LOCUS       NM_008468               5711 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus karyopherin subunit alpha 6 (Kpna6), mRNA.
ACCESSION   NM_008468
VERSION     NM_008468.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5711)
  AUTHORS   Liu,N., Qadri,F., Busch,H., Huegel,S., Sihn,G., Chuykin,I.,
            Hartmann,E., Bader,M. and Rother,F.
  TITLE     Kpna6 deficiency causes infertility in male mice by disrupting
            spermatogenesis
  JOURNAL   Development 148 (19) (2021)
   PUBMED   34473250
  REMARK    GeneRIF: Kpna6 deficiency causes infertility in male mice by
            disrupting spermatogenesis.
REFERENCE   2  (bases 1 to 5711)
  AUTHORS   Rios,J.J., Denton,K., Russell,J., Kozlitina,J., Ferreira,C.R.,
            Lewanda,A.F., Mayfield,J.E., Moresco,E., Ludwig,S., Tang,M., Li,X.,
            Lyon,S., Khanshour,A., Paria,N., Khalid,A., Li,Y., Xie,X.,
            Feng,J.Q., Xu,Q., Lu,Y., Hammer,R.E., Wise,C.A. and Beutler,B.
  TITLE     Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice
  JOURNAL   J Bone Miner Res 36 (8), 1548-1565 (2021)
   PUBMED   33905568
REFERENCE   3  (bases 1 to 5711)
  AUTHORS   Marvaldi,L., Panayotis,N., Alber,S., Dagan,S.Y., Okladnikov,N.,
            Koppel,I., Di Pizio,A., Song,D.A., Tzur,Y., Terenzio,M., Rishal,I.,
            Gordon,D., Rother,F., Hartmann,E., Bader,M. and Fainzilber,M.
  TITLE     Importin alpha3 regulates chronic pain pathways in peripheral
            sensory neurons
  JOURNAL   Science 369 (6505), 842-846 (2020)
   PUBMED   32792398
REFERENCE   4  (bases 1 to 5711)
  AUTHORS   Panayotis,N., Sheinin,A., Dagan,S.Y., Tsoory,M.M., Rother,F.,
            Vadhvani,M., Meshcheriakova,A., Koley,S., Marvaldi,L., Song,D.A.,
            Reuveny,E., Eickholt,B.J., Hartmann,E., Bader,M., Michaelevski,I.
            and Fainzilber,M.
  TITLE     Importin alpha5 Regulates Anxiety through MeCP2 and Sphingosine
            Kinase 1
  JOURNAL   Cell Rep 25 (11), 3169-3179 (2018)
   PUBMED   30540948
REFERENCE   5  (bases 1 to 5711)
  AUTHORS   Bertram,S., Thiele,S., Dreier,C., Resa-Infante,P., Preuss,A., van
            Riel,D., Mok,C.K.P., Schwalm,F., Peiris,J.S.M., Klenk,H.D. and
            Gabriel,G.
  TITLE     H7N9 Influenza A Virus Exhibits Importin-alpha7-Mediated
            Replication in the Mammalian Respiratory Tract
  JOURNAL   Am J Pathol 187 (4), 831-840 (2017)
   PUBMED   28189564
REFERENCE   6  (bases 1 to 5711)
  AUTHORS   Hatayama,M., Tomizawa,T., Sakai-Kato,K., Bouvagnet,P., Kose,S.,
            Imamoto,N., Yokoyama,S., Utsunomiya-Tate,N., Mikoshiba,K.,
            Kigawa,T. and Aruga,J.
  TITLE     Functional and structural basis of the nuclear localization signal
            in the ZIC3 zinc finger domain
  JOURNAL   Hum Mol Genet 17 (22), 3459-3473 (2008)
   PUBMED   18716025
REFERENCE   7  (bases 1 to 5711)
  AUTHORS   Sakakida,Y., Miyamoto,Y., Nagoshi,E., Akashi,M., Nakamura,T.J.,
            Mamine,T., Kasahara,M., Minami,Y., Yoneda,Y. and Takumi,T.
  TITLE     Importin alpha/beta mediates nuclear transport of a mammalian
            circadian clock component, mCRY2, together with mPER2, through a
            bipartite nuclear localization signal
  JOURNAL   J Biol Chem 280 (14), 13272-13278 (2005)
   PUBMED   15689618
REFERENCE   8  (bases 1 to 5711)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 5711)
  AUTHORS   Kamei,Y., Yuba,S., Nakayama,T. and Yoneda,Y.
  TITLE     Three distinct classes of the alpha-subunit of the nuclear
            pore-targeting complex (importin-alpha) are differentially
            expressed in adult mouse tissues
  JOURNAL   J Histochem Cytochem 47 (3), 363-372 (1999)
   PUBMED   10026238
REFERENCE   10 (bases 1 to 5711)
  AUTHORS   Tsuji,L., Takumi,T., Imamoto,N. and Yoneda,Y.
  TITLE     Identification of novel homologues of mouse importin alpha, the
            alpha subunit of the nuclear pore-targeting complex, and their
            tissue-specific expression
  JOURNAL   FEBS Lett 416 (1), 30-34 (1997)
   PUBMED   9369227
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ082540.1, AK046371.1 and AL671759.10.
            
            On Apr 21, 2009 this sequence version replaced NM_008468.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154882.1, AK046371.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                CJ082540.1         22-63
            43-2250             AK046371.1         2-2209
            2251-5711           AL671759.10        73956-77416         c
FEATURES             Location/Qualifiers
     source          1..5711
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 63.28 cM"
     gene            1..5711
                     /gene="Kpna6"
                     /gene_synonym="IPOA7; Kpna5; NPI-2"
                     /note="karyopherin subunit alpha 6"
                     /db_xref="GeneID:16650"
                     /db_xref="MGI:MGI:1100836"
     exon            1..91
                     /gene="Kpna6"
                     /gene_synonym="IPOA7; Kpna5; NPI-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1698
                     /gene="Kpna6"
                     /gene_synonym="IPOA7; Kpna5; NPI-2"
                     /note="importin alpha 7; importin alpha-S2; karyopherin
                     (importin) alpha 5; karyopherin (importin) alpha 6"
                     /codon_start=1
                     /product="importin subunit alpha-7"
                     /protein_id="NP_032494.3"
                     /db_xref="CCDS:CCDS18701.1"
                     /db_xref="GeneID:16650"
                     /db_xref="MGI:MGI:1100836"
                     /translation="METMASPGKDNYRMKSYKNNALNPEEMRRRREEEGIQLRKQKRE
                     QQLFKRRNVELINEEAAMFDSLLMDSYVSSTTGESVITREMVEMLFSDDSDLQLATTQ
                     KFRKLLSKEPSPPIDEVINTPGVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQT
                     KIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSLCRDYVLNCSILNPLLTLL
                     TKSTRLTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACWAL
                     SYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILN
                     CSALPCLLHLLSSSKESIRKEACWTISNITAGNRAQIQAVIDANIFPVLIEILQKAEF
                     RTRKEAAWAITNATSGGTPEQIRYLVSLGCIKPLCDLLTVMDSKIVQVALNGLENILR
                     LGEQESKRSGSGVNPYCGLIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEDDD
                     SSLAPQVDETQQQFIFQQPEAPMEGFQL"
     exon            92..225
                     /gene="Kpna6"
                     /gene_synonym="IPOA7; Kpna5; NPI-2"
                     /inference="alignment:Splign:2.1.0"
     exon            226..318
                     /gene="Kpna6"
                     /gene_synonym="IPOA7; Kpna5; NPI-2"
                     /inference="alignment:Splign:2.1.0"
     exon            319..418
                     /gene="Kpna6"
                     /gene_synonym="IPOA7; Kpna5; NPI-2"
                     /inference="alignment:Splign:2.1.0"
     exon            419..513
                     /gene="Kpna6"
                     /gene_synonym="IPOA7; Kpna5; NPI-2"
                     /inference="alignment:Splign:2.1.0"
     exon            514..645
                     /gene="Kpna6"
                     /gene_synonym="IPOA7; Kpna5; NPI-2"
                     /inference="alignment:Splign:2.1.0"
     exon            646..734
                     /gene="Kpna6"
                     /gene_synonym="IPOA7; Kpna5; NPI-2"
                     /inference="alignment:Splign:2.1.0"
     exon            735..834
                     /gene="Kpna6"
                     /gene_synonym="IPOA7; Kpna5; NPI-2"
                     /inference="alignment:Splign:2.1.0"
     exon            835..998
                     /gene="Kpna6"
                     /gene_synonym="IPOA7; Kpna5; NPI-2"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1077
                     /gene="Kpna6"
                     /gene_synonym="IPOA7; Kpna5; NPI-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1203
                     /gene="Kpna6"
                     /gene_synonym="IPOA7; Kpna5; NPI-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1331
                     /gene="Kpna6"
                     /gene_synonym="IPOA7; Kpna5; NPI-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1510
                     /gene="Kpna6"
                     /gene_synonym="IPOA7; Kpna5; NPI-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..5711
                     /gene="Kpna6"
                     /gene_synonym="IPOA7; Kpna5; NPI-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2184..2189
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kpna6"
                     /gene_synonym="IPOA7; Kpna5; NPI-2"
                     /note="hexamer: AACAAA"
     polyA_site      2210
                     /gene="Kpna6"
                     /gene_synonym="IPOA7; Kpna5; NPI-2"
                     /note="major polyA site"
     regulatory      5684..5689
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kpna6"
                     /gene_synonym="IPOA7; Kpna5; NPI-2"
                     /note="hexamer: AATAAA"
     polyA_site      5710
                     /gene="Kpna6"
                     /gene_synonym="IPOA7; Kpna5; NPI-2"
                     /note="major polyA site"
ORIGIN      
        1 gtcctgcagg tccgccatat tgtctgccga ggctaccgct gaagctaccg ctgcggccgc
       61 cgccaagtcc gagcgagcgg agccgcgatg gagaccatgg caagcccagg gaaggacaat
      121 tatcgaatga agagctataa gaacaatgcc ttaaaccctg aggaaatgag acgaaggagg
      181 gaggaagagg gcattcagct tcggaaacag aagcgggaac aacaactttt taaacggaga
      241 aatgtagagc tgattaatga agaagctgcc atgtttgata gtctgctgat ggattcctac
      301 gtgagctcta caactgggga gagcgtgatc acgagagaga tggtagagat gctcttctcg
      361 gacgactctg acttgcagtt agcaaccacg cagaaattcc ggaaactcct gtccaaagag
      421 ccgagtcctc caatagatga agttattaac actccaggag tagttgatcg gtttgtggag
      481 tttctgaaga gaaatgagaa ttgtacattg cagtttgaag ctgcctgggc tctaacaaac
      541 attgcctctg gaacgtctca gcagaccaaa attgtcattg aagcaggagc tgtccccatt
      601 tttatagagt tacttaactc agactttgaa gatgtacaag aacaggcagt gtgggcgctt
      661 ggaaacatcg ctggagatag ctcgctttgc agggattatg tcttgaattg ctccatcctt
      721 aaccccttgt taacactcct tactaagtcc acacgactga caatgacacg gaatgcagtc
      781 tgggccctgt caaacctctg ccgaggcaag aaccctcctc cagagtttgc aaaggtctct
      841 ccttgtttgc ctgtattgtc ccgactgctc ttcagcagtg actcagactt gctggcagat
      901 gcttgctggg ccctctccta cctgtctgat ggccccaatg agaagatcca ggcagtcata
      961 gactctggag tctgccggag attggtagag cttctgatgc acaacgatta caaagtggcg
     1021 tctcctgcct tgagagctgt gggtaatatt gtcactgggg atgacatcca gacccaggtc
     1081 attcttaatt gttcagccct cccttgcctc ctccacctac tgagcagctc taaggaatca
     1141 atccggaagg aagcttgctg gaccatttca aacatcactg ctggcaacag ggctcaaata
     1201 caggctgtca tagatgcaaa catcttccct gtattgattg aaatccttca gaaagcagag
     1261 ttccgtacaa ggaaagaagc agcctgggcc atcaccaacg ccacatcagg aggaactcct
     1321 gagcaaatca ggtacctggt atcactgggc tgcattaagc ccctgtgtga cttgctgact
     1381 gtaatggatt caaaaattgt gcaagtggcc ctcaatggac tagagaacat tcttcggctt
     1441 ggagagcaag aaagcaagcg tagtggctca ggggtcaatc cctactgtgg cctcatcgag
     1501 gaagcctatg gcttggataa aattgagttt ctccagagcc acgagaacca ggaaatctac
     1561 cagaaggcct ttgacctcat tgagcactac tttggtgtag aggatgacga cagcagcctg
     1621 gctcctcagg tggatgagac gcaacagcag ttcatcttcc agcagcctga ggcccccatg
     1681 gagggcttcc agctataatg tctgcctccg gggaggggag ggcacgggaa gcaccagcag
     1741 ccagcagaga gaggagcagc cttctggtgg gcaggagagc agccacccca ccagcagccc
     1801 cgcacacctg ctgccccgag actgtgctct cgacctgttc atccccttcc ctggagggag
     1861 caagcgccct ctggacagac agaaccatct gaggctcaca ttgggttttg agacaagaag
     1921 gggacgtgtg ggtttctctt ccttacacta ttttggctgc acatgtcttt aacccaggag
     1981 cccaggggta gacaaaggag gactgaggta atcaatttgc acctttaaaa tttttttctt
     2041 ttattttctt tagtggtgac ttccttccca attatctttc ttcatccatc ccagtcctct
     2101 gccctgacgt gtgtaactct tgggtacttg agcagatgga atattccaga ggtgggaggt
     2161 gggaggggag gggagaagtc ccaaacaaag tgttcttgct ctgacccata ttaatcttgt
     2221 atgcttggat tatttaattt tttcttttgc acatttttct tgtattaagg ttgttcttcc
     2281 caaaaagctg gatttagtaa cccagccacc agcatcgtct ggaaatagag gctaatgggg
     2341 aggcccccat gagacaaaga tccctccctc cctctaaccc tatgcctaag acctctttag
     2401 tttgggagga tccccctcac tctcctggag caagtatacc agtggagtgg aagggagggg
     2461 cacaggcctt tagacagggc ttctcctgtg tagctactga ccctgtttcc tacccacctc
     2521 ctaaatggtg cgacccaact tcatttgttt acttgaaaat tcacctcaga gttgaatgaa
     2581 cctctgaggt ggctgtgttt tctcctgagc ttgagatggg gggctgtggt ccttccttct
     2641 cctgaggaga aagtccttgc tctgatgacc cctaagttgc agaggaggtt ggagttagtg
     2701 tcgtgtatcg ggatagtcat gaatccctgc ctttggcctt tcttcttcct tctgccatag
     2761 ctggatcatg tatatttcac ttccaaagga gagaatggca aaaagttctg ttgttttttt
     2821 aatagtctgt attttaagta ggtcagtctt aattggtttt aggaggacaa actggatgtg
     2881 agtgggatac tgtgaggaag accagaaaga cgaacaagtt tctgctcaca gggctgaact
     2941 cagtccttat tttctctgct tgtattctgg gccaccactt gggaccaact ctcacttctg
     3001 gaacctttat gaagtaaatc agctgggtct gattgttccc agcctgaagg gagcaaggcc
     3061 tgatggagtc tgctgctctc tctgttcctt gctcccaagc aaaaagcatc ctgccttctc
     3121 taactcactg ttacccacaa tgaaccctgt tggcatctcc cttctaaaga tccttgtacc
     3181 tagcttgcat ttccctttct ccctctttcc ccctcccacc tctctccccc ctcctcctct
     3241 cttccctccc tctctctccc cctccctctc tccctccctc cttcttgaat aaagacagtt
     3301 cagtacctca gaggctgacc tgttttcagg ggttacacag tacactaaaa ccaagctctg
     3361 ggagctgggt acagtgtcag ctgggcagac cacctgtgga ggtggcagca cagtgccctg
     3421 ctgtggtgat cccccacacc cttagccgct ctctagaaca gcactgttcc tcctgttcca
     3481 gcagatctct ctgtgcccca catttgcaga tctgaagttg aggttcttgc tgctggcctc
     3541 tgcctttccg tctgccgtct ctcctttagt tttgagttcc tgctccagat tcctcttcag
     3601 ggcaggcagt taatactgaa aagttcaacc aacattggac cacgctggcg agtgccttcc
     3661 gggaaggcaa ggtgctggcc cttttgtttt taacctgact gaaactgctc ctagttcaaa
     3721 gaaaagtcct ctatgaagcc atcatcgtcc ttatctgaag agtagacccc tgaacctctc
     3781 aagtgacagt taggaccctg gccctggagc cagatcctca gcatgagaca caaatgtcct
     3841 gctttcctct gcccgttttc cattatctct ggcttcagag cagatcctgt gccacatgga
     3901 agaggttggt tatctatcta gctgctctac tctaggtgtc cctcacagtc ggctcctggc
     3961 cgactgactt cagtttccag ccctccccag tgatcatggc cctggatgtt ggttgtagcc
     4021 ttttggtatt actgtatgag ttccagcttg cttggtaccg ttgttacctg ggtctgtgca
     4081 cacaagtgct tccgaggagc aggtattggt agcctggttt ggaagacctt ttggtgtccc
     4141 ctttacccgg gaccttgtat ctaccacttc ccctttctgc tgcccctggg agtcatcccc
     4201 agtagcctat gttctgaagc taactgtggg ctagagctgc agtgggattt tagctgaggg
     4261 agaggaaaag acggtgcttc tgcgtggagt ttctttcttt gaaaccaagc cggtacaaag
     4321 acacacttcc cacacagagg aagtgtgttt ctgtctgcct gcagagctag cagctcacag
     4381 ttctacacgt cctggaggcc tctgcactct ttattcagac cccagctctt ctcttccagg
     4441 ctcactcatt ttggtatcca tcctcttggg tatttttcag gcttagattc taacttctca
     4501 aaggaaaaaa acccaaactt ctccaggtcc ctgcagatcc aggacggaga caggatagtt
     4561 agtgacaagc ttccctagca ggctggggaa gtgtgcaagg ctaggtgcac tgaactatag
     4621 attctgagca gtggcagctt caagccgcac ttccctgaga ggtggtaaga gacaggcttc
     4681 ctggcacatt ctagaccagt tttgtccagt atattttttt tttgttttat cttttgtatt
     4741 cttttgttaa gccaacaaac tgagaatttg cccctgtaag gatccatgtg gtagatacta
     4801 gctgctcttt ggccaaaggc cttcatagct gactcaatct cccagtctat cccctagtcc
     4861 caccccagga tgcacagcaa gggaagaagc taaggtcaac gccaacaaat ctgagtgaaa
     4921 acttgttttc cttctgagag agcatcttgt ctgaagcctg aactatgtgc aggaccaaag
     4981 ctggctgtga gaaaagcagc cagaaaccgg ggcgccctat taccagaggg gagtgctctt
     5041 gtgaccgtgt cttcaagggc ttaggcttac ctacctgctt gtaggccagc ctgacttctg
     5101 atgctcacac tagcacacaa agctgatgat gcccactcac cctgcactcc tgtggctctg
     5161 acgttaaggt ttctgtttag agaaaagaac tgtgtagcat gtgcagggaa ctgtgaagga
     5221 agactgagac cgcctggaaa cctgtcaggg gctcacacca cgaactctca gaagttgggc
     5281 aggggtgctg gctttgttag ccggcttttt tgggaaatgc tttttttgac ctgttatata
     5341 aatgaagtgg gtatgaggtc tcagctaccc agcagatgga acatcgccca gggacagctt
     5401 ggggtttcca ggtaagaacc ctagaaaggt ggatttaatc ctcacaggtt ttgttttcca
     5461 aattcatttg cttttatttt tctaagaact gtaaactcta ttttttcatg ttctcagggc
     5521 ccctgggtag acaaacaaag cttgatttca gagcagaaat aggccaagaa accatggcgt
     5581 tgcgtgtgct gagtccagac aaatgatatt tatatacaca tccaaatttg aagagaaaat
     5641 gtatttcttt aggtttcaaa cactgtaata gatacaaagc aaaaataaaa acctgttgca
     5701 aagttctaaa t
//
