LOCUS       NM_028629               2738 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus keratinocyte expressed, proline-rich (Kprp), mRNA.
ACCESSION   NM_028629 XM_001000620 XM_904796 XM_974337
VERSION     NM_028629.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2738)
  AUTHORS   Suga,H., Oka,T., Sugaya,M., Sato,Y., Ishii,T., Nishida,H.,
            Ishikawa,S., Fukayama,M. and Sato,S.
  TITLE     Keratinocyte Proline-Rich Protein Deficiency in Atopic Dermatitis
            Leads to Barrier Disruption
  JOURNAL   J Invest Dermatol 139 (9), 1867-1875 (2019)
   PUBMED   30905808
  REMARK    GeneRIF: Heterozygous knockout (Kprp+/-) mice exhibited reduced
            KPRP expression to level like that of human atopic dermatitis (AD)
            lesional skin. Kprp+/- mice showed abnormal desmosome structure and
            detachment of lower layers of the stratum corneum. Percutaneous
            inflammation by topical application of croton oil or oxazolone was
            enhanced, and epicutaneous immunization with ovalbumin induced a
            high level of IgE in Kprp+/- mice.
REFERENCE   2  (bases 1 to 2738)
  AUTHORS   Brown,S.J., Tilli,C.M., Jackson,B., Avilion,A.A., MacLeod,M.C.,
            Maltais,L.J., Lovering,R.C. and Byrne,C.
  TITLE     Rodent Lce gene clusters; new nomenclature, gene organization, and
            divergence of human and rodent genes
  JOURNAL   J Invest Dermatol 127 (7), 1782-1786 (2007)
   PUBMED   17410201
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127247.3, AK003253.1 and AI117574.1.
            
            On or before Aug 25, 2006 this sequence version replaced
            XM_001000620.1, XM_904796.2, XM_974337.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CJ094778.1, BC141372.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AC127247.3         38402-38434
            34-2078             AC127247.3         39880-41924
            2079-2726           AK003253.1         369-1016
            2727-2738           AI117574.1         1-12                c
FEATURES             Location/Qualifiers
     source          1..2738
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.14 cM"
     gene            1..2738
                     /gene="Kprp"
                     /gene_synonym="1110001M24Rik"
                     /note="keratinocyte expressed, proline-rich"
                     /db_xref="GeneID:433619"
                     /db_xref="MGI:MGI:1920981"
     exon            1..33
                     /gene="Kprp"
                     /gene_synonym="1110001M24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            34..2729
                     /gene="Kprp"
                     /gene_synonym="1110001M24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..2035
                     /gene="Kprp"
                     /gene_synonym="1110001M24Rik"
                     /codon_start=1
                     /product="keratinocyte proline-rich protein"
                     /protein_id="NP_082905.1"
                     /db_xref="CCDS:CCDS38517.1"
                     /db_xref="GeneID:433619"
                     /db_xref="MGI:MGI:1920981"
                     /translation="MCDQQPIQCCVPIPQCCVKGSSFGPSQFSYANNQVLVEAPCEMK
                     VLECAAPCPVQVSQTACQSSTTEVKGQAPCKTTKGKCQAPCQSKTTQVKYQPKTTEIK
                     CQAPCQTQVSCVQCQAPCQSQVSYVQIPQPPQTYYVECPPVYYTETRYVEYPVSTYMP
                     APALQPGYTYVECPAVGQGQGQGQGGFSTQYQYQGSYGSCTPQSQSRRSYSSCGPQNQ
                     SQASYSYCEPQFQSGPSYTNCGPQRQSQASYGNCTSQLQSRASYSNCSSQRRSGATFS
                     TCAPRCQSQGTYGSYTSQRRSQSTSRCLPPRRLQPSYRSCSPPRHSEPCYSSCLPSRC
                     SSGSYNYCTPPRRSEPIYGSHCPPRGRPSGCSQRCGPKCRVEISSPCCPRQVPPQRCP
                     VQIPPFRGRSQSCPRQPSWGVSCPDLRPRADPHPFPRSCRPQHLDRSPESSRQRCPVP
                     APRPYPRPQPCPSPEPRPYPRPQPCPSPEPRPRPCPQPCPSPEPRPCPPLRRFSEPCL
                     YPEPCSAPQPVPHPAPRPVPRPRPVHCENPGPRPQPCPLPHPEPMPRPAPCSSPEPCG
                     QPVRCPSPCSGPNPVPYRQELGCHESNPCRLDTEGPRCGSYNFTQRQESNGSCESGDV
                     FSGSHGLSGCGDQGNTCGGMNCGAYGGAKGAYF"
     regulatory      2707..2712
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kprp"
                     /gene_synonym="1110001M24Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2729
                     /gene="Kprp"
                     /gene_synonym="1110001M24Rik"
                     /note="major polyA site"
ORIGIN      
        1 ttagcctgaa tgactttgtg cctgctgagg agggtcttgc ttactcacct gcaccaggac
       61 catgtgtgac cagcaaccga ttcagtgttg tgtgccgata ccccagtgct gtgtcaaggg
      121 ttcctccttt ggcccctcac agttttctta cgccaacaac caggtgctgg tggaagctcc
      181 atgtgagatg aaagttctgg aatgtgctgc accatgccca gttcaagttt ctcagactgc
      241 atgccagtcc agtaccactg aagtgaaggg ccaggctcca tgtaagacca ccaaaggcaa
      301 atgccaggcc ccgtgccagt caaagactac ccaggtgaaa taccagccta agaccactga
      361 gataaagtgc caggctccct gccagactca ggtttcctgt gttcaatgcc aggctccatg
      421 tcaatctcag gtttcctacg tgcaaatccc acaacctcct cagacctatt atgtagagtg
      481 tcctccagtg tactatacag agactcgtta tgtggaatat ccggtttcaa cctacatgcc
      541 tgctccagcc cttcagcctg gctacactta tgtagaatgt cccgcagtgg gccagggcca
      601 gggccagggc cagggaggct tctccactca gtaccagtat cagggctcct acggtagctg
      661 cactcctcaa tcacagtcac ggcgttctta cagcagctgt ggtccacaga atcaatctca
      721 ggcttcctac agttactgtg agcctcaatt tcagtccggg ccttcctaca ccaactgtgg
      781 cccccagcgc cagtcacagg cttcctatgg caactgcacc tcccaactcc agtctcgagc
      841 atcctacagc aactgctcct cccagcgtcg gtccggggct acctttagca cctgtgcacc
      901 ccgatgccag tcccagggca cctatggaag ctacacttca cagcgccggt ctcagagtac
      961 cagccgatgc ctccctcctc gtcggctcca gccttcttat cgcagctgct ctccaccaag
     1021 acattctgaa ccctgttata gcagctgcct gccatccaga tgctcttcag gctcctacaa
     1081 ctattgcact ccaccccgcc gctcagagcc catctatggt agccactgtc cacctcgggg
     1141 ccgcccttca ggctgttctc aaagatgtgg acccaaatgc agggtagaga tttcctcccc
     1201 ttgctgccca aggcaagttc ccccgcagag gtgtcctgtc cagattcctc ccttcagagg
     1261 aagatcccag agctgtcccc ggcaaccctc ttggggtgtc tcctgcccag acctgaggcc
     1321 acgtgcagac ccacacccat tcccaaggtc ttgtaggcca cagcatcttg accggtctcc
     1381 agaatcatca cggcagaggt gcccagttcc tgcaccacgt ccatatccac gtccacagcc
     1441 atgcccaagc ccagaacccc gtccgtatcc tcgtccacag ccttgcccaa gtccagaacc
     1501 ccgcccacgt ccttgtccac agccatgccc aagtccagaa cctcgcccat gtcctccatt
     1561 aaggcgattt tcagaaccct gtctgtatcc agaaccatgc tcagctcctc aaccagtgcc
     1621 acatccagca ccacgcccag tgccacgtcc gcgcccagtt cactgtgaga atccaggtcc
     1681 acgtccacag ccttgtcctc ttcctcatcc agagccaatg ccacgtccag cgccctgttc
     1741 cagtccagag ccttgtgggc aacccgttcg ttgtcccagt ccctgctcag gtcccaatcc
     1801 agtaccttac cgccaagaac taggctgtca tgaatctaac ccatgtcgcc tggataccga
     1861 aggcccgcgc tgtggctcat ataacttcac ccaaaggcaa gagagtaatg gcagctgtga
     1921 atctggtgat gtcttttcag gatcacacgg tctaagtggt tgtggagacc aaggaaatac
     1981 ctgtggtggc atgaactgtg gggcttatgg tggagcaaag ggagcctact tttaaacaaa
     2041 agtatagcct aaatgtatta ggttctttag agtgtttccc attcttatat ggttcattat
     2101 ttccacagac attgtgattc tccctgcttc aaagttgtta tccaaattcc ttgcatgtca
     2161 tctcaggttc tgcacctgag tctctgacat cattccagcc ttatgtctca ttcctcctct
     2221 gcacacagct ttaataacta gaccagcttg gccacaagta cattccttgg gtgttcctcc
     2281 cgacagtccc cagatgctct tgcctctgca gaggtgtcct cagcctgaac catttctcat
     2341 ctgtttccca ggatccaaaa ttgtacctgc ctttcaataa ctcctccttg aatccttttg
     2401 ttgtggtggt ctgtttctac ccatagagcc tcttcagact tcttagaatt cactacccct
     2461 aatgtcattc attcatttag caagtgcttt tcaacactct cgaattattt aacttctctt
     2521 ctaagttact gccttttctg cccaactaga ttgcaaactt tcttccaagt ggagtcagta
     2581 tacccttaaa tctctgtggc tatcttagat cgggtaatag ttgaacatgg ttgtggttgg
     2641 cagcttgagt catgttctgt cctgttggga aagtatagaa actgggacaa taggaggata
     2701 tataacaata aaaactgcat atattcacaa aaaaaaaa
//
