LOCUS       NM_008379               5909 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus karyopherin subunit beta 1 (Kpnb1), mRNA.
ACCESSION   NM_008379
VERSION     NM_008379.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5909)
  AUTHORS   Abeditashi,M., Weber,J.J., Pereira Sena,P., Velic,A., Kalimeri,M.,
            Incebacak Eltemur,R.D., Schmidt,J., Hubener-Schmid,J., Hauser,S.,
            Macek,B., Riess,O. and Schmidt,T.
  TITLE     KPNB1 modulates the Machado-Joseph disease protein ataxin-3 through
            activation of the mitochondrial protease CLPP
  JOURNAL   Cell Mol Life Sci 79 (8), 401 (2022)
   PUBMED   35794401
  REMARK    GeneRIF: KPNB1 modulates the Machado-Joseph disease protein
            ataxin-3 through activation of the mitochondrial protease CLPP.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5909)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5909)
  AUTHORS   Hervera,A., De Virgiliis,F., Palmisano,I., Zhou,L., Tantardini,E.,
            Kong,G., Hutson,T., Danzi,M.C., Perry,R.B., Santos,C.X.C.,
            Kapustin,A.N., Fleck,R.A., Del Rio,J.A., Carroll,T., Lemmon,V.,
            Bixby,J.L., Shah,A.M., Fainzilber,M. and Di Giovanni,S.
  TITLE     Reactive oxygen species regulate axonal regeneration through the
            release of exosomal NADPH oxidase 2 complexes into injured axons
  JOURNAL   Nat Cell Biol 20 (3), 307-319 (2018)
   PUBMED   29434374
  REMARK    Erratum:[Nat Cell Biol. 2018 Sep;20(9):1098. doi:
            10.1038/s41556-018-0063-x. PMID: 29520084]
REFERENCE   4  (bases 1 to 5909)
  AUTHORS   Lodhi,I.J., Dean,J.M., He,A., Park,H., Tan,M., Feng,C., Song,H.,
            Hsu,F.F. and Semenkovich,C.F.
  TITLE     PexRAP Inhibits PRDM16-Mediated Thermogenic Gene Expression
  JOURNAL   Cell Rep 20 (12), 2766-2774 (2017)
   PUBMED   28930673
REFERENCE   5  (bases 1 to 5909)
  AUTHORS   Perry,R.B., Rishal,I., Doron-Mandel,E., Kalinski,A.L.,
            Medzihradszky,K.F., Terenzio,M., Alber,S., Koley,S., Lin,A.,
            Rozenbaum,M., Yudin,D., Sahoo,P.K., Gomes,C., Shinder,V.,
            Geraisy,W., Huebner,E.A., Woolf,C.J., Yaron,A., Burlingame,A.L.,
            Twiss,J.L. and Fainzilber,M.
  TITLE     Nucleolin-Mediated RNA Localization Regulates Neuron Growth and
            Cycling Cell Size
  JOURNAL   Cell Rep 16 (6), 1664-1676 (2016)
   PUBMED   27477284
REFERENCE   6  (bases 1 to 5909)
  AUTHORS   Huber,J., Cronshagen,U., Kadokura,M., Marshallsay,C., Wada,T.,
            Sekine,M. and Luhrmann,R.
  TITLE     Snurportin1, an m3G-cap-specific nuclear import receptor with a
            novel domain structure
  JOURNAL   EMBO J 17 (14), 4114-4126 (1998)
   PUBMED   9670026
REFERENCE   7  (bases 1 to 5909)
  AUTHORS   Matsuda,Y., Hamatani,K., Itoh,M., Takahashi,E.I., Araki,R. and
            Abe,M.
  TITLE     Localization of the importin-beta gene to mouse chromosome 11D and
            rat chromosome 10q32.1
  JOURNAL   Genomics 36 (1), 213-215 (1996)
   PUBMED   8812441
REFERENCE   8  (bases 1 to 5909)
  AUTHORS   Imamoto,N., Shimamoto,T., Kose,S., Takao,T., Tachibana,T.,
            Matsubae,M., Sekimoto,T., Shimonishi,Y. and Yoneda,Y.
  TITLE     The nuclear pore-targeting complex binds to nuclear pores after
            association with a karyophile
  JOURNAL   FEBS Lett 368 (3), 415-419 (1995)
   PUBMED   7635189
REFERENCE   9  (bases 1 to 5909)
  AUTHORS   Gorlich,D., Kostka,S., Kraft,R., Dingwall,C., Laskey,R.A.,
            Hartmann,E. and Prehn,S.
  TITLE     Two different subunits of importin cooperate to recognize nuclear
            localization signals and bind them to the nuclear envelope
  JOURNAL   Curr Biol 5 (4), 383-392 (1995)
   PUBMED   7627554
REFERENCE   10 (bases 1 to 5909)
  AUTHORS   Moroianu,J., Blobel,G. and Radu,A.
  TITLE     Previously identified protein of uncertain function is karyopherin
            alpha and together with karyopherin beta docks import substrate at
            nuclear pore complexes
  JOURNAL   Proc Natl Acad Sci U S A 92 (6), 2008-2011 (1995)
   PUBMED   7892216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK147175.1, BC052438.1 and AL627445.21.
            
            On Feb 17, 2006 this sequence version replaced NM_008379.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147175.1, AK077709.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-245               AK147175.1         20-264
            246-3608            BC052438.1         1-3363
            3609-5909           AL627445.21        48923-51223         c
FEATURES             Location/Qualifiers
     source          1..5909
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 60.95 cM"
     gene            1..5909
                     /gene="Kpnb1"
                     /gene_synonym="Impnb; IPOB"
                     /note="karyopherin subunit beta 1"
                     /db_xref="GeneID:16211"
                     /db_xref="MGI:MGI:107532"
     exon            1..347
                     /gene="Kpnb1"
                     /gene_synonym="Impnb; IPOB"
                     /inference="alignment:Splign:2.1.0"
     exon            348..406
                     /gene="Kpnb1"
                     /gene_synonym="Impnb; IPOB"
                     /inference="alignment:Splign:2.1.0"
     exon            407..589
                     /gene="Kpnb1"
                     /gene_synonym="Impnb; IPOB"
                     /inference="alignment:Splign:2.1.0"
     exon            590..790
                     /gene="Kpnb1"
                     /gene_synonym="Impnb; IPOB"
                     /inference="alignment:Splign:2.1.0"
     exon            791..943
                     /gene="Kpnb1"
                     /gene_synonym="Impnb; IPOB"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1003
                     /gene="Kpnb1"
                     /gene_synonym="Impnb; IPOB"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1093
                     /gene="Kpnb1"
                     /gene_synonym="Impnb; IPOB"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1204
                     /gene="Kpnb1"
                     /gene_synonym="Impnb; IPOB"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1306
                     /gene="Kpnb1"
                     /gene_synonym="Impnb; IPOB"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1531
                     /gene="Kpnb1"
                     /gene_synonym="Impnb; IPOB"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1723
                     /gene="Kpnb1"
                     /gene_synonym="Impnb; IPOB"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1854
                     /gene="Kpnb1"
                     /gene_synonym="Impnb; IPOB"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..2002
                     /gene="Kpnb1"
                     /gene_synonym="Impnb; IPOB"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2074
                     /gene="Kpnb1"
                     /gene_synonym="Impnb; IPOB"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2219
                     /gene="Kpnb1"
                     /gene_synonym="Impnb; IPOB"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2302
                     /gene="Kpnb1"
                     /gene_synonym="Impnb; IPOB"
                     /inference="alignment:Splign:2.1.0"
     exon            2303..2410
                     /gene="Kpnb1"
                     /gene_synonym="Impnb; IPOB"
                     /inference="alignment:Splign:2.1.0"
     exon            2411..2554
                     /gene="Kpnb1"
                     /gene_synonym="Impnb; IPOB"
                     /inference="alignment:Splign:2.1.0"
     exon            2555..2660
                     /gene="Kpnb1"
                     /gene_synonym="Impnb; IPOB"
                     /inference="alignment:Splign:2.1.0"
     exon            2661..2775
                     /gene="Kpnb1"
                     /gene_synonym="Impnb; IPOB"
                     /inference="alignment:Splign:2.1.0"
     exon            2776..2937
                     /gene="Kpnb1"
                     /gene_synonym="Impnb; IPOB"
                     /inference="alignment:Splign:2.1.0"
     exon            2938..5909
                     /gene="Kpnb1"
                     /gene_synonym="Impnb; IPOB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4064..4069
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kpnb1"
                     /gene_synonym="Impnb; IPOB"
                     /note="hexamer: GATAAA"
     polyA_site      4087
                     /gene="Kpnb1"
                     /gene_synonym="Impnb; IPOB"
                     /note="major polyA site"
     regulatory      5876..5881
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kpnb1"
                     /gene_synonym="Impnb; IPOB"
                     /note="hexamer: AATAAA"
     polyA_site      5904
                     /gene="Kpnb1"
                     /gene_synonym="Impnb; IPOB"
                     /note="major polyA site"
ORIGIN      
        1 tttctccctc cgccgcccga gcagcagccg cgctccgagc tgcccccggg gtccctcccc
       61 cgccgccaga ggagcagctg ctgccgccta gcacattagg agggcggaag gaaggaagga
      121 gagcggggag gaaggggagc cggagcgcct ggccagaggc agccggtgaa tgggcttgtg
      181 gtgaccccca ccccccaccc caccctccct tcccacccga cccccaaccc ccatccccag
      241 tcggagccgc cgcccgacag gccgggccgc cgtcttgcga ggagtccccg ccgccgtcac
      301 ctccgccatg gagctcataa ccatcctcga gaagaccgtg tctccggatc ggctggagct
      361 ggaagcggcg cagaagttcc tcgagcgtgc ggccgtggag aatctgccca cgttccttgt
      421 ggaactgtcc agagtgctgg caaacccagg aaacagtcag gttgccagag ttgcagctgg
      481 tctacaaatt aagaactctt tgacatcgaa agatccagat atcaaggcac aataccagca
      541 gaggtggctc gctattgatg ctaatgctcg acgggaagtc aagaactatg ttttgcagac
      601 gttgggcaca gaaacgtacc ggcctagttc ggcctcacag tgtgtggctg gtattgcttg
      661 tgcagagatc ccagtaagcc agtggccaga gctaattcct cagctggtag ccaatgtcac
      721 aaaccccaac agcacagagc atatgaaaga gtccacattg gaagctattg gttacatttg
      781 ccaagatata gacccagagc agctacagga taagtccaat gagatcctga ctgccataat
      841 ccaggggatg aggaaggagg agcctagtaa caatgtgaag ctggctgcta ccaatgcact
      901 cctgaactca ctagagttca ccaaagcaaa ctttgacaaa gagtctgaaa ggcactttat
      961 catgcaagtg gtctgtgaag ccacacagtg tccagacaca agggtaagag tggctgcttt
     1021 acagaatcta gtgaagataa tgtccttgta ttaccagtac atggagacat acatgggtcc
     1081 tgcccttttt gcaatcacaa ttgaagcaat gaaaagtgac attgatgagg tggctctcca
     1141 agggatagag ttctggtcca atgtctgtga tgaggaaatg gatttggcca ttgaggcttc
     1201 agaggcagca gagcaaggac gccccccgga gcacaccagc aaattttacg ccaagggagc
     1261 actgcagtac ttggtgccca tcctcacaca gacactgact aaacaggatg aaaacgatga
     1321 cgacgatgac tggaaccctt gcaaagcagc tggggtgtgc ctcatgctcc tgtccacctg
     1381 ctgtgaagat gacattgtgc cgcatgtcct tccctttatt aaagagcaca tcaagaaccc
     1441 tgactggcga taccgggatg cagcagtgat ggcttttggc agtatcttgg aaggaccaga
     1501 gcctaatcaa ctgaaaccat tagtcataca ggctatgccc accctaatag aactaatgaa
     1561 agaccccagt gtagttgttc gagacacaac agcgtggact gtgggcagga tctgtgagct
     1621 gctgcctgaa gccgccatca acgatgtcta cctggcaccc cttttacagt gtctgattga
     1681 gggcctcagt gctgagccca gggtggcttc aaatgtgtgc tgggcttttt ccagtctggc
     1741 tgaagctgcg tatgaagctg cagatgtagc tgatgatcaa gaagaaccag ccacctattg
     1801 tctgtcttct tcctttgaac ttatagttca gaagctattg gagaccaccg acagacccga
     1861 tggacaccag aataacctga gaagctctgc gtatgagtct ctcatggaaa tcgtaaagaa
     1921 cagtgccaag gattgttacc ctgccgtgca gaagaccacc ctggtcatta tggaacggct
     1981 gcagcaggtg cttcagatgg agtcccatat ccagagcaca tccgacagaa tccagttcaa
     2041 tgacctccag tctctactct gcgcgactct tcagaatgtt ctccggaaag tgcagcatca
     2101 agatgctctg cagatctctg atgtggtcat ggcctccctg ttaaggatgt tccaaagcac
     2161 agctgggtct gggggagtgc aagaagatgc cctgatggca gttagcacac tggtggaagt
     2221 gttgggtggt gaattcctca agtacatgga ggcctttaaa ccattcctgg gcattggact
     2281 gaaaaattat gctgagtacc aggtatgttt ggcagctgtt ggcttagttg gagacttgtg
     2341 ccgagccctg cagtctaaca tcttgccttt ctgtgacgag gtgatgcagc tgctcctgga
     2401 gaacttgggg aatgagaatg tccacaggtc tgtgaagcca cagattctgt ctgtgtttgg
     2461 tgatattgct cttgccattg gtggagagtt taaaaaatac ttagaggttg tattgaatac
     2521 tctacagcag gcctcccaag cccaggttga caagtcagac tttgacatgg tggattatct
     2581 gaatgagcta agagaaagct gcttggaagc ttatacggga atcgtccagg gattgaaggg
     2641 agatcaggaa aacgtacacc cggatgtaat gctggtacag cccagagtag aatttatttt
     2701 gtcttttatt gatcacattg ctggagatga ggatcatacg gacggagtgg tagcctgtgc
     2761 tgctggtctg ataggggact tgtgtacagc cttcgggaag gatgtactga agttagtaga
     2821 agctaggcca atgatccatg aactattaac tgaagggcgg agatcgaaga ctaacaaagc
     2881 aaagaccctc gctacgtggg caaccaagga actgaggaaa ctgaagaacc aggcttgatc
     2941 tggtaccact gggatgatga cctgagaccc ccactggaaa tctccaatct tttgaaaaac
     3001 ccggaagtga ggagtgtgca cggatgctga atgcttggga atgagaggat gagtgagtga
     3061 ggcttgaaaa caccacactg aaaatcctgc cacagccaac agcagcagcg ctgttagaca
     3121 tgagctaagt aagcactgag tttgtagaaa acataacatc agccatcttg gaacagagaa
     3181 acaatggatt tacttactta ttaaaaacaa aaaagctgtc tcttcccagg gaaggctaga
     3241 actagctttc ctgtcttggc cggtgccgaa tgggtgactg atttgggaga ggaggacctg
     3301 ggttcacctg tggggctgtg ttgtgaaagg cagcctggcc cctgctactg aggagaaaga
     3361 tggagcccgg gtcttgagcc caccttcact gtaccgttgc acttggtact gtctatgtgc
     3421 ccttgagaag gcgcgtgggg gatttcacag tctgagaatg agtgtgtgtg agtgaggcgg
     3481 tacccacatt ctcaacttca agtcattgca gtttcttttt cccagaaaac aaaggggttt
     3541 gatgttgcat ttcataaact aactgaagtt ctggctactg atgcagcaca agagacgtgt
     3601 ttttttttta aatgaggaaa gacgctgttt aggtttggtt tggtttcatt ttaattactc
     3661 tagggaaaac actgacgaat ggtcagcgct cctgtcctga tcttttcatc aaggcgcctt
     3721 tcctgtacta tggttcagct gtgaatgtag ctatgggggg aggggggaga aaggagaact
     3781 ctggagttag aggatataga aaataaaagt acagttgtta caaagaaaat gcagacttca
     3841 aagacagaaa aagccacaac ccaaaccaaa atttaaatgc ttgaaattgg catcataaac
     3901 aagctctctc ctgacttgta ttgtggcagt cggaatgccc ccagaaaact gtgccaaaga
     3961 gtttagaaaa caaatgtaca ataaaagtaa atacactcaa aaccgcaaac ttcaggtaac
     4021 tattttgaat tgcaaatgac gaaaatttaa tgttgaacga tctgataaaa taaccatttg
     4081 gaaactgctt ggccttctgt ccctttcttt gactgactgc aatgcggtat tggtctcttg
     4141 ctgcactcca aaccaactaa ccactaagac agtgtgtgtg tatccgtata cacagcatac
     4201 acacacacta aatacaactg ttgtgatgaa aatggcacca ggaagaaggc tctatttttc
     4261 cactgaagtt gaagattagt aaaatggtgt cagatggtga ccctgctcgc acgctttagt
     4321 aattttttaa agtgtggtgt gctgtgatta taataaatca gaattatttt tccttttaca
     4381 agggaacaag gcaccctgag ttttagagtc tttcagcaat aagaaagcat ttcagtaagc
     4441 tggccctctt ggctcgtgca gatagtagga gattagctgg cgttttgaat atgctgcttt
     4501 aaaaaacagt agacaccgag gaagttttta ttgcttcctg gtagtgtgga agaaacacaa
     4561 gaccctcatt cccatttcca tttccattgt agtcaaaggt attggcttag gtttctcccg
     4621 tgctcctttc atcccctccc tgcctgagcc tgttcctaag tgggattggc tccgcttgcc
     4681 tgtccgtacg aaatgcagcg tctgtagtag ctctttacag ggtatcagat attgtgcctt
     4741 ttggtgccag gttcagagtc aaagtgccga tctgatctgt gaaccagtgt acaaaaaaag
     4801 tatttgaagg agaaatgctc cattatgagc aaagctctct aggagtccaa gccctcggga
     4861 gaagcccagg cctctgaacg ccttgtttcc atcttagctg tttttttcag atttactaac
     4921 cattcctgat actagatagg gttggaacag ggcttaggga agggggcaga aatattgggg
     4981 gaaaggaaaa acaatgtgat cattcctcag tgctacccat ttctgtcctg tgtgggctgc
     5041 ttagcgagac agcagaggat gaagtacacc gagaaccctg atgaaaacaa gaccttgcct
     5101 gtgttttgtc gtgttctgtt ccagggaagc agttgacaag tgctgttact aatcctttct
     5161 cccagatgca ttcagtgctc gagaggagga aatgggctga ttggattgtg gtcttggtgc
     5221 cttgctgttc tattctgcac tggttacgca ttttaatcct cttttagtta ccttcagcta
     5281 ctgttttcta tggtttgggt gtctgtcctt aatcagttcg taccacataa ggcaaatgaa
     5341 tgcgaaatgc attctgtcca ctcactgtct gggccttccc caccctgagt cttggcacat
     5401 tccttcaaga atgtagttac cgtctgcttg ggaagatgtc agtgcaaatg tgaagaaaat
     5461 gggcatcgga tagacttggg tttgccacaa gtggcatctg cctgcaccaa ttacattggt
     5521 taattttgct tttcattttt ctcagttacc cccagtcctc cctctctgtt gaaatgttga
     5581 agatttagct gtcagaggca actgtgatcc tgccttaggg actggagaag tggagggact
     5641 tgctcagtat ggtgttctaa tgttcagaac caagcagtct ccttacttac tattttaaga
     5701 tgtgtgtagt ttgactttag aagaagttca aattccatcc actttgatag catcaatctg
     5761 taattggcat tcagaatgcc cttggcatgc cagtctgtga aggcattaaa gacctgttaa
     5821 aacacttgag cccaacttta ttaaccaaaa ctgataccac cacctttatc ttctgaataa
     5881 agtccgcttt atttttattt tcaacattt
//
