LOCUS       NM_008467               3726 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus karyopherin subunit alpha 4 (Kpna4), mRNA.
ACCESSION   NM_008467
VERSION     NM_008467.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3726)
  AUTHORS   Sakurai,K., Morita,M., Aomine,Y., Matsumoto,M., Moriyama,T.,
            Kasahara,E., Sekiyama,A., Otani,M., Oshima,R., Loveland,K.L.,
            Yamada,M., Yoneda,Y., Oka,M., Hikida,T. and Miyamoto,Y.
  TITLE     Importin alpha4 deficiency induces psychiatric disorder-related
            behavioral deficits and neuroinflammation in mice
  JOURNAL   Transl Psychiatry 14 (1), 426 (2024)
   PUBMED   39379355
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3726)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3726)
  AUTHORS   Empitu,M.A., Kikyo,M., Shirata,N., Yamada,H., Makino,S.I.,
            Kadariswantiningsih,I.N., Aizawa,M., Patrakka,J., Nishimori,K. and
            Asanuma,K.
  TITLE     Inhibition of Importin- alpha -Mediated Nuclear Localization of
            Dendrin Attenuates Podocyte Loss and Glomerulosclerosis
  JOURNAL   J Am Soc Nephrol 34 (7), 1222-1239 (2023)
   PUBMED   37134307
  REMARK    GeneRIF: Inhibition of Importin- alpha -Mediated Nuclear
            Localization of Dendrin Attenuates Podocyte Loss and
            Glomerulosclerosis.
REFERENCE   4  (bases 1 to 3726)
  AUTHORS   Miyamoto,Y., Sasaki,M., Miyata,H., Monobe,Y., Nagai,M., Otani,M.,
            Whiley,P.A.F., Morohoshi,A., Oki,S., Matsuda,J., Akagi,K.I.,
            Adachi,J., Okabe,M., Ikawa,M., Yoneda,Y., Loveland,K.L. and Oka,M.
  TITLE     Genetic loss of importin alpha4 causes abnormal sperm morphology
            and impacts on male fertility in mouse
  JOURNAL   FASEB J 34 (12), 16224-16242 (2020)
   PUBMED   33058343
REFERENCE   5  (bases 1 to 3726)
  AUTHORS   Marvaldi,L., Panayotis,N., Alber,S., Dagan,S.Y., Okladnikov,N.,
            Koppel,I., Di Pizio,A., Song,D.A., Tzur,Y., Terenzio,M., Rishal,I.,
            Gordon,D., Rother,F., Hartmann,E., Bader,M. and Fainzilber,M.
  TITLE     Importin alpha3 regulates chronic pain pathways in peripheral
            sensory neurons
  JOURNAL   Science 369 (6505), 842-846 (2020)
   PUBMED   32792398
  REMARK    GeneRIF: Importin alpha3 regulates chronic pain pathways in
            peripheral sensory neurons.
REFERENCE   6  (bases 1 to 3726)
  AUTHORS   Theiss,A.L., Jenkins,A.K., Okoro,N.I., Klapproth,J.M., Merlin,D.
            and Sitaraman,S.V.
  TITLE     Prohibitin inhibits tumor necrosis factor alpha-induced nuclear
            factor-kappa B nuclear translocation via the novel mechanism of
            decreasing importin alpha3 expression
  JOURNAL   Mol Biol Cell 20 (20), 4412-4423 (2009)
   PUBMED   19710421
  REMARK    GeneRIF: Expression of importin alpha3, a protein involved in
            p50/p65 nuclear import, was decreased in colonic mucosa cells of
            transgenic mice overexpressing human prohibitin.
REFERENCE   7  (bases 1 to 3726)
  AUTHORS   Hogarth,C.A., Jans,D.A. and Loveland,K.L.
  TITLE     Subcellular distribution of importins correlates with germ cell
            maturation
  JOURNAL   Dev Dyn 236 (8), 2311-2320 (2007)
   PUBMED   17654710
  REMARK    GeneRIF: In postnatal testes, importin alpha3 and alpha4 in
            spermatocytes, spermatids, and Sertoli cells display cytoplasmic
            and nuclear localization, respectively.
REFERENCE   8  (bases 1 to 3726)
  AUTHORS   Sakakida,Y., Miyamoto,Y., Nagoshi,E., Akashi,M., Nakamura,T.J.,
            Mamine,T., Kasahara,M., Minami,Y., Yoneda,Y. and Takumi,T.
  TITLE     Importin alpha/beta mediates nuclear transport of a mammalian
            circadian clock component, mCRY2, together with mPER2, through a
            bipartite nuclear localization signal
  JOURNAL   J Biol Chem 280 (14), 13272-13278 (2005)
   PUBMED   15689618
REFERENCE   9  (bases 1 to 3726)
  AUTHORS   Kamei,Y., Yuba,S., Nakayama,T. and Yoneda,Y.
  TITLE     Three distinct classes of the alpha-subunit of the nuclear
            pore-targeting complex (importin-alpha) are differentially
            expressed in adult mouse tissues
  JOURNAL   J Histochem Cytochem 47 (3), 363-372 (1999)
   PUBMED   10026238
REFERENCE   10 (bases 1 to 3726)
  AUTHORS   Tsuji,L., Takumi,T., Imamoto,N. and Yoneda,Y.
  TITLE     Identification of novel homologues of mouse importin alpha, the
            alpha subunit of the nuclear pore-targeting complex, and their
            tissue-specific expression
  JOURNAL   FEBS Lett 416 (1), 30-34 (1997)
   PUBMED   9369227
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC119847.12.
            
            On Apr 27, 2007 this sequence version replaced NM_008467.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052162.1, AK147920.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-361               AC119847.12        136375-136735       c
            362-406             AC119847.12        111847-111891       c
            407-496             AC119847.12        110984-111073       c
            497-526             AC119847.12        110845-110874       c
            527-579             AC119847.12        110695-110747       c
            580-675             AC119847.12        105163-105258       c
            676-761             AC119847.12        104296-104381       c
            762-848             AC119847.12        102453-102539       c
            849-1018            AC119847.12        99551-99720         c
            1019-1063           AC119847.12        99419-99463         c
            1064-1195           AC119847.12        97100-97231         c
            1196-1324           AC119847.12        95330-95458         c
            1325-1429           AC119847.12        93693-93797         c
            1430-1501           AC119847.12        90802-90873         c
            1502-1664           AC119847.12        89020-89182         c
            1665-1759           AC119847.12        86393-86487         c
            1760-3726           AC119847.12        81864-83830         c
FEATURES             Location/Qualifiers
     source          1..3726
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 32.18 cM"
     gene            1..3726
                     /gene="Kpna4"
                     /gene_synonym="1110058D08Rik; IPOA3; qip1"
                     /note="karyopherin subunit alpha 4"
                     /db_xref="GeneID:16649"
                     /db_xref="MGI:MGI:1100848"
     exon            1..361
                     /gene="Kpna4"
                     /gene_synonym="1110058D08Rik; IPOA3; qip1"
                     /inference="alignment:Splign:2.1.0"
     exon            362..406
                     /gene="Kpna4"
                     /gene_synonym="1110058D08Rik; IPOA3; qip1"
                     /inference="alignment:Splign:2.1.0"
     exon            407..496
                     /gene="Kpna4"
                     /gene_synonym="1110058D08Rik; IPOA3; qip1"
                     /inference="alignment:Splign:2.1.0"
     exon            497..526
                     /gene="Kpna4"
                     /gene_synonym="1110058D08Rik; IPOA3; qip1"
                     /inference="alignment:Splign:2.1.0"
     exon            527..579
                     /gene="Kpna4"
                     /gene_synonym="1110058D08Rik; IPOA3; qip1"
                     /inference="alignment:Splign:2.1.0"
     exon            580..675
                     /gene="Kpna4"
                     /gene_synonym="1110058D08Rik; IPOA3; qip1"
                     /inference="alignment:Splign:2.1.0"
     exon            676..761
                     /gene="Kpna4"
                     /gene_synonym="1110058D08Rik; IPOA3; qip1"
                     /inference="alignment:Splign:2.1.0"
     exon            762..848
                     /gene="Kpna4"
                     /gene_synonym="1110058D08Rik; IPOA3; qip1"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1018
                     /gene="Kpna4"
                     /gene_synonym="1110058D08Rik; IPOA3; qip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1063
                     /gene="Kpna4"
                     /gene_synonym="1110058D08Rik; IPOA3; qip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1195
                     /gene="Kpna4"
                     /gene_synonym="1110058D08Rik; IPOA3; qip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1324
                     /gene="Kpna4"
                     /gene_synonym="1110058D08Rik; IPOA3; qip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1429
                     /gene="Kpna4"
                     /gene_synonym="1110058D08Rik; IPOA3; qip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1501
                     /gene="Kpna4"
                     /gene_synonym="1110058D08Rik; IPOA3; qip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1664
                     /gene="Kpna4"
                     /gene_synonym="1110058D08Rik; IPOA3; qip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1759
                     /gene="Kpna4"
                     /gene_synonym="1110058D08Rik; IPOA3; qip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..3726
                     /gene="Kpna4"
                     /gene_synonym="1110058D08Rik; IPOA3; qip1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3696..3701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kpna4"
                     /gene_synonym="1110058D08Rik; IPOA3; qip1"
                     /note="hexamer: ATTAAA"
     polyA_site      3726
                     /gene="Kpna4"
                     /gene_synonym="1110058D08Rik; IPOA3; qip1"
                     /note="major polyA site"
ORIGIN      
        1 aaagccgggc cctcagatcg aggctgcctc cccctctcag ccggcagcac attccgccgc
       61 cgttgccgcc gccgccgctg gccccgcagt cgtcttcgcc agagctgctg tggtacccga
      121 gctcagggca ggagaggcca gccaggaagc ggaggcccgg cgggcgagag gaagcgagcg
      181 gacgggcggg cgacgcaggc ggcggccggc ttcctgggag cgtctgtgcg gcgcggtggt
      241 tggggcggat cccgcggggc ccgggcgggt ggggagagtc gccggcccgg ccatggcgga
      301 caacgagaaa ttggacaacc aacggctcaa gaattttaag aacaaaggcc gtgacttgga
      361 gactatgaga agacaacgaa atgaagttgt agttgaatta aggaagaata aaagagatga
      421 acatctctta aagagaagga atgtaccaca agaagatatc tgtgaagact ccgatataga
      481 tggtgattat agagtgcaaa atacctctct agaagctatt gttcaaaatg cttcaagtga
      541 taaccaagga attcaattaa gtgcagttca agctgctagg aagcttttat ccagtgatcg
      601 aaatccacca attgatgact taataaaatc tggaatattg cctattttag ttcattgtct
      661 tgaaagagat gacaatcctt ctttacagtt tgaagctgcg tgggctttga caaacattgc
      721 atctggaacg tctgaacaaa cgcaagcagt ggttcagtcc aatgctgtgc cacttttctt
      781 gaggcttctg cattcacccc atcagaatgt ctgtgaacag gcagtatggg cgttgggaaa
      841 catcataggt gatggacctc agtgtagaga ttatgtgata agtcttggag ttgtaaaacc
      901 tctgctttca ttcataagtc catctattcc tataacattc ttaagaaatg ttacctgggt
      961 tatggtcaat ttatgtcgcc acaaagaccc accaccacca atggagacaa ttcaggagat
     1021 tcttccagct ctttgtgtat taattcatca cacagatgta aatatcctgg tagatactgt
     1081 ctgggccctg tcttacctta cggatgctgg caatgaacag atacagatgg taatagactc
     1141 tggcatagtt cctcacttgg ttccgctact cagccaccag gaagttaaag ttcagactgc
     1201 tgcactgcga gctgtgggca acattgtcac tggaactgat gagcaaacac aagtagtttt
     1261 aaactgtgat gctctctcac acttcccagc actcctcact catcccaaag agaaaattaa
     1321 taaagaagca gtgtggttcc tctccaacat cactgcagga aatcaacagc aggttcaggc
     1381 agtaattgat gccaatcttg taccaatgat aatacacctt ttggataagg gagattttgg
     1441 cactcagaaa gaagctgcct gggccataag taacttaaca atcagcggaa ggaaagacca
     1501 agtggcctat cttatccaac aaaatgttat tccacctttt tgcaatttgc tgactgtaaa
     1561 agatgcacaa gttgtgcaag tagtacttga tggactaagt aatatattaa aaatggctga
     1621 agatcaagca gaaaccatag ccaatctcat agaagaatgt ggtggactgg agaaaattga
     1681 acaacttcag aatcatgaaa atgaggacat ctacaaattg gcctatgaga tcattgacca
     1741 gttcttctct tcagatgata ttgatgaaga tcctagcctt gttccagagt cagttcaagg
     1801 tggaacattt ggtttcaatt catcgaccaa tgtaccaaca gaggggttcc agttttagga
     1861 agatgttgtg gaggttaggt acaatgcagc accgagaaac atatatatat atacacatat
     1921 atataaaaag ggttgatcca tcaagcttgg ctcatgggat ctgctgctgc attaaatcgg
     1981 gagagaaaat gtgaagattt catttggaac cacagaaaat gcccaaatga ggtcaaggtg
     2041 gcgagtgggt gcgagtgaga atgagtggca atgtaaggaa aacttgacac gaatgcttat
     2101 ttaggttgag aggaaagggc tacaggtcac aggtcttcgg tgcctgagac ggagcattga
     2161 cttactctat caattgagaa gtgaaatgcc atcatcatca agccttgtaa gcataaaagc
     2221 gatgcccata taagtcaagg aaatgagccc aggcctcgct gtgaagcagt gtgtgaatgg
     2281 acagtgttga atgggtgtct ggctccgtgc tagagagcca ggttcatctt tcaaatctag
     2341 ggctcttcgc gcatgaagca gactcctagt cctggggtga ctgtgtaacg agagtatggt
     2401 tgtggtgctg tatgtggacg catgcaagct tgatttgcct tcagggggct gataacagac
     2461 ctagtagatc atcaaagtga gatcgatcac aagtgttaat gtacactgga catgaaaaca
     2521 aagaccggtt tagcagcaga cattggttta ctctgcagcc tgtgttttct attctccctc
     2581 taccttatcc cccaccccca ccccacccca cccctttttt atttagtttt atttacttta
     2641 cctagtatgg cttttttagt tgcttctcaa gtcagaaaac ttcaggaagg tttccctgtg
     2701 catttgcacc agatgagtgt ttgatgctat gaaaagcttt ccatatcatc aaaactaatt
     2761 tgtgtagatt tttgcatgaa aaaaatcata aatttccctc acaatagact gtgttgcagt
     2821 acacaagttg ccataatagt ataaaatgtg cttttaaagc cattcttttc attttcagag
     2881 ataacataaa gatctttgca tgaagtaaat ctacagcata gttcattttt agattttgtt
     2941 gagtcctgta aagaagaaaa gtttcagttg tgatagaata ccgtgctgtg tttaaatgtt
     3001 aacttgtttt caaactttgt tttctatgaa aatgatatgg aaacttctaa aatggaattt
     3061 ggtgcatatg tactgctgaa taaagaccga tgaagaggtt tgagtagatg tacaaatcaa
     3121 gtaatggttt gaacaccttt aataatatgc ctaatctgtt taattgtttt agaatctttt
     3181 tatcttagat gtaggcagcc atgaacaatc tattttgagc cactttaggg agaaaaactt
     3241 tgtattttta aaacttgcat aaaaattatg caagtggttt ttataaattg gaataatacc
     3301 tcagttttga ggttatgcac actaaattaa atatgtcata aattaatttg tacaaaaaga
     3361 actctttata aggtggctca ttgtaggaaa tcctgtgcct tcccctttga gcacaagtgt
     3421 tgcatgaaca acagtttgct ataagaaaca taccaggtta gccaccatta gcatctatat
     3481 ctactttgtg tttaaaaatc aactggtaat tctgaaacac tgtagaatgg ataaaaatta
     3541 ttttgtgatc ataactcttt gttgaactag agtatttttg cagcattcct tgtcatcaaa
     3601 aacatggtta aactttaaaa ctagaagcag cagaaaacta gcttgtaaaa tttattcaag
     3661 tagagtacag gctaggctgt cttggggaaa taaacattaa aacttaaagc aatgttttac
     3721 aagggg
//
