LOCUS       NM_028416               2135 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Mus musculus kringle containing transmembrane protein 2 (Kremen2),
            mRNA.
ACCESSION   NM_028416
VERSION     NM_028416.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2135)
  AUTHORS   Sun,Y., Gao,Y., Dong,M., Li,J., Li,X., He,N., Song,H., Zhang,M.,
            Ji,K., Wang,J., Gu,Y., Wang,Y., Du,L., Liu,Y., Wang,Q., Zhai,H.,
            Sun,D., Liu,Q. and Xu,C.
  TITLE     Kremen2 drives the progression of non-small cell lung cancer by
            preventing SOCS3-mediated degradation of EGFR
  JOURNAL   J Exp Clin Cancer Res 42 (1), 140 (2023)
   PUBMED   37270563
  REMARK    GeneRIF: Kremen2 drives the progression of non-small cell lung
            cancer by preventing SOCS3-mediated degradation of EGFR.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2135)
  AUTHORS   Van Otterloo,E., Milanda,I., Pike,H., Thompson,J.A., Li,H.,
            Jones,K.L. and Williams,T.
  TITLE     AP-2alpha and AP-2beta cooperatively function in the craniofacial
            surface ectoderm to regulate chromatin and gene expression dynamics
            during facial development
  JOURNAL   Elife 11, e70511 (2022)
   PUBMED   35333176
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2135)
  AUTHORS   Sumia,I., Pierani,A. and Causeret,F.
  TITLE     Kremen1-induced cell death is regulated by homo- and
            heterodimerization
  JOURNAL   Cell Death Discov 5, 91 (2019)
   PUBMED   31069116
  REMARK    GeneRIF: Kremen2 antagonizes the apoptotic activity of Kremen1
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2135)
  AUTHORS   Sima,J., Yan,Z., Chen,Y., Lehrmann,E., Zhang,Y., Nagaraja,R.,
            Wang,W., Wang,Z. and Schlessinger,D.
  TITLE     Eda-activated RelB recruits an SWI/SNF (BAF) chromatin-remodeling
            complex and initiates gene transcription in skin appendage
            formation
  JOURNAL   Proc Natl Acad Sci U S A 115 (32), 8173-8178 (2018)
   PUBMED   30037996
REFERENCE   5  (bases 1 to 2135)
  AUTHORS   Staring,J., van den Hengel,L.G., Raaben,M., Blomen,V.A.,
            Carette,J.E. and Brummelkamp,T.R.
  TITLE     KREMEN1 Is a Host Entry Receptor for a Major Group of Enteroviruses
  JOURNAL   Cell Host Microbe 23 (5), 636-643 (2018)
   PUBMED   29681460
REFERENCE   6  (bases 1 to 2135)
  AUTHORS   Carter,M., Chen,X., Slowinska,B., Minnerath,S., Glickstein,S.,
            Shi,L., Campagne,F., Weinstein,H. and Ross,M.E.
  TITLE     Crooked tail (Cd) model of human folate-responsive neural tube
            defects is mutated in Wnt coreceptor lipoprotein receptor-related
            protein 6
  JOURNAL   Proc Natl Acad Sci U S A 102 (36), 12843-12848 (2005)
   PUBMED   16126904
REFERENCE   7  (bases 1 to 2135)
  AUTHORS   De Langhe,S.P., Sala,F.G., Del Moral,P.M., Fairbanks,T.J.,
            Yamada,K.M., Warburton,D., Burns,R.C. and Bellusci,S.
  TITLE     Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt
            signaling in branching morphogenesis of the mouse embryonic lung
  JOURNAL   Dev Biol 277 (2), 316-331 (2005)
   PUBMED   15617677
REFERENCE   8  (bases 1 to 2135)
  AUTHORS   Chu,E.Y., Hens,J., Andl,T., Kairo,A., Yamaguchi,T.P., Brisken,C.,
            Glick,A., Wysolmerski,J.J. and Millar,S.E.
  TITLE     Canonical WNT signaling promotes mammary placode development and is
            essential for initiation of mammary gland morphogenesis
  JOURNAL   Development 131 (19), 4819-4829 (2004)
   PUBMED   15342465
REFERENCE   9  (bases 1 to 2135)
  AUTHORS   Davidson,G., Mao,B., del Barco Barrantes,I. and Niehrs,C.
  TITLE     Kremen proteins interact with Dickkopf1 to regulate anteroposterior
            CNS patterning
  JOURNAL   Development 129 (24), 5587-5596 (2002)
   PUBMED   12421700
  REMARK    Erratum:[Development. 2003 Jan;130(2):425.]
REFERENCE   10 (bases 1 to 2135)
  AUTHORS   Mao,B., Wu,W., Davidson,G., Marhold,J., Li,M., Mechler,B.M.,
            Delius,H., Hoppe,D., Stannek,P., Walter,C., Glinka,A. and Niehrs,C.
  TITLE     Kremen proteins are Dickkopf receptors that regulate
            Wnt/beta-catenin signalling
  JOURNAL   Nature 417 (6889), 664-667 (2002)
   PUBMED   12050670
  REMARK    GeneRIF: Kremen proteins are Dickkopf receptors that regulate
            Wnt/beta-catenin signalling.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AJ457192.1.
            
            On Dec 11, 2009 this sequence version replaced NM_028416.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ457192.1, BC120532.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2036              AJ457192.1         13-2048
            2037-2135           AJ457192.1         2050-2148
FEATURES             Location/Qualifiers
     source          1..2135
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.03 cM"
     gene            1..2135
                     /gene="Kremen2"
                     /gene_synonym="2900054E04Rik; Krm2"
                     /note="kringle containing transmembrane protein 2"
                     /db_xref="GeneID:73016"
                     /db_xref="MGI:MGI:1920266"
     exon            1..91
                     /gene="Kremen2"
                     /gene_synonym="2900054E04Rik; Krm2"
                     /inference="alignment:Splign:2.1.0"
     exon            92..260
                     /gene="Kremen2"
                     /gene_synonym="2900054E04Rik; Krm2"
                     /inference="alignment:Splign:2.1.0"
     exon            261..435
                     /gene="Kremen2"
                     /gene_synonym="2900054E04Rik; Krm2"
                     /inference="alignment:Splign:2.1.0"
     exon            436..527
                     /gene="Kremen2"
                     /gene_synonym="2900054E04Rik; Krm2"
                     /inference="alignment:Splign:2.1.0"
     exon            528..652
                     /gene="Kremen2"
                     /gene_synonym="2900054E04Rik; Krm2"
                     /inference="alignment:Splign:2.1.0"
     exon            653..806
                     /gene="Kremen2"
                     /gene_synonym="2900054E04Rik; Krm2"
                     /inference="alignment:Splign:2.1.0"
     exon            807..1139
                     /gene="Kremen2"
                     /gene_synonym="2900054E04Rik; Krm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1265
                     /gene="Kremen2"
                     /gene_synonym="2900054E04Rik; Krm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1344
                     /gene="Kremen2"
                     /gene_synonym="2900054E04Rik; Krm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..2117
                     /gene="Kremen2"
                     /gene_synonym="2900054E04Rik; Krm2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2097..2102
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kremen2"
                     /gene_synonym="2900054E04Rik; Krm2"
                     /note="hexamer: AATAAA"
     polyA_site      2117
                     /gene="Kremen2"
                     /gene_synonym="2900054E04Rik; Krm2"
                     /note="major polyA site"
ORIGIN      
        1 cccgcgatca gggtcaggga gtggcgtttt cttattcaag ccagccgcgg cgggacctgg
       61 ggagacagaa gcgtgaggat tccgggaaaa tgtcacctgg gagatcctag accccgtggg
      121 tgtcccaggc cgtgttccgt ccaaggcacc atctctttga ttagggaaga tggggacacc
      181 acatctgcag ggcttcctcc tcctcttccc attgctgctg cggctgcacg gggcctcagc
      241 agggagcctg cacagtccag gcttgtccga atgcttccag gtgaacggcg ctgactaccg
      301 aggccaccag aactacaccg gcccacgcgg agctggacgc ccttgtcttt tctgggacca
      361 gacacagcag cacagctaca gcagcgccag cgaccctcag ggccgctggg ggttgggtgc
      421 gcataacttc tgtaggaacc cagacggtga tgtgcagccc tggtgctacg tggcagagac
      481 agaagagggc atctactggc gctactgtga tatccccaca tgtcacatgc ctgggtacct
      541 gggctgcttc gtggactctg gggcaccccc tgctctcagt ggtcccagtg gcacctccac
      601 aaagctcact gtccaagtgt gccttcgatt ctgccgcatg aagggctacc agctggctgg
      661 tgtggaggct ggttatgcct gcttctgtgg ctctgaaagt gacctggccc gcggacgtcc
      721 agcccctgcc accgactgtg accagatctg ttttggccac ccaggccagc tctgtggagg
      781 cgatggacga ctaggcatct atgaagtgtc tgtgggctcc tgccagggaa actggtcggc
      841 tcctcaagga gtcatctact ccccggattt tccggatgag tatggaccag accggaactg
      901 cagctgggta ttgggccaac tgggcgctgt gctagaactc accttccgcc tcttcgagtt
      961 ggctgattct cgagaccggc tggagctacg cgacgtctcg tccggcaacc tactccgtgc
     1021 cttcgacggc gcccatccgc cgcctccggg accgctgcgc ctgcgcactg ctgcgctgct
     1081 gctcaccttc cgcagcgacg caagaggcca tgctcaaggc ttcgcgctca cctaccgcgg
     1141 gctgcaggat acagtggagg gcagagcatc tccagaggat tcaactgaga gtctcgcagg
     1201 ggaccccgat ggggctaacg cgagctgcag ccccaagccc ggagctgcac aggcttcgat
     1261 aggtgcccga gtcttctcca ccgtgacggc cttctctgtg ctgctgctgt tgctcctgtc
     1321 cctactgcgt ttgctgcgtc gacggagctg tctgctggct ccaggaaaag ggtctctggc
     1381 catgggacct tcccggggcc ccgggagaag ctgggctgtg tggtaccgcc ggccccgagg
     1441 ggtggccctg ccctgtcccc caggggactc tcaggctgag ggtcctgctg cgggctaccg
     1501 tcccctgagt gcctccagcc agagctcctt gcgctcgctc gtctctgctc tctgacccca
     1561 gacgtacgtg agtccatcac cacttctgcc agcgagatgg acacccgaga tattatgcag
     1621 caccctacct cgaccttgtg cccctttaaa agcagctcgg tctctgatca tctcgggaag
     1681 accagaagat cggacaggaa gcatccagtg ctatttggga acttggcctg acccttgggg
     1741 tccagatgac tgaagccaaa ggacaaaggg aatccaacac cctaattcat ggaccttgat
     1801 gtgatgggtg gtgtttggtt tcagggttct ttgcgcctct tttggggatg gtcctggact
     1861 gctgccctcg atgaaaggtt aggggccaac aaaagtgatc taaagccggg cgtggtggcg
     1921 catgccttta gtcccagcac tcgggaggca gaggcaggag gatttctggc cagcctggtc
     1981 tacaaagtga gttccaggac agccaaggct atacagagaa accctgtctc aaaaaacaaa
     2041 acaaaacaaa aacaaaaaca aaacaaaagt gatctaaaga ctcagtatag acttaaaata
     2101 aaaggcctat tttggtaaaa aaaaaaaaaa aaaaa
//
