Characterization and chromosomal localization of the
            cornea-specific murine keratin gene Krt1.12
  JOURNAL   J Biol Chem 269 (40), 24627-24636 (1994)
   PUBMED   7523376
REFERENCE   10 (bases 1 to 1854)
  AUTHORS   Liu,C.Y., Zhu,G., Westerhausen-Larson,A., Converse,R., Kao,C.W.,
            Sun,T.T. and Kao,W.W.
  TITLE     Cornea-specific expression of K12 keratin during mouse development
  JOURNAL   Curr Eye Res 12 (11), 963-974 (1993)
   PUBMED   7508359
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK053362.1, CK627700.1, AK143182.1 and AL591165.17.
            
            On Nov 17, 2006 this sequence version replaced NM_010661.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK053362.1, AK143182.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               AK053362.1         2-104
            104-643             CK627700.1         90-629
            644-1843            AK143182.1         643-1842
            1844-1854           AL591165.17        55313-55323         c
FEATURES             Location/Qualifiers
     source          1..1854
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 62.92 cM"
     gene            1..1854
                     /gene="Krt12"
                     /gene_synonym="K12; Krt-12; Krt1-12"
                     /note="keratin 12"
                     /db_xref="GeneID:268482"
                     /db_xref="MGI:MGI:96687"
     exon            1..589
                     /gene="Krt12"
                     /gene_synonym="K12; Krt-12; Krt1-12"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1507
                     /gene="Krt12"
                     /gene_synonym="K12; Krt-12; Krt1-12"
                     /note="CK-12; cytokeratin-12; keratin complex 1, acidic,
                     gene 12; Keratin, type I cytoskeletal 12 (Cytokeratin 12)"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 12"
                     /protein_id="NP_034791.2"
                     /db_xref="CCDS:CCDS36306.1"
                     /db_xref="GeneID:268482"
                     /db_xref="MGI:MGI:96687"
                     /translation="MSLSVCTSALSRRSSSQNGAAGRPWGASASSVAGGYGGSASGFG
                     VGCGGLFSAASMFGSSSGFSGGSAGCLPGLGSAYGGPLRGGAGGMGIGMGIAGSSGGG
                     SLCIFSGNDGGLLSGSEKETMQNLNDRLASYLGKVRSLEEANAELENKIREWYETRRT
                     RDAGSQSDYSKYYPLIEDLKNKIVSARVSNAQLLLQIDNARLAAEDFRMKYENELALR
                     QTVEADINGLRRVLDELTLTRADLEAQLETLTEELAYMKKNHEEELQSFQAGGPGEVN
                     VEMDAAPGVDLTKVLNEMRAQYEAMAEQNRKDAEAWFLEKSRELRKEISSNTEQLQSS
                     KSEVTDLKRMVQNLEIELQSQLAMKSSLEGSLAETEGGYCCQLSQVQQLIGSLEEQLQ
                     QVRADAERQNADHQRLLGVKARLEMEIETYRRLLEGDSQGDGFDESSSLSVSKPQTPS
                     VDSSKDPNKTRKIKTVVQEIVNGEVVSSQVQELEEEM"
     exon            590..672
                     /gene="Krt12"
                     /gene_synonym="K12; Krt-12; Krt1-12"
                     /inference="alignment:Splign:2.1.0"
     exon            673..829
                     /gene="Krt12"
                     /gene_synonym="K12; Krt-12; Krt1-12"
                     /inference="alignment:Splign:2.1.0"
     exon            830..991
                     /gene="Krt12"
                     /gene_synonym="K12; Krt-12; Krt1-12"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1117
                     /gene="Krt12"
                     /gene_synonym="K12; Krt-12; Krt1-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1338
                     /gene="Krt12"
                     /gene_synonym="K12; Krt-12; Krt1-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1409
                     /gene="Krt12"
                     /gene_synonym="K12; Krt-12; Krt1-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1854
                     /gene="Krt12"
                     /gene_synonym="K12; Krt-12; Krt1-12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1828..1833
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt12"
                     /gene_synonym="K12; Krt-12; Krt1-12"
                     /note="hexamer: ATTAAA"
     polyA_site      1849
                     /gene="Krt12"
                     /gene_synonym="K12; Krt-12; Krt1-12"
                     /note="major polyA site"
ORIGIN      
        1 agcactgcgg tctctcttgg gtcaccacct ctccagcaac agcatgtcgc tttcagtctg
       61 cacctctgcg ctgtccagga ggtcttcctc acagaatggg gcggcaggca gaccttgggg
      121 tgcatctgct tctagtgttg ccggcggcta tgggggatcg gcctctggct ttggagttgg
      181 ctgtggaggc ctcttttctg ctgcttccat gtttggttct agttctggct ttagcggtgg
      241 ctctgcaggt tgcttgccgg ggcttggctc tgcctatggg ggacctctga gaggtggcgc
      301 gggaggaatg gggataggga tggggatagc tggaagctcg ggcggtggct ctctgtgtat
      361 cttttctggc aatgatggag gtcttctttc tggttctgag aaagaaacca tgcaaaatct
      421 aaatgacaga ctagcttcct acctgggtaa ggttcgctct ctagaggagg ctaatgcaga
      481 actggaaaac aaaattcgag agtggtatga aacacggaga accagagacg ctgggtctca
      541 gagtgattac agtaaatact acccactgat tgaagacttg aagaataaga tcgtttctgc
      601 cagagtcagc aacgcccagc tcctcctgca gattgacaac gcaaggctgg ctgccgagga
      661 cttcaggatg aagtatgaga atgagctggc cctgcgccag accgtggagg ccgacatcaa
      721 cgggctgcga agggtgctgg acgagctgac cctgactaga gccgacctgg aagcccagct
      781 tgagaccctc actgaggagc tggcttacat gaagaagaac cacgaagagg aactccaaag
      841 tttccaggca ggtggtccag gtgaggtcaa tgtagaaatg gacgcggccc ctggagtgga
      901 tctcaccaag gtcctcaatg aaatgagagc ccagtatgaa gccatggctg agcaaaatcg
      961 gaaagatgca gaggcctggt ttcttgaaaa gagcagagag ctccgaaaag agatcagcag
     1021 caacacggag cagcttcagt ccagcaagag cgaggtcacc gacctgaagc gcatggtgca
     1081 gaacctagag attgaactcc agtcccagct cgccatgaag tcgtccctgg aaggctcgct
     1141 ggctgaaacc gagggtgggt actgctgcca actgtctcag gtgcagcagc tgatcggcag
     1201 cctggaggag caactccaac aggtgcgggc tgacgcggag cgccagaatg cggaccacca
     1261 gcggctgctg ggcgtcaagg ctcgcctgga gatggagatt gagacctacc gccggctgct
     1321 ggagggggac agccaaggcg acggttttga cgagagctca tccctttctg tctccaaacc
     1381 gcagacacca tcagtcgatt cctctaaaga cccaaataaa actcgaaaaa tcaagacagt
     1441 cgtgcaggag atagtgaatg gcgaagtggt ctcatcccag gttcaggaac ttgaagaaga
     1501 gatgtaaggc ctcacacggg ctcctctggg atgcgaagtt tccagccagg agttactgct
     1561 tccgtgcgct atatgaattc agcacctgtt ttggccagtt tccttttcct tggattctct
     1621 atgcaggttg ggtcttgtta gcatttctga aacaatatcc aatttacaag tctctgtggc
     1681 tctgctggtc ttcattgcaa ccccagatca ccttacacct tcctgggcct gaagaagtct
     1741 ttccactaag tttttctggt cgcctggacc atttgtttaa tcccacagct ttgacggaac
     1801 cgtatgggtt taacaacact aactttaatt aaagattaat ggcaatgaag tgaa
//
