LOCUS       NM_008473               2462 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus keratin 1 (Krt1), mRNA.
ACCESSION   NM_008473
VERSION     NM_008473.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2462)
  AUTHORS   Deng,Z., Carpinelli,M.R., Butt,T., Magor,G.W., Zhao,P.,
            Gillinder,K.R., Perkins,A.C. and Jane,S.M.
  TITLE     Single-cell transcriptomics reveals the cellular identity of a
            novel progenitor population crucial for murine neural tube closure
  JOURNAL   Heliyon 10 (17), e37259 (2024)
   PUBMED   39296075
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2462)
  AUTHORS   Lin,Y., Tang,W., Huang,P., Wang,Z., Duan,L., Jia,C., Sun,R., Liu,L.
            and Shen,J.
  TITLE     Denticleless E3 ubiquitin protein ligase (DTL) maintains the
            proliferation and differentiation of epidermis and hair follicles
            during skin development
  JOURNAL   Dev Dyn 253 (7), 635-647 (2024)
   PUBMED   38131461
REFERENCE   3  (bases 1 to 2462)
  AUTHORS   Wang,D., Li,H., Chandel,N.S., Dou,Y. and Yi,R.
  TITLE     MOF-mediated histone H4 Lysine 16 acetylation governs mitochondrial
            and ciliary functions by controlling gene promoters
  JOURNAL   Nat Commun 14 (1), 4404 (2023)
   PUBMED   37479688
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2462)
  AUTHORS   Deng,Z., Butt,T., Arhatari,B.D., Darido,C., Auden,A., Swaroop,D.,
            Partridge,D.D., Haigh,K., Nguyen,T., Haigh,J.J., Carpinelli,M.R.
            and Jane,S.M.
  TITLE     Dysregulation of Grainyhead-like 3 expression causes widespread
            developmental defects
  JOURNAL   Dev Dyn 252 (5), 647-667 (2023)
   PUBMED   36606449
REFERENCE   5  (bases 1 to 2462)
  AUTHORS   Laporte,E., De Vriendt,S., Hoekx,J. and Vankelecom,H.
  TITLE     Interleukin-6 is dispensable in pituitary normal development and
            homeostasis but needed for pituitary stem cell activation following
            local injury
  JOURNAL   Front Endocrinol (Lausanne) 13, 1092063 (2022)
   PUBMED   36619565
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2462)
  AUTHORS   Beier,D.R., Dushkin,H. and Sussman,D.J.
  TITLE     Mapping genes in the mouse using single-strand conformation
            polymorphism analysis of recombinant inbred strains and
            interspecific crosses
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 9102-9106 (1992)
   PUBMED   1409609
REFERENCE   7  (bases 1 to 2462)
  AUTHORS   Fuchs,E., Esteves,R.A. and Coulombe,P.A.
  TITLE     Transgenic mice expressing a mutant keratin 10 gene reveal the
            likely genetic basis for epidermolytic hyperkeratosis
  JOURNAL   Proc Natl Acad Sci U S A 89 (15), 6906-6910 (1992)
   PUBMED   1379726
REFERENCE   8  (bases 1 to 2462)
  AUTHORS   Kartasova,T., Roop,D.R. and Yuspa,S.H.
  TITLE     Relationship between the expression of differentiation-specific
            keratins 1 and 10 and cell proliferation in epidermal tumors
  JOURNAL   Mol Carcinog 6 (1), 18-25 (1992)
   PUBMED   1380247
REFERENCE   9  (bases 1 to 2462)
  AUTHORS   Finch,J., Andrews,K., Krieg,P., Furstenberger,G., Slaga,T.,
            Ootsuyama,A., Tanooka,H. and Bowden,G.T.
  TITLE     Identification of a cloned sequence activated during multi-stage
            carcinogenesis in mouse skin
  JOURNAL   Carcinogenesis 12 (8), 1519-1522 (1991)
   PUBMED   1713533
REFERENCE   10 (bases 1 to 2462)
  AUTHORS   Itoh,N., Yonehara,S., Schreurs,J., Gorman,D.M., Maruyama,K.,
            Ishii,A., Yahara,I., Arai,K. and Miyajima,A.
  TITLE     Cloning of an interleukin-3 receptor gene: a member of a distinct
            receptor gene family
  JOURNAL   Science 247 (4940), 324-327 (1990)
   PUBMED   2404337
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK019521.1, BC117843.1 and AI840489.1.
            
            On Feb 23, 2007 this sequence version replaced NM_008473.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK019521.1, BC117842.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-498               AK019521.1         2-499
            499-2294            BC117843.1         466-2261
            2295-2462           AI840489.1         1-168               c
FEATURES             Location/Qualifiers
     source          1..2462
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 57.06 cM"
     gene            1..2462
                     /gene="Krt1"
                     /gene_synonym="Krt-2.1; Krt2-1; Krt86"
                     /note="keratin 1"
                     /db_xref="GeneID:16678"
                     /db_xref="MGI:MGI:96698"
     exon            1..674
                     /gene="Krt1"
                     /gene_synonym="Krt-2.1; Krt2-1; Krt86"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1973
                     /gene="Krt1"
                     /gene_synonym="Krt-2.1; Krt2-1; Krt86"
                     /note="K1; CK-1; cytokeratin-1; 67 kDa cytokeratin;
                     type-II keratin Kb1; keratin 86; keratin complex 2, basic,
                     gene 1"
                     /codon_start=1
                     /product="keratin, type II cytoskeletal 1"
                     /protein_id="NP_032499.2"
                     /db_xref="CCDS:CCDS37221.1"
                     /db_xref="GeneID:16678"
                     /db_xref="MGI:MGI:96698"
                     /translation="MSLQCSSRSLCRGGGGSRNFSSGSAGLVSFQRRSTSSSMRRSGG
                     GGGGRFSGGGFCGSSGSGFGSKSLMNLGGGRSISKSVAGGGGSFCGGFGGGSYGGGGF
                     GGGSYGGGGFGGGSFGGGGFGGSGFGGGLGGGGGFGSGGGFGGGRFGSMGPVCPPGGI
                     QEVTINQSLLQPLNVEVDPQIQKVKSQEREQIKSLNDKFASFIDKVRFLEQQNQVLQT
                     KWELLQQVDTTTRTQNLDPFFENYISILRRKVDSLKSDQSRMDSELKNMQDLVEEYRT
                     KYEDEINKRTNAENEFVTIKKDVDSAYMTKVELQAKADALQQDIDFFSALYQMEMSQM
                     QTQISETNVVLSMDNNRSLDLDGIISEVKAQYDSICQRSKAEAETFYQSKYEELQITA
                     GKHGDSVRNTKMEISELNRMIQRLRSEIDGCKKQISQIQQNINDAEQRGEKALKDAQN
                     KLNEIEDALSQCKEDLARLLRDFQELMNTKLALDMEIATYKKLLEGEEIRMSGECTPN
                     VSVSVSTSHTSMSGSSSRGGGSGGGRYGGGGSYGGGSGGGSYGGSSGGGGSGGSYGGG
                     SGGGSYGGGSGGGSSGSHRGGSGGGGGSSGGSYGGSSGGGRGGSSSGGGGVKSSGSST
                     VKFVSTSYSRGTK"
     exon            675..889
                     /gene="Krt1"
                     /gene_synonym="Krt-2.1; Krt2-1; Krt86"
                     /inference="alignment:Splign:2.1.0"
     exon            890..950
                     /gene="Krt1"
                     /gene_synonym="Krt-2.1; Krt2-1; Krt86"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1046
                     /gene="Krt1"
                     /gene_synonym="Krt-2.1; Krt2-1; Krt86"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1211
                     /gene="Krt1"
                     /gene_synonym="Krt-2.1; Krt2-1; Krt86"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1337
                     /gene="Krt1"
                     /gene_synonym="Krt-2.1; Krt2-1; Krt86"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1558
                     /gene="Krt1"
                     /gene_synonym="Krt-2.1; Krt2-1; Krt86"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1593
                     /gene="Krt1"
                     /gene_synonym="Krt-2.1; Krt2-1; Krt86"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..2447
                     /gene="Krt1"
                     /gene_synonym="Krt-2.1; Krt2-1; Krt86"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2423..2428
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krt1"
                     /gene_synonym="Krt-2.1; Krt2-1; Krt86"
                     /note="hexamer: AATAAA"
     polyA_site      2447
                     /gene="Krt1"
                     /gene_synonym="Krt-2.1; Krt2-1; Krt86"
                     /note="major polyA site"
ORIGIN      
        1 agaggagttc tcagctcctt ccatctcttg tctttgctct cacctctctc taaggcatca
       61 tgagtctaca gtgtagctcc aggtccctgt gccgcggtgg cggtggcagc aggaacttca
      121 gctcaggctc tgctggccta gtcagcttcc agcgcagatc caccagcagc tctatgcgcc
      181 gcagcggtgg aggtggtggt gggagatttt caggaggagg cttctgtggg agttctggta
      241 gtggctttgg aagtaagagt cttatgaacc ttggaggcgg taggagcatc tccaagagtg
      301 tggctggagg tggtggcagc ttctgtggtg gctttggggg tggcagctac ggcggtggtg
      361 gctttggggg tggcagctac ggcggtggtg gctttggggg tggcagcttc ggcggtggtg
      421 gctttggagg gagtggtttt ggcggaggtc ttggtggtgg tggtggtttt ggtagtggag
      481 gtggttttgg tggtggtaga tttggtagta tggggcctgt ctgtccccct ggtggcatcc
      541 aggaagtgac catcaaccaa agccttctgc aacccctcaa cgttgaggtt gaccctcaga
      601 ttcaaaaagt gaagtctcag gagagagagc agatcaagtc actcaatgac aagtttgcct
      661 ccttcatcga caaggtgcgc ttcctagagc aacaaaacca ggtgctacaa accaaatggg
      721 agctgctgca gcaggtagac accacaaccc ggacccaaaa cttagaccct ttttttgaga
      781 actatatcag catcctcaga aggaaggtgg actcgctgaa gagtgaccag tcacggatgg
      841 attctgagct gaagaacatg caagacctgg tggaagagta caggaccaag tacgaggatg
      901 aaatcaacaa gaggaccaac gcagagaatg agttcgtgac catcaagaag gatgtggatt
      961 cagcttacat gaccaaagtt gagcttcagg ccaaggcaga tgccctccag caagacattg
     1021 acttcttctc tgcactctac caaatggaaa tgtctcagat gcaaactcaa atcagcgaaa
     1081 ccaatgttgt cctgtccatg gacaacaacc gcagtttgga tctggatggc atcatctcgg
     1141 aagtcaaggc ccagtatgat agcatttgcc agaggagcaa ggctgaagct gagacctttt
     1201 accagagcaa gtacgaagag ctgcagatca ctgctggcaa acatggagac agtgtgagaa
     1261 ataccaagat ggagatttct gagctgaatc gaatgatcca gagacttcga tctgaaattg
     1321 atggttgcaa gaagcagatc tcccaaatac agcagaacat caatgatgct gagcagcgtg
     1381 gtgagaaagc actcaaagat gcccagaaca agctgaatga gatagaggat gcattgtcgc
     1441 aatgcaagga ggatcttgcc agattgctgc gtgacttcca ggagctgatg aacactaagc
     1501 tggccctgga catggagatt gccacataca agaaacttct ggaaggagag gagatcagga
     1561 tgtctggaga gtgcactccc aacgtgagcg tgtcggtgag caccagccac accagcatga
     1621 gcggaagcag tagccgaggc ggcggcagcg gcggcggcag atacggaggc ggtggcagtt
     1681 atggcggcgg ctctggaggc ggcagctacg gcggcagttc tggaggcgga ggcagtggtg
     1741 gcagctacgg cggcggctcc ggaggcggca gctacggcgg cggctccgga ggcggcagca
     1801 gtggaagcca cagaggtggc tctggagggg gcggtggcag ctccggaggc agctacggtg
     1861 gctcctctgg cggaggccgg ggaggatcca gctcaggtgg cggtggcgtt aagtcctctg
     1921 gcagttctac cgtgaagttt gtttccacca gttactcccg agggaccaaa taaagaggtg
     1981 accaccgccc cattagctct gcctttccat caaggccaaa catggctggc aagaccaaga
     2041 tcaatcccac cagccttatt agagaaaaga gctatggtta attgcacaga ttaggcttat
     2101 tttctctgcg ctttcttttc tgctcctctt gcaaagaagt tttcatatta gtagcagtct
     2161 gagtcccatg gtaacaatcc cactttatgt tctgctgaac tgccatcagt tcatcaccaa
     2221 catgacattt caaagaggac ttcagatcta gggcttcctt gcctggcatg cccagagcac
     2281 tgggttgccc cttagcatcc catatcctgc agcacgctga gctgctttgg ttttgtacat
     2341 aaggtgtttg cgagtttgtc ttttatggag cgctctgaac gaccccaccc cacccccaaa
     2401 ccccgtttct ttgttttgct gcaataaact gcattagaaa ctctcaaaaa aaaaaaaaaa
     2461 aa
//
