LOCUS       NM_010660               2124 bp    mRNA    linear   ROD 07-JAN-2025
DEFINITION  Mus musculus keratin 10 (Krt10), mRNA.
ACCESSION   NM_010660 XM_283025
VERSION     NM_010660.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2124)
  AUTHORS   Wang,Q., Zeng,S., Liang,Y., Zhou,R. and Wang,D.
  TITLE     ASH2L Mediates Epidermal Differentiation and Hair Follicle
            Morphogenesis through H3K4me3 Modification
  JOURNAL   J Invest Dermatol 144 (11), 2406-2416 (2024)
   PUBMED   38582368
REFERENCE   2  (bases 1 to 2124)
  AUTHORS   Olczak,A., Pieczonka,T.D., Lawicki,S., Lukaszyk,K.,
            Pulawska-Czub,A., Cambier,L. and Kobielak,K.
  TITLE     The overexpression of R-spondin 3 affects hair morphogenesis and
            hair development along with the formation and maturation of the
            hair follicle stem cells
  JOURNAL   Front Physiol 15, 1424077 (2024)
   PUBMED   39351282
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2124)
  AUTHORS   Liu,H., Su,P., Li,Y., Hoover,A., Hu,S., King,S.A., Zhao,J.,
            Guan,J.L., Chen,S.Y., Zhao,Y., Tan,M. and Wu,X.
  TITLE     VAMP2 controls murine epidermal differentiation and carcinogenesis
            by regulation of nucleophagy
  JOURNAL   Dev Cell 59 (15), 2005-2016 (2024)
   PUBMED   38810653
REFERENCE   4  (bases 1 to 2124)
  AUTHORS   Kimura,E., Mongan,M., Xiao,B., Christianto,A., Wang,J.,
            Carreira,V.S., Bolon,B., Zhang,X., Burns,K.A., Biesiada,J.,
            Medvedovic,M., Puga,A. and Xia,Y.
  TITLE     MAP3K1 regulates female reproductive tract development
  JOURNAL   Dis Model Mech 17 (3) (2024)
   PUBMED   38501211
REFERENCE   5  (bases 1 to 2124)
  AUTHORS   Villeneuve,C., Hashmi,A., Ylivinkka,I., Lawson-Keister,E.,
            Miroshnikova,Y.A., Perez-Gonzalez,C., Myllymaki,S.M., Bertillot,F.,
            Yadav,B., Zhang,T., Matic Vignjevic,D., Mikkola,M.L., Manning,M.L.
            and Wickstrom,S.A.
  TITLE     Mechanical forces across compartments coordinate cell shape and
            fate transitions to generate tissue architecture
  JOURNAL   Nat Cell Biol 26 (2), 207-218 (2024)
   PUBMED   38302719
REFERENCE   6  (bases 1 to 2124)
  AUTHORS   Fuchs,E., Esteves,R.A. and Coulombe,P.A.
  TITLE     Transgenic mice expressing a mutant keratin 10 gene reveal the
            likely genetic basis for epidermolytic hyperkeratosis
  JOURNAL   Proc Natl Acad Sci U S A 89 (15), 6906-6910 (1992)
   PUBMED   1379726
REFERENCE   7  (bases 1 to 2124)
  AUTHORS   Kartasova,T., Roop,D.R. and Yuspa,S.H.
  TITLE     Relationship between the expression of differentiation-specific
            keratins 1 and 10 and cell proliferation in epidermal tumors
  JOURNAL   Mol Carcinog 6 (1), 18-25 (1992)
   PUBMED   1380247
REFERENCE   8  (bases 1 to 2124)
  AUTHORS   Kaytes,P.S., McNab,A.R., Rea,T.J., Groppi,V., Kawabe,T.T.,
            Buhl,A.E., Bertolino,A.P., Hatzenbuhler,N.T. and Vogeli,G.
  TITLE     Hair-specific keratins: characterization and expression of a mouse
            type I keratin gene
  JOURNAL   J Invest Dermatol 97 (5), 835-842 (1991)
   PUBMED   1717610
REFERENCE   9  (bases 1 to 2124)
  AUTHORS   Lussier,M., Filion,M., Compton,J.G., Nadeau,J.H., Lapointe,L. and
            Royal,A.
  TITLE     The mouse keratin 19-encoding gene: sequence, structure and
            chromosomal assignment
  JOURNAL   Gene 95 (2), 203-213 (1990)
   PUBMED   1701153
REFERENCE   10 (bases 1 to 2124)
  AUTHORS   Ouellet,T., Lussier,M., Babai,F., Lapointe,L. and Royal,A.
  TITLE     Differential expression of the epidermal K1 and K10 keratin genes
            during mouse embryo development
  JOURNAL   Biochem Cell Biol 68 (2), 448-453 (1990)
   PUBMED   1693084
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB648004.1, AK076508.1 and AI173281.1.
            
            On Aug 23, 2006 this sequence version replaced NM_010660.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK081402.1, AK076508.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BB648004.1         2-4
            4-2087              AK076508.1         2-2085
            2088-2124           AI173281.1         1-37                c
FEATURES             Location/Qualifiers
     source          1..2124
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 62.92 cM"
     gene            1..2124
                     /gene="Krt10"
                     /gene_synonym="D130054E02Rik; K10; K1C1; Krt-1.10;
                     Krt1-10"
                     /note="keratin 10"
                     /db_xref="GeneID:16661"
                     /db_xref="MGI:MGI:96685"
     exon            1..626
                     /gene="Krt10"
                     /gene_synonym="D130054E02Rik; K10; K1C1; Krt-1.10;
                     Krt1-10"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1718
                     /gene="Krt10"
                     /gene_synonym="D130054E02Rik; K10; K1C1; Krt-1.10;
                     Krt1-10"
                     /note="epidermal keratin 10; intermediate filament
                     protein; CK-10; cytokeratin-10; 56 kDa cytokeratin;
                     keratin, type I cytoskeletal 59 kDa; keratin complex 1,
                     acidic, gene 10; suprabasal cytokeratin 10"
                     /codon_start=1
                     /product="keratin, type I cytoskeletal 10"
                     /protein_id="NP_034790.2"
                     /db_xref="CCDS:CCDS25380.1"
                     /db_xref="GeneID:16661"
                     /db_xref="MGI:MGI:96685"
                     /translation="MSVLYSSSSKQFSSSRSGGGGGGGSVRVSSTRGSLGGGYSSGGF
                     SGGSFSRGSSGGGCFGGSSGGYGGFGGGGSFGGGYGGSSFGGGYGGSSFGGGSFGGGG
                     SFGGGSFGGGSYGGGFGGGGFGGDGGSLLSGNEKVTMQNLNDRLASYMDKVRALEESN
                     YELEGKIKEWYEKHGNSSQREPRDYSKYYKTIEDLKGQILTLTTDNANVLLQIDNARL
                     AADDFRLKYENEVTLRQSVEADINGLRRVLDELTLSKSDLEMQIESLNEELAYLKKNH
                     EEEMRDLQNVSTGDVNVEMNAAPGVDLTQLLNNMRNQYEQLAEKNRKDAEEWFNQKSK
                     ELTTEIDSNIEQMSSHKSEITELRRTVQGLEIELQSQLALKQSLEASLAETEGRYCVQ
                     LSQIQSQISALEEQLQQIRAETECQNAEYQQLLDIKTRLENEIQTYRSLLEGEGSSSG
                     GGGGRGGGSHGGSYGGSSGGGSYGGSSGGGGSYGGSSGGGGSYGGGSSGGGSHGGSSG
                     GGYGGGSSSGGAGGHGGSSGGGYGGGSSSGGQGGSGGFKSSGGGDQSSKGPRY"
     exon            627..709
                     /gene="Krt10"
                     /gene_synonym="D130054E02Rik; K10; K1C1; Krt-1.10;
                     Krt1-10"
                     /inference="alignment:Splign:2.1.0"
     exon            710..866
                     /gene="Krt10"
                     /gene_synonym="D130054E02Rik; K10; K1C1; Krt-1.10;
                     Krt1-10"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1028
                     /gene="Krt10"
                     /gene_synonym="D130054E02Rik; K10; K1C1; Krt-1.10;
                     Krt1-10"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1154
                     /gene="Krt10"
                     /gene_synonym="D130054E02Rik; K10; K1C1; Krt-1.10;
                     Krt1-10"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1372
                     /gene="Krt10"
                     /gene_synonym="D130054E02Rik; K10; K1C1; Krt-1.10;
                     Krt1-10"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1711
                     /gene="Krt10"
                     /gene_synonym="D130054E02Rik; K10; K1C1; Krt-1.10;
                     Krt1-10"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..2094
                     /gene="Krt10"
                     /gene_synonym="D130054E02Rik; K10; K1C1; Krt-1.10;
                     Krt1-10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2062..2067
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt10"
                     /gene_synonym="D130054E02Rik; K10; K1C1; Krt-1.10;
                     Krt1-10"
                     /note="hexamer: AATAAA"
     polyA_site      2094
                     /gene="Krt10"
                     /gene_synonym="D130054E02Rik; K10; K1C1; Krt-1.10;
                     Krt1-10"
                     /note="major polyA site"
ORIGIN      
        1 agcaggcact ccctgggcta cactacacca ccatgtctgt tctatacagc tccagcagca
       61 agcagttctc ttcctcccgc agtggaggag gaggcggtgg tggatccgtc agggtttcca
      121 gcaccagggg ctctcttggt ggagggtata gctcaggagg cttcagcggt ggctctttta
      181 gccgtgggag ctctggggga ggttgctttg ggggctcatc aggtggttac ggaggttttg
      241 gaggaggagg cagctttggg ggaggctatg gaggaagcag ctttggggga ggctatggag
      301 gtagcagttt tgggggtggc agcttcggtg gaggtggcag cttcggtgga ggcagctttg
      361 gtggcggtag ctatggagga ggctttggcg gtggtggatt cggaggagat ggtggcagcc
      421 ttctctccgg aaacgagaag gtgaccatgc agaacctgaa cgaccgcctg gcctcctaca
      481 tggacaaagt ccgggctctg gaagagtcaa actacgagct ggagggtaaa atcaaggagt
      541 ggtacgagaa gcatggcaac tcaagccagc gagagccccg ggactacagc aaatactaca
      601 aaaccatcga ggaccttaag gggcagatcc tcaccctgac aactgacaat gccaacgtgc
      661 tgctgcagat tgacaatgcc cgcctggcag ctgatgactt caggctgaaa tacgagaatg
      721 aggtgaccct gcgccagagc gtggaggccg acatcaatgg cctgcgcagg gtactggatg
      781 agctgaccct tagcaagtct gacctggaaa tgcagatcga aagtctgaac gaagagctgg
      841 cctacctaaa gaagaaccac gaagaggaaa tgagagacct tcaaaatgtg tccactggtg
      901 atgtgaatgt ggaaatgaac gctgccccag gggttgacct gactcagctg ctgaacaaca
      961 tgagaaacca atacgaacaa cttgcagaaa agaatcgcaa ggatgctgaa gagtggttca
     1021 atcagaagag caaggaactc accacagaaa tcgacagcaa cattgaacaa atgtccagcc
     1081 ataagtctga aatcactgaa ttgagacgta ctgttcaggg tctggagatt gaactacagt
     1141 cccagctggc cctgaaacaa tcgctggaag cctccttggc agaaacagaa ggtcgctact
     1201 gcgtgcagct ctcccagatt caaagccaga tctccgccct ggaggaacag ctgcaacaga
     1261 ttcgggctga gaccgagtgc cagaacgccg agtaccaaca actcctagac atcaagaccc
     1321 gactggagaa cgagattcag acctaccgca gcctgctaga aggagaggga agctccagcg
     1381 gtggcggcgg cggacgcggc ggcggcagcc acggcggtag ctacggcgga agctccggtg
     1441 gcggaagcta cggcggaagt tccggcggcg gcggcagcta cggcggaagt tccggcggcg
     1501 gcggcagcta cggcggcgga agctccgggg gcggtagcca cggaggcagt tccggtggcg
     1561 gctacggcgg cggaagttcc agcggtggtg ctggtggtca cggcggcagt tccggtggcg
     1621 gctacggcgg cggaagttcc agcggaggcc agggcggaag cggaggtttc aagtcttccg
     1681 gtggcggcga ccaatcatct aaaggaccaa gatactaaca aaaccaaagt gatcaggacg
     1741 attattgagg aggtgacacc tgagggtaga gtcctttcgt ctatgattga atcagaaacc
     1801 aagaaacact tctattaagc tgcatagaag agtctcttca tacgggccac tggacagacg
     1861 tgtggaaaac ataaatgtcc aagaaacact tttgtcttaa tggtctgtgg aaataggttc
     1921 actccttgaa attaaggtct aaaaggtgtt ttgtggtttc tgtatttctt cttttcatct
     1981 atcagaaagt gttcttttgt ggagaaaaaa gaagaaaact ttctcactta cttattaatt
     2041 tctcatttac taataaattt caataaactt tcttactgat gcaaactata aaaaaaaaaa
     2101 aaaaaaaaaa aaaaaaaaaa aaaa
//
