LOCUS       NM_030675               6105 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus KRIT1, ankyrin repeat containing (Krit1), transcript
            variant 1, mRNA.
ACCESSION   NM_030675
VERSION     NM_030675.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6105)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6105)
  AUTHORS   Cici,M., Dilmac,S., Aytac,G. and Tanriover,G.
  TITLE     Cerebral cavernous malformation proteins, CCM1, CCM2 and CCM3, are
            decreased in metastatic lesions in a murine breast carcinoma model
  JOURNAL   Biotech Histochem 99 (2), 76-83 (2024)
   PUBMED   38293758
  REMARK    GeneRIF: Cerebral cavernous malformation proteins, CCM1, CCM2 and
            CCM3, are decreased in metastatic lesions in a murine breast
            carcinoma model.
REFERENCE   3  (bases 1 to 6105)
  AUTHORS   McCurdy,S., Lin,J., Shenkar,R., Moore,T., Lightle,R., Faurobert,E.,
            Lopez-Ramirez,M.A., Awad,I. and Ginsberg,M.H.
  TITLE     beta1 integrin monoclonal antibody treatment ameliorates cerebral
            cavernous malformations
  JOURNAL   FASEB J 36 (12), e22629 (2022)
   PUBMED   36349990
REFERENCE   4  (bases 1 to 6105)
  AUTHORS   Dai,Z., Li,J., Li,Y., Wang,R., Yan,H., Xiong,Z., Wu,S., Yang,X.,
            Lu,D., Zhang,D., Li,G., Wang,Y., Men,C., Du,W., Zheng,X. and Shi,C.
  TITLE     Role of pericytes in the development of cerebral cavernous
            malformations
  JOURNAL   iScience 25 (12), 105642 (2022)
   PUBMED   36465134
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6105)
  AUTHORS   Mastrocola,R., Aimaretti,E., Ferreira Alves,G., Cento,A.S.,
            Fornelli,C., Dal Bello,F., Ferraris,C., Goitre,L., Perrelli,A. and
            Retta,S.F.
  TITLE     Heterozygous Loss of KRIT1 in Mice Affects Metabolic Functions of
            the Liver, Promoting Hepatic Oxidative and Glycative Stress
  JOURNAL   Int J Mol Sci 23 (19), 11151 (2022)
   PUBMED   36232456
  REMARK    GeneRIF: Heterozygous Loss of KRIT1 in Mice Affects Metabolic
            Functions of the Liver, Promoting Hepatic Oxidative and Glycative
            Stress.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6105)
  AUTHORS   Denier,C., Gasc,J.M., Chapon,F., Domenga,V., Lescoat,C., Joutel,A.
            and Tournier-Lasserve,E.
  TITLE     Krit1/cerebral cavernous malformation 1 mRNA is preferentially
            expressed in neurons and epithelial cells in embryo and adult
  JOURNAL   Mech Dev 117 (1-2), 363-367 (2002)
   PUBMED   12204286
  REMARK    GeneRIF: Krit1 mRNA expression during mouse development from E7.5
            to E20.5 and in adult tissues
REFERENCE   7  (bases 1 to 6105)
  AUTHORS   Kehrer-Sawatzki,H., Wilda,M., Braun,V.M., Richter,H.P. and
            Hameister,H.
  TITLE     Mutation and expression analysis of the KRIT1 gene associated with
            cerebral cavernous malformations (CCM1)
  JOURNAL   Acta Neuropathol 104 (3), 231-240 (2002)
   PUBMED   12172908
  REMARK    GeneRIF: evidence of differential Krit1 and Rap1A expression during
            mouse ontogenesis and suggest a more widespread functional
            significance of Krit1, not restricted to vascular endothelial
            cells.
REFERENCE   8  (bases 1 to 6105)
  AUTHORS   Eerola,I., McIntyre,B. and Vikkula,M.
  TITLE     Identification of eight novel 5'-exons in cerebral capillary
            malformation gene-1 (CCM1) encoding KRIT1
  JOURNAL   Biochim Biophys Acta 1517 (3), 464-467 (2001)
   PUBMED   11342228
REFERENCE   9  (bases 1 to 6105)
  AUTHORS   Sahoo,T., Goenaga-Diaz,E., Serebriiskii,I.G., Thomas,J.W.,
            Kotova,E., Cuellar,J.G., Peloquin,J.M., Golemis,E., Beitinjaneh,F.,
            Green,E.D., Johnson,E.W. and Marchuk,D.A.
  TITLE     Computational and experimental analyses reveal previously
            undetected coding exons of the KRIT1 (CCM1) gene
  JOURNAL   Genomics 71 (1), 123-126 (2001)
   PUBMED   11161805
REFERENCE   10 (bases 1 to 6105)
  AUTHORS   Zhang,J., Clatterbuck,R.E., Rigamonti,D. and Dietz,H.C.
  TITLE     Cloning of the murine Krit1 cDNA reveals novel mammalian 5' coding
            exons
  JOURNAL   Genomics 70 (3), 392-395 (2000)
   PUBMED   11161791
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB855141.1, BB619038.1, BC141042.1, AK041574.1 and AK087107.1.
            
            On Jan 1, 2010 this sequence version replaced NM_030675.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Isoform 1 is also known as Krit1A.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF310134.1, BC016087.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               BB855141.1         1-108
            109-156             BB619038.1         91-138
            157-2564            BC141042.1         1-2408
            2565-5596           AK041574.1         580-3611
            5597-6105           AK087107.1         1207-1715
FEATURES             Location/Qualifiers
     source          1..6105
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 2.26 cM"
     gene            1..6105
                     /gene="Krit1"
                     /gene_synonym="2010007K12Rik; A630036P20Rik; Ccm1"
                     /note="KRIT1, ankyrin repeat containing"
                     /db_xref="GeneID:79264"
                     /db_xref="MGI:MGI:1930618"
     exon            1..319
                     /gene="Krit1"
                     /gene_synonym="2010007K12Rik; A630036P20Rik; Ccm1"
                     /inference="alignment:Splign:2.1.0"
     exon            320..423
                     /gene="Krit1"
                     /gene_synonym="2010007K12Rik; A630036P20Rik; Ccm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             322..2532
                     /gene="Krit1"
                     /gene_synonym="2010007K12Rik; A630036P20Rik; Ccm1"
                     /note="isoform 1 is encoded by transcript variant 1; Krev
                     interaction trapped protein 1; krev interaction trapped 1;
                     cerebral cavernous malformations 1 protein homolog"
                     /codon_start=1
                     /product="krev interaction trapped protein 1 isoform 1"
                     /protein_id="NP_109600.2"
                     /db_xref="CCDS:CCDS39002.1"
                     /db_xref="GeneID:79264"
                     /db_xref="MGI:MGI:1930618"
                     /translation="MGNPENIEDAYVAVIRPKNTASLNSREYRAKSYEILLHEVPIEG
                     QKKKRKKVLLETKLQSNSEIAQGILDYVVETTKPISPANQGIKGKRVVLMRKFPLDGE
                     KTGREAALFIVPSVVKDNTKYAYTPGCPIFYCLQDIMRVCSESSTHFATLTARMLIAL
                     DKWLDERHAQSHFIPALFRPSPLERIKTNVINPAYAAELGQVDNSLHMGYSALEIKSK
                     MLALEKADTCIYNPLFGSDLQYTNRVDKVVINPYFGLGAPDYSKIQIPKQEKWQRSMS
                     SVVEDKERQWVDDFPLHRNACEGDSELLSHLLDKGLSVNQLDNDHWAPIHYACWYGKV
                     EATRILLEKGKCNPNLLNGQLSSPLHFAAGGGHAEIVQILLTHPDIDRHITDQQGRSP
                     LNVCEENKQNNWEEAAKLLKDAINKPYEKVRIYRMDGSYRSVELKHGNNTTAQQIMEG
                     MRLSQETQRYFTIWICSENLSLQFKPYHKPLQQVHDWPEILAELTNLDPQRETPQLFL
                     RRDVGLPLEVEKKIEDPLAILILFDEARYNLLKGFYTAPDAKLITLASLLLQIVYGNY
                     ESKKHKQGFLNEETLKSIVPITKLKSKAPHWINRILHEYKNLSLSEGVSKEMHHLQRM
                     FLQNCWEIPTYGAAFFTGQIFTKASPSNHKVIPVYVGVNIKGLHLLNMETKALLISLK
                     YCCFTWQLGDAGTCFQIHSMENKMSFIVHTKQAGLVVKLLMKLNGQLMPSERNS"
     exon            424..583
                     /gene="Krit1"
                     /gene_synonym="2010007K12Rik; A630036P20Rik; Ccm1"
                     /inference="alignment:Splign:2.1.0"
     exon            584..676
                     /gene="Krit1"
                     /gene_synonym="2010007K12Rik; A630036P20Rik; Ccm1"
                     /inference="alignment:Splign:2.1.0"
     exon            677..806
                     /gene="Krit1"
                     /gene_synonym="2010007K12Rik; A630036P20Rik; Ccm1"
                     /inference="alignment:Splign:2.1.0"
     exon            807..1050
                     /gene="Krit1"
                     /gene_synonym="2010007K12Rik; A630036P20Rik; Ccm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1166
                     /gene="Krit1"
                     /gene_synonym="2010007K12Rik; A630036P20Rik; Ccm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1310
                     /gene="Krit1"
                     /gene_synonym="2010007K12Rik; A630036P20Rik; Ccm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1467
                     /gene="Krit1"
                     /gene_synonym="2010007K12Rik; A630036P20Rik; Ccm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1575
                     /gene="Krit1"
                     /gene_synonym="2010007K12Rik; A630036P20Rik; Ccm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1732
                     /gene="Krit1"
                     /gene_synonym="2010007K12Rik; A630036P20Rik; Ccm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1884
                     /gene="Krit1"
                     /gene_synonym="2010007K12Rik; A630036P20Rik; Ccm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..2051
                     /gene="Krit1"
                     /gene_synonym="2010007K12Rik; A630036P20Rik; Ccm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2139
                     /gene="Krit1"
                     /gene_synonym="2010007K12Rik; A630036P20Rik; Ccm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2346
                     /gene="Krit1"
                     /gene_synonym="2010007K12Rik; A630036P20Rik; Ccm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..2463
                     /gene="Krit1"
                     /gene_synonym="2010007K12Rik; A630036P20Rik; Ccm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..6105
                     /gene="Krit1"
                     /gene_synonym="2010007K12Rik; A630036P20Rik; Ccm1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2926..2931
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krit1"
                     /gene_synonym="2010007K12Rik; A630036P20Rik; Ccm1"
                     /note="hexamer: AATAAA"
     polyA_site      2949
                     /gene="Krit1"
                     /gene_synonym="2010007K12Rik; A630036P20Rik; Ccm1"
                     /note="major polyA site"
     regulatory      3015..3020
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krit1"
                     /gene_synonym="2010007K12Rik; A630036P20Rik; Ccm1"
                     /note="hexamer: ATTAAA"
     polyA_site      3036
                     /gene="Krit1"
                     /gene_synonym="2010007K12Rik; A630036P20Rik; Ccm1"
     regulatory      4064..4069
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krit1"
                     /gene_synonym="2010007K12Rik; A630036P20Rik; Ccm1"
                     /note="hexamer: ATTAAA"
     polyA_site      4091
                     /gene="Krit1"
                     /gene_synonym="2010007K12Rik; A630036P20Rik; Ccm1"
     polyA_site      4259
                     /gene="Krit1"
                     /gene_synonym="2010007K12Rik; A630036P20Rik; Ccm1"
     regulatory      5825..5830
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krit1"
                     /gene_synonym="2010007K12Rik; A630036P20Rik; Ccm1"
                     /note="hexamer: AATAGA"
     polyA_site      5851
                     /gene="Krit1"
                     /gene_synonym="2010007K12Rik; A630036P20Rik; Ccm1"
     regulatory      6077..6082
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Krit1"
                     /gene_synonym="2010007K12Rik; A630036P20Rik; Ccm1"
                     /note="hexamer: AATAAA"
     polyA_site      6098
                     /gene="Krit1"
                     /gene_synonym="2010007K12Rik; A630036P20Rik; Ccm1"
ORIGIN      
        1 gaagttattg cccggcgccg gtagcggtgg gatggcgagc tgaggccttt gggagcccga
       61 agctggtgga gaggctgaag ggttcctgga gccgagggag aggaaggacg gtggggaaca
      121 ggtgccctga gacccgaact cgcggggcgg cttttggtga caatccaggg gcttcctgcc
      181 acaggaagtt ggggtgggcc tcctagatag gcagaaggaa tgagaaaacg gtgacgggct
      241 ggctccgcca tccttcgact gccgccccac ccactgactt ggatgtagcg gctcgggaga
      301 ggatccgccg cccgcccggc aatgggaaat ccagaaaaca tcgaagatgc ttacgttgca
      361 gttattcgtc caaagaacac tgctagtctc aactcccggg agtatagagc taagtcctat
      421 gaaattttat tgcatgaagt tcccattgaa ggacagaaaa aaaagcgaaa gaaagttttg
      481 ctggaaacta aacttcaaag caacagtgaa atagcacaag gcatattgga ctatgtagta
      541 gaaactacca aaccaatttc tcctgcaaac caggggatta aagggaaacg agtggtgctg
      601 atgaggaagt ttcctctgga cggagagaag acaggcagag aagcagcact gtttatcgtg
      661 ccatcagttg tcaaagataa tactaaatat gcatatactc ctggatgccc aattttttac
      721 tgcttacaag atattatgag agtttgtagt gaatccagta ctcactttgc aacacttaca
      781 gcaaggatgt taatagcctt ggataagtgg ttagatgaac gtcatgcgca gtctcacttt
      841 attccagctt tattccgacc ttctcccctt gaacggataa agacaaatgt cataaaccct
      901 gcgtatgctg ctgaattagg ccaggtagac aattcactac atatgggcta tagtgcacta
      961 gaaataaaga gtaaaatgct agccctagag aaagcagaca cctgcattta caaccctttg
     1021 tttggatcag atcttcagta tacaaatcgg gtagataaag tggtaataaa tccatacttt
     1081 ggtctcggag ctccagacta ctcaaaaatc caaattccca aacaggaaaa atggcagcga
     1141 agcatgagca gcgttgtgga agacaaagaa cgacagtggg ttgatgactt tcctttacat
     1201 cgaaatgcct gtgaaggaga ttcagaatta ctgagccatc ttctcgataa aggactttca
     1261 gtcaaccaac tagataatga ccactgggca cccattcatt atgcatgctg gtatggaaaa
     1321 gttgaggcca ctcgcatatt attagagaaa ggaaagtgca atccaaacct tttaaatggg
     1381 cagctcagct caccgcttca ctttgctgct ggaggcggcc atgctgaaat agtgcagatc
     1441 ctcctgactc acccagacat tgacaggcac ataacagatc aacaaggaag atccccatta
     1501 aatgtttgtg aagaaaacaa acaaaataac tgggaagaag ctgcaaaatt gttgaaagac
     1561 gccattaaca agccatatga aaaagttcga atctatagaa tggatggatc ataccgttct
     1621 gttgaactaa agcatggcaa taataccaca gcacagcaga taatggaggg aatgcggctc
     1681 tctcaggaaa ctcagcgata tttcactatt tggatctgtt cagaaaatct tagtcttcag
     1741 ttcaagcctt atcataaacc cttgcaacaa gttcatgact ggccagaaat acttgctgaa
     1801 ttgactaatt tggatccaca aagagaaaca ccacagcttt tcctaagaag agatgtggga
     1861 cttcctttag aagttgagaa aaagattgaa gacccactag ctattcttat tctctttgat
     1921 gaagccagat ataatttact gaagggcttt tatacagctc ctgatgctaa actgataaca
     1981 ctggcaagtc tactgttaca aatagtttat gggaattatg agagtaaaaa gcacaaacaa
     2041 ggtttcttaa atgaagaaac tctgaaatcc atcgtaccta ttactaaact gaaaagtaag
     2101 gcgcctcact ggataaaccg aatactccat gagtacaaga atctgagtct gagtgagggc
     2161 gtcagtaagg aaatgcacca cctgcagcgc atgttcctac agaactgctg ggagatccct
     2221 acgtacggag ccgccttctt cacaggacag atatttacaa aggcaagccc aagcaatcat
     2281 aaagtcatcc ctgtgtatgt aggagtgaat ataaaaggac ttcatctcct gaacatggaa
     2341 actaaggcat tactcatcag tctcaagtac tgttgcttta cgtggcagct gggagatgct
     2401 ggtacttgtt ttcaaatcca tagtatggaa aataaaatga gctttatagt acacacaaaa
     2461 caggctggcc ttgtggtaaa gctgctaatg aagttaaatg gacaactaat gccctctgaa
     2521 agaaattcat gaaaagaatt tgaatttgag tacaaaccac cacattttgt aatgtagatt
     2581 tttttccatg aaagatttct gaaaatatga cttaacaaag catgtagttt catatagtat
     2641 gtatatgctg ttacatatat tgtacagaat ctgtactcat gtttggtgtg taatatacca
     2701 cttagttttg tatgatatgc tcataagctc ttctaatttt tgagagaaac acataaaaat
     2761 agatcagcag tctggattat attagacaaa atagtatgct ttataaaaag ttatttttgg
     2821 taaatagtaa agaatttagt gtggaatgtg atgaaattaa aatatagctt tgatataatt
     2881 ttgtgtgtta cttcaaatat tctgaaaacc aacatgattt gaataaataa aatgtatttt
     2941 gtacttgaat ctattattta aaccatttct tctgtaatct ataagcctat cttaaggtgt
     3001 ttttaaacct cttaattaaa ggtgtctcta ccacaagatg ggtttccttg catcggtcct
     3061 agtgtcttta cacactgatg agtccagacg ctcactccct gcacagtttt ccatcctctg
     3121 ggtgtaccaa ggatggtttg ggaataattt cttaatttta aatctcagat ctaattaaat
     3181 tagaccactg gctgtcatat caaagcacac acacaagcag ataattttta tgtcattttc
     3241 tactcttgac attaactttt tattctaaat gatactatat gtaagcctta ttaatattag
     3301 aattatgtag ttaagtgagg ctatttttta ctaaccctcc ccatgccccc ctttccttct
     3361 aacactcttc cctgcttaaa cctttccatt cctatttcta cttttacagc acctgtgata
     3421 taacacctga caccccttca atagtccctt tctagtgtcc tggcttgtac aggcactcca
     3481 agttaaacac agttcagtct atgatccaca aatcagagag aacatttggc atttgtattt
     3541 tctggatgtg ggttacttca tgcagtataa ttttccagtt ccactcatta accttcaatt
     3601 gtaataattt aactcatttt acagatgaat agaattccat tgtacatatg tatgtgtgta
     3661 tgggtgggta ggtggacgga tgggtggatc tatagctaga taacattttc attttccttc
     3721 tatcttttga tgaactggtc ccatttcctg catattgtca agagcagcaa tgaacaggaa
     3781 tggtcccaca tctctatgag gcttgagagc cctgtggggt aaatgcccag gagtgggacg
     3841 gctaccacgt ggagattcta ctttgagctt tgcaaagagc ctccacactg atctctccag
     3901 aggatgcacc agtcgacact ctcaccatca atgagatgtt cctcttcctc ttaccaaagt
     3961 tttcattttc atttgccaag tgactaactg aacctttttc ttaaatgtaa tttgttatat
     4021 gtgagggttt tatatacagt cagtgtgcgt tgtaacagta tctattaaaa gtcaattaag
     4081 ttaatctaaa atgctaacct agctacatag cacatttgac atgattgccc agatgggaag
     4141 ggaaaacatt gatttacaat aacttgtaac ccttttggat tctgaaaatg ttcatatatc
     4201 tatcgatgtg gaacttgtta acgtgtttag cagccataca tattttttct tttgagaaat
     4261 ctctctctgt tcagatctat gactcatttt taattgagct acttgttttc ttggtgtttt
     4321 gttttttgag ttgaatactt aatagcaatc atgttggaca tagatctagc aaagacttgc
     4381 tctcatctcc tagcctggag gctacgtctt cccttgattg atcacttcct ctgctgtaca
     4441 gaagctctca cttttttctt cagtcgttgg ccatataccc tgagcaacca gagccccact
     4501 gaggaaagtc cttatctata gctctatcgt gtacagagtc cctacttttt ttcctagttt
     4561 cagattgtct gtggcattct tcagtcaata tgaagctggg ttttttgtgc agggttagaa
     4621 atagtgaagt cacttccgtc taatgcatgt agacatcagt tttcccaacg ccattcattg
     4681 aagatgccgt tttctttttt aaaaattaag tggctgtaat ggcgtgactt atgtctgggt
     4741 cttctctttc gctgatttaa atgcattttt atgccagtat cacaattttt tttggttttg
     4801 cttttgttta gtgtgggttt tcaagacagg gtttctctat gtcctagaac tcagactggc
     4861 ctcgaactca gagagcttcc tttttctgct aggattaaag ataggtgtca ccatcaccta
     4921 gcaccatgcc attttgtatt aatgtgactg cagtatatct tgaaaccaga tgtggtggtt
     4981 tgaatgaaaa tagccccttt gactcacaag tttgaatgtt tgattcccag ttggtaaggc
     5041 tgtttgggaa gaattaggag ataaatcctt gttggaggag gtgtatgagg cccagtcccc
     5101 tctctgcctc ctgctaatga atcagatgga aggttctcag cttacatatc atgtaagcac
     5161 atgctagtgg ccatgtctga ccacctgttg ctgtttccta ccacagtggt cgtagactaa
     5221 caccctgtaa ctgttagcaa gcccccagtt aatgctttct ttcataagtt gccttgatca
     5281 tggtatctct tcactgtagt agaacaataa ctaagacact gggtatggta atgccttctg
     5341 tattatgttt gcctaggact gctttggata tctgtgatct ttgtacttct atatcaatgt
     5401 taagattttt gtttttcagt ttctgtgagt atggcatgag aattttgatt ggaatagcat
     5461 tggtcctgtc tattgctttt attaggatag tttctttcac aactttaagt cttatccatt
     5521 agcatgggat gtctttcagt ctttgttttc tttgaaccta tgggttttgg gattgtttgt
     5581 ttactgttgt caattccctg atttctctaa gtgtgccatt ggtatgcagt ggatttttat
     5641 gttaatcttg tatactgctg ctttgctgaa agtctagatc agctctagtt tcctgatgat
     5701 atgttagggt ttcttgtgtg tagtattgta tcaccaactg acagcgatac ttgacttgtt
     5761 tcccagtcct atctttttta tttccttctc tttgtcatgt tgctgtacct tgaacactat
     5821 tttaaataga agtagagaat ggccagcctc atattgtccc tgattttaat agaattgcct
     5881 cacgtttttc tccattgagc attttattga ctatgagtca tatgtagctt tcattggatt
     5941 gaagtatact ctctacgggg tttctcaaag gatacatttt cactgtgaac tgtatttact
     6001 cataactgcc caaatttctt cagttgatga gtgagcagac aagtatatcc atatatgcaa
     6061 taggatgcta ctcaacaata aacaattgat gaacattata tgaat
//
