LOCUS       NM_001403243            4798 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus Kirsten rat sarcoma viral oncogene homolog (Kras),
            transcript variant 5, mRNA.
ACCESSION   NM_001403243 XM_006506918
VERSION     NM_001403243.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4798)
  AUTHORS   Tang,Z., Hu,J., Li,X.C., Wang,W., Zhang,H.Y., Guo,Y.Y., Shuai,X.,
            Chu,Q., Xie,C., Lin,D. and Zhong,B.
  TITLE     A subset of neutrophils activates anti-tumor immunity and inhibits
            non-small-cell lung cancer progression
  JOURNAL   Dev Cell 60 (3), 379-395 (2025)
   PUBMED   39515330
REFERENCE   2  (bases 1 to 4798)
  AUTHORS   Koo,H., Park,K.C., Sohn,H.A., Kang,M., Kim,D.J., Park,Z.Y.,
            Park,S., Min,S.H., Park,S.H., You,Y.M., Han,Y., Kim,B.K., Lee,C.H.,
            Kim,Y.S., Chung,S.J., Yeom,Y.I. and Lee,D.C.
  TITLE     Anti-proteolytic regulation of KRAS by USP9X/NDRG3 in KRAS-driven
            cancer development
  JOURNAL   Nat Commun 16 (1), 628 (2025)
   PUBMED   39819877
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4798)
  AUTHORS   Greenwood,H.E., Barber,A.R., Edwards,R.S., Tyrrell,W.E.,
            George,M.E., Dos Santos,S.N., Baark,F., Tanc,M., Khalil,E.,
            Falzone,A., Ward,N.P., DeBlasi,J.M., Torrente,L., Soni,P.N.,
            Pearce,D.R., Firth,G., Smith,L.M., Vilhelmsson Timmermand,O.,
            Huebner,A., Swanton,C., Hynds,R.E., DeNicola,G.M. and Witney,T.H.
  TITLE     Imaging NRF2 activation in non-small cell lung cancer with positron
            emission tomography
  JOURNAL   Nat Commun 15 (1), 10484 (2024)
   PUBMED   39690148
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4798)
  AUTHORS   Hanggi,K., Li,J., Gangadharan,A., Liu,X., Celias,D.P.,
            Osunmakinde,O., Keske,A., Davis,J., Ahmad,F., Giron,A.,
            Anadon,C.M., Gardner,A., DeNardo,D.G., Shaw,T.I., Beg,A.A., Yu,X.
            and Ruffell,B.
  TITLE     Interleukin-1alpha release during necrotic-like cell death
            generates myeloid-driven immunosuppression that restricts
            anti-tumor immunity
  JOURNAL   Cancer Cell 42 (12), 2015-2031 (2024)
   PUBMED   39577420
REFERENCE   5  (bases 1 to 4798)
  AUTHORS   Pedrosa,P., Zhang,Z., Nunez-Quintela,V., Macias,D., Ge,J.,
            Denholm,M., Dyas,A., Estevez-Souto,V., Lado-Fernandez,P.,
            Gonzalez,P., Gomez,M., Martin,J.E., Da Silva-Alvarez,S., Collado,M.
            and Munoz-Espin,D.
  TITLE     Inhibition of lung tumorigenesis by transient reprogramming in
            cancer cells
  JOURNAL   Cell Death Dis 15 (11), 857 (2024)
   PUBMED   39587064
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4798)
  AUTHORS   Foroni,L., Boehm,T., White,L., Forster,A., Sherrington,P.,
            Liao,X.B., Brannan,C.I., Jenkins,N.A., Copeland,N.G. and
            Rabbitts,T.H.
  TITLE     The rhombotin gene family encode related LIM-domain proteins whose
            differing expression suggests multiple roles in mouse development
  JOURNAL   J Mol Biol 226 (3), 747-761 (1992)
   PUBMED   1507224
REFERENCE   7  (bases 1 to 4798)
  AUTHORS   Lord,P.G., Hardaker,K.J., Loughlin,J.M., Marsden,A.M. and
            Orton,T.C.
  TITLE     Point mutation analysis of ras genes in spontaneous and chemically
            induced C57Bl/10J mouse liver tumours
  JOURNAL   Carcinogenesis 13 (8), 1383-1387 (1992)
   PUBMED   1499088
REFERENCE   8  (bases 1 to 4798)
  AUTHORS   You,M., Wang,Y., Stoner,G., You,L., Maronpot,R., Reynolds,S.H. and
            Anderson,M.
  TITLE     Parental bias of Ki-ras oncogenes detected in lung tumors from
            mouse hybrids
  JOURNAL   Proc Natl Acad Sci U S A 89 (13), 5804-5808 (1992)
   PUBMED   1352876
REFERENCE   9  (bases 1 to 4798)
  AUTHORS   Seldin,M.F., Mattei,M.G. and Hendy,G.N.
  TITLE     Localization of mouse parathyroid hormone-like peptide gene (Pthlh)
            to distal chromosome 6 using interspecific backcross mice and in
            situ hybridization
  JOURNAL   Cytogenet Cell Genet 60 (3-4), 252-254 (1992)
   PUBMED   1354597
REFERENCE   10 (bases 1 to 4798)
  AUTHORS   Scolnick,E.M., Papageorge,A.G. and Shih,T.Y.
  TITLE     Guanine nucleotide-binding activity as an assay for src protein of
            rat-derived murine sarcoma viruses
  JOURNAL   Proc Natl Acad Sci U S A 76 (10), 5355-5359 (1979)
   PUBMED   228288
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157091.6.
            
            On Mar 29, 2022 this sequence version replaced XM_006506918.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253011.2316306.1,
                                           SRR10662774.90841.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               AC157091.6         148099-148289       c
            192-313             AC157091.6         144745-144866       c
            314-492             AC157091.6         132298-132476       c
            493-652             AC157091.6         130145-130304       c
            653-776             AC157091.6         123124-123247       c
            777-4798            AC157091.6         114753-118774       c
FEATURES             Location/Qualifiers
     source          1..4798
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 77.37 cM"
     gene            1..4798
                     /gene="Kras"
                     /gene_synonym="c-K-ras; c-Ki-ras; K-ras; K-Ras; K-Ras 2;
                     Ki-ras; Kras-2; Kras2; p21B; ras"
                     /note="Kirsten rat sarcoma viral oncogene homolog"
                     /db_xref="GeneID:16653"
                     /db_xref="MGI:MGI:96680"
     exon            1..191
                     /gene="Kras"
                     /gene_synonym="c-K-ras; c-Ki-ras; K-ras; K-Ras; K-Ras 2;
                     Ki-ras; Kras-2; Kras2; p21B; ras"
                     /inference="alignment:Splign:2.1.0"
     exon            192..313
                     /gene="Kras"
                     /gene_synonym="c-K-ras; c-Ki-ras; K-ras; K-Ras; K-Ras 2;
                     Ki-ras; Kras-2; Kras2; p21B; ras"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..772
                     /gene="Kras"
                     /gene_synonym="c-K-ras; c-Ki-ras; K-ras; K-Ras; K-Ras 2;
                     Ki-ras; Kras-2; Kras2; p21B; ras"
                     /EC_number="3.6.5.2"
                     /note="isoform 2 is encoded by transcript variant 5;
                     Kirsten rat sarcoma oncogene 2, expressed; p21 protein;
                     v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog;
                     GTPase KRas"
                     /codon_start=1
                     /product="GTPase KRas isoform 2"
                     /protein_id="NP_001390172.1"
                     /db_xref="GeneID:16653"
                     /db_xref="MGI:MGI:96680"
                     /translation="MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQV
                     VIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKR
                     VKDSEDVPMVLVGNKCDLPSRTVDTKQAQELARSYGIPFIETSAKTRQRVEDAFYTLV
                     REIRQYRLKKISKEEKTPGCVKIKKCVIM"
     exon            314..492
                     /gene="Kras"
                     /gene_synonym="c-K-ras; c-Ki-ras; K-ras; K-Ras; K-Ras 2;
                     Ki-ras; Kras-2; Kras2; p21B; ras"
                     /inference="alignment:Splign:2.1.0"
     exon            493..652
                     /gene="Kras"
                     /gene_synonym="c-K-ras; c-Ki-ras; K-ras; K-Ras; K-Ras 2;
                     Ki-ras; Kras-2; Kras2; p21B; ras"
                     /inference="alignment:Splign:2.1.0"
     exon            653..776
                     /gene="Kras"
                     /gene_synonym="c-K-ras; c-Ki-ras; K-ras; K-Ras; K-Ras 2;
                     Ki-ras; Kras-2; Kras2; p21B; ras"
                     /inference="alignment:Splign:2.1.0"
     exon            777..4798
                     /gene="Kras"
                     /gene_synonym="c-K-ras; c-Ki-ras; K-ras; K-Ras; K-Ras 2;
                     Ki-ras; Kras-2; Kras2; p21B; ras"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2011..2016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kras"
                     /gene_synonym="c-K-ras; c-Ki-ras; K-ras; K-Ras; K-Ras 2;
                     Ki-ras; Kras-2; Kras2; p21B; ras"
                     /note="hexamer: AATAAA"
     polyA_site      2033
                     /gene="Kras"
                     /gene_synonym="c-K-ras; c-Ki-ras; K-ras; K-Ras; K-Ras 2;
                     Ki-ras; Kras-2; Kras2; p21B; ras"
                     /note="major polyA site"
     regulatory      4776..4781
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kras"
                     /gene_synonym="c-K-ras; c-Ki-ras; K-ras; K-Ras; K-Ras 2;
                     Ki-ras; Kras-2; Kras2; p21B; ras"
                     /note="hexamer: AATAAA"
     polyA_site      4798
                     /gene="Kras"
                     /gene_synonym="c-K-ras; c-Ki-ras; K-ras; K-Ras; K-Ras 2;
                     Ki-ras; Kras-2; Kras2; p21B; ras"
ORIGIN      
        1 gattcggcag gcggcggccg cggcggctga ggcggcagcg ctgtggcggc ggctgagacg
       61 gcaggggaag gcggcggcgg ctcggcccgg agtcccgctc ccgcgccatt tcggacccgg
      121 agcgagcgcg gcgcgggcct gaaggcggcg gcgggagcct gaggcgcggc ggctccgcgg
      181 cgcggagaga ggcctgctga aaatgactga gtataaactt gtggtggttg gagctggtgg
      241 cgtaggcaag agcgccttga cgatacagct aattcagaat cactttgtgg atgagtatga
      301 ccctacgata gaggactcct acaggaaaca agtagtaatt gatggagaaa cctgtctctt
      361 ggatattctc gacacagcag gtcaagagga gtacagtgca atgagggacc agtacatgag
      421 aactggggag ggctttcttt gtgtatttgc cataaataat actaaatcat ttgaagatat
      481 tcaccattat agagaacaaa ttaaaagagt aaaggactct gaagatgtgc ctatggtcct
      541 ggtagggaat aagtgtgatt tgccttctag aacagtagac acgaaacagg ctcaggagtt
      601 agcaaggagt tacgggattc cgttcattga gacctcagca aagacaagac agagagtgga
      661 ggatgctttt tatacattgg tgagagagat ccgacagtac agattgaaaa aaatcagcaa
      721 agaagaaaag actcctggct gtgtgaaaat taaaaaatgc gttataatgt aatctgggtg
      781 ttgacgatgc cttctataca ttagtccgag aaattcgaaa acataaagaa aagatgagca
      841 aagatgggaa gaagaagaag aagaagtcaa ggacaaggtg tacagttatg tgaatacttt
      901 gtactctttc ttaaggcaca cttaagtaaa agtgtgattt ttgtacatta cactaaatta
      961 ttagcatttg ttttagcatt acctaatctt tttttttctt ctgttcgtgc aaactgtcag
     1021 cttttatctc aaatgcttat tttaaaagaa cagtggaaac cttctttttt ctaagtgcca
     1081 gtattccctg ggttttggac ttaaactagc aatgcctgtg gaagagacta aagacctgag
     1141 actctgtctt gggatttggt gcatgcagtt gattccttgc tagttctctt accaactgtg
     1201 aacactgatg ggaagcagga taatgaagct tccggaccat ccctgctctg tgtccatcta
     1261 ctcatccaat ggagtcatta gcagtcaatc gccgcttcac tggacactga ggggtcacag
     1321 acttaggctc cctttgagtc gcgtccagcg tgtcctagac tttatcatct ttcagaggcg
     1381 taggcagact gttcacaaag gctttctgta gctttccact gcaattaatc ttggtcactc
     1441 cctcaaatag tatatttttt ctagaaaagg ggaaaaatgg aaaaaaaaag gcaatggaaa
     1501 atgttgaaat ccattcagtt tccatgttag ctaaattact gtaagattcc tataatagct
     1561 tttcctggta aggcagaccc agtatgaaat agtaataacc atttgggcta tatttacatg
     1621 ctactaaatt tttgtaataa ttcaaacaac tttagcatat ataaaaagtt ctcataagaa
     1681 ttaagtacaa ttcccctttg tcagattgtt cttatcctaa ctttcaagtc ttttttgaat
     1741 ttctgttgtt gaaagtagtt ttaatggttg tgaagctgaa gatgatctga gacagttata
     1801 gcttggcagg tgttgaggag accagagttg cagggttggg ccttacgtga acctgtgacg
     1861 aacgctactg ggttttgcag cactgctgca ttcaatgttg gcgacgcatt gtttggtcaa
     1921 cataggggat aaggagactt tgatggctta gtataatgca ttctcaccat gtaacagtcc
     1981 tactgacaaa tcaagaaatt tgtttataat aataaaaaat ttttaaaaat ttcgatgttc
     2041 gcttcaaggt tgagattttg gggtaggagg ctacaacaag agtaaatctt aaagcaaggt
     2101 tttaagaagg tttgaaaatg caggtttgac tagtctctca actctagcta aacaaacatt
     2161 cccaagtact tcccaaatct gataggtatt taaaattatc taatgcttta agaatagtta
     2221 acaggaaaaa aatctcctca gtgcacttaa agcaaccctt cacatcattt gaaatgagat
     2281 ggaaatatca ctggactatg aggactggat gtctgtctga ttttaagcaa atcactgtct
     2341 gcttggtttt gaatcatctc aaagacatta acctcccagc cgtgtaacat agtttacatg
     2401 ttgacacacc tagttatcaa gctcagcaca atctgtaact gttttacatg gattaacatc
     2461 ttcactgcca gtcttgggca aattgtgcaa gaggtaaaat ttatatttca gtatccattc
     2521 tcccatttca ggactcccct ccaacattat gctggctttc agcctgtctc tcacctgccc
     2581 atcacttagt gtagttttaa taatttcccc cacttcaaac tttgtttcca ctatggacaa
     2641 cttcatgaac tttgcccact aaggtaggta catcaaagct gccctatggc tttcttcccc
     2701 gggactgaaa ataacagaca ccatagtggg atttaaacta atagatggtt ttcagggcca
     2761 ctacaacaat tcaatctcaa tcctttggac ttcattcctg ctgcccaggc cactggtgcc
     2821 tcagtaggaa ttttcaaaat tagtgtgaac agacagagca cagtccagtg gaaggtgagc
     2881 ttaatcttca tctagccatc atcatggtaa gtgatagatt ctattgtttt aataaataca
     2941 gtctaacaat gaaaaacact tcgaagtttc aatcataaag ctgtcttttt aaaaatttta
     3001 tttactcaac atttattcag tgcttgtcat attctgggaa ttacactagg cactcagggt
     3061 gcggtgtcct caatccttgg ccagtggtat gtagcatgat ctgtaatacc actaaataag
     3121 gcatatagca tatgacttag acataatgaa atacatgatt tgagttttgc agagaggagt
     3181 ttgggtttgt acattccctt cccccccagt ttagcaagaa ttgtttgctg tgaatccaat
     3241 gcaactttta aatcaaacta ctttatataa ttatttcatt tttctaaagg aacagaagta
     3301 ccctaaacta tttttttgaa atgttctaaa ctgtacatat tcatagaaca ttctttgggt
     3361 gaattttaag tcttaaaatg caattagtaa tacttctcat ttctattcag aggaacaggt
     3421 gtacttcaaa agctgcagtg tataatcaga tatttttaat ggacaatgtg ttaaagaagt
     3481 ggtaattacc actatgtaaa tttgaattgt gttacacttt ggttaacaaa aggggaaaga
     3541 atcctagaaa caaatatgtt atctagttac tgcagcctta aagtccttgt tgaagttaaa
     3601 aagcaatgct aagttacagt cataggcatt aacatgttta tgggaaggat atagtaggca
     3661 aatacaattt gagtaaatat tttcagtagg gaattttagg ctctactgac tgagtcacac
     3721 tgcataggaa tttagatctt aacttttata ggttatcgac ctttgccacc attgcacaat
     3781 tttgtcctaa cataaataca agttctgtga ggcatgtcaa aagttacagt ttgcataaat
     3841 tcatctcatt ttgtattcca ctgattttac attttcctca aacatacata catacataca
     3901 tacaacacac acacactcac acatgaaggg tttttttttt gtaggcaata aaaatttaac
     3961 taatttccat ttgttaaaaa gtagtgattt attgagaatt atgcagtcat tttttaaacc
     4021 caaaagttat ttaaaggtga atttatactc aataacttct gtgtaatact gggtagcatg
     4081 aattctgcat tgaaaaattg aacagataat accaatagct gtaaattctg tcaaaacatg
     4141 aaaattattt ctaaagaagt acattagttt tcaaagaaca gttattagaa tcagatctgt
     4201 ggtttagttc aataatttga agtgcctgtt tgggatggtg gtaggcattt tagatgaatt
     4261 tgggaaaaat aaagttctgc agaaatgcca gtttcagacc ccgctaaccc gctgagtggg
     4321 ctgtgtgctg tgttagctcc agtgccccaa tcccgtttca tgtcttcatg ttgaaacact
     4381 tctgcatttt tatttgagtg ccaatttctt actagtgcta tttcttagtg taacatgttt
     4441 acctgggatg tattttaact atttttgtat agtgtaaact gaaacatgca cattttgtac
     4501 attgtgcttt ccttctttcc attccttttc tttctgtttt gtttgtttgt ttgtttgttt
     4561 gtttgttatg ggacatatgc agtgtgatcc agttgttttc catcctttgg ttgcgctgac
     4621 ctagggaatg ttggtcatat caaacattaa atttaaaagt gaccactctt aattaaaatt
     4681 aacttttaaa tgtttatagg agtacgtgct gtgaagtgat ctgaaatttg taatattttt
     4741 gtcatgaacc gtactgctcc taatcattgt aatgtaataa aaatagttat ggtgacta
//
