LOCUS       NM_001347531            2118 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus karyopherin subunit alpha 7 (Kpna7), transcript
            variant 1, mRNA.
ACCESSION   NM_001347531 XM_017320943
VERSION     NM_001347531.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2118)
  AUTHORS   Wang,W., Miyamoto,Y., Chen,B., Shi,J., Diao,F., Zheng,W., Li,Q.,
            Yu,L., Li,L., Xu,Y., Wu,L., Mao,X., Fu,J., Li,B., Yan,Z., Shi,R.,
            Xue,X., Mu,J., Zhang,Z., Wu,T., Zhao,L., Wang,W., Zhou,Z., Dong,J.,
            Li,Q., Jin,L., He,L., Sun,X., Lin,G., Kuang,Y., Wang,L. and Sang,Q.
  TITLE     Karyopherin alpha deficiency contributes to human preimplantation
            embryo arrest
  JOURNAL   J Clin Invest 133 (2), e159951 (2023)
   PUBMED   36647821
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2118)
  AUTHORS   Bertram,S., Thiele,S., Dreier,C., Resa-Infante,P., Preuss,A., van
            Riel,D., Mok,C.K.P., Schwalm,F., Peiris,J.S.M., Klenk,H.D. and
            Gabriel,G.
  TITLE     H7N9 Influenza A Virus Exhibits Importin-alpha7-Mediated
            Replication in the Mammalian Respiratory Tract
  JOURNAL   Am J Pathol 187 (4), 831-840 (2017)
   PUBMED   28189564
  REMARK    GeneRIF: a decreased H7N9 influenza A virus polymerase activity
            when importin-alpha7 was silenced by siRNA, is reported.
REFERENCE   3  (bases 1 to 2118)
  AUTHORS   Mihalas,B.P., Western,P.S., Loveland,K.L., McLaughlin,E.A. and
            Holt,J.E.
  TITLE     Changing expression and subcellular distribution of karyopherins
            during murine oogenesis
  JOURNAL   Reproduction 150 (6), 485-496 (2015)
   PUBMED   26399853
REFERENCE   4  (bases 1 to 2118)
  AUTHORS   Rother,F., Shmidt,T., Popova,E., Krivokharchenko,A., Hugel,S.,
            Vilianovich,L., Ridders,M., Tenner,K., Alenina,N., Kohler,M.,
            Hartmann,E. and Bader,M.
  TITLE     Importin alpha7 is essential for zygotic genome activation and
            early mouse development
  JOURNAL   PLoS One 6 (3), e18310 (2011)
   PUBMED   21479251
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2118)
  AUTHORS   Hu,J., Wang,F., Yuan,Y., Zhu,X., Wang,Y., Zhang,Y., Kou,Z., Wang,S.
            and Gao,S.
  TITLE     Novel importin-alpha family member Kpna7 is required for normal
            fertility and fecundity in the mouse
  JOURNAL   J Biol Chem 285 (43), 33113-33122 (2010)
   PUBMED   20699224
  REMARK    GeneRIF: knocking out of Kpna7 induced abnormalities of gene
            expression (dppa2, dppa4, and piwil2) and epigenetic modifications
            (down-regulation of histone H3K27me3). Biochemical analysis showed
            that KPNA7 interacts with KPNB1 (importin-beta1).
REFERENCE   6  (bases 1 to 2118)
  AUTHORS   Pawlowski,R., Rajakyla,E.K., Vartiainen,M.K. and Treisman,R.
  TITLE     An actin-regulated importin alpha/beta-dependent extended bipartite
            NLS directs nuclear import of MRTF-A
  JOURNAL   EMBO J 29 (20), 3448-3458 (2010)
   PUBMED   20818336
REFERENCE   7  (bases 1 to 2118)
  AUTHORS   Kelley,J.B., Talley,A.M., Spencer,A., Gioeli,D. and Paschal,B.M.
  TITLE     Karyopherin alpha7 (KPNA7), a divergent member of the importin
            alpha family of nuclear import receptors
  JOURNAL   BMC Cell Biol 11, 63 (2010)
   PUBMED   20701745
  REMARK    GeneRIF: a novel importin alpha family member with distinct
            subcellular localization and nuclear localization signal binding
            characteristics
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113295.5.
            
            On Nov 30, 2016 this sequence version replaced XM_017320943.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: FJ717333.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849374 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                AC113295.5         42461-42549
            90-218              AC113295.5         43185-43313
            219-301             AC113295.5         44533-44615
            302-570             AC113295.5         45312-45580
            571-633             AC113295.5         48104-48166
            634-716             AC113295.5         49288-49370
            717-980             AC113295.5         53261-53524
            981-1211            AC113295.5         56436-56666
            1212-1394           AC113295.5         57624-57806
            1395-1541           AC113295.5         60680-60826
            1542-1627           AC113295.5         64778-64863
            1628-2118           AC113295.5         66295-66785
FEATURES             Location/Qualifiers
     source          1..2118
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 84.91 cM"
     gene            1..2118
                     /gene="Kpna7"
                     /gene_synonym="Gm1055"
                     /note="karyopherin subunit alpha 7"
                     /db_xref="GeneID:381686"
                     /db_xref="MGI:MGI:2141165"
     exon            1..89
                     /gene="Kpna7"
                     /gene_synonym="Gm1055"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1586
                     /gene="Kpna7"
                     /gene_synonym="Gm1055"
                     /note="isoform 1 is encoded by transcript variant 1;
                     importin alpha 2; nuclear transport receptor; importin
                     subunit alpha-8; karyopherin alpha 7 (importin alpha 8)"
                     /codon_start=1
                     /product="importin subunit alpha-8 isoform 1"
                     /protein_id="NP_001334460.1"
                     /db_xref="CCDS:CCDS84996.1"
                     /db_xref="GeneID:381686"
                     /db_xref="MGI:MGI:2141165"
                     /translation="MATSKAPKERLKNYKYRGKEMSLPRQQRIASSLQLRKTRKDEQV
                     LKRRNIDLFSSDMVSQALVKEVNFTLDDIIQAVNSSDPILHFRATRAAREMISQENTP
                     PLNLIIEAGLIPKLVDFLKATPHPKLQFEAAWVLTNIASGTSEQTRAVVKEGAIQPLI
                     ELLCSPHLTVSEQAVWALGNIADRKMPDTQVQIFTPSTREAKAGDCAEFRDCVISNNA
                     IPHLINLISKGIPITFLRNISWTLSNLCRNKDPYPSESAVRQMLPPLCQLLLHRDNEI
                     LADTCWALSYLTKGGKEYIHHVVTTGILPRLVELMTSSELSISIPCLHTIGNIVAGTD
                     EQTQMAIDAGMLKVLGQVLKHPKTSIQVLAAWTMSNVAAGPRHQVEQLLCNLLPILVD
                     LLRNAELKVQKEVVCTVINIATGASQDQLTLLAHSGILEPMLSLLSAPDLEVVIIVLD
                     IISYLLQHIDNLQEKKRLYFQIEKFGGFEKIECLQHHHNISISNSALDIIEKYFCEDG
                     DGDSLPGPGLRV"
     exon            90..218
                     /gene="Kpna7"
                     /gene_synonym="Gm1055"
                     /inference="alignment:Splign:2.1.0"
     exon            219..301
                     /gene="Kpna7"
                     /gene_synonym="Gm1055"
                     /inference="alignment:Splign:2.1.0"
     exon            302..570
                     /gene="Kpna7"
                     /gene_synonym="Gm1055"
                     /inference="alignment:Splign:2.1.0"
     exon            571..633
                     /gene="Kpna7"
                     /gene_synonym="Gm1055"
                     /inference="alignment:Splign:2.1.0"
     exon            634..716
                     /gene="Kpna7"
                     /gene_synonym="Gm1055"
                     /inference="alignment:Splign:2.1.0"
     exon            717..980
                     /gene="Kpna7"
                     /gene_synonym="Gm1055"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1211
                     /gene="Kpna7"
                     /gene_synonym="Gm1055"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1394
                     /gene="Kpna7"
                     /gene_synonym="Gm1055"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1541
                     /gene="Kpna7"
                     /gene_synonym="Gm1055"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1627
                     /gene="Kpna7"
                     /gene_synonym="Gm1055"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..2118
                     /gene="Kpna7"
                     /gene_synonym="Gm1055"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2080..2085
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kpna7"
                     /gene_synonym="Gm1055"
                     /note="hexamer: AATATA"
     regulatory      2091..2096
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kpna7"
                     /gene_synonym="Gm1055"
                     /note="hexamer: ATTAAA"
     polyA_site      2101
                     /gene="Kpna7"
                     /gene_synonym="Gm1055"
                     /note="major polyA site"
     polyA_site      2118
                     /gene="Kpna7"
                     /gene_synonym="Gm1055"
                     /note="major polyA site"
ORIGIN      
        1 gtggtgtctt tccttcagtc aacatggcta cctcaaaggc tcccaaagag aggctgaaga
       61 actataagta ccgaggcaaa gaaatgtcat tgccacgaca acagaggatt gcttccagtc
      121 tacaactccg gaagaccagg aaagatgagc aggtgctaaa gagaagaaat atcgatctgt
      181 tctccagtga catggtttct caagcactag tcaaagaggt caacttcact ctggacgaca
      241 tcatccaagc ggtgaatagt tcagatccaa tcctgcattt tcgggctacc cgggctgcca
      301 gggaaatgat ctcgcaggaa aatacccctc ctctcaattt gattattgag gccgggctca
      361 ttcccaagct ggtggacttc ctgaaggcga cacctcaccc caagctgcag ttcgaggccg
      421 catgggtgct caccaacatt gcctcaggaa cttcagagca gacccgagct gttgtgaaag
      481 agggtgccat tcagcccctg attgaactcc tctgttcccc acacctgaca gtgtctgagc
      541 aggcagtgtg ggcccttggg aatatcgctg acagaaagat gccagacacg caggtgcaga
      601 tctttactcc cagcacacgg gaggcaaagg caggagactg tgcagaattc agagactgtg
      661 tcatctccaa taatgccatc ccacacctga tcaaccttat ttcaaaaggc ataccaatca
      721 catttcttcg gaacatctca tggactttgt ccaacttatg ccgaaacaaa gatccatatc
      781 ccagtgagag cgccgtgcgg cagatgctac ctcccctctg tcaactcctg ctgcatcgtg
      841 ataatgagat cctcgcagat acctgctggg ccctgtccta cctgaccaag ggtggcaaag
      901 agtatatcca tcatgtggtg accactggca tcctgcccag gcttgtagag cttatgacca
      961 gctcggaact cagcatctcg ataccttgtc tccacactat aggcaacatt gtggcaggaa
     1021 cagatgaaca gacccagatg gctatcgatg ctggcatgct gaaggtgttg ggccaggtcc
     1081 tgaagcaccc gaagacctcc atccaggtgc tggctgcctg gaccatgagc aacgtggccg
     1141 ctgggcccag acaccaagtg gagcagcttt tgtgtaactt gctgcctatt ttggtagacc
     1201 tactaaggaa tgcagaatta aaagtccaga aggaggttgt gtgcactgtg attaacattg
     1261 caacaggagc ctctcaggac cagctgactc tgcttgccca ctcgggaatc ttggagccaa
     1321 tgctgagtct gctctccgcc ccagacttgg aggtggtcat catcgtccta gacatcattt
     1381 cttatctcct ccagcatata gacaatctac aagagaagaa aaggctgtat tttcagatag
     1441 aaaaatttgg tggctttgaa aaaattgagt gtttacagca ccaccacaac atttccatca
     1501 gcaatagcgc cctggacatc atcgagaaat acttctgtga ggatggagat ggtgacagtt
     1561 tgcccgggcc tgggctgaga gtgtgaatat gtggggtact aagacatctc acacaccgga
     1621 ttgtatgtca gccagagtac cgatcgatca tggacttcca cgtggcgtgg cttctggcga
     1681 tagtactgac cacggacatc cacatggtct ctggtggcag tacagatatt ggacatctga
     1741 gctgggcccc tctgccacag caagagccac ggacaacatc acagccctcc acagcagcac
     1801 aggccagtga catcaacacg gcttcagggg gcagcagaga cccgacacca tggcatgact
     1861 gtcagtggta acacaagcca ccgacatcaa tacctccccc tgctgcagca ggaccacaga
     1921 cggacccaag cacggccctg ggcagcagca gtcaaatata cgtggcaaac attttttatc
     1981 agccgaggga tcaacgaggg accatgtctt ttgtttttgt tgccgttatt aatctttttt
     2041 tgttagtctg tttcttttga ttggggaact gagattatta atatatagtt attaaaaagc
     2101 atgtattatt tcctgtca
//
