LOCUS       NM_032396               4943 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Mus musculus kringle containing transmembrane protein 1 (Kremen1),
            mRNA.
ACCESSION   NM_032396
VERSION     NM_032396.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4943)
  AUTHORS   Xian,G., Huang,R., Xu,M., Zhao,H., Xu,X., Chen,Y., Ren,H., Xu,D.
            and Zeng,Q.
  TITLE     Noncoding RNA regulates the expression of Krm1 and Dkk2 to
            synergistically affect aortic valve lesions
  JOURNAL   Exp Mol Med 56 (7), 1560-1573 (2024)
   PUBMED   38945954
  REMARK    GeneRIF: Noncoding RNA regulates the expression of Krm1 and Dkk2 to
            synergistically affect aortic valve lesions.
REFERENCE   2  (bases 1 to 4943)
  AUTHORS   Li,X., Liu,Z., Yan,X., Tian,Y., Liu,K., Zhao,Y., Shao,J., Hao,P.
            and Zhang,C.
  TITLE     VP2 residue N142 of coxsackievirus A10 is critical for the
            interaction with KREMEN1 receptor and neutralizing antibodies and
            the pathogenicity in mice
  JOURNAL   PLoS Pathog 19 (10), e1011662 (2023)
   PUBMED   37788227
  REMARK    GeneRIF: VP2 residue N142 of coxsackievirus A10 is critical for the
            interaction with KREMEN1 receptor and neutralizing antibodies and
            the pathogenicity in mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4943)
  AUTHORS   Matern,M.S., Durruthy-Durruthy,R., Birol,O., Darmanis,S.,
            Scheibinger,M., Groves,A.K. and Heller,S.
  TITLE     Transcriptional dynamics of delaminating neuroblasts in the mouse
            otic vesicle
  JOURNAL   Cell Rep 42 (6), 112545 (2023)
   PUBMED   37227818
REFERENCE   4  (bases 1 to 4943)
  AUTHORS   Van Otterloo,E., Milanda,I., Pike,H., Thompson,J.A., Li,H.,
            Jones,K.L. and Williams,T.
  TITLE     AP-2alpha and AP-2beta cooperatively function in the craniofacial
            surface ectoderm to regulate chromatin and gene expression dynamics
            during facial development
  JOURNAL   Elife 11, e70511 (2022)
   PUBMED   35333176
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4943)
  AUTHORS   Staring,J., van den Hengel,L.G., Raaben,M., Blomen,V.A.,
            Carette,J.E. and Brummelkamp,T.R.
  TITLE     KREMEN1 Is a Host Entry Receptor for a Major Group of Enteroviruses
  JOURNAL   Cell Host Microbe 23 (5), 636-643 (2018)
   PUBMED   29681460
REFERENCE   6  (bases 1 to 4943)
  AUTHORS   De Langhe,S.P., Sala,F.G., Del Moral,P.M., Fairbanks,T.J.,
            Yamada,K.M., Warburton,D., Burns,R.C. and Bellusci,S.
  TITLE     Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt
            signaling in branching morphogenesis of the mouse embryonic lung
  JOURNAL   Dev Biol 277 (2), 316-331 (2005)
   PUBMED   15617677
REFERENCE   7  (bases 1 to 4943)
  AUTHORS   Chu,E.Y., Hens,J., Andl,T., Kairo,A., Yamaguchi,T.P., Brisken,C.,
            Glick,A., Wysolmerski,J.J. and Millar,S.E.
  TITLE     Canonical WNT signaling promotes mammary placode development and is
            essential for initiation of mammary gland morphogenesis
  JOURNAL   Development 131 (19), 4819-4829 (2004)
   PUBMED   15342465
REFERENCE   8  (bases 1 to 4943)
  AUTHORS   Davidson,G., Mao,B., del Barco Barrantes,I. and Niehrs,C.
  TITLE     Kremen proteins interact with Dickkopf1 to regulate anteroposterior
            CNS patterning
  JOURNAL   Development 129 (24), 5587-5596 (2002)
   PUBMED   12421700
  REMARK    Erratum:[Development. 2003 Jan;130(2):425.]
REFERENCE   9  (bases 1 to 4943)
  AUTHORS   Mao,B., Wu,W., Davidson,G., Marhold,J., Li,M., Mechler,B.M.,
            Delius,H., Hoppe,D., Stannek,P., Walter,C., Glinka,A. and Niehrs,C.
  TITLE     Kremen proteins are Dickkopf receptors that regulate
            Wnt/beta-catenin signalling
  JOURNAL   Nature 417 (6889), 664-667 (2002)
   PUBMED   12050670
  REMARK    GeneRIF: Kremen proteins are Dickkopf receptors that regulate
            Wnt/beta-catenin signalling
REFERENCE   10 (bases 1 to 4943)
  AUTHORS   Nakamura,T., Aoki,S., Kitajima,K., Takahashi,T., Matsumoto,K. and
            Nakamura,T.
  TITLE     Molecular cloning and characterization of Kremen, a novel
            kringle-containing transmembrane protein
  JOURNAL   Biochim Biophys Acta 1518 (1-2), 63-72 (2001)
   PUBMED   11267660
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC082546.1 and BC049771.1.
            
            On Feb 28, 2006 this sequence version replaced NM_032396.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082546.1, AK141321.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-854               BC082546.1         1-854
            855-1043            BC049771.1         779-967
            1044-4943           BC082546.1         1044-4943
FEATURES             Location/Qualifiers
     source          1..4943
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 3.36 cM"
     gene            1..4943
                     /gene="Kremen1"
                     /gene_synonym="Kremen; Krm1"
                     /note="kringle containing transmembrane protein 1"
                     /db_xref="GeneID:84035"
                     /db_xref="MGI:MGI:1933988"
     exon            1..176
                     /gene="Kremen1"
                     /gene_synonym="Kremen; Krm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1507
                     /gene="Kremen1"
                     /gene_synonym="Kremen; Krm1"
                     /EC_number="2.3.2.27"
                     /note="kremen protein 1; dickkopf receptor; kringle
                     domain-containing transmembrane protein 1;
                     kringle-containing protein marking the eye and the nose;
                     kringle-coding gene marking the eye and the nose"
                     /codon_start=1
                     /product="kremen protein 1 precursor"
                     /protein_id="NP_115772.2"
                     /db_xref="CCDS:CCDS24399.1"
                     /db_xref="GeneID:84035"
                     /db_xref="MGI:MGI:1933988"
                     /translation="MAPPAARLALLSAAALTLAARPAPGPRSGPECFTANGADYRGTQ
                     SWTALQGGKPCLFWNETFQHPYNTLKYPNGEGGLGEHNYCRNPDGDVSPWCYVAEHED
                     GVYWKYCEIPACQMPGNLGCYKDHGNPPPLTGTSKTSNKLTIQTCISFCRSQRFKFAG
                     MESGYACFCGNNPDYWKHGEAASTECNSVCFGDHTQPCGGDGRIILFDTLVGACGGNY
                     SAMAAVVYSPDFPDTYATGRVCYWTIRVPGASRIHFNFTLFDIRDSADMVELLDGYTH
                     RVLVRLSGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQATKEEPPQERPAVNQ
                     TLAEVITEQANLSVSAAHSSKVLYVITPSPSHPPQTAPGSHSWAPSVGANSHRVEGWT
                     VYGLATLLILTVTAVVAKILLHVTFKSHRVPASGDLRDCRQPGASGDIWTIFYEPSTT
                     ISIFKKKLKGQSQQDDRNPLVSD"
     exon            177..339
                     /gene="Kremen1"
                     /gene_synonym="Kremen; Krm1"
                     /inference="alignment:Splign:2.1.0"
     exon            340..431
                     /gene="Kremen1"
                     /gene_synonym="Kremen; Krm1"
                     /inference="alignment:Splign:2.1.0"
     exon            432..556
                     /gene="Kremen1"
                     /gene_synonym="Kremen; Krm1"
                     /inference="alignment:Splign:2.1.0"
     exon            557..710
                     /gene="Kremen1"
                     /gene_synonym="Kremen; Krm1"
                     /inference="alignment:Splign:2.1.0"
     exon            711..1043
                     /gene="Kremen1"
                     /gene_synonym="Kremen; Krm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1253
                     /gene="Kremen1"
                     /gene_synonym="Kremen; Krm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1338
                     /gene="Kremen1"
                     /gene_synonym="Kremen; Krm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..4908
                     /gene="Kremen1"
                     /gene_synonym="Kremen; Krm1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4883..4888
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kremen1"
                     /gene_synonym="Kremen; Krm1"
                     /note="hexamer: AATAAA"
     polyA_site      4908
                     /gene="Kremen1"
                     /gene_synonym="Kremen; Krm1"
                     /note="major polyA site"
ORIGIN      
        1 ccgtcctgct cccatggccg cccccggctc ccggtgctgc cccctctgcc ccgggccgcg
       61 cccgggggtc ccgcactgac ggcccatggc gccgcccgcc gcccgtctcg cgctgctctc
      121 cgccgctgcg ctcactctgg cggcccggcc cgcgcccggt ccccgctccg gccccgagtg
      181 cttcacagcc aacggtgcag attacagggg aacacagagc tggacagcgc tgcaaggtgg
      241 gaagccatgt ctgttctgga acgagacttt ccagcatccg tacaacacgc tgaagtaccc
      301 caacggggaa ggaggactgg gcgagcacaa ttattgcaga aatccagatg gagacgtgag
      361 cccttggtgc tacgtggccg agcatgagga cggagtctac tggaagtact gtgaaattcc
      421 tgcctgccag atgcctggaa accttggctg ctacaaggat catggaaacc cacctcctct
      481 cacgggcacc agtaaaacct ctaacaagct caccatacaa acctgtatca gcttctgtcg
      541 gagtcagaga ttcaagtttg ctgggatgga gtcaggctat gcctgcttct gtgggaacaa
      601 tcctgactac tggaagcacg gggaggcggc cagcaccgag tgcaatagtg tctgcttcgg
      661 ggaccacacg cagccctgcg gtggggacgg caggattatc ctctttgaca ctctcgtggg
      721 cgcctgcggt gggaactact cagccatggc agccgtggtg tactcccctg acttccctga
      781 cacctacgcc actggcagag tctgctactg gaccatccgg gttccaggag cctctcgcat
      841 ccatttcaac ttcaccctgt ttgatatcag ggactctgca gacatggtgg agctgctgga
      901 cggctacacc caccgcgtcc tggtccggct cagtgggagg agccgcccgc ctctgtcttt
      961 caatgtctct ctggattttg tcattttgta tttcttctct gatcgcatca atcaggccca
     1021 gggatttgct gtgttgtacc aagccaccaa ggaggaaccg ccacaggaga gacctgctgt
     1081 caaccagacc ctggcagagg tgatcaccga gcaagccaac ctcagtgtca gcgctgccca
     1141 ctcctccaaa gtcctctatg tcatcacccc cagccccagc caccctccgc agactgcccc
     1201 aggtagccat tcctgggcac cgtcagttgg ggccaacagc cacagagtgg aaggatggac
     1261 tgtgtacggc ctggcgaccc tcctcatcct cacagtcaca gcagttgtcg caaagattct
     1321 tctgcatgtc acatttaaat ctcatcgagt ccctgcatca ggagacctta gggactgtcg
     1381 tcagcctggg gcttctggag atatctggac cattttctat gaaccttcca ctacaatctc
     1441 catctttaag aagaagctca agggtcagag tcaacaagat gaccgcaatc ccctcgtgag
     1501 tgactgaagc ccacgcctgc atgagaggct ccgctccaag ctcgagtttg ctcccctgag
     1561 ttctcctctg atgagttccc tgccttccca ttcaccacca tctcttttgg gagcaccctg
     1621 ctttagaggc agcccagcct gggatcctcc atcacatgta ccagcctggc tgctctgctg
     1681 gggatggtaa gacaggccca ggctgacagg acacagctgg acctgactcc agaagactct
     1741 tgggtggtgg ggaggtatag tgtaggatga gttttcttgc ttcttctctg ttttgtccac
     1801 atacagatcg gtttcccctg tctttacagt ttgcaataga gccagactga aagaactgtc
     1861 aggttttcta ggctggcctg gttccccact aagagtggca ttggcgccct agaggcccag
     1921 aggcccagtg taggcttgga gctttctctg ctgccaacta ccatgtgtca tctagtccga
     1981 ggggactgag agcagggcca caccagatgt catctttcta gagggttctt tttagtaccc
     2041 actgaccaat ggggcaagcc tgaggattgg tccatctgtt tgtccatgga acagacacag
     2101 tgaacttcct ggatactaga cttaactagc ctagccctca agtagttgcc aatcctgtgg
     2161 aatcagaatt cagcctgtct tcctgtcctc agcccaagcc tgtagcctag agctggggct
     2221 gtagcctaga gctggggctg tagcctagag ctggggctgt agcacagagc tggggctgta
     2281 gcctagagct ggggctgtag cacagagctg gggctgtagc ctagagctgg ggctgtagca
     2341 cagagctggg gctgtagcac agagctgggg ctgtagccta gagctggggc tgtagcacag
     2401 agctggggct gtaactcagc gatcaagagc ttgctttgta tacatcggac cctaggttct
     2461 atcccagcac tatcagaagg tgggagagaa aaagactgca ccatagcatg cgggcagcat
     2521 ctgtggttcc tacgtgaggt gtcatcattt taaaagcaga tcaaaactac cgcgagtttt
     2581 gtcctttgtc ccttatcatg ggagcagagt aggagtaagg gctctggtct tgctcattgt
     2641 cccccagaca gggaggcagg aaaaggtcag gcttgggaac tggagatcct cccaggaaaa
     2701 gctgcaagat tgagagaccc agctgcagtt gggagaggaa gggccatccc cgactgagaa
     2761 gtcctgcagt ctggaagtgg cctttgtcag cagcagctgt gccctgaagg tagaccttgg
     2821 tcactctcct gccagccctt gagcctctgc tctcctgggt accctcctgg aacaccatgc
     2881 taaccttccc cgagtctctc agtcactgcc attgaggcct ctcctctagc tgctgctccc
     2941 caggactgtc tggggccatc tggggatcag ggagaggcag caggagtact gacgaggcag
     3001 tgacctgagc tgatgagtca accagaggac accagagtct acagtgggct ggctgctggc
     3061 tcagctccta tgggaggcct acaggggtac taagctaggg ggtcatcatc tcatttgatc
     3121 tgggaaaggc tacaggctcc tggatgtgaa gacaggccca ctacataaga agaccactgg
     3181 aaatagactg acaggagcag gttccactct aggctgtcca tagcgtttgc aggactcccc
     3241 tgagaccaag tgttgagtca cagagtgcca tgtgcgtagt gcataaagga tatgggttct
     3301 taaccaggga aggctcatag caggccagga cattttttca gctcagagca ctggccccag
     3361 gcttcctcta agccaccact cacctgtctc ttcctatctc ggacacagga agcaagcccc
     3421 agtgtggtgg cagctgcggc tcagcattgg tgtccccagg aagggcggtg gatgtgccca
     3481 cgctcctttt gctgtgggcc tggcacagcc caacactgca gggcccacct tctctcttgg
     3541 ggggtaggga cacataagga aaactaaccc acctccaaca acagcagagg acagtgggaa
     3601 ggaagggctg taaatcaccc aggccagacc tccagaaatg acaggcacag tctgttagaa
     3661 cctgtaggca gccagtcaca gagggccttt gtgctggtaa caccctgcct ggagcatagg
     3721 ggtaagccga gggagaagag cagccctcag agacatcagc taaaaacata ggtgccctat
     3781 gtccctccct tcctgtcaca ctgcttacaa agcagagaca gagtaggaaa gaggtcttca
     3841 tcctctccca catcagcaag gatagggctg cggctgccta aagtgagcaa ggagaacaga
     3901 gctctggact tctctaaatg tgggctctgg cttcagactc ctcagccaaa agctcttgaa
     3961 gatcaaagct ctggcgggta cagctgtcct ggcctgtggg ccagcccatg ggatgtgcct
     4021 gggccaggtg ccaccccacg gctcactgtc atcccaggag ggaccccacc tgatgctcct
     4081 catcatccgc tggcctgaca ctatcagagc tcgcgccggc tgttgccagg gacagactga
     4141 ctacacttga ccttcaagag cacttagaag tggatggcct ccagactctg tcagcctctg
     4201 caggggccac acaagtctcc cgagccaagt ccacaagcct ccatggttcc ctggctcctc
     4261 tcctgtggag tgtcctgttt gatgtctgag gtctgctttg ggtaccgccc tgggaactgc
     4321 taacctccga ttggtccctt tgtgtctctg tttactgtcc tcttctacct ccaggtcact
     4381 tagctctggc tgctctggct gggagtgggg ggtggggatg ctggctgcac ccccaccctg
     4441 gtctgccaac agaacctggg ggcctcacac gggctcctgt cttgccaagc tggagctgag
     4501 cacactggcc caggctgagt ggggcagagc aaacaagtgg aaggggatct ctcaccttag
     4561 agggaggtgg ccgaaggtgt agatccagcg agggagctgc catccccgcc accttcatag
     4621 cagcaagacc ttcccatttc caatctcacc ctccagcagg gatatgactt tggacaacaa
     4681 ggctttattt gtaaatatgc tcttaatatg caactttgag aataagatag aaacatcatg
     4741 tattttaaaa tataaaatga agtgtgacac actgtataca atttaatata tatttttagg
     4801 attttgttat ttaagaaaat ggaatgtgat ggtacttaac ttttacaaaa gagagaaaat
     4861 gttattttta ctgtttgaag aaaataaata ttctcattgt tgtagaaaaa aaaaaaaaaa
     4921 aaaaaaaaaa aaaaaaaaaa aaa
//
